Amino acid dipepetide frequency for Valsa sordida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.614AlaAla: 10.614 ± 0.091
1.032AlaCys: 1.032 ± 0.016
4.719AlaAsp: 4.719 ± 0.03
5.562AlaGlu: 5.562 ± 0.047
3.133AlaPhe: 3.133 ± 0.029
6.802AlaGly: 6.802 ± 0.048
1.842AlaHis: 1.842 ± 0.023
4.029AlaIle: 4.029 ± 0.032
4.149AlaLys: 4.149 ± 0.035
7.753AlaLeu: 7.753 ± 0.044
2.168AlaMet: 2.168 ± 0.025
2.996AlaAsn: 2.996 ± 0.026
5.173AlaPro: 5.173 ± 0.046
3.568AlaGln: 3.568 ± 0.032
5.456AlaArg: 5.456 ± 0.043
7.535AlaSer: 7.535 ± 0.052
5.644AlaThr: 5.644 ± 0.042
5.882AlaVal: 5.882 ± 0.04
1.237AlaTrp: 1.237 ± 0.017
2.215AlaTyr: 2.215 ± 0.025
0.0AlaXaa: 0.0 ± 0.0
Cys
0.918CysAla: 0.918 ± 0.017
0.234CysCys: 0.234 ± 0.008
0.643CysAsp: 0.643 ± 0.013
0.574CysGlu: 0.574 ± 0.012
0.488CysPhe: 0.488 ± 0.011
0.938CysGly: 0.938 ± 0.015
0.3CysHis: 0.3 ± 0.007
0.633CysIle: 0.633 ± 0.012
0.461CysLys: 0.461 ± 0.011
1.173CysLeu: 1.173 ± 0.018
0.259CysMet: 0.259 ± 0.008
0.401CysAsn: 0.401 ± 0.009
0.652CysPro: 0.652 ± 0.014
0.4CysGln: 0.4 ± 0.009
0.679CysArg: 0.679 ± 0.012
0.836CysSer: 0.836 ± 0.016
0.624CysThr: 0.624 ± 0.013
0.76CysVal: 0.76 ± 0.012
0.192CysTrp: 0.192 ± 0.007
0.341CysTyr: 0.341 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.065AspAla: 5.065 ± 0.036
0.626AspCys: 0.626 ± 0.011
4.984AspAsp: 4.984 ± 0.05
4.872AspGlu: 4.872 ± 0.041
2.261AspPhe: 2.261 ± 0.024
4.767AspGly: 4.767 ± 0.038
1.319AspHis: 1.319 ± 0.018
2.918AspIle: 2.918 ± 0.024
2.484AspLys: 2.484 ± 0.023
5.123AspLeu: 5.123 ± 0.036
1.444AspMet: 1.444 ± 0.017
1.954AspAsn: 1.954 ± 0.019
3.471AspPro: 3.471 ± 0.028
1.895AspGln: 1.895 ± 0.02
3.155AspArg: 3.155 ± 0.034
4.063AspSer: 4.063 ± 0.035
3.062AspThr: 3.062 ± 0.023
3.908AspVal: 3.908 ± 0.03
0.918AspTrp: 0.918 ± 0.014
1.645AspTyr: 1.645 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
5.979GluAla: 5.979 ± 0.043
0.591GluCys: 0.591 ± 0.013
4.628GluAsp: 4.628 ± 0.039
5.695GluGlu: 5.695 ± 0.063
1.869GluPhe: 1.869 ± 0.019
4.154GluGly: 4.154 ± 0.033
1.399GluHis: 1.399 ± 0.019
2.751GluIle: 2.751 ± 0.029
3.58GluLys: 3.58 ± 0.033
5.194GluLeu: 5.194 ± 0.039
1.534GluMet: 1.534 ± 0.019
2.102GluAsn: 2.102 ± 0.024
2.917GluPro: 2.917 ± 0.031
2.523GluGln: 2.523 ± 0.026
3.941GluArg: 3.941 ± 0.038
3.876GluSer: 3.876 ± 0.031
3.436GluThr: 3.436 ± 0.027
3.812GluVal: 3.812 ± 0.031
0.882GluTrp: 0.882 ± 0.014
1.628GluTyr: 1.628 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.941PheAla: 2.941 ± 0.026
0.504PheCys: 0.504 ± 0.011
2.272PheAsp: 2.272 ± 0.022
2.111PheGlu: 2.111 ± 0.025
1.489PhePhe: 1.489 ± 0.022
2.845PheGly: 2.845 ± 0.028
0.81PheHis: 0.81 ± 0.013
1.642PheIle: 1.642 ± 0.023
1.454PheLys: 1.454 ± 0.018
3.199PheLeu: 3.199 ± 0.032
0.816PheMet: 0.816 ± 0.015
1.347PheAsn: 1.347 ± 0.019
1.863PhePro: 1.863 ± 0.02
1.309PheGln: 1.309 ± 0.018
1.899PheArg: 1.899 ± 0.02
2.797PheSer: 2.797 ± 0.025
2.048PheThr: 2.048 ± 0.024
2.342PheVal: 2.342 ± 0.022
0.613PheTrp: 0.613 ± 0.013
1.053PheTyr: 1.053 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
6.097GlyAla: 6.097 ± 0.048
0.855GlyCys: 0.855 ± 0.014
4.221GlyAsp: 4.221 ± 0.034
4.064GlyGlu: 4.064 ± 0.03
2.803GlyPhe: 2.803 ± 0.028
7.285GlyGly: 7.285 ± 0.078
1.848GlyHis: 1.848 ± 0.021
3.348GlyIle: 3.348 ± 0.029
3.448GlyLys: 3.448 ± 0.033
6.43GlyLeu: 6.43 ± 0.042
1.763GlyMet: 1.763 ± 0.022
2.601GlyAsn: 2.601 ± 0.028
3.836GlyPro: 3.836 ± 0.038
2.778GlyGln: 2.778 ± 0.024
4.492GlyArg: 4.492 ± 0.039
6.1GlySer: 6.1 ± 0.044
4.253GlyThr: 4.253 ± 0.038
4.639GlyVal: 4.639 ± 0.035
1.208GlyTrp: 1.208 ± 0.017
2.151GlyTyr: 2.151 ± 0.025
0.0GlyXaa: 0.0 ± 0.0
His
1.867HisAla: 1.867 ± 0.021
0.311HisCys: 0.311 ± 0.008
1.396HisAsp: 1.396 ± 0.018
1.34HisGlu: 1.34 ± 0.017
0.859HisPhe: 0.859 ± 0.012
1.83HisGly: 1.83 ± 0.022
0.897HisHis: 0.897 ± 0.017
1.119HisIle: 1.119 ± 0.012
0.924HisLys: 0.924 ± 0.016
2.111HisLeu: 2.111 ± 0.02
0.534HisMet: 0.534 ± 0.011
0.81HisAsn: 0.81 ± 0.014
1.58HisPro: 1.58 ± 0.022
0.976HisGln: 0.976 ± 0.016
1.47HisArg: 1.47 ± 0.02
1.654HisSer: 1.654 ± 0.021
1.193HisThr: 1.193 ± 0.015
1.469HisVal: 1.469 ± 0.02
0.33HisTrp: 0.33 ± 0.007
0.672HisTyr: 0.672 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
3.858IleAla: 3.858 ± 0.033
0.668IleCys: 0.668 ± 0.013
2.689IleAsp: 2.689 ± 0.024
2.672IleGlu: 2.672 ± 0.024
1.762IlePhe: 1.762 ± 0.021
2.991IleGly: 2.991 ± 0.03
1.049IleHis: 1.049 ± 0.016
2.255IleIle: 2.255 ± 0.025
2.077IleLys: 2.077 ± 0.022
4.05IleLeu: 4.05 ± 0.038
1.069IleMet: 1.069 ± 0.017
1.681IleAsn: 1.681 ± 0.019
2.78IlePro: 2.78 ± 0.026
1.726IleGln: 1.726 ± 0.02
2.583IleArg: 2.583 ± 0.024
3.426IleSer: 3.426 ± 0.033
2.693IleThr: 2.693 ± 0.027
2.964IleVal: 2.964 ± 0.027
0.7IleTrp: 0.7 ± 0.013
1.271IleTyr: 1.271 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
4.501LysAla: 4.501 ± 0.04
0.453LysCys: 0.453 ± 0.01
2.795LysAsp: 2.795 ± 0.029
3.333LysGlu: 3.333 ± 0.037
1.371LysPhe: 1.371 ± 0.017
3.055LysGly: 3.055 ± 0.027
1.102LysHis: 1.102 ± 0.017
2.055LysIle: 2.055 ± 0.025
3.376LysLys: 3.376 ± 0.043
3.823LysLeu: 3.823 ± 0.032
1.065LysMet: 1.065 ± 0.017
1.594LysAsn: 1.594 ± 0.019
2.687LysPro: 2.687 ± 0.025
1.809LysGln: 1.809 ± 0.024
3.268LysArg: 3.268 ± 0.035
3.212LysSer: 3.212 ± 0.03
2.788LysThr: 2.788 ± 0.025
2.826LysVal: 2.826 ± 0.028
0.648LysTrp: 0.648 ± 0.011
1.306LysTyr: 1.306 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
8.114LeuAla: 8.114 ± 0.054
1.121LeuCys: 1.121 ± 0.016
5.268LeuAsp: 5.268 ± 0.033
5.377LeuGlu: 5.377 ± 0.042
3.033LeuPhe: 3.033 ± 0.029
6.145LeuGly: 6.145 ± 0.041
2.036LeuHis: 2.036 ± 0.024
3.455LeuIle: 3.455 ± 0.033
3.996LeuLys: 3.996 ± 0.037
7.83LeuLeu: 7.83 ± 0.054
1.822LeuMet: 1.822 ± 0.019
2.899LeuAsn: 2.899 ± 0.028
5.334LeuPro: 5.334 ± 0.04
3.598LeuGln: 3.598 ± 0.032
5.619LeuArg: 5.619 ± 0.038
6.758LeuSer: 6.758 ± 0.048
4.565LeuThr: 4.565 ± 0.029
5.573LeuVal: 5.573 ± 0.043
1.197LeuTrp: 1.197 ± 0.015
2.224LeuTyr: 2.224 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
2.553MetAla: 2.553 ± 0.026
0.241MetCys: 0.241 ± 0.006
1.399MetAsp: 1.399 ± 0.017
1.345MetGlu: 1.345 ± 0.021
0.767MetPhe: 0.767 ± 0.013
1.638MetGly: 1.638 ± 0.019
0.483MetHis: 0.483 ± 0.008
0.966MetIle: 0.966 ± 0.014
1.008MetLys: 1.008 ± 0.014
1.888MetLeu: 1.888 ± 0.023
0.633MetMet: 0.633 ± 0.013
0.783MetAsn: 0.783 ± 0.014
1.407MetPro: 1.407 ± 0.018
0.88MetGln: 0.88 ± 0.015
1.343MetArg: 1.343 ± 0.018
1.972MetSer: 1.972 ± 0.021
1.355MetThr: 1.355 ± 0.016
1.43MetVal: 1.43 ± 0.016
0.293MetTrp: 0.293 ± 0.008
0.557MetTyr: 0.557 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.007AsnAla: 3.007 ± 0.029
0.417AsnCys: 0.417 ± 0.01
1.921AsnAsp: 1.921 ± 0.021
1.926AsnGlu: 1.926 ± 0.022
1.301AsnPhe: 1.301 ± 0.02
3.013AsnGly: 3.013 ± 0.028
0.788AsnHis: 0.788 ± 0.012
1.843AsnIle: 1.843 ± 0.022
1.544AsnLys: 1.544 ± 0.018
3.055AsnLeu: 3.055 ± 0.024
0.869AsnMet: 0.869 ± 0.014
1.538AsnAsn: 1.538 ± 0.024
2.292AsnPro: 2.292 ± 0.022
1.203AsnGln: 1.203 ± 0.018
1.79AsnArg: 1.79 ± 0.017
2.623AsnSer: 2.623 ± 0.025
2.15AsnThr: 2.15 ± 0.023
2.203AsnVal: 2.203 ± 0.025
0.535AsnTrp: 0.535 ± 0.012
1.01AsnTyr: 1.01 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
5.794ProAla: 5.794 ± 0.058
0.48ProCys: 0.48 ± 0.01
3.45ProAsp: 3.45 ± 0.029
3.896ProGlu: 3.896 ± 0.039
1.978ProPhe: 1.978 ± 0.024
4.52ProGly: 4.52 ± 0.038
1.289ProHis: 1.289 ± 0.017
2.309ProIle: 2.309 ± 0.022
2.599ProLys: 2.599 ± 0.027
4.557ProLeu: 4.557 ± 0.04
1.183ProMet: 1.183 ± 0.018
2.031ProAsn: 2.031 ± 0.025
5.394ProPro: 5.394 ± 0.069
2.56ProGln: 2.56 ± 0.032
3.633ProArg: 3.633 ± 0.036
5.783ProSer: 5.783 ± 0.05
3.879ProThr: 3.879 ± 0.035
3.785ProVal: 3.785 ± 0.034
0.754ProTrp: 0.754 ± 0.012
1.531ProTyr: 1.531 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.703GlnAla: 3.703 ± 0.03
0.421GlnCys: 0.421 ± 0.01
2.183GlnAsp: 2.183 ± 0.022
2.431GlnGlu: 2.431 ± 0.028
1.172GlnPhe: 1.172 ± 0.014
2.584GlnGly: 2.584 ± 0.027
1.108GlnHis: 1.108 ± 0.02
1.67GlnIle: 1.67 ± 0.02
1.874GlnLys: 1.874 ± 0.02
3.313GlnLeu: 3.313 ± 0.032
0.917GlnMet: 0.917 ± 0.014
1.432GlnAsn: 1.432 ± 0.022
2.66GlnPro: 2.66 ± 0.035
2.745GlnGln: 2.745 ± 0.048
2.609GlnArg: 2.609 ± 0.026
2.881GlnSer: 2.881 ± 0.032
2.171GlnThr: 2.171 ± 0.023
2.233GlnVal: 2.233 ± 0.023
0.554GlnTrp: 0.554 ± 0.011
1.103GlnTyr: 1.103 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
5.014ArgAla: 5.014 ± 0.036
0.66ArgCys: 0.66 ± 0.013
3.549ArgAsp: 3.549 ± 0.035
3.867ArgGlu: 3.867 ± 0.038
2.026ArgPhe: 2.026 ± 0.022
4.057ArgGly: 4.057 ± 0.036
1.6ArgHis: 1.6 ± 0.021
2.689ArgIle: 2.689 ± 0.026
3.381ArgLys: 3.381 ± 0.033
5.475ArgLeu: 5.475 ± 0.039
1.386ArgMet: 1.386 ± 0.017
2.145ArgAsn: 2.145 ± 0.023
3.725ArgPro: 3.725 ± 0.032
2.64ArgGln: 2.64 ± 0.027
5.331ArgArg: 5.331 ± 0.046
4.585ArgSer: 4.585 ± 0.042
3.181ArgThr: 3.181 ± 0.024
3.406ArgVal: 3.406 ± 0.029
0.932ArgTrp: 0.932 ± 0.014
1.608ArgTyr: 1.608 ± 0.018
0.0ArgXaa: 0.0 ± 0.0
Ser
6.797SerAla: 6.797 ± 0.052
0.801SerCys: 0.801 ± 0.013
4.143SerAsp: 4.143 ± 0.037
3.923SerGlu: 3.923 ± 0.031
2.773SerPhe: 2.773 ± 0.025
5.883SerGly: 5.883 ± 0.039
1.801SerHis: 1.801 ± 0.021
3.607SerIle: 3.607 ± 0.032
3.457SerLys: 3.457 ± 0.03
6.64SerLeu: 6.64 ± 0.043
1.789SerMet: 1.789 ± 0.021
2.796SerAsn: 2.796 ± 0.026
5.515SerPro: 5.515 ± 0.054
3.151SerGln: 3.151 ± 0.027
4.814SerArg: 4.814 ± 0.042
8.704SerSer: 8.704 ± 0.08
5.369SerThr: 5.369 ± 0.043
4.485SerVal: 4.485 ± 0.033
1.071SerTrp: 1.071 ± 0.015
2.045SerTyr: 2.045 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
5.58ThrAla: 5.58 ± 0.04
0.702ThrCys: 0.702 ± 0.012
2.945ThrAsp: 2.945 ± 0.028
3.072ThrGlu: 3.072 ± 0.021
2.146ThrPhe: 2.146 ± 0.022
4.404ThrGly: 4.404 ± 0.038
1.209ThrHis: 1.209 ± 0.017
2.866ThrIle: 2.866 ± 0.026
2.557ThrLys: 2.557 ± 0.024
4.831ThrLeu: 4.831 ± 0.036
1.267ThrMet: 1.267 ± 0.017
2.063ThrAsn: 2.063 ± 0.025
4.285ThrPro: 4.285 ± 0.039
2.03ThrGln: 2.03 ± 0.022
3.117ThrArg: 3.117 ± 0.028
5.199ThrSer: 5.199 ± 0.048
4.549ThrThr: 4.549 ± 0.044
3.864ThrVal: 3.864 ± 0.037
0.862ThrTrp: 0.862 ± 0.016
1.605ThrTyr: 1.605 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
5.717ValAla: 5.717 ± 0.037
0.796ValCys: 0.796 ± 0.014
4.044ValAsp: 4.044 ± 0.028
3.989ValGlu: 3.989 ± 0.032
2.438ValPhe: 2.438 ± 0.024
4.213ValGly: 4.213 ± 0.037
1.379ValHis: 1.379 ± 0.017
2.829ValIle: 2.829 ± 0.027
2.873ValLys: 2.873 ± 0.027
5.692ValLeu: 5.692 ± 0.042
1.388ValMet: 1.388 ± 0.017
2.145ValAsn: 2.145 ± 0.021
3.77ValPro: 3.77 ± 0.032
2.369ValGln: 2.369 ± 0.026
3.554ValArg: 3.554 ± 0.029
4.563ValSer: 4.563 ± 0.034
3.675ValThr: 3.675 ± 0.031
4.69ValVal: 4.69 ± 0.032
0.901ValTrp: 0.901 ± 0.016
1.79ValTyr: 1.79 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
1.225TrpAla: 1.225 ± 0.018
0.197TrpCys: 0.197 ± 0.006
0.977TrpAsp: 0.977 ± 0.017
0.867TrpGlu: 0.867 ± 0.017
0.527TrpPhe: 0.527 ± 0.012
0.968TrpGly: 0.968 ± 0.016
0.358TrpHis: 0.358 ± 0.009
0.671TrpIle: 0.671 ± 0.013
0.745TrpLys: 0.745 ± 0.012
1.33TrpLeu: 1.33 ± 0.018
0.389TrpMet: 0.389 ± 0.009
0.598TrpAsn: 0.598 ± 0.011
0.632TrpPro: 0.632 ± 0.013
0.554TrpGln: 0.554 ± 0.011
0.947TrpArg: 0.947 ± 0.013
1.02TrpSer: 1.02 ± 0.016
0.93TrpThr: 0.93 ± 0.013
0.909TrpVal: 0.909 ± 0.014
0.285TrpTrp: 0.285 ± 0.009
0.442TrpTyr: 0.442 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.165TyrAla: 2.165 ± 0.026
0.4TyrCys: 0.4 ± 0.01
1.707TyrAsp: 1.707 ± 0.02
1.58TyrGlu: 1.58 ± 0.018
1.157TyrPhe: 1.157 ± 0.018
2.127TyrGly: 2.127 ± 0.028
0.722TyrHis: 0.722 ± 0.012
1.309TyrIle: 1.309 ± 0.019
1.077TyrLys: 1.077 ± 0.015
2.498TyrLeu: 2.498 ± 0.023
0.646TyrMet: 0.646 ± 0.011
1.11TyrAsn: 1.11 ± 0.016
1.431TyrPro: 1.431 ± 0.017
1.051TyrGln: 1.051 ± 0.015
1.558TyrArg: 1.558 ± 0.017
1.972TyrSer: 1.972 ± 0.024
1.587TyrThr: 1.587 ± 0.02
1.637TyrVal: 1.637 ± 0.02
0.46TyrTrp: 0.46 ± 0.01
0.956TyrTyr: 0.956 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.002
Statistics based on 9818 proteins (4954655 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski