Amino acid dipepetide frequency for Nitrococcus mobilis Nb-231

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.265AlaAla: 14.265 ± 0.173
1.292AlaCys: 1.292 ± 0.037
5.771AlaAsp: 5.771 ± 0.081
7.561AlaGlu: 7.561 ± 0.114
3.707AlaPhe: 3.707 ± 0.065
9.488AlaGly: 9.488 ± 0.108
2.556AlaHis: 2.556 ± 0.049
5.409AlaIle: 5.409 ± 0.084
3.087AlaLys: 3.087 ± 0.064
13.722AlaLeu: 13.722 ± 0.158
2.536AlaMet: 2.536 ± 0.054
2.781AlaAsn: 2.781 ± 0.074
4.586AlaPro: 4.586 ± 0.072
4.666AlaGln: 4.666 ± 0.08
9.006AlaArg: 9.006 ± 0.116
5.16AlaSer: 5.16 ± 0.073
5.282AlaThr: 5.282 ± 0.077
8.466AlaVal: 8.466 ± 0.104
1.591AlaTrp: 1.591 ± 0.041
2.641AlaTyr: 2.641 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.115CysAla: 1.115 ± 0.033
0.165CysCys: 0.165 ± 0.013
0.523CysAsp: 0.523 ± 0.026
0.634CysGlu: 0.634 ± 0.027
0.403CysPhe: 0.403 ± 0.02
1.021CysGly: 1.021 ± 0.031
0.325CysHis: 0.325 ± 0.023
0.447CysIle: 0.447 ± 0.022
0.254CysLys: 0.254 ± 0.014
1.134CysLeu: 1.134 ± 0.032
0.198CysMet: 0.198 ± 0.013
0.26CysAsn: 0.26 ± 0.016
0.57CysPro: 0.57 ± 0.024
0.386CysGln: 0.386 ± 0.02
0.977CysArg: 0.977 ± 0.033
0.598CysSer: 0.598 ± 0.022
0.507CysThr: 0.507 ± 0.021
0.748CysVal: 0.748 ± 0.025
0.151CysTrp: 0.151 ± 0.011
0.32CysTyr: 0.32 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.529AspAla: 5.529 ± 0.071
0.569AspCys: 0.569 ± 0.028
2.64AspAsp: 2.64 ± 0.064
3.68AspGlu: 3.68 ± 0.069
2.026AspPhe: 2.026 ± 0.048
4.034AspGly: 4.034 ± 0.062
1.226AspHis: 1.226 ± 0.035
2.479AspIle: 2.479 ± 0.051
1.454AspLys: 1.454 ± 0.042
5.484AspLeu: 5.484 ± 0.075
0.919AspMet: 0.919 ± 0.032
1.342AspAsn: 1.342 ± 0.036
3.119AspPro: 3.119 ± 0.058
1.851AspGln: 1.851 ± 0.052
4.093AspArg: 4.093 ± 0.057
2.535AspSer: 2.535 ± 0.049
2.56AspThr: 2.56 ± 0.064
3.362AspVal: 3.362 ± 0.061
1.006AspTrp: 1.006 ± 0.033
1.752AspTyr: 1.752 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
7.275GluAla: 7.275 ± 0.114
0.579GluCys: 0.579 ± 0.028
2.55GluAsp: 2.55 ± 0.052
3.537GluGlu: 3.537 ± 0.081
1.95GluPhe: 1.95 ± 0.043
3.974GluGly: 3.974 ± 0.068
1.829GluHis: 1.829 ± 0.042
3.378GluIle: 3.378 ± 0.062
1.743GluLys: 1.743 ± 0.057
7.568GluLeu: 7.568 ± 0.102
1.212GluMet: 1.212 ± 0.037
1.442GluAsn: 1.442 ± 0.041
3.146GluPro: 3.146 ± 0.061
3.538GluGln: 3.538 ± 0.066
6.785GluArg: 6.785 ± 0.091
2.869GluSer: 2.869 ± 0.056
2.942GluThr: 2.942 ± 0.053
4.318GluVal: 4.318 ± 0.073
0.815GluTrp: 0.815 ± 0.028
1.351GluTyr: 1.351 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.648PheAla: 3.648 ± 0.066
0.406PheCys: 0.406 ± 0.02
2.292PheAsp: 2.292 ± 0.055
2.26PheGlu: 2.26 ± 0.05
1.28PhePhe: 1.28 ± 0.039
3.064PheGly: 3.064 ± 0.062
0.833PheHis: 0.833 ± 0.028
1.656PheIle: 1.656 ± 0.039
0.975PheLys: 0.975 ± 0.033
3.367PheLeu: 3.367 ± 0.063
0.72PheMet: 0.72 ± 0.025
1.061PheAsn: 1.061 ± 0.032
1.457PhePro: 1.457 ± 0.037
1.223PheGln: 1.223 ± 0.036
2.329PheArg: 2.329 ± 0.055
1.942PheSer: 1.942 ± 0.041
1.885PheThr: 1.885 ± 0.052
2.367PheVal: 2.367 ± 0.058
0.461PheTrp: 0.461 ± 0.022
0.967PheTyr: 0.967 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
7.839GlyAla: 7.839 ± 0.103
1.019GlyCys: 1.019 ± 0.033
3.841GlyAsp: 3.841 ± 0.074
5.025GlyGlu: 5.025 ± 0.074
3.105GlyPhe: 3.105 ± 0.056
6.495GlyGly: 6.495 ± 0.097
1.943GlyHis: 1.943 ± 0.05
4.08GlyIle: 4.08 ± 0.07
2.821GlyLys: 2.821 ± 0.065
8.668GlyLeu: 8.668 ± 0.095
1.945GlyMet: 1.945 ± 0.049
2.182GlyAsn: 2.182 ± 0.079
2.835GlyPro: 2.835 ± 0.061
3.035GlyGln: 3.035 ± 0.063
6.376GlyArg: 6.376 ± 0.092
4.184GlySer: 4.184 ± 0.072
3.858GlyThr: 3.858 ± 0.068
6.055GlyVal: 6.055 ± 0.089
1.422GlyTrp: 1.422 ± 0.036
2.516GlyTyr: 2.516 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.44HisAla: 2.44 ± 0.048
0.368HisCys: 0.368 ± 0.017
1.24HisAsp: 1.24 ± 0.037
1.357HisGlu: 1.357 ± 0.037
0.929HisPhe: 0.929 ± 0.03
2.141HisGly: 2.141 ± 0.052
0.729HisHis: 0.729 ± 0.028
1.14HisIle: 1.14 ± 0.032
0.651HisLys: 0.651 ± 0.025
2.497HisLeu: 2.497 ± 0.052
0.462HisMet: 0.462 ± 0.021
0.681HisAsn: 0.681 ± 0.029
1.582HisPro: 1.582 ± 0.041
0.854HisGln: 0.854 ± 0.027
2.218HisArg: 2.218 ± 0.05
1.247HisSer: 1.247 ± 0.038
1.186HisThr: 1.186 ± 0.035
1.504HisVal: 1.504 ± 0.041
0.509HisTrp: 0.509 ± 0.021
0.872HisTyr: 0.872 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.74IleAla: 5.74 ± 0.072
0.503IleCys: 0.503 ± 0.019
3.394IleAsp: 3.394 ± 0.054
3.788IleGlu: 3.788 ± 0.064
1.455IlePhe: 1.455 ± 0.038
4.302IleGly: 4.302 ± 0.074
1.23IleHis: 1.23 ± 0.034
2.179IleIle: 2.179 ± 0.055
1.473IleLys: 1.473 ± 0.043
4.243IleLeu: 4.243 ± 0.076
0.856IleMet: 0.856 ± 0.031
1.526IleAsn: 1.526 ± 0.035
2.411IlePro: 2.411 ± 0.053
1.534IleGln: 1.534 ± 0.042
3.811IleArg: 3.811 ± 0.062
2.435IleSer: 2.435 ± 0.05
2.693IleThr: 2.693 ± 0.056
3.547IleVal: 3.547 ± 0.064
0.575IleTrp: 0.575 ± 0.024
1.175IleTyr: 1.175 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.351LysAla: 3.351 ± 0.068
0.216LysCys: 0.216 ± 0.014
1.264LysAsp: 1.264 ± 0.038
1.587LysGlu: 1.587 ± 0.046
0.675LysPhe: 0.675 ± 0.03
2.127LysGly: 2.127 ± 0.056
0.711LysHis: 0.711 ± 0.029
1.357LysIle: 1.357 ± 0.043
1.008LysLys: 1.008 ± 0.044
3.137LysLeu: 3.137 ± 0.067
0.557LysMet: 0.557 ± 0.022
0.729LysAsn: 0.729 ± 0.031
1.645LysPro: 1.645 ± 0.048
1.206LysGln: 1.206 ± 0.037
2.637LysArg: 2.637 ± 0.06
1.511LysSer: 1.511 ± 0.046
1.616LysThr: 1.616 ± 0.043
1.978LysVal: 1.978 ± 0.058
0.319LysTrp: 0.319 ± 0.02
0.661LysTyr: 0.661 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
14.016LeuAla: 14.016 ± 0.15
1.165LeuCys: 1.165 ± 0.035
6.198LeuAsp: 6.198 ± 0.073
7.204LeuGlu: 7.204 ± 0.091
3.633LeuPhe: 3.633 ± 0.067
8.693LeuGly: 8.693 ± 0.111
2.658LeuHis: 2.658 ± 0.052
5.498LeuIle: 5.498 ± 0.084
3.084LeuLys: 3.084 ± 0.057
12.149LeuLeu: 12.149 ± 0.15
2.14LeuMet: 2.14 ± 0.05
2.831LeuAsn: 2.831 ± 0.055
6.035LeuPro: 6.035 ± 0.081
4.384LeuGln: 4.384 ± 0.082
9.161LeuArg: 9.161 ± 0.104
6.239LeuSer: 6.239 ± 0.094
5.767LeuThr: 5.767 ± 0.069
7.49LeuVal: 7.49 ± 0.1
1.362LeuTrp: 1.362 ± 0.041
2.631LeuTyr: 2.631 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.521MetAla: 2.521 ± 0.05
0.138MetCys: 0.138 ± 0.011
1.08MetAsp: 1.08 ± 0.04
1.145MetGlu: 1.145 ± 0.033
0.516MetPhe: 0.516 ± 0.022
1.489MetGly: 1.489 ± 0.037
0.472MetHis: 0.472 ± 0.023
1.004MetIle: 1.004 ± 0.032
0.709MetLys: 0.709 ± 0.026
2.381MetLeu: 2.381 ± 0.049
0.414MetMet: 0.414 ± 0.02
0.647MetAsn: 0.647 ± 0.026
1.117MetPro: 1.117 ± 0.036
0.921MetGln: 0.921 ± 0.032
1.668MetArg: 1.668 ± 0.038
1.286MetSer: 1.286 ± 0.04
1.174MetThr: 1.174 ± 0.032
1.426MetVal: 1.426 ± 0.04
0.184MetTrp: 0.184 ± 0.015
0.325MetTyr: 0.325 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.022AsnAla: 3.022 ± 0.079
0.283AsnCys: 0.283 ± 0.019
1.248AsnAsp: 1.248 ± 0.037
1.442AsnGlu: 1.442 ± 0.042
0.858AsnPhe: 0.858 ± 0.026
2.162AsnGly: 2.162 ± 0.07
0.652AsnHis: 0.652 ± 0.026
1.368AsnIle: 1.368 ± 0.041
0.713AsnLys: 0.713 ± 0.03
2.75AsnLeu: 2.75 ± 0.048
0.543AsnMet: 0.543 ± 0.023
0.769AsnAsn: 0.769 ± 0.03
1.792AsnPro: 1.792 ± 0.043
0.926AsnGln: 0.926 ± 0.028
2.301AsnArg: 2.301 ± 0.049
1.196AsnSer: 1.196 ± 0.04
1.453AsnThr: 1.453 ± 0.04
1.69AsnVal: 1.69 ± 0.044
0.396AsnTrp: 0.396 ± 0.019
0.691AsnTyr: 0.691 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
5.479ProAla: 5.479 ± 0.079
0.401ProCys: 0.401 ± 0.019
2.843ProAsp: 2.843 ± 0.058
3.648ProGlu: 3.648 ± 0.072
1.691ProPhe: 1.691 ± 0.049
4.251ProGly: 4.251 ± 0.063
1.119ProHis: 1.119 ± 0.035
2.309ProIle: 2.309 ± 0.056
1.367ProLys: 1.367 ± 0.041
5.17ProLeu: 5.17 ± 0.078
1.133ProMet: 1.133 ± 0.035
1.368ProAsn: 1.368 ± 0.035
2.612ProPro: 2.612 ± 0.066
2.104ProGln: 2.104 ± 0.048
3.431ProArg: 3.431 ± 0.061
2.64ProSer: 2.64 ± 0.053
2.41ProThr: 2.41 ± 0.05
3.871ProVal: 3.871 ± 0.069
0.782ProTrp: 0.782 ± 0.031
1.21ProTyr: 1.21 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.658GlnAla: 5.658 ± 0.088
0.351GlnCys: 0.351 ± 0.018
1.642GlnAsp: 1.642 ± 0.043
2.092GlnGlu: 2.092 ± 0.046
1.158GlnPhe: 1.158 ± 0.036
3.016GlnGly: 3.016 ± 0.051
1.03GlnHis: 1.03 ± 0.031
1.906GlnIle: 1.906 ± 0.049
1.071GlnLys: 1.071 ± 0.038
4.264GlnLeu: 4.264 ± 0.069
0.772GlnMet: 0.772 ± 0.028
0.864GlnAsn: 0.864 ± 0.029
2.271GlnPro: 2.271 ± 0.05
2.005GlnGln: 2.005 ± 0.056
4.177GlnArg: 4.177 ± 0.069
1.999GlnSer: 1.999 ± 0.042
1.955GlnThr: 1.955 ± 0.041
2.805GlnVal: 2.805 ± 0.054
0.628GlnTrp: 0.628 ± 0.028
0.867GlnTyr: 0.867 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
8.441ArgAla: 8.441 ± 0.109
0.976ArgCys: 0.976 ± 0.031
3.842ArgAsp: 3.842 ± 0.062
5.237ArgGlu: 5.237 ± 0.089
3.395ArgPhe: 3.395 ± 0.059
5.403ArgGly: 5.403 ± 0.085
2.298ArgHis: 2.298 ± 0.05
4.606ArgIle: 4.606 ± 0.063
2.336ArgLys: 2.336 ± 0.057
10.701ArgLeu: 10.701 ± 0.114
1.922ArgMet: 1.922 ± 0.041
2.077ArgAsn: 2.077 ± 0.041
3.791ArgPro: 3.791 ± 0.063
3.677ArgGln: 3.677 ± 0.067
7.852ArgArg: 7.852 ± 0.111
4.222ArgSer: 4.222 ± 0.076
3.621ArgThr: 3.621 ± 0.053
5.678ArgVal: 5.678 ± 0.085
1.421ArgTrp: 1.421 ± 0.039
2.644ArgTyr: 2.644 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
5.764SerAla: 5.764 ± 0.078
0.529SerCys: 0.529 ± 0.023
2.619SerAsp: 2.619 ± 0.061
3.097SerGlu: 3.097 ± 0.056
1.787SerPhe: 1.787 ± 0.042
4.87SerGly: 4.87 ± 0.073
1.12SerHis: 1.12 ± 0.029
2.404SerIle: 2.404 ± 0.05
1.476SerLys: 1.476 ± 0.041
5.526SerLeu: 5.526 ± 0.088
1.222SerMet: 1.222 ± 0.04
1.4SerAsn: 1.4 ± 0.043
2.474SerPro: 2.474 ± 0.06
1.807SerGln: 1.807 ± 0.047
3.972SerArg: 3.972 ± 0.063
2.792SerSer: 2.792 ± 0.067
2.536SerThr: 2.536 ± 0.057
3.655SerVal: 3.655 ± 0.063
0.754SerTrp: 0.754 ± 0.029
1.348SerTyr: 1.348 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.679ThrAla: 5.679 ± 0.079
0.422ThrCys: 0.422 ± 0.022
