Amino acid dipepetide frequency for Rachicladosporium sp. CCFEE 5018

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.804AlaAla: 10.804 ± 0.054
1.045AlaCys: 1.045 ± 0.013
4.864AlaAsp: 4.864 ± 0.023
5.892AlaGlu: 5.892 ± 0.033
3.239AlaPhe: 3.239 ± 0.021
6.783AlaGly: 6.783 ± 0.035
2.001AlaHis: 2.001 ± 0.015
4.255AlaIle: 4.255 ± 0.027
4.788AlaLys: 4.788 ± 0.03
8.508AlaLeu: 8.508 ± 0.032
2.23AlaMet: 2.23 ± 0.018
3.12AlaAsn: 3.12 ± 0.02
5.667AlaPro: 5.667 ± 0.033
3.997AlaGln: 3.997 ± 0.025
5.596AlaArg: 5.596 ± 0.032
8.1AlaSer: 8.1 ± 0.044
6.325AlaThr: 6.325 ± 0.032
6.12AlaVal: 6.12 ± 0.028
1.279AlaTrp: 1.279 ± 0.012
2.363AlaTyr: 2.363 ± 0.02
0.0AlaXaa: 0.0 ± 0.0
Cys
0.933CysAla: 0.933 ± 0.011
0.202CysCys: 0.202 ± 0.005
0.594CysAsp: 0.594 ± 0.008
0.562CysGlu: 0.562 ± 0.009
0.456CysPhe: 0.456 ± 0.008
0.885CysGly: 0.885 ± 0.013
0.287CysHis: 0.287 ± 0.007
0.611CysIle: 0.611 ± 0.01
0.498CysLys: 0.498 ± 0.007
1.051CysLeu: 1.051 ± 0.012
0.239CysMet: 0.239 ± 0.006
0.379CysAsn: 0.379 ± 0.007
0.571CysPro: 0.571 ± 0.01
0.376CysGln: 0.376 ± 0.007
0.654CysArg: 0.654 ± 0.011
0.767CysSer: 0.767 ± 0.009
0.677CysThr: 0.677 ± 0.009
0.713CysVal: 0.713 ± 0.009
0.178CysTrp: 0.178 ± 0.005
0.336CysTyr: 0.336 ± 0.006
0.0CysXaa: 0.0 ± 0.0
Asp
5.525AspAla: 5.525 ± 0.029
0.578AspCys: 0.578 ± 0.008
4.452AspAsp: 4.452 ± 0.034
4.64AspGlu: 4.64 ± 0.028
2.243AspPhe: 2.243 ± 0.019
4.301AspGly: 4.301 ± 0.024
1.295AspHis: 1.295 ± 0.012
2.643AspIle: 2.643 ± 0.018
2.168AspLys: 2.168 ± 0.019
5.253AspLeu: 5.253 ± 0.027
1.281AspMet: 1.281 ± 0.012
1.634AspAsn: 1.634 ± 0.014
3.196AspPro: 3.196 ± 0.019
1.749AspGln: 1.749 ± 0.016
3.168AspArg: 3.168 ± 0.023
4.012AspSer: 4.012 ± 0.025
3.026AspThr: 3.026 ± 0.02
3.948AspVal: 3.948 ± 0.023
0.884AspTrp: 0.884 ± 0.01
1.528AspTyr: 1.528 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
5.936GluAla: 5.936 ± 0.033
0.567GluCys: 0.567 ± 0.008
4.257GluAsp: 4.257 ± 0.029
5.111GluGlu: 5.111 ± 0.036
1.604GluPhe: 1.604 ± 0.015
4.263GluGly: 4.263 ± 0.027
1.477GluHis: 1.477 ± 0.016
2.791GluIle: 2.791 ± 0.019
3.427GluLys: 3.427 ± 0.031
5.163GluLeu: 5.163 ± 0.03
1.484GluMet: 1.484 ± 0.013
1.786GluAsn: 1.786 ± 0.014
2.615GluPro: 2.615 ± 0.019
2.538GluGln: 2.538 ± 0.02
4.281GluArg: 4.281 ± 0.032
3.983GluSer: 3.983 ± 0.025
3.354GluThr: 3.354 ± 0.021
3.98GluVal: 3.98 ± 0.024
