Amino acid dipepetide frequency for Tetragenococcus muriaticus 3MR10-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.846AlaAla: 4.846 ± 0.105
0.486AlaCys: 0.486 ± 0.031
3.607AlaAsp: 3.607 ± 0.075
4.532AlaGlu: 4.532 ± 0.088
3.276AlaPhe: 3.276 ± 0.071
4.843AlaGly: 4.843 ± 0.104
1.077AlaHis: 1.077 ± 0.043
5.552AlaIle: 5.552 ± 0.116
4.724AlaLys: 4.724 ± 0.096
6.782AlaLeu: 6.782 ± 0.11
1.97AlaMet: 1.97 ± 0.069
3.216AlaAsn: 3.216 ± 0.069
1.984AlaPro: 1.984 ± 0.06
3.404AlaGln: 3.404 ± 0.082
2.618AlaArg: 2.618 ± 0.07
4.261AlaSer: 4.261 ± 0.075
3.874AlaThr: 3.874 ± 0.085
4.829AlaVal: 4.829 ± 0.099
0.537AlaTrp: 0.537 ± 0.028
2.293AlaTyr: 2.293 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.345CysAla: 0.345 ± 0.025
0.088CysCys: 0.088 ± 0.013
0.327CysAsp: 0.327 ± 0.024
0.306CysGlu: 0.306 ± 0.024
0.279CysPhe: 0.279 ± 0.021
0.518CysGly: 0.518 ± 0.029
0.17CysHis: 0.17 ± 0.016
0.407CysIle: 0.407 ± 0.028
0.269CysLys: 0.269 ± 0.022
0.566CysLeu: 0.566 ± 0.031
0.145CysMet: 0.145 ± 0.015
0.172CysAsn: 0.172 ± 0.017
0.246CysPro: 0.246 ± 0.02
0.248CysGln: 0.248 ± 0.021
0.248CysArg: 0.248 ± 0.022
0.391CysSer: 0.391 ± 0.026
0.272CysThr: 0.272 ± 0.021
0.396CysVal: 0.396 ± 0.023
0.062CysTrp: 0.062 ± 0.01
0.263CysTyr: 0.263 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.485AspAla: 3.485 ± 0.089
0.255AspCys: 0.255 ± 0.022
2.986AspAsp: 2.986 ± 0.096
5.108AspGlu: 5.108 ± 0.098
2.937AspPhe: 2.937 ± 0.073
3.184AspGly: 3.184 ± 0.079
1.195AspHis: 1.195 ± 0.047
4.155AspIle: 4.155 ± 0.097
3.471AspLys: 3.471 ± 0.077
5.421AspLeu: 5.421 ± 0.114
1.444AspMet: 1.444 ± 0.057
2.504AspAsn: 2.504 ± 0.074
2.125AspPro: 2.125 ± 0.072
2.654AspGln: 2.654 ± 0.078
2.175AspArg: 2.175 ± 0.063
3.05AspSer: 3.05 ± 0.076
3.105AspThr: 3.105 ± 0.082
3.941AspVal: 3.941 ± 0.089
0.681AspTrp: 0.681 ± 0.037
2.723AspTyr: 2.723 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.262GluAla: 5.262 ± 0.099
0.301GluCys: 0.301 ± 0.022
4.88GluAsp: 4.88 ± 0.125
8.076GluGlu: 8.076 ± 0.161
2.641GluPhe: 2.641 ± 0.07
3.966GluGly: 3.966 ± 0.094
1.241GluHis: 1.241 ± 0.047
5.822GluIle: 5.822 ± 0.098
6.653GluLys: 6.653 ± 0.124
7.194GluLeu: 7.194 ± 0.126
2.29GluMet: 2.29 ± 0.064
4.917GluAsn: 4.917 ± 0.091
1.955GluPro: 1.955 ± 0.061
4.029GluGln: 4.029 ± 0.106
3.045GluArg: 3.045 ± 0.074
3.434GluSer: 3.434 ± 0.097
4.27GluThr: 4.27 ± 0.089
5.154GluVal: 5.154 ± 0.108
0.649GluTrp: 0.649 ± 0.032