2.582ThrAsp: 2.582 ± 0.049
2.789ThrGlu: 2.789 ± 0.056
1.471ThrPhe: 1.471 ± 0.04
4.562ThrGly: 4.562 ± 0.07
1.221ThrHis: 1.221 ± 0.036
2.281ThrIle: 2.281 ± 0.054
1.184ThrLys: 1.184 ± 0.043
6.222ThrLeu: 6.222 ± 0.087
0.872ThrMet: 0.872 ± 0.03
1.205ThrAsn: 1.205 ± 0.037
2.919ThrPro: 2.919 ± 0.059
1.837ThrGln: 1.837 ± 0.044
3.621ThrArg: 3.621 ± 0.062
2.356ThrSer: 2.356 ± 0.05
2.475ThrThr: 2.475 ± 0.05
3.984ThrVal: 3.984 ± 0.082
0.612ThrTrp: 0.612 ± 0.021
1.126ThrTyr: 1.126 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
8.027ValAla: 8.027 ± 0.1
0.792ValCys: 0.792 ± 0.027
4.144ValAsp: 4.144 ± 0.066
4.515ValGlu: 4.515 ± 0.085
2.597ValPhe: 2.597 ± 0.053
5.086ValGly: 5.086 ± 0.074
1.604ValHis: 1.604 ± 0.035
3.65ValIle: 3.65 ± 0.062
1.942ValLys: 1.942 ± 0.048
8.089ValLeu: 8.089 ± 0.114
1.472ValMet: 1.472 ± 0.036
2.024ValAsn: 2.024 ± 0.046
3.377ValPro: 3.377 ± 0.072
2.553ValGln: 2.553 ± 0.047
5.542ValArg: 5.542 ± 0.079
3.81ValSer: 3.81 ± 0.058
3.715ValThr: 3.715 ± 0.065
5.562ValVal: 5.562 ± 0.094
0.878ValTrp: 0.878 ± 0.034
1.783ValTyr: 1.783 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.184TrpAla: 1.184 ± 0.037
0.192TrpCys: 0.192 ± 0.012
0.641TrpAsp: 0.641 ± 0.024
0.768TrpGlu: 0.768 ± 0.024
0.504TrpPhe: 0.504 ± 0.024
0.897TrpGly: 0.897 ± 0.034
0.374TrpHis: 0.374 ± 0.02
0.686TrpIle: 0.686 ± 0.025
0.332TrpLys: 0.332 ± 0.018
2.198TrpLeu: 2.198 ± 0.051
0.325TrpMet: 0.325 ± 0.018
0.404TrpAsn: 0.404 ± 0.02
0.708TrpPro: 0.708 ± 0.027
0.811TrpGln: 0.811 ± 0.028
1.484TrpArg: 1.484 ± 0.042
0.85TrpSer: 0.85 ± 0.031
0.575TrpThr: 0.575 ± 0.025
0.982TrpVal: 0.982 ± 0.033
0.258TrpTrp: 0.258 ± 0.015
0.383TrpTyr: 0.383 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.581TyrAla: 2.581 ± 0.048
0.371TyrCys: 0.371 ± 0.017
1.306TyrAsp: 1.306 ± 0.034
1.434TyrGlu: 1.434 ± 0.039
1.052TyrPhe: 1.052 ± 0.035
2.169TyrGly: 2.169 ± 0.048
0.677TyrHis: 0.677 ± 0.025
1.033TyrIle: 1.033 ± 0.031
0.612TyrLys: 0.612 ± 0.026
3.071TyrLeu: 3.071 ± 0.059
0.397TyrMet: 0.397 ± 0.018
0.661TyrAsn: 0.661 ± 0.025
1.392TyrPro: 1.392 ± 0.037
1.211TyrGln: 1.211 ± 0.033
2.698TyrArg: 2.698 ± 0.05
1.278TyrSer: 1.278 ± 0.038
1.211TyrThr: 1.211 ± 0.036
1.674TyrVal: 1.674 ± 0.039
0.434TyrTrp: 0.434 ± 0.021
0.749TyrTyr: 0.749 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3484 proteins (1019986 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski