Amino acid dipepetide frequency for Nitratireductor indicus C115

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.802AlaAla: 15.802 ± 0.143	1.045AlaCys: 1.045 ± 0.028	6.492AlaAsp: 6.492 ± 0.067	7.809AlaGlu: 7.809 ± 0.089	4.809AlaPhe: 4.809 ± 0.058	10.959AlaGly: 10.959 ± 0.102	2.17AlaHis: 2.17 ± 0.044	6.744AlaIle: 6.744 ± 0.08	3.702AlaLys: 3.702 ± 0.059	13.456AlaLeu: 13.456 ± 0.122	3.692AlaMet: 3.692 ± 0.057	2.897AlaAsn: 2.897 ± 0.046	5.066AlaPro: 5.066 ± 0.067	3.589AlaGln: 3.589 ± 0.059	8.813AlaArg: 8.813 ± 0.09	6.611AlaSer: 6.611 ± 0.08	5.544AlaThr: 5.544 ± 0.069	8.728AlaVal: 8.728 ± 0.079	1.366AlaTrp: 1.366 ± 0.03	2.554AlaTyr: 2.554 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.932CysAla: 0.932 ± 0.029	0.09CysCys: 0.09 ± 0.008	0.513CysAsp: 0.513 ± 0.021	0.446CysGlu: 0.446 ± 0.017	0.326CysPhe: 0.326 ± 0.016	0.907CysGly: 0.907 ± 0.026	0.234CysHis: 0.234 ± 0.013	0.409CysIle: 0.409 ± 0.017	0.2CysLys: 0.2 ± 0.013	0.779CysLeu: 0.779 ± 0.021	0.158CysMet: 0.158 ± 0.01	0.196CysAsn: 0.196 ± 0.013	0.434CysPro: 0.434 ± 0.018	0.229CysGln: 0.229 ± 0.015	0.631CysArg: 0.631 ± 0.022	0.451CysSer: 0.451 ± 0.017	0.392CysThr: 0.392 ± 0.017	0.59CysVal: 0.59 ± 0.022	0.112CysTrp: 0.112 ± 0.009	0.198CysTyr: 0.198 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.56AspAla: 6.56 ± 0.071	0.492AspCys: 0.492 ± 0.021	2.915AspAsp: 2.915 ± 0.057	3.72AspGlu: 3.72 ± 0.056	2.283AspPhe: 2.283 ± 0.036	4.942AspGly: 4.942 ± 0.073	1.138AspHis: 1.138 ± 0.03	3.216AspIle: 3.216 ± 0.044	1.77AspLys: 1.77 ± 0.039	5.563AspLeu: 5.563 ± 0.068	1.547AspMet: 1.547 ± 0.029	1.356AspAsn: 1.356 ± 0.031	3.196AspPro: 3.196 ± 0.052	1.485AspGln: 1.485 ± 0.033	4.15AspArg: 4.15 ± 0.056	1.956AspSer: 1.956 ± 0.04	2.614AspThr: 2.614 ± 0.042	3.845AspVal: 3.845 ± 0.055	0.897AspTrp: 0.897 ± 0.027	1.446AspTyr: 1.446 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.341GluAla: 8.341 ± 0.089	0.38GluCys: 0.38 ± 0.015	3.03GluAsp: 3.03 ± 0.045	4.118GluGlu: 4.118 ± 0.068	1.883GluPhe: 1.883 ± 0.038	4.917GluGly: 4.917 ± 0.064	1.265GluHis: 1.265 ± 0.03	3.735GluIle: 3.735 ± 0.059	2.82GluLys: 2.82 ± 0.045	5.41GluLeu: 5.41 ± 0.068	1.716GluMet: 1.716 ± 0.036	1.921GluAsn: 1.921 ± 0.034	2.792GluPro: 2.792 ± 0.052	2.074GluGln: 2.074 ± 0.044	5.379GluArg: 5.379 ± 0.076	2.372GluSer: 2.372 ± 0.038	3.974GluThr: 3.974 ± 0.055	3.912GluVal: 3.912 ± 0.052	0.713GluTrp: 0.713 ± 0.022	1.068GluTyr: 1.068 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.681PheAla: 4.681 ± 0.065	0.39PheCys: 0.39 ± 0.017	2.558PheAsp: 2.558 ± 0.049	2.344PheGlu: 2.344 ± 0.04	1.638PhePhe: 1.638 ± 0.039	3.823PheGly: 3.823 ± 0.06	0.782PheHis: 0.782 ± 0.023	1.973PheIle: 1.973 ± 0.043	1.023PheLys: 1.023 ± 0.032	3.837PheLeu: 3.837 ± 0.061	0.893PheMet: 0.893 ± 0.026	1.069PheAsn: 1.069 ± 0.027	1.688PhePro: 1.688 ± 0.037	1.048PheGln: 1.048 ± 0.027	2.401PheArg: 2.401 ± 0.046	2.618PheSer: 2.618 ± 0.043	2.0PheThr: 2.0 ± 0.042	2.892PheVal: 2.892 ± 0.043	0.585PheTrp: 0.585 ± 0.024	0.926PheTyr: 0.926 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.386GlyAla: 9.386 ± 0.099	0.822GlyCys: 0.822 ± 0.024	4.377GlyAsp: 4.377 ± 0.067	5.279GlyGlu: 5.279 ± 0.06	3.888GlyPhe: 3.888 ± 0.058	7.331GlyGly: 7.331 ± 0.104	1.867GlyHis: 1.867 ± 0.037	5.06GlyIle: 5.06 ± 0.062	3.489GlyLys: 3.489 ± 0.048	9.119GlyLeu: 9.119 ± 0.091	2.528GlyMet: 2.528 ± 0.052	2.306GlyAsn: 2.306 ± 0.046	3.342GlyPro: 3.342 ± 0.047	2.726GlyGln: 2.726 ± 0.042	6.115GlyArg: 6.115 ± 0.073	4.851GlySer: 4.851 ± 0.062	4.523GlyThr: 4.523 ± 0.077	6.152GlyVal: 6.152 ± 0.074	1.284GlyTrp: 1.284 ± 0.033	2.294GlyTyr: 2.294 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.163HisAla: 2.163 ± 0.038	0.233HisCys: 0.233 ± 0.011	1.176HisAsp: 1.176 ± 0.028	1.131HisGlu: 1.131 ± 0.03	0.841HisPhe: 0.841 ± 0.029	1.842HisGly: 1.842 ± 0.038	0.525HisHis: 0.525 ± 0.024	0.974HisIle: 0.974 ± 0.026	0.537HisLys: 0.537 ± 0.02	1.97HisLeu: 1.97 ± 0.041	0.488HisMet: 0.488 ± 0.018	0.448HisAsn: 0.448 ± 0.017	1.199HisPro: 1.199 ± 0.033	0.533HisGln: 0.533 ± 0.02	1.396HisArg: 1.396 ± 0.036	0.929HisSer: 0.929 ± 0.023	0.82HisThr: 0.82 ± 0.026	1.507HisVal: 1.507 ± 0.034	0.32HisTrp: 0.32 ± 0.015	0.544HisTyr: 0.544 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.714IleAla: 7.714 ± 0.079	0.547IleCys: 0.547 ± 0.02	3.644IleAsp: 3.644 ± 0.051	3.822IleGlu: 3.822 ± 0.052	1.893IlePhe: 1.893 ± 0.04	5.206IleGly: 5.206 ± 0.068	0.957IleHis: 0.957 ± 0.024	2.518IleIle: 2.518 ± 0.052	1.34IleLys: 1.34 ± 0.026	5.015IleLeu: 5.015 ± 0.074	1.187IleMet: 1.187 ± 0.028	1.425IleAsn: 1.425 ± 0.032	2.422IlePro: 2.422 ± 0.041	1.167IleGln: 1.167 ± 0.025	3.518IleArg: 3.518 ± 0.053	3.189IleSer: 3.189 ± 0.052	2.602IleThr: 2.602 ± 0.04	4.609IleVal: 4.609 ± 0.059	0.603IleTrp: 0.603 ± 0.02	1.176IleTyr: 1.176 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.429LysAla: 4.429 ± 0.064	0.164LysCys: 0.164 ± 0.01	1.708LysAsp: 1.708 ± 0.034	1.879LysGlu: 1.879 ± 0.038	0.826LysPhe: 0.826 ± 0.026	2.805LysGly: 2.805 ± 0.042	0.594LysHis: 0.594 ± 0.02	1.718LysIle: 1.718 ± 0.035	1.41LysLys: 1.41 ± 0.038	3.349LysLeu: 3.349 ± 0.046	0.804LysMet: 0.804 ± 0.024	0.936LysAsn: 0.936 ± 0.023	2.229LysPro: 2.229 ± 0.043	0.994LysGln: 0.994 ± 0.022	2.533LysArg: 2.533 ± 0.044	1.905LysSer: 1.905 ± 0.038	2.053LysThr: 2.053 ± 0.041	2.428LysVal: 2.428 ± 0.044	0.362LysTrp: 0.362 ± 0.015	0.568LysTyr: 0.568 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.051LeuAla: 13.051 ± 0.124	0.901LeuCys: 0.901 ± 0.026	5.794LeuAsp: 5.794 ± 0.06	5.687LeuGlu: 5.687 ± 0.072	3.959LeuPhe: 3.959 ± 0.063	8.329LeuGly: 8.329 ± 0.081	1.718LeuHis: 1.718 ± 0.031	5.291LeuIle: 5.291 ± 0.062	3.788LeuLys: 3.788 ± 0.053	9.509LeuLeu: 9.509 ± 0.114	2.439LeuMet: 2.439 ± 0.041	2.63LeuAsn: 2.63 ± 0.042	5.355LeuPro: 5.355 ± 0.068	2.65LeuGln: 2.65 ± 0.039	6.49LeuArg: 6.49 ± 0.066	7.063LeuSer: 7.063 ± 0.084	5.319LeuThr: 5.319 ± 0.055	7.572LeuVal: 7.572 ± 0.089	1.071LeuTrp: 1.071 ± 0.027	2.136LeuTyr: 2.136 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.291MetAla: 3.291 ± 0.052	0.154MetCys: 0.154 ± 0.012	1.143MetAsp: 1.143 ± 0.033	1.365MetGlu: 1.365 ± 0.029	0.754MetPhe: 0.754 ± 0.022	1.994MetGly: 1.994 ± 0.036	0.446MetHis: 0.446 ± 0.016	1.492MetIle: 1.492 ± 0.035	1.133MetLys: 1.133 ± 0.029	2.687MetLeu: 2.687 ± 0.049	0.735MetMet: 0.735 ± 0.021	0.917MetAsn: 0.917 ± 0.023	1.541MetPro: 1.541 ± 0.034	0.88MetGln: 0.88 ± 0.022	2.058MetArg: 2.058 ± 0.039	1.673MetSer: 1.673 ± 0.036	1.883MetThr: 1.883 ± 0.035	1.837MetVal: 1.837 ± 0.041	0.228MetTrp: 0.228 ± 0.011	0.295MetTyr: 0.295 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.32AsnAla: 3.32 ± 0.045	0.237AsnCys: 0.237 ± 0.016	1.47AsnAsp: 1.47 ± 0.032	1.453AsnGlu: 1.453 ± 0.034	0.988AsnPhe: 0.988 ± 0.027	2.585AsnGly: 2.585 ± 0.045	0.493AsnHis: 0.493 ± 0.018	1.415AsnIle: 1.415 ± 0.03	0.723AsnLys: 0.723 ± 0.025	2.606AsnLeu: 2.606 ± 0.04	0.643AsnMet: 0.643 ± 0.023	0.701AsnAsn: 0.701 ± 0.024	1.891AsnPro: 1.891 ± 0.04	0.765AsnGln: 0.765 ± 0.024	1.902AsnArg: 1.902 ± 0.035	1.255AsnSer: 1.255 ± 0.033	1.269AsnThr: 1.269 ± 0.028	1.938AsnVal: 1.938 ± 0.039	0.411AsnTrp: 0.411 ± 0.017	0.651AsnTyr: 0.651 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.875ProAla: 5.875 ± 0.066	0.308ProCys: 0.308 ± 0.013	3.343ProAsp: 3.343 ± 0.049	3.976ProGlu: 3.976 ± 0.054	2.096ProPhe: 2.096 ± 0.043	4.352ProGly: 4.352 ± 0.055	0.98ProHis: 0.98 ± 0.025	2.233ProIle: 2.233 ± 0.04	1.566ProLys: 1.566 ± 0.036	4.613ProLeu: 4.613 ± 0.056	1.179ProMet: 1.179 ± 0.03	1.232ProAsn: 1.232 ± 0.03	2.164ProPro: 2.164 ± 0.045	1.674ProGln: 1.674 ± 0.034	2.805ProArg: 2.805 ± 0.045	2.755ProSer: 2.755 ± 0.046	2.159ProThr: 2.159 ± 0.036	4.304ProVal: 4.304 ± 0.056	0.664ProTrp: 0.664 ± 0.021	1.143ProTyr: 1.143 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.678GlnAla: 3.678 ± 0.05	0.191GlnCys: 0.191 ± 0.013	1.422GlnAsp: 1.422 ± 0.036	1.696GlnGlu: 1.696 ± 0.039	0.98GlnPhe: 0.98 ± 0.024	2.234GlnGly: 2.234 ± 0.037	0.566GlnHis: 0.566 ± 0.021	1.809GlnIle: 1.809 ± 0.039	1.208GlnLys: 1.208 ± 0.033	2.575GlnLeu: 2.575 ± 0.047	0.893GlnMet: 0.893 ± 0.025	0.906GlnAsn: 0.906 ± 0.023	1.555GlnPro: 1.555 ± 0.035	1.027GlnGln: 1.027 ± 0.029	2.306GlnArg: 2.306 ± 0.039	1.723GlnSer: 1.723 ± 0.039	1.655GlnThr: 1.655 ± 0.034	2.103GlnVal: 2.103 ± 0.039	0.352GlnTrp: 0.352 ± 0.016	0.54GlnTyr: 0.54 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.561ArgAla: 7.561 ± 0.077	0.475ArgCys: 0.475 ± 0.018	3.96ArgAsp: 3.96 ± 0.053	4.555ArgGlu: 4.555 ± 0.07	3.141ArgPhe: 3.141 ± 0.045	4.715ArgGly: 4.715 ± 0.056	1.713ArgHis: 1.713 ± 0.039	4.301ArgIle: 4.301 ± 0.059	2.609ArgLys: 2.609 ± 0.045	7.833ArgLeu: 7.833 ± 0.092	1.972ArgMet: 1.972 ± 0.031	2.064ArgAsn: 2.064 ± 0.036	3.346ArgPro: 3.346 ± 0.048	2.573ArgGln: 2.573 ± 0.044	5.564ArgArg: 5.564 ± 0.072	3.837ArgSer: 3.837 ± 0.059	3.228ArgThr: 3.228 ± 0.048	4.63ArgVal: 4.63 ± 0.062	0.901ArgTrp: 0.901 ± 0.023	1.723ArgTyr: 1.723 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.403SerAla: 6.403 ± 0.077	0.417SerCys: 0.417 ± 0.016	3.044SerAsp: 3.044 ± 0.054	3.136SerGlu: 3.136 ± 0.051	2.354SerPhe: 2.354 ± 0.044	6.088SerGly: 6.088 ± 0.089	1.057SerHis: 1.057 ± 0.029	3.003SerIle: 3.003 ± 0.047	1.611SerLys: 1.611 ± 0.03	5.604SerLeu: 5.604 ± 0.07	1.542SerMet: 1.542 ± 0.032	1.447SerAsn: 1.447 ± 0.033	2.662SerPro: 2.662 ± 0.043	1.584SerGln: 1.584 ± 0.035	3.743SerArg: 3.743 ± 0.06	3.105SerSer: 3.105 ± 0.055	2.704SerThr: 2.704 ± 0.047	4.232SerVal: 4.232 ± 0.065	0.76SerTrp: 0.76 ± 0.022	1.315SerTyr: 1.315 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.032ThrAla: 6.032 ± 0.068	0.385ThrCys: 0.385 ± 0.017	2.6ThrAsp: 2.6 ± 0.041	2.639ThrGlu: 2.639 ± 0.042	1.976ThrPhe: 1.976 ± 0.036	5.279ThrGly: 5.279 ± 0.083	0.942ThrHis: 0.942 ± 0.025	2.993ThrIle: 2.993 ± 0.051	1.36ThrLys: 1.36 ± 0.031	5.637ThrLeu: 5.637 ± 0.068	1.262ThrMet: 1.262 ± 0.029	1.275ThrAsn: 1.275 ± 0.035	3.072ThrPro: 3.072 ± 0.047	1.29ThrGln: 1.29 ± 0.032	3.266ThrArg: 3.266 ± 0.046	2.668ThrSer: 2.668 ± 0.05	2.611ThrThr: 2.611 ± 0.047	4.536ThrVal: 4.536 ± 0.065	0.572ThrTrp: 0.572 ± 0.021	1.125ThrTyr: 1.125 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.022ValAla: 9.022 ± 0.082	0.616ValCys: 0.616 ± 0.022	3.942ValAsp: 3.942 ± 0.053	4.885ValGlu: 4.885 ± 0.068	3.024ValPhe: 3.024 ± 0.052	5.469ValGly: 5.469 ± 0.074	1.371ValHis: 1.371 ± 0.029	4.106ValIle: 4.106 ± 0.055	2.31ValLys: 2.31 ± 0.047	7.476ValLeu: 7.476 ± 0.075	1.992ValMet: 1.992 ± 0.038	1.996ValAsn: 1.996 ± 0.039	3.748ValPro: 3.748 ± 0.049	1.881ValGln: 1.881 ± 0.038	4.764ValArg: 4.764 ± 0.066	4.842ValSer: 4.842 ± 0.051	4.397ValThr: 4.397 ± 0.062	5.618ValVal: 5.618 ± 0.07	0.848ValTrp: 0.848 ± 0.026	1.495ValTyr: 1.495 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.173TrpAla: 1.173 ± 0.033	0.144TrpCys: 0.144 ± 0.011	0.562TrpAsp: 0.562 ± 0.019	0.561TrpGlu: 0.561 ± 0.021	0.555TrpPhe: 0.555 ± 0.018	0.84TrpGly: 0.84 ± 0.027	0.307TrpHis: 0.307 ± 0.014	0.632TrpIle: 0.632 ± 0.022	0.506TrpLys: 0.506 ± 0.019	1.491TrpLeu: 1.491 ± 0.037	0.348TrpMet: 0.348 ± 0.014	0.45TrpAsn: 0.45 ± 0.017	0.649TrpPro: 0.649 ± 0.021	0.543TrpGln: 0.543 ± 0.021	1.085TrpArg: 1.085 ± 0.026	0.802TrpSer: 0.802 ± 0.024	0.676TrpThr: 0.676 ± 0.023	0.775TrpVal: 0.775 ± 0.023	0.2TrpTrp: 0.2 ± 0.014	0.276TrpTyr: 0.276 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.433TyrAla: 2.433 ± 0.043	0.235TyrCys: 0.235 ± 0.012	1.4TyrAsp: 1.4 ± 0.032	1.318TyrGlu: 1.318 ± 0.033	0.954TyrPhe: 0.954 ± 0.027	2.127TyrGly: 2.127 ± 0.039	0.452TyrHis: 0.452 ± 0.018	0.93TyrIle: 0.93 ± 0.027	0.589TyrLys: 0.589 ± 0.02	2.221TyrLeu: 2.221 ± 0.036	0.486TyrMet: 0.486 ± 0.018	0.543TyrAsn: 0.543 ± 0.019	1.073TyrPro: 1.073 ± 0.024	0.707TyrGln: 0.707 ± 0.026	1.779TyrArg: 1.779 ± 0.035	1.207TyrSer: 1.207 ± 0.036	1.098TyrThr: 1.098 ± 0.031	1.594TyrVal: 1.594 ± 0.032	0.326TyrTrp: 0.326 ± 0.016	0.584TyrTyr: 0.584 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4821 proteins (1483311 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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