2.286GluTyr: 2.286 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.163PheAla: 3.163 ± 0.078
0.345PheCys: 0.345 ± 0.026
2.924PheAsp: 2.924 ± 0.066
2.832PheGlu: 2.832 ± 0.07
2.452PhePhe: 2.452 ± 0.086
3.082PheGly: 3.082 ± 0.09
0.893PheHis: 0.893 ± 0.037
3.557PheIle: 3.557 ± 0.093
2.042PheLys: 2.042 ± 0.061
4.655PheLeu: 4.655 ± 0.105
1.089PheMet: 1.089 ± 0.048
2.035PheAsn: 2.035 ± 0.064
1.632PhePro: 1.632 ± 0.051
1.685PheGln: 1.685 ± 0.054
1.513PheArg: 1.513 ± 0.056
3.711PheSer: 3.711 ± 0.095
2.564PheThr: 2.564 ± 0.079
3.163PheVal: 3.163 ± 0.083
0.465PheTrp: 0.465 ± 0.029
1.95PheTyr: 1.95 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.539GlyAla: 4.539 ± 0.108
0.394GlyCys: 0.394 ± 0.026
3.225GlyAsp: 3.225 ± 0.077
4.212GlyGlu: 4.212 ± 0.091
3.214GlyPhe: 3.214 ± 0.078
4.395GlyGly: 4.395 ± 0.135
1.14GlyHis: 1.14 ± 0.044
5.55GlyIle: 5.55 ± 0.104
4.51GlyLys: 4.51 ± 0.094
6.144GlyLeu: 6.144 ± 0.097
1.885GlyMet: 1.885 ± 0.06
2.839GlyAsn: 2.839 ± 0.067
1.501GlyPro: 1.501 ± 0.048
2.454GlyGln: 2.454 ± 0.059
2.436GlyArg: 2.436 ± 0.077
3.706GlySer: 3.706 ± 0.088
3.752GlyThr: 3.752 ± 0.087
4.814GlyVal: 4.814 ± 0.108
0.645GlyTrp: 0.645 ± 0.034
2.633GlyTyr: 2.633 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.087HisAla: 1.087 ± 0.041
0.136HisCys: 0.136 ± 0.017
0.911HisAsp: 0.911 ± 0.042
1.254HisGlu: 1.254 ± 0.041
1.063HisPhe: 1.063 ± 0.047
1.275HisGly: 1.275 ± 0.051
0.465HisHis: 0.465 ± 0.029
1.156HisIle: 1.156 ± 0.04
0.941HisLys: 0.941 ± 0.039
2.023HisLeu: 2.023 ± 0.068
0.507HisMet: 0.507 ± 0.029
0.695HisAsn: 0.695 ± 0.038
0.958HisPro: 0.958 ± 0.043
0.835HisGln: 0.835 ± 0.038
0.812HisArg: 0.812 ± 0.04
1.024HisSer: 1.024 ± 0.039
0.96HisThr: 0.96 ± 0.045
1.128HisVal: 1.128 ± 0.042
0.256HisTrp: 0.256 ± 0.02
0.877HisTyr: 0.877 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.969IleAla: 5.969 ± 0.121
0.576IleCys: 0.576 ± 0.032
4.714IleAsp: 4.714 ± 0.086
5.256IleGlu: 5.256 ± 0.101
3.404IlePhe: 3.404 ± 0.094
5.469IleGly: 5.469 ± 0.111
1.422IleHis: 1.422 ± 0.051
5.371IleIle: 5.371 ± 0.125
4.019IleLys: 4.019 ± 0.088
6.894IleLeu: 6.894 ± 0.113
1.658IleMet: 1.658 ± 0.057
3.324IleAsn: 3.324 ± 0.085
2.951IlePro: 2.951 ± 0.076
3.227IleGln: 3.227 ± 0.084
2.88IleArg: 2.88 ± 0.067
4.724IleSer: 4.724 ± 0.095
4.277IleThr: 4.277 ± 0.091
5.088IleVal: 5.088 ± 0.117
0.559IleTrp: 0.559 ± 0.032
2.571IleTyr: 2.571 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.233LysAla: 4.233 ± 0.097
0.205LysCys: 0.205 ± 0.017
3.709LysAsp: 3.709 ± 0.079
6.97LysGlu: 6.97 ± 0.142
1.865LysPhe: 1.865 ± 0.058
3.663LysGly: 3.663 ± 0.085
1.064LysHis: 1.064 ± 0.049
4.684LysIle: 4.684 ± 0.101
6.011LysLys: 6.011 ± 0.132
4.843LysLeu: 4.843 ± 0.098
2.109LysMet: 2.109 ± 0.061
3.837LysAsn: 3.837 ± 0.091
1.699LysPro: 1.699 ± 0.055
3.715LysGln: 3.715 ± 0.094
3.236LysArg: 3.236 ± 0.079
3.094LysSer: 3.094 ± 0.091
3.893LysThr: 3.893 ± 0.078
4.116LysVal: 4.116 ± 0.092
0.575LysTrp: 0.575 ± 0.033
2.12LysTyr: 2.12 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
7.585LeuAla: 7.585 ± 0.121
0.546LeuCys: 0.546 ± 0.03
5.516LeuAsp: 5.516 ± 0.098
6.485LeuGlu: 6.485 ± 0.11
4.671LeuPhe: 4.671 ± 0.097
6.102LeuGly: 6.102 ± 0.113
1.713LeuHis: 1.713 ± 0.062
6.521LeuIle: 6.521 ± 0.128
5.902LeuLys: 5.902 ± 0.12
9.894LeuLeu: 9.894 ± 0.17
2.359LeuMet: 2.359 ± 0.064
4.585LeuAsn: 4.585 ± 0.09
3.964LeuPro: 3.964 ± 0.079
4.498LeuGln: 4.498 ± 0.097
3.545LeuArg: 3.545 ± 0.083
6.841LeuSer: 6.841 ± 0.115
5.958LeuThr: 5.958 ± 0.095
5.994LeuVal: 5.994 ± 0.124
0.709LeuTrp: 0.709 ± 0.037
3.087LeuTyr: 3.087 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
1.95MetAla: 1.95 ± 0.05
0.087MetCys: 0.087 ± 0.012
1.607MetAsp: 1.607 ± 0.058
1.925MetGlu: 1.925 ± 0.059
0.875MetPhe: 0.875 ± 0.038
1.678MetGly: 1.678 ± 0.055
0.456MetHis: 0.456 ± 0.027
2.136MetIle: 2.136 ± 0.068
2.099MetLys: 2.099 ± 0.056
2.258MetLeu: 2.258 ± 0.068
0.822MetMet: 0.822 ± 0.041
1.505MetAsn: 1.505 ± 0.051
0.981MetPro: 0.981 ± 0.04
1.225MetGln: 1.225 ± 0.044
1.015MetArg: 1.015 ± 0.041
1.694MetSer: 1.694 ± 0.051
1.775MetThr: 1.775 ± 0.054
1.844MetVal: 1.844 ± 0.055
0.143MetTrp: 0.143 ± 0.016
0.758MetTyr: 0.758 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.972AsnAla: 2.972 ± 0.075
0.299AsnCys: 0.299 ± 0.025
2.855AsnAsp: 2.855 ± 0.065
4.128AsnGlu: 4.128 ± 0.098
2.175AsnPhe: 2.175 ± 0.07
3.289AsnGly: 3.289 ± 0.083
1.165AsnHis: 1.165 ± 0.041
3.49AsnIle: 3.49 ± 0.083
3.073AsnLys: 3.073 ± 0.07
4.318AsnLeu: 4.318 ± 0.091
1.3AsnMet: 1.3 ± 0.043
2.353AsnAsn: 2.353 ± 0.096
1.864AsnPro: 1.864 ± 0.059
2.663AsnGln: 2.663 ± 0.081
1.952AsnArg: 1.952 ± 0.063
2.417AsnSer: 2.417 ± 0.071
2.443AsnThr: 2.443 ± 0.065
3.106AsnVal: 3.106 ± 0.072
0.585AsnTrp: 0.585 ± 0.035
2.058AsnTyr: 2.058 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.224ProAla: 2.224 ± 0.07
0.152ProCys: 0.152 ± 0.016
1.832ProAsp: 1.832 ± 0.052
3.285ProGlu: 3.285 ± 0.078
1.731ProPhe: 1.731 ± 0.065
2.016ProGly: 2.016 ± 0.058
0.608ProHis: 0.608 ± 0.03
2.599ProIle: 2.599 ± 0.069
2.12ProLys: 2.12 ± 0.062
3.294ProLeu: 3.294 ± 0.082
0.826ProMet: 0.826 ± 0.039
1.726ProAsn: 1.726 ± 0.054
0.718ProPro: 0.718 ± 0.041
1.409ProGln: 1.409 ± 0.051
1.089ProArg: 1.089 ± 0.042
2.051ProSer: 2.051 ± 0.065
1.978ProThr: 1.978 ± 0.055
2.382ProVal: 2.382 ± 0.066
0.339ProTrp: 0.339 ± 0.022
1.328ProTyr: 1.328 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
3.716GlnAla: 3.716 ± 0.085
0.154GlnCys: 0.154 ± 0.019
2.374GlnAsp: 2.374 ± 0.074
4.507GlnGlu: 4.507 ± 0.104
1.83GlnPhe: 1.83 ± 0.051
2.546GlnGly: 2.546 ± 0.067
0.707GlnHis: 0.707 ± 0.032
3.167GlnIle: 3.167 ± 0.072
3.771GlnLys: 3.771 ± 0.095
4.848GlnLeu: 4.848 ± 0.099
1.331GlnMet: 1.331 ± 0.053
2.355GlnAsn: 2.355 ± 0.069
1.395GlnPro: 1.395 ± 0.052
2.717GlnGln: 2.717 ± 0.095
2.054GlnArg: 2.054 ± 0.059
2.387GlnSer: 2.387 ± 0.067
2.933GlnThr: 2.933 ± 0.071
3.045GlnVal: 3.045 ± 0.073
0.481GlnTrp: 0.481 ± 0.028
1.43GlnTyr: 1.43 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
2.27ArgAla: 2.27 ± 0.074
0.256ArgCys: 0.256 ± 0.023
1.887ArgAsp: 1.887 ± 0.056
2.79ArgGlu: 2.79 ± 0.068
1.938ArgPhe: 1.938 ± 0.068
2.23ArgGly: 2.23 ± 0.067
0.679ArgHis: 0.679 ± 0.033
2.79ArgIle: 2.79 ± 0.065
3.004ArgLys: 3.004 ± 0.079
4.107ArgLeu: 4.107 ± 0.094
1.206ArgMet: 1.206 ± 0.05
1.977ArgAsn: 1.977 ± 0.061
1.3ArgPro: 1.3 ± 0.049
1.977ArgGln: 1.977 ± 0.058
1.874ArgArg: 1.874 ± 0.062
2.286ArgSer: 2.286 ± 0.067
2.067ArgThr: 2.067 ± 0.057
2.532ArgVal: 2.532 ± 0.068
0.401ArgTrp: 0.401 ± 0.029
1.657ArgTyr: 1.657 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.573SerAla: 3.573 ± 0.093
0.35SerCys: 0.35 ± 0.025
3.283SerAsp: 3.283 ± 0.087
4.256SerGlu: 4.256 ± 0.096
3.255SerPhe: 3.255 ± 0.076
4.316SerGly: 4.316 ± 0.089
1.178SerHis: 1.178 ± 0.048
4.551SerIle: 4.551 ± 0.099
3.361SerLys: 3.361 ± 0.069
6.075SerLeu: 6.075 ± 0.12
1.589SerMet: 1.589 ± 0.059
2.751SerAsn: 2.751 ± 0.074
1.855SerPro: 1.855 ± 0.064
2.783SerGln: 2.783 ± 0.07
2.215SerArg: 2.215 ± 0.062
3.976SerSer: 3.976 ± 0.119
3.267SerThr: 3.267 ± 0.075
4.038SerVal: 4.038 ± 0.065
0.622SerTrp: 0.622 ± 0.037
2.443SerTyr: 2.443 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
3.796ThrAla: 3.796 ± 0.07
0.306ThrCys: 0.306 ± 0.023
3.151ThrAsp: 3.151 ± 0.075
4.111ThrGlu: 4.111 ± 0.087
2.64ThrPhe: 2.64 ± 0.071
3.872ThrGly: 3.872 ± 0.083
1.066ThrHis: 1.066 ± 0.041
4.694ThrIle: 4.694 ± 0.091
3.465ThrLys: 3.465 ± 0.081
5.617ThrLeu: 5.617 ± 0.105
1.457ThrMet: 1.457 ± 0.053
2.657ThrAsn: 2.657 ± 0.076
2.405ThrPro: 2.405 ± 0.069
2.555ThrGln: 2.555 ± 0.079
2.035ThrArg: 2.035 ± 0.056
3.617ThrSer: 3.617 ± 0.082
3.518ThrThr: 3.518 ± 0.09
4.074ThrVal: 4.074 ± 0.078
0.449ThrTrp: 0.449 ± 0.027
2.016ThrTyr: 2.016 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.053ValAla: 5.053 ± 0.104
0.408ValCys: 0.408 ± 0.027
4.189ValAsp: 4.189 ± 0.09
4.781ValGlu: 4.781 ± 0.093
3.032ValPhe: 3.032 ± 0.071
4.576ValGly: 4.576 ± 0.099
1.057ValHis: 1.057 ± 0.041
5.214ValIle: 5.214 ± 0.11
3.75ValLys: 3.75 ± 0.083
6.337ValLeu: 6.337 ± 0.113
1.726ValMet: 1.726 ± 0.061
3.108ValAsn: 3.108 ± 0.072
2.491ValPro: 2.491 ± 0.066
2.613ValGln: 2.613 ± 0.072
2.41ValArg: 2.41 ± 0.064
4.438ValSer: 4.438 ± 0.094
4.261ValThr: 4.261 ± 0.082
4.857ValVal: 4.857 ± 0.098
0.509ValTrp: 0.509 ± 0.032
2.366ValTyr: 2.366 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.469TrpAla: 0.469 ± 0.03
0.071TrpCys: 0.071 ± 0.013
0.456TrpAsp: 0.456 ± 0.028
0.598TrpGlu: 0.598 ± 0.032
0.442TrpPhe: 0.442 ± 0.031
0.569TrpGly: 0.569 ± 0.031
0.214TrpHis: 0.214 ± 0.018
0.663TrpIle: 0.663 ± 0.035
0.539TrpLys: 0.539 ± 0.031
1.142TrpLeu: 1.142 ± 0.049
0.263TrpMet: 0.263 ± 0.021
0.403TrpAsn: 0.403 ± 0.027
0.24TrpPro: 0.24 ± 0.019
0.732TrpGln: 0.732 ± 0.036
0.4TrpArg: 0.4 ± 0.028
0.504TrpSer: 0.504 ± 0.03
0.44TrpThr: 0.44 ± 0.03
0.545TrpVal: 0.545 ± 0.03
0.103TrpTrp: 0.103 ± 0.016
0.35TrpTyr: 0.35 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.173TyrAla: 2.173 ± 0.058
0.301TyrCys: 0.301 ± 0.027
2.164TyrAsp: 2.164 ± 0.07
2.654TyrGlu: 2.654 ± 0.072
2.033TyrPhe: 2.033 ± 0.066
2.403TyrGly: 2.403 ± 0.061
0.85TyrHis: 0.85 ± 0.043
2.274TyrIle: 2.274 ± 0.06
1.918TyrLys: 1.918 ± 0.057
4.063TyrLeu: 4.063 ± 0.083
0.856TyrMet: 0.856 ± 0.032
1.547TyrAsn: 1.547 ± 0.061
1.443TyrPro: 1.443 ± 0.048
2.329TyrGln: 2.329 ± 0.072
1.674TyrArg: 1.674 ± 0.06
2.134TyrSer: 2.134 ± 0.058
1.892TyrThr: 1.892 ± 0.054
2.131TyrVal: 2.131 ± 0.061
0.371TyrTrp: 0.371 ± 0.029
1.554TyrTyr: 1.554 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2262 proteins (565595 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski