Amino acid dipepetide frequency for Thiorhodococcus minor

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.141AlaAla: 14.141 ± 0.138	1.309AlaCys: 1.309 ± 0.03	6.499AlaAsp: 6.499 ± 0.076	8.37AlaGlu: 8.37 ± 0.089	3.781AlaPhe: 3.781 ± 0.054	9.026AlaGly: 9.026 ± 0.096	2.325AlaHis: 2.325 ± 0.042	5.46AlaIle: 5.46 ± 0.063	3.308AlaLys: 3.308 ± 0.052	13.886AlaLeu: 13.886 ± 0.11	2.962AlaMet: 2.962 ± 0.046	2.425AlaAsn: 2.425 ± 0.039	5.298AlaPro: 5.298 ± 0.072	4.39AlaGln: 4.39 ± 0.065	9.012AlaArg: 9.012 ± 0.085	6.362AlaSer: 6.362 ± 0.067	5.146AlaThr: 5.146 ± 0.057	7.84AlaVal: 7.84 ± 0.071	1.671AlaTrp: 1.671 ± 0.034	2.473AlaTyr: 2.473 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.147CysAla: 1.147 ± 0.034	0.16CysCys: 0.16 ± 0.011	0.588CysAsp: 0.588 ± 0.018	0.64CysGlu: 0.64 ± 0.021	0.348CysPhe: 0.348 ± 0.016	1.053CysGly: 1.053 ± 0.03	0.377CysHis: 0.377 ± 0.019	0.454CysIle: 0.454 ± 0.016	0.244CysLys: 0.244 ± 0.013	1.035CysLeu: 1.035 ± 0.026	0.191CysMet: 0.191 ± 0.012	0.241CysAsn: 0.241 ± 0.013	0.601CysPro: 0.601 ± 0.022	0.335CysGln: 0.335 ± 0.014	0.837CysArg: 0.837 ± 0.025	0.57CysSer: 0.57 ± 0.021	0.518CysThr: 0.518 ± 0.029	0.673CysVal: 0.673 ± 0.019	0.131CysTrp: 0.131 ± 0.008	0.265CysTyr: 0.265 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.286AspAla: 7.286 ± 0.07	0.666AspCys: 0.666 ± 0.024	3.418AspAsp: 3.418 ± 0.053	3.527AspGlu: 3.527 ± 0.05	2.307AspPhe: 2.307 ± 0.042	4.896AspGly: 4.896 ± 0.061	1.28AspHis: 1.28 ± 0.03	2.616AspIle: 2.616 ± 0.044	1.485AspLys: 1.485 ± 0.032	7.047AspLeu: 7.047 ± 0.069	1.207AspMet: 1.207 ± 0.026	1.133AspAsn: 1.133 ± 0.03	3.809AspPro: 3.809 ± 0.054	2.275AspGln: 2.275 ± 0.043	4.556AspArg: 4.556 ± 0.055	2.686AspSer: 2.686 ± 0.041	2.518AspThr: 2.518 ± 0.045	3.643AspVal: 3.643 ± 0.05	1.215AspTrp: 1.215 ± 0.027	1.805AspTyr: 1.805 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.788GluAla: 7.788 ± 0.091	0.481GluCys: 0.481 ± 0.017	3.343GluAsp: 3.343 ± 0.041	3.722GluGlu: 3.722 ± 0.064	1.276GluPhe: 1.276 ± 0.029	4.498GluGly: 4.498 ± 0.051	1.613GluHis: 1.613 ± 0.033	3.586GluIle: 3.586 ± 0.053	1.665GluLys: 1.665 ± 0.04	7.045GluLeu: 7.045 ± 0.076	1.376GluMet: 1.376 ± 0.029	1.22GluAsn: 1.22 ± 0.026	3.377GluPro: 3.377 ± 0.055	3.284GluGln: 3.284 ± 0.047	6.586GluArg: 6.586 ± 0.075	3.332GluSer: 3.332 ± 0.041	3.841GluThr: 3.841 ± 0.047	4.455GluVal: 4.455 ± 0.057	0.707GluTrp: 0.707 ± 0.021	1.084GluTyr: 1.084 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.673PheAla: 3.673 ± 0.047	0.379PheCys: 0.379 ± 0.014	2.313PheAsp: 2.313 ± 0.039	2.175PheGlu: 2.175 ± 0.036	1.366PhePhe: 1.366 ± 0.036	2.984PheGly: 2.984 ± 0.042	0.7PheHis: 0.7 ± 0.02	1.397PheIle: 1.397 ± 0.028	0.918PheLys: 0.918 ± 0.023	3.377PheLeu: 3.377 ± 0.054	0.677PheMet: 0.677 ± 0.022	0.886PheAsn: 0.886 ± 0.022	1.472PhePro: 1.472 ± 0.031	1.102PheGln: 1.102 ± 0.023	2.162PheArg: 2.162 ± 0.04	2.036PheSer: 2.036 ± 0.04	1.572PheThr: 1.572 ± 0.031	2.512PheVal: 2.512 ± 0.044	0.481PheTrp: 0.481 ± 0.017	0.913PheTyr: 0.913 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	8.289GlyAla: 8.289 ± 0.079	1.067GlyCys: 1.067 ± 0.027	4.586GlyAsp: 4.586 ± 0.06	4.978GlyGlu: 4.978 ± 0.056	3.119GlyPhe: 3.119 ± 0.039	6.185GlyGly: 6.185 ± 0.083	1.849GlyHis: 1.849 ± 0.032	4.284GlyIle: 4.284 ± 0.057	2.69GlyLys: 2.69 ± 0.038	9.462GlyLeu: 9.462 ± 0.088	2.092GlyMet: 2.092 ± 0.038	1.814GlyAsn: 1.814 ± 0.037	3.05GlyPro: 3.05 ± 0.046	3.1GlyGln: 3.1 ± 0.04	6.35GlyArg: 6.35 ± 0.071	4.547GlySer: 4.547 ± 0.067	3.783GlyThr: 3.783 ± 0.056	5.694GlyVal: 5.694 ± 0.065	1.432GlyTrp: 1.432 ± 0.026	2.443GlyTyr: 2.443 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.405HisAla: 2.405 ± 0.035	0.32HisCys: 0.32 ± 0.015	1.103HisAsp: 1.103 ± 0.027	1.157HisGlu: 1.157 ± 0.025	0.885HisPhe: 0.885 ± 0.023	1.864HisGly: 1.864 ± 0.034	0.657HisHis: 0.657 ± 0.022	0.882HisIle: 0.882 ± 0.026	0.503HisLys: 0.503 ± 0.02	2.698HisLeu: 2.698 ± 0.044	0.394HisMet: 0.394 ± 0.016	0.459HisAsn: 0.459 ± 0.018	1.619HisPro: 1.619 ± 0.033	0.894HisGln: 0.894 ± 0.027	1.837HisArg: 1.837 ± 0.034	1.041HisSer: 1.041 ± 0.023	0.86HisThr: 0.86 ± 0.021	1.304HisVal: 1.304 ± 0.031	0.496HisTrp: 0.496 ± 0.019	0.68HisTyr: 0.68 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.147IleAla: 6.147 ± 0.062	0.474IleCys: 0.474 ± 0.016	3.427IleAsp: 3.427 ± 0.05	3.582IleGlu: 3.582 ± 0.047	1.386IlePhe: 1.386 ± 0.032	4.32IleGly: 4.32 ± 0.057	1.052IleHis: 1.052 ± 0.027	1.708IleIle: 1.708 ± 0.036	1.317IleLys: 1.317 ± 0.034	4.859IleLeu: 4.859 ± 0.063	0.772IleMet: 0.772 ± 0.023	1.221IleAsn: 1.221 ± 0.03	2.542IlePro: 2.542 ± 0.04	1.749IleGln: 1.749 ± 0.031	3.512IleArg: 3.512 ± 0.047	2.47IleSer: 2.47 ± 0.045	2.179IleThr: 2.179 ± 0.038	2.999IleVal: 2.999 ± 0.048	0.528IleTrp: 0.528 ± 0.017	1.09IleTyr: 1.09 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.346LysAla: 3.346 ± 0.055	0.2LysCys: 0.2 ± 0.01	1.632LysAsp: 1.632 ± 0.036	1.566LysGlu: 1.566 ± 0.04	0.59LysPhe: 0.59 ± 0.018	2.314LysGly: 2.314 ± 0.041	0.663LysHis: 0.663 ± 0.02	1.286LysIle: 1.286 ± 0.032	0.974LysLys: 0.974 ± 0.03	2.903LysLeu: 2.903 ± 0.046	0.496LysMet: 0.496 ± 0.018	0.601LysAsn: 0.601 ± 0.021	1.702LysPro: 1.702 ± 0.034	1.116LysGln: 1.116 ± 0.029	2.486LysArg: 2.486 ± 0.045	1.438LysSer: 1.438 ± 0.036	1.714LysThr: 1.714 ± 0.034	1.938LysVal: 1.938 ± 0.04	0.281LysTrp: 0.281 ± 0.011	0.561LysTyr: 0.561 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.096LeuAla: 14.096 ± 0.126	1.066LeuCys: 1.066 ± 0.027	7.297LeuAsp: 7.297 ± 0.07	7.486LeuGlu: 7.486 ± 0.072	3.731LeuPhe: 3.731 ± 0.06	9.337LeuGly: 9.337 ± 0.088	2.239LeuHis: 2.239 ± 0.038	5.502LeuIle: 5.502 ± 0.067	3.363LeuLys: 3.363 ± 0.047	12.212LeuLeu: 12.212 ± 0.118	2.571LeuMet: 2.571 ± 0.043	2.368LeuAsn: 2.368 ± 0.044	5.982LeuPro: 5.982 ± 0.067	3.576LeuGln: 3.576 ± 0.049	8.665LeuArg: 8.665 ± 0.094	7.046LeuSer: 7.046 ± 0.072	5.793LeuThr: 5.793 ± 0.064	8.123LeuVal: 8.123 ± 0.081	1.385LeuTrp: 1.385 ± 0.033	2.466LeuTyr: 2.466 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.588MetAla: 2.588 ± 0.041	0.137MetCys: 0.137 ± 0.009	1.202MetAsp: 1.202 ± 0.029	1.175MetGlu: 1.175 ± 0.029	0.462MetPhe: 0.462 ± 0.017	1.629MetGly: 1.629 ± 0.032	0.467MetHis: 0.467 ± 0.015	1.006MetIle: 1.006 ± 0.023	0.721MetLys: 0.721 ± 0.026	2.493MetLeu: 2.493 ± 0.049	0.475MetMet: 0.475 ± 0.018	0.546MetAsn: 0.546 ± 0.019	1.386MetPro: 1.386 ± 0.03	0.836MetGln: 0.836 ± 0.023	1.761MetArg: 1.761 ± 0.036	1.535MetSer: 1.535 ± 0.03	1.535MetThr: 1.535 ± 0.029	1.429MetVal: 1.429 ± 0.033	0.15MetTrp: 0.15 ± 0.009	0.312MetTyr: 0.312 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.556AsnAla: 2.556 ± 0.038	0.276AsnCys: 0.276 ± 0.013	1.262AsnAsp: 1.262 ± 0.035	1.112AsnGlu: 1.112 ± 0.026	0.682AsnPhe: 0.682 ± 0.02	1.9AsnGly: 1.9 ± 0.038	0.457AsnHis: 0.457 ± 0.017	1.014AsnIle: 1.014 ± 0.029	0.556AsnLys: 0.556 ± 0.018	2.655AsnLeu: 2.655 ± 0.045	0.425AsnMet: 0.425 ± 0.016	0.565AsnAsn: 0.565 ± 0.022	1.59AsnPro: 1.59 ± 0.033	0.802AsnGln: 0.802 ± 0.022	1.822AsnArg: 1.822 ± 0.033	0.907AsnSer: 0.907 ± 0.027	0.916AsnThr: 0.916 ± 0.025	1.422AsnVal: 1.422 ± 0.033	0.332AsnTrp: 0.332 ± 0.015	0.548AsnTyr: 0.548 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.737ProAla: 5.737 ± 0.066	0.44ProCys: 0.44 ± 0.016	3.758ProAsp: 3.758 ± 0.048	4.575ProGlu: 4.575 ± 0.06	1.785ProPhe: 1.785 ± 0.033	4.536ProGly: 4.536 ± 0.051	1.011ProHis: 1.011 ± 0.028	2.352ProIle: 2.352 ± 0.04	1.541ProLys: 1.541 ± 0.032	5.152ProLeu: 5.152 ± 0.059	1.153ProMet: 1.153 ± 0.027	1.159ProAsn: 1.159 ± 0.028	2.891ProPro: 2.891 ± 0.054	1.784ProGln: 1.784 ± 0.026	3.279ProArg: 3.279 ± 0.044	3.317ProSer: 3.317 ± 0.051	2.483ProThr: 2.483 ± 0.042	3.832ProVal: 3.832 ± 0.052	0.825ProTrp: 0.825 ± 0.024	1.168ProTyr: 1.168 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.071GlnAla: 5.071 ± 0.059	0.344GlnCys: 0.344 ± 0.017	2.028GlnAsp: 2.028 ± 0.036	2.108GlnGlu: 2.108 ± 0.037	0.956GlnPhe: 0.956 ± 0.022	3.265GlnGly: 3.265 ± 0.051	0.816GlnHis: 0.816 ± 0.021	1.86GlnIle: 1.86 ± 0.035	0.827GlnLys: 0.827 ± 0.024	4.039GlnLeu: 4.039 ± 0.057	0.781GlnMet: 0.781 ± 0.022	0.647GlnAsn: 0.647 ± 0.021	2.071GlnPro: 2.071 ± 0.037	1.638GlnGln: 1.638 ± 0.036	3.296GlnArg: 3.296 ± 0.052	2.073GlnSer: 2.073 ± 0.038	1.925GlnThr: 1.925 ± 0.032	3.127GlnVal: 3.127 ± 0.045	0.501GlnTrp: 0.501 ± 0.017	0.695GlnTyr: 0.695 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.273ArgAla: 8.273 ± 0.099	0.786ArgCys: 0.786 ± 0.022	4.555ArgAsp: 4.555 ± 0.069	5.024ArgGlu: 5.024 ± 0.064	3.177ArgPhe: 3.177 ± 0.044	5.0ArgGly: 5.0 ± 0.057	2.069ArgHis: 2.069 ± 0.034	4.353ArgIle: 4.353 ± 0.052	2.12ArgLys: 2.12 ± 0.037	10.337ArgLeu: 10.337 ± 0.108	1.793ArgMet: 1.793 ± 0.034	1.685ArgAsn: 1.685 ± 0.029	3.974ArgPro: 3.974 ± 0.052	3.259ArgGln: 3.259 ± 0.046	6.67ArgArg: 6.67 ± 0.086	3.9ArgSer: 3.9 ± 0.05	3.296ArgThr: 3.296 ± 0.046	5.394ArgVal: 5.394 ± 0.062	1.302ArgTrp: 1.302 ± 0.033	2.167ArgTyr: 2.167 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.287SerAla: 6.287 ± 0.078	0.586SerCys: 0.586 ± 0.028	3.111SerAsp: 3.111 ± 0.047	3.401SerGlu: 3.401 ± 0.043	1.979SerPhe: 1.979 ± 0.04	5.383SerGly: 5.383 ± 0.063	1.158SerHis: 1.158 ± 0.028	2.48SerIle: 2.48 ± 0.043	1.47SerLys: 1.47 ± 0.031	6.115SerLeu: 6.115 ± 0.058	1.264SerMet: 1.264 ± 0.029	1.224SerAsn: 1.224 ± 0.03	3.052SerPro: 3.052 ± 0.053	2.083SerGln: 2.083 ± 0.034	4.041SerArg: 4.041 ± 0.046	3.118SerSer: 3.118 ± 0.058	2.722SerThr: 2.722 ± 0.043	3.734SerVal: 3.734 ± 0.056	0.783SerTrp: 0.783 ± 0.023	1.33SerTyr: 1.33 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.358ThrAla: 5.358 ± 0.054	0.499ThrCys: 0.499 ± 0.022	2.794ThrAsp: 2.794 ± 0.044	2.925ThrGlu: 2.925 ± 0.043	1.528ThrPhe: 1.528 ± 0.03	4.383ThrGly: 4.383 ± 0.057	1.089ThrHis: 1.089 ± 0.031	2.091ThrIle: 2.091 ± 0.04	1.211ThrLys: 1.211 ± 0.026	6.276ThrLeu: 6.276 ± 0.062	0.869ThrMet: 0.869 ± 0.024	1.053ThrAsn: 1.053 ± 0.03	3.173ThrPro: 3.173 ± 0.046	1.939ThrGln: 1.939 ± 0.038	3.407ThrArg: 3.407 ± 0.045	2.523ThrSer: 2.523 ± 0.046	2.526ThrThr: 2.526 ± 0.048	3.097ThrVal: 3.097 ± 0.055	0.732ThrTrp: 0.732 ± 0.022	1.119ThrTyr: 1.119 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.844ValAla: 7.844 ± 0.069	0.735ValCys: 0.735 ± 0.025	4.319ValAsp: 4.319 ± 0.058	4.693ValGlu: 4.693 ± 0.058	2.423ValPhe: 2.423 ± 0.043	5.239ValGly: 5.239 ± 0.065	1.374ValHis: 1.374 ± 0.027	3.445ValIle: 3.445 ± 0.051	1.939ValLys: 1.939 ± 0.04	7.679ValLeu: 7.679 ± 0.078	1.585ValMet: 1.585 ± 0.03	1.676ValAsn: 1.676 ± 0.032	3.214ValPro: 3.214 ± 0.05	2.213ValGln: 2.213 ± 0.034	5.2ValArg: 5.2 ± 0.063	4.196ValSer: 4.196 ± 0.066	3.548ValThr: 3.548 ± 0.052	5.287ValVal: 5.287 ± 0.065	0.867ValTrp: 0.867 ± 0.025	1.615ValTyr: 1.615 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.171TrpAla: 1.171 ± 0.027	0.17TrpCys: 0.17 ± 0.012	0.705TrpAsp: 0.705 ± 0.019	0.82TrpGlu: 0.82 ± 0.023	0.368TrpPhe: 0.368 ± 0.016	0.997TrpGly: 0.997 ± 0.028	0.323TrpHis: 0.323 ± 0.014	0.741TrpIle: 0.741 ± 0.021	0.379TrpLys: 0.379 ± 0.016	2.135TrpLeu: 2.135 ± 0.041	0.365TrpMet: 0.365 ± 0.016	0.335TrpAsn: 0.335 ± 0.015	0.72TrpPro: 0.72 ± 0.023	0.651TrpGln: 0.651 ± 0.017	1.32TrpArg: 1.32 ± 0.031	0.963TrpSer: 0.963 ± 0.025	0.747TrpThr: 0.747 ± 0.024	1.018TrpVal: 1.018 ± 0.03	0.247TrpTrp: 0.247 ± 0.012	0.329TrpTyr: 0.329 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.484TyrAla: 2.484 ± 0.039	0.312TyrCys: 0.312 ± 0.013	1.433TyrAsp: 1.433 ± 0.032	1.242TyrGlu: 1.242 ± 0.03	0.946TyrPhe: 0.946 ± 0.03	2.002TyrGly: 2.002 ± 0.039	0.54TyrHis: 0.54 ± 0.02	0.815TyrIle: 0.815 ± 0.024	0.575TyrLys: 0.575 ± 0.021	2.901TyrLeu: 2.901 ± 0.046	0.399TyrMet: 0.399 ± 0.016	0.54TyrAsn: 0.54 ± 0.021	1.254TyrPro: 1.254 ± 0.032	1.043TyrGln: 1.043 ± 0.027	2.338TyrArg: 2.338 ± 0.038	1.262TyrSer: 1.262 ± 0.03	0.968TyrThr: 0.968 ± 0.028	1.569TyrVal: 1.569 ± 0.034	0.438TyrTrp: 0.438 ± 0.016	0.643TyrTyr: 0.643 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5194 proteins (1678515 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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