0.835GluTrp: 0.835 ± 0.011
1.532GluTyr: 1.532 ± 0.015
0.0GluXaa: 0.0 ± 0.0
Phe
3.375PheAla: 3.375 ± 0.021
0.466PheCys: 0.466 ± 0.009
2.197PheAsp: 2.197 ± 0.015
2.036PheGlu: 2.036 ± 0.017
1.299PhePhe: 1.299 ± 0.014
2.807PheGly: 2.807 ± 0.022
0.766PheHis: 0.766 ± 0.008
1.463PheIle: 1.463 ± 0.016
1.309PheLys: 1.309 ± 0.013
2.938PheLeu: 2.938 ± 0.021
0.71PheMet: 0.71 ± 0.01
1.24PheAsn: 1.24 ± 0.014
1.676PhePro: 1.676 ± 0.014
1.121PheGln: 1.121 ± 0.013
1.76PheArg: 1.76 ± 0.015
2.542PheSer: 2.542 ± 0.019
2.165PheThr: 2.165 ± 0.017
2.23PheVal: 2.23 ± 0.015
0.559PheTrp: 0.559 ± 0.01
0.935PheTyr: 0.935 ± 0.012
0.0PheXaa: 0.0 ± 0.0
Gly
6.089GlyAla: 6.089 ± 0.031
0.781GlyCys: 0.781 ± 0.011
3.871GlyAsp: 3.871 ± 0.021
4.143GlyGlu: 4.143 ± 0.027
2.722GlyPhe: 2.722 ± 0.022
6.61GlyGly: 6.61 ± 0.049
1.674GlyHis: 1.674 ± 0.016
3.285GlyIle: 3.285 ± 0.025
3.826GlyLys: 3.826 ± 0.026
6.157GlyLeu: 6.157 ± 0.032
1.907GlyMet: 1.907 ± 0.017
2.509GlyAsn: 2.509 ± 0.019
3.202GlyPro: 3.202 ± 0.021
2.655GlyGln: 2.655 ± 0.021
4.346GlyArg: 4.346 ± 0.03
6.0GlySer: 6.0 ± 0.033
4.304GlyThr: 4.304 ± 0.026
4.75GlyVal: 4.75 ± 0.023
1.202GlyTrp: 1.202 ± 0.013
2.153GlyTyr: 2.153 ± 0.018
0.0GlyXaa: 0.0 ± 0.0
His
2.223HisAla: 2.223 ± 0.018
0.322HisCys: 0.322 ± 0.006
1.424HisAsp: 1.424 ± 0.013
1.385HisGlu: 1.385 ± 0.013
0.88HisPhe: 0.88 ± 0.011
1.763HisGly: 1.763 ± 0.012
0.801HisHis: 0.801 ± 0.013
1.074HisIle: 1.074 ± 0.011
0.877HisLys: 0.877 ± 0.01
2.169HisLeu: 2.169 ± 0.019
0.496HisMet: 0.496 ± 0.007
0.791HisAsn: 0.791 ± 0.011
1.548HisPro: 1.548 ± 0.016
0.892HisGln: 0.892 ± 0.012
1.504HisArg: 1.504 ± 0.015
1.766HisSer: 1.766 ± 0.014
1.396HisThr: 1.396 ± 0.015
1.524HisVal: 1.524 ± 0.016
0.351HisTrp: 0.351 ± 0.007
0.666HisTyr: 0.666 ± 0.008
0.0HisXaa: 0.0 ± 0.0
Ile
4.49IleAla: 4.49 ± 0.024
0.644IleCys: 0.644 ± 0.01
2.832IleAsp: 2.832 ± 0.022
2.706IleGlu: 2.706 ± 0.02
1.648IlePhe: 1.648 ± 0.016
3.069IleGly: 3.069 ± 0.022
0.977IleHis: 0.977 ± 0.012
2.056IleIle: 2.056 ± 0.017
1.912IleLys: 1.912 ± 0.015
3.897IleLeu: 3.897 ± 0.023
0.944IleMet: 0.944 ± 0.011
1.569IleAsn: 1.569 ± 0.015
2.591IlePro: 2.591 ± 0.018
1.444IleGln: 1.444 ± 0.014
2.51IleArg: 2.51 ± 0.02
3.398IleSer: 3.398 ± 0.02
2.891IleThr: 2.891 ± 0.026
2.966IleVal: 2.966 ± 0.018
0.644IleTrp: 0.644 ± 0.01
1.228IleTyr: 1.228 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
4.736LysAla: 4.736 ± 0.03
0.443LysCys: 0.443 ± 0.007
2.646LysAsp: 2.646 ± 0.021
3.006LysGlu: 3.006 ± 0.026
1.233LysPhe: 1.233 ± 0.014
3.195LysGly: 3.195 ± 0.024
1.152LysHis: 1.152 ± 0.012
1.966LysIle: 1.966 ± 0.016
3.023LysLys: 3.023 ± 0.033
4.025LysLeu: 4.025 ± 0.026
0.989LysMet: 0.989 ± 0.011
1.352LysAsn: 1.352 ± 0.014
2.802LysPro: 2.802 ± 0.022
1.917LysGln: 1.917 ± 0.015
3.589LysArg: 3.589 ± 0.026
3.448LysSer: 3.448 ± 0.019
2.76LysThr: 2.76 ± 0.02
2.899LysVal: 2.899 ± 0.02
0.629LysTrp: 0.629 ± 0.011
1.251LysTyr: 1.251 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
8.448LeuAla: 8.448 ± 0.037
1.081LeuCys: 1.081 ± 0.013
5.148LeuAsp: 5.148 ± 0.026
5.33LeuGlu: 5.33 ± 0.03
2.918LeuPhe: 2.918 ± 0.019
5.88LeuGly: 5.88 ± 0.034
2.3LeuHis: 2.3 ± 0.018
3.615LeuIle: 3.615 ± 0.025
3.916LeuLys: 3.916 ± 0.027
8.089LeuLeu: 8.089 ± 0.044
1.694LeuMet: 1.694 ± 0.015
2.852LeuAsn: 2.852 ± 0.02
5.667LeuPro: 5.667 ± 0.033
3.879LeuGln: 3.879 ± 0.026
5.903LeuArg: 5.903 ± 0.03
6.844LeuSer: 6.844 ± 0.034
5.123LeuThr: 5.123 ± 0.027
5.1LeuVal: 5.1 ± 0.03
1.106LeuTrp: 1.106 ± 0.016
2.227LeuTyr: 2.227 ± 0.018
0.0LeuXaa: 0.0 ± 0.0
Met
2.375MetAla: 2.375 ± 0.016
0.227MetCys: 0.227 ± 0.006
1.223MetAsp: 1.223 ± 0.014
1.237MetGlu: 1.237 ± 0.015
0.7MetPhe: 0.7 ± 0.01
1.51MetGly: 1.51 ± 0.016
0.548MetHis: 0.548 ± 0.009
0.916MetIle: 0.916 ± 0.011
0.976MetLys: 0.976 ± 0.011
2.015MetLeu: 2.015 ± 0.02
0.561MetMet: 0.561 ± 0.009
0.725MetAsn: 0.725 ± 0.008
1.459MetPro: 1.459 ± 0.016
1.009MetGln: 1.009 ± 0.013
1.398MetArg: 1.398 ± 0.013
1.937MetSer: 1.937 ± 0.017
1.261MetThr: 1.261 ± 0.014
1.202MetVal: 1.202 ± 0.012
0.257MetTrp: 0.257 ± 0.006
0.551MetTyr: 0.551 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
3.443AsnAla: 3.443 ± 0.021
0.356AsnCys: 0.356 ± 0.008
1.887AsnAsp: 1.887 ± 0.015
1.817AsnGlu: 1.817 ± 0.015
1.185AsnPhe: 1.185 ± 0.014
3.285AsnGly: 3.285 ± 0.027
0.704AsnHis: 0.704 ± 0.009
1.68AsnIle: 1.68 ± 0.013
1.28AsnLys: 1.28 ± 0.012
2.791AsnLeu: 2.791 ± 0.022
0.745AsnMet: 0.745 ± 0.01
1.213AsnAsn: 1.213 ± 0.016
2.096AsnPro: 2.096 ± 0.019
0.996AsnGln: 0.996 ± 0.013
1.64AsnArg: 1.64 ± 0.016
2.34AsnSer: 2.34 ± 0.02
2.152AsnThr: 2.152 ± 0.018
2.232AsnVal: 2.232 ± 0.018
0.462AsnTrp: 0.462 ± 0.007
0.906AsnTyr: 0.906 ± 0.01
0.0AsnXaa: 0.0 ± 0.0
Pro
6.135ProAla: 6.135 ± 0.037
0.424ProCys: 0.424 ± 0.008
3.114ProAsp: 3.114 ± 0.019
3.469ProGlu: 3.469 ± 0.023
1.839ProPhe: 1.839 ± 0.014
4.027ProGly: 4.027 ± 0.026
1.346ProHis: 1.346 ± 0.016
2.405ProIle: 2.405 ± 0.017
2.627ProLys: 2.627 ± 0.022
4.623ProLeu: 4.623 ± 0.025
1.155ProMet: 1.155 ± 0.012
2.011ProAsn: 2.011 ± 0.018
5.413ProPro: 5.413 ± 0.055
2.533ProGln: 2.533 ± 0.022
3.408ProArg: 3.408 ± 0.024
6.039ProSer: 6.039 ± 0.039
4.304ProThr: 4.304 ± 0.031
3.552ProVal: 3.552 ± 0.021
0.681ProTrp: 0.681 ± 0.01
1.505ProTyr: 1.505 ± 0.015
0.0ProXaa: 0.0 ± 0.0
Gln
3.847GlnAla: 3.847 ± 0.025
0.421GlnCys: 0.421 ± 0.008
2.083GlnAsp: 2.083 ± 0.015
2.095GlnGlu: 2.095 ± 0.017
1.068GlnPhe: 1.068 ± 0.011
2.493GlnGly: 2.493 ± 0.018
1.22GlnHis: 1.22 ± 0.014
1.769GlnIle: 1.769 ± 0.015
1.706GlnLys: 1.706 ± 0.017
3.329GlnLeu: 3.329 ± 0.022
0.916GlnMet: 0.916 ± 0.014
1.312GlnAsn: 1.312 ± 0.014
2.619GlnPro: 2.619 ± 0.024
2.77GlnGln: 2.77 ± 0.04
2.875GlnArg: 2.875 ± 0.022
3.25GlnSer: 3.25 ± 0.023
2.434GlnThr: 2.434 ± 0.021
2.195GlnVal: 2.195 ± 0.016
0.579GlnTrp: 0.579 ± 0.008
1.228GlnTyr: 1.228 ± 0.013
0.0GlnXaa: 0.0 ± 0.0
Arg
5.284ArgAla: 5.284 ± 0.032
0.653ArgCys: 0.653 ± 0.008
3.496ArgAsp: 3.496 ± 0.023
4.097ArgGlu: 4.097 ± 0.03
1.942ArgPhe: 1.942 ± 0.017
3.912ArgGly: 3.912 ± 0.03
1.554ArgHis: 1.554 ± 0.014
2.687ArgIle: 2.687 ± 0.017
3.666ArgLys: 3.666 ± 0.022
5.403ArgLeu: 5.403 ± 0.029
1.43ArgMet: 1.43 ± 0.013
2.077ArgAsn: 2.077 ± 0.016
3.616ArgPro: 3.616 ± 0.027
2.762ArgGln: 2.762 ± 0.021
5.253ArgArg: 5.253 ± 0.036
4.979ArgSer: 4.979 ± 0.034
3.601ArgThr: 3.601 ± 0.024
3.486ArgVal: 3.486 ± 0.021
0.868ArgTrp: 0.868 ± 0.01
1.577ArgTyr: 1.577 ± 0.014
0.0ArgXaa: 0.0 ± 0.0
Ser
7.655SerAla: 7.655 ± 0.039
0.726SerCys: 0.726 ± 0.011
4.29SerAsp: 4.29 ± 0.025
4.009SerGlu: 4.009 ± 0.026
2.629SerPhe: 2.629 ± 0.018
5.815SerGly: 5.815 ± 0.033
1.873SerHis: 1.873 ± 0.018
3.648SerIle: 3.648 ± 0.021
3.584SerLys: 3.584 ± 0.022
6.764SerLeu: 6.764 ± 0.031
1.77SerMet: 1.77 ± 0.016
2.789SerAsn: 2.789 ± 0.021
5.475SerPro: 5.475 ± 0.041
3.108SerGln: 3.108 ± 0.024
4.915SerArg: 4.915 ± 0.033
8.389SerSer: 8.389 ± 0.062
6.104SerThr: 6.104 ± 0.037
4.533SerVal: 4.533 ± 0.025
1.022SerTrp: 1.022 ± 0.012
2.021SerTyr: 2.021 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
6.34ThrAla: 6.34 ± 0.03
0.715ThrCys: 0.715 ± 0.011
2.924ThrAsp: 2.924 ± 0.02
3.051ThrGlu: 3.051 ± 0.022
2.197ThrPhe: 2.197 ± 0.018
4.391ThrGly: 4.391 ± 0.028
1.386ThrHis: 1.386 ± 0.013
2.958ThrIle: 2.958 ± 0.024
2.652ThrLys: 2.652 ± 0.02
5.61ThrLeu: 5.61 ± 0.036
1.254ThrMet: 1.254 ± 0.013
2.112ThrAsn: 2.112 ± 0.017
4.733ThrPro: 4.733 ± 0.035
2.278ThrGln: 2.278 ± 0.02
3.32ThrArg: 3.32 ± 0.019
5.926ThrSer: 5.926 ± 0.039
4.852ThrThr: 4.852 ± 0.045
3.827ThrVal: 3.827 ± 0.029
0.858ThrTrp: 0.858 ± 0.012
1.673ThrTyr: 1.673 ± 0.016
0.0ThrXaa: 0.0 ± 0.0
Val
5.826ValAla: 5.826 ± 0.029
0.744ValCys: 0.744 ± 0.01
3.712ValAsp: 3.712 ± 0.023
4.083ValGlu: 4.083 ± 0.024
2.215ValPhe: 2.215 ± 0.021
4.178ValGly: 4.178 ± 0.029
1.439ValHis: 1.439 ± 0.014
2.694ValIle: 2.694 ± 0.017
3.118ValLys: 3.118 ± 0.02
5.561ValLeu: 5.561 ± 0.029
1.366ValMet: 1.366 ± 0.014
2.177ValAsn: 2.177 ± 0.018
3.653ValPro: 3.653 ± 0.022
2.508ValGln: 2.508 ± 0.016
3.731ValArg: 3.731 ± 0.022
4.446ValSer: 4.446 ± 0.024
3.658ValThr: 3.658 ± 0.03
4.373ValVal: 4.373 ± 0.031
0.851ValTrp: 0.851 ± 0.012
1.716ValTyr: 1.716 ± 0.017
0.0ValXaa: 0.0 ± 0.0
Trp
1.09TrpAla: 1.09 ± 0.012
0.19TrpCys: 0.19 ± 0.005
0.841TrpAsp: 0.841 ± 0.011
0.81TrpGlu: 0.81 ± 0.01
0.488TrpPhe: 0.488 ± 0.008
0.863TrpGly: 0.863 ± 0.012
0.366TrpHis: 0.366 ± 0.007
0.655TrpIle: 0.655 ± 0.009
0.698TrpLys: 0.698 ± 0.009
1.337TrpLeu: 1.337 ± 0.014
0.342TrpMet: 0.342 ± 0.007
0.536TrpAsn: 0.536 ± 0.008
0.605TrpPro: 0.605 ± 0.009
0.647TrpGln: 0.647 ± 0.01
0.994TrpArg: 0.994 ± 0.013
1.029TrpSer: 1.029 ± 0.011
0.929TrpThr: 0.929 ± 0.012
0.834TrpVal: 0.834 ± 0.01
0.257TrpTrp: 0.257 ± 0.006
0.416TrpTyr: 0.416 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.419TyrAla: 2.419 ± 0.019
0.381TyrCys: 0.381 ± 0.007
1.667TyrAsp: 1.667 ± 0.016
1.503TyrGlu: 1.503 ± 0.014
1.093TyrPhe: 1.093 ± 0.012
2.156TyrGly: 2.156 ± 0.021
0.686TyrHis: 0.686 ± 0.009
1.246TyrIle: 1.246 ± 0.011
1.011TyrLys: 1.011 ± 0.012
2.437TyrLeu: 2.437 ± 0.017
0.576TyrMet: 0.576 ± 0.009
1.028TyrAsn: 1.028 ± 0.012
1.405TyrPro: 1.405 ± 0.014
1.03TyrGln: 1.03 ± 0.012
1.498TyrArg: 1.498 ± 0.015
1.924TyrSer: 1.924 ± 0.019
1.745TyrThr: 1.745 ± 0.017
1.586TyrVal: 1.586 ± 0.015
0.421TyrTrp: 0.421 ± 0.007
0.885TyrTyr: 0.885 ± 0.011
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18035 proteins (8397328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski