Amino acid dipepetide frequency for Saprochaete ingens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.416AlaAla: 9.416 ± 0.287
0.724AlaCys: 0.724 ± 0.016
3.532AlaAsp: 3.532 ± 0.149
3.997AlaGlu: 3.997 ± 0.115
2.572AlaPhe: 2.572 ± 0.034
4.272AlaGly: 4.272 ± 0.048
1.476AlaHis: 1.476 ± 0.022
4.027AlaIle: 4.027 ± 0.038
3.605AlaLys: 3.605 ± 0.04
6.573AlaLeu: 6.573 ± 0.082
1.349AlaMet: 1.349 ± 0.023
2.859AlaAsn: 2.859 ± 0.027
4.191AlaPro: 4.191 ± 0.06
3.189AlaGln: 3.189 ± 0.108
3.598AlaArg: 3.598 ± 0.048
7.892AlaSer: 7.892 ± 0.195
5.349AlaThr: 5.349 ± 0.065
4.565AlaVal: 4.565 ± 0.06
0.641AlaTrp: 0.641 ± 0.014
1.882AlaTyr: 1.882 ± 0.026
0.0AlaXaa: 0.0 ± 0.0
Cys
0.687CysAla: 0.687 ± 0.017
0.179CysCys: 0.179 ± 0.007
0.524CysAsp: 0.524 ± 0.014
0.519CysGlu: 0.519 ± 0.014
0.49CysPhe: 0.49 ± 0.014
0.704CysGly: 0.704 ± 0.017
0.259CysHis: 0.259 ± 0.01
0.628CysIle: 0.628 ± 0.014
0.503CysLys: 0.503 ± 0.012
0.89CysLeu: 0.89 ± 0.019
0.175CysMet: 0.175 ± 0.007
0.412CysAsn: 0.412 ± 0.01
0.449CysPro: 0.449 ± 0.013
0.299CysGln: 0.299 ± 0.01
0.463CysArg: 0.463 ± 0.013
0.836CysSer: 0.836 ± 0.023
0.551CysThr: 0.551 ± 0.013
0.659CysVal: 0.659 ± 0.013
0.106CysTrp: 0.106 ± 0.005
0.302CysTyr: 0.302 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
3.742AspAla: 3.742 ± 0.197
0.453AspCys: 0.453 ± 0.014
5.264AspAsp: 5.264 ± 0.148
4.7AspGlu: 4.7 ± 0.077
2.201AspPhe: 2.201 ± 0.026
2.901AspGly: 2.901 ± 0.036
1.045AspHis: 1.045 ± 0.019
3.133AspIle: 3.133 ± 0.034
2.78AspLys: 2.78 ± 0.067
4.9AspLeu: 4.9 ± 0.047
1.037AspMet: 1.037 ± 0.02
2.651AspAsn: 2.651 ± 0.04
2.746AspPro: 2.746 ± 0.038
1.667AspGln: 1.667 ± 0.024
2.143AspArg: 2.143 ± 0.03
5.066AspSer: 5.066 ± 0.116
2.822AspThr: 2.822 ± 0.034
3.096AspVal: 3.096 ± 0.037
0.521AspTrp: 0.521 ± 0.013
1.785AspTyr: 1.785 ± 0.024
0.0AspXaa: 0.0 ± 0.0
Glu
4.583GluAla: 4.583 ± 0.139
0.514GluCys: 0.514 ± 0.013
4.4GluAsp: 4.4 ± 0.092
6.691GluGlu: 6.691 ± 0.113
2.12GluPhe: 2.12 ± 0.025
2.677GluGly: 2.677 ± 0.032
1.132GluHis: 1.132 ± 0.019
3.52GluIle: 3.52 ± 0.042
4.34GluLys: 4.34 ± 0.06
4.906GluLeu: 4.906 ± 0.051
1.164GluMet: 1.164 ± 0.017
3.152GluAsn: 3.152 ± 0.041
2.521GluPro: 2.521 ± 0.046
2.394GluGln: 2.394 ± 0.039
2.821GluArg: 2.821 ± 0.037
5.763GluSer: 5.763 ± 0.232
3.704GluThr: 3.704 ± 0.042
3.121GluVal: 3.121 ± 0.04
0.631GluTrp: 0.631 ± 0.015
2.019GluTyr: 2.019 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
2.568PheAla: 2.568 ± 0.031
0.461PheCys: 0.461 ± 0.011
2.368PheAsp: 2.368 ± 0.03
2.274PheGlu: 2.274 ± 0.029
1.813PhePhe: 1.813 ± 0.029
2.595PheGly: 2.595 ± 0.036
0.834PheHis: 0.834 ± 0.017
2.125PheIle: 2.125 ± 0.029
1.994PheLys: 1.994 ± 0.028
3.359PheLeu: 3.359 ± 0.039
0.72PheMet: 0.72 ± 0.015
1.833PheAsn: 1.833 ± 0.026
1.803PhePro: 1.803 ± 0.024
1.38PheGln: 1.38 ± 0.021
1.559PheArg: 1.559 ± 0.02
3.88PheSer: 3.88 ± 0.039
2.167PheThr: 2.167 ± 0.025
2.432PheVal: 2.432 ± 0.031
0.502PheTrp: 0.502 ± 0.013
1.238PheTyr: 1.238 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
4.038GlyAla: 4.038 ± 0.056
0.574GlyCys: 0.574 ± 0.016
2.816GlyAsp: 2.816 ± 0.036
2.693GlyGlu: 2.693 ± 0.034
2.375GlyPhe: 2.375 ± 0.033
4.866GlyGly: 4.866 ± 0.079
1.31GlyHis: 1.31 ± 0.022
3.296GlyIle: 3.296 ± 0.037
2.892GlyLys: 2.892 ± 0.038
4.729GlyLeu: 4.729 ± 0.046
1.01GlyMet: 1.01 ± 0.017
2.809GlyAsn: 2.809 ± 0.035
2.781GlyPro: 2.781 ± 0.041
1.72GlyGln: 1.72 ± 0.023
2.468GlyArg: 2.468 ± 0.033
6.719GlySer: 6.719 ± 0.149
3.671GlyThr: 3.671 ± 0.054
3.572GlyVal: 3.572 ± 0.041
0.639GlyTrp: 0.639 ± 0.015
1.908GlyTyr: 1.908 ± 0.029
0.0GlyXaa: 0.0 ± 0.0
His
1.4HisAla: 1.4 ± 0.023
0.215HisCys: 0.215 ± 0.008
1.051HisAsp: 1.051 ± 0.019
1.18HisGlu: 1.18 ± 0.021
0.849HisPhe: 0.849 ± 0.014
1.317HisGly: 1.317 ± 0.022
1.395HisHis: 1.395 ± 0.034
1.328HisIle: 1.328 ± 0.021
1.15HisLys: 1.15 ± 0.018
2.028HisLeu: 2.028 ± 0.025
0.433HisMet: 0.433 ± 0.011
1.161HisAsn: 1.161 ± 0.022
1.349HisPro: 1.349 ± 0.022
1.343HisGln: 1.343 ± 0.036
1.193HisArg: 1.193 ± 0.02
2.137HisSer: 2.137 ± 0.031
1.248HisThr: 1.248 ± 0.022
1.245HisVal: 1.245 ± 0.019
0.196HisTrp: 0.196 ± 0.007
0.72HisTyr: 0.72 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.853IleAla: 3.853 ± 0.039
0.635IleCys: 0.635 ± 0.014
3.27IleAsp: 3.27 ± 0.04
3.243IleGlu: 3.243 ± 0.036
2.185IlePhe: 2.185 ± 0.035
2.774IleGly: 2.774 ± 0.036
1.249IleHis: 1.249 ± 0.02
3.03IleIle: 3.03 ± 0.037
3.052IleLys: 3.052 ± 0.038
4.719IleLeu: 4.719 ± 0.048
1.011IleMet: 1.011 ± 0.017
2.726IleAsn: 2.726 ± 0.028
3.35IlePro: 3.35 ± 0.032
2.014IleGln: 2.014 ± 0.028
2.443IleArg: 2.443 ± 0.03
5.466IleSer: 5.466 ± 0.048
3.321IleThr: 3.321 ± 0.036
3.548IleVal: 3.548 ± 0.035
0.555IleTrp: 0.555 ± 0.014
1.736IleTyr: 1.736 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.812LysAla: 3.812 ± 0.07
0.527LysCys: 0.527 ± 0.015
3.095LysAsp: 3.095 ± 0.036
4.005LysGlu: 4.005 ± 0.058
1.966LysPhe: 1.966 ± 0.024
2.337LysGly: 2.337 ± 0.03
1.23LysHis: 1.23 ± 0.019
3.174LysIle: 3.174 ± 0.034
4.637LysLys: 4.637 ± 0.068
4.606LysLeu: 4.606 ± 0.047
1.003LysMet: 1.003 ± 0.015
2.81LysAsn: 2.81 ± 0.031
2.89LysPro: 2.89 ± 0.037
2.347LysGln: 2.347 ± 0.03
3.256LysArg: 3.256 ± 0.04
4.797LysSer: 4.797 ± 0.058
3.442LysThr: 3.442 ± 0.038
3.016LysVal: 3.016 ± 0.034
0.532LysTrp: 0.532 ± 0.014
1.844LysTyr: 1.844 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
6.591LeuAla: 6.591 ± 0.059
0.972LeuCys: 0.972 ± 0.019
4.791LeuAsp: 4.791 ± 0.072
5.513LeuGlu: 5.513 ± 0.057
3.309LeuPhe: 3.309 ± 0.038
4.722LeuGly: 4.722 ± 0.043
1.903LeuHis: 1.903 ± 0.028
4.151LeuIle: 4.151 ± 0.045
5.007LeuLys: 5.007 ± 0.048
7.569LeuLeu: 7.569 ± 0.073
1.474LeuMet: 1.474 ± 0.022
3.906LeuAsn: 3.906 ± 0.04
4.928LeuPro: 4.928 ± 0.046
3.68LeuGln: 3.68 ± 0.045
4.469LeuArg: 4.469 ± 0.044
7.979LeuSer: 7.979 ± 0.051
4.868LeuThr: 4.868 ± 0.044
5.061LeuVal: 5.061 ± 0.053
0.86LeuTrp: 0.86 ± 0.018
2.557LeuTyr: 2.557 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
1.552MetAla: 1.552 ± 0.024
0.188MetCys: 0.188 ± 0.007
1.008MetAsp: 1.008 ± 0.02
0.988MetGlu: 0.988 ± 0.015
0.717MetPhe: 0.717 ± 0.017
1.044MetGly: 1.044 ± 0.019
0.353MetHis: 0.353 ± 0.01
0.88MetIle: 0.88 ± 0.017
0.934MetLys: 0.934 ± 0.018
1.545MetLeu: 1.545 ± 0.023
0.409MetMet: 0.409 ± 0.01
0.77MetAsn: 0.77 ± 0.017
0.917MetPro: 0.917 ± 0.017
0.622MetGln: 0.622 ± 0.014
0.877MetArg: 0.877 ± 0.016
1.807MetSer: 1.807 ± 0.022
1.125MetThr: 1.125 ± 0.017
1.109MetVal: 1.109 ± 0.021
0.152MetTrp: 0.152 ± 0.007
0.52MetTyr: 0.52 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.881AsnAla: 2.881 ± 0.036
0.46AsnCys: 0.46 ± 0.012
2.792AsnAsp: 2.792 ± 0.038
2.734AsnGlu: 2.734 ± 0.032
1.758AsnPhe: 1.758 ± 0.023
3.222AsnGly: 3.222 ± 0.037
1.187AsnHis: 1.187 ± 0.024
2.898AsnIle: 2.898 ± 0.033
2.707AsnLys: 2.707 ± 0.036
3.775AsnLeu: 3.775 ± 0.036
0.874AsnMet: 0.874 ± 0.017
5.034AsnAsn: 5.034 ± 0.098
2.501AsnPro: 2.501 ± 0.031
1.832AsnGln: 1.832 ± 0.029
1.853AsnArg: 1.853 ± 0.026
5.121AsnSer: 5.121 ± 0.06
3.364AsnThr: 3.364 ± 0.042
2.586AsnVal: 2.586 ± 0.028
0.415AsnTrp: 0.415 ± 0.012
1.404AsnTyr: 1.404 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
4.198ProAla: 4.198 ± 0.06
0.441ProCys: 0.441 ± 0.016
2.456ProAsp: 2.456 ± 0.029
3.44ProGlu: 3.44 ± 0.04
1.948ProPhe: 1.948 ± 0.024
3.005ProGly: 3.005 ± 0.044
1.228ProHis: 1.228 ± 0.021
2.988ProIle: 2.988 ± 0.031
2.939ProLys: 2.939 ± 0.043
4.602ProLeu: 4.602 ± 0.045
0.796ProMet: 0.796 ± 0.016
2.307ProAsn: 2.307 ± 0.029
4.799ProPro: 4.799 ± 0.088
2.757ProGln: 2.757 ± 0.056
2.32ProArg: 2.32 ± 0.029
6.376ProSer: 6.376 ± 0.07
3.933ProThr: 3.933 ± 0.046
3.605ProVal: 3.605 ± 0.044
0.416ProTrp: 0.416 ± 0.012
1.5ProTyr: 1.5 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
2.942GlnAla: 2.942 ± 0.102
0.304GlnCys: 0.304 ± 0.01
1.792GlnAsp: 1.792 ± 0.024
2.479GlnGlu: 2.479 ± 0.042
1.448GlnPhe: 1.448 ± 0.023
1.809GlnGly: 1.809 ± 0.028
1.393GlnHis: 1.393 ± 0.035
2.083GlnIle: 2.083 ± 0.026
2.314GlnLys: 2.314 ± 0.032
3.548GlnLeu: 3.548 ± 0.046
0.739GlnMet: 0.739 ± 0.016
2.075GlnAsn: 2.075 ± 0.034
2.529GlnPro: 2.529 ± 0.056
8.473GlnGln: 8.473 ± 0.272
1.948GlnArg: 1.948 ± 0.026
3.411GlnSer: 3.411 ± 0.041
2.383GlnThr: 2.383 ± 0.05
2.185GlnVal: 2.185 ± 0.034
0.338GlnTrp: 0.338 ± 0.01
1.302GlnTyr: 1.302 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
3.42ArgAla: 3.42 ± 0.042
0.439ArgCys: 0.439 ± 0.012
2.427ArgAsp: 2.427 ± 0.033
2.872ArgGlu: 2.872 ± 0.042
1.8ArgPhe: 1.8 ± 0.025
2.513ArgGly: 2.513 ± 0.036
1.195ArgHis: 1.195 ± 0.022
2.564ArgIle: 2.564 ± 0.031
3.063ArgLys: 3.063 ± 0.036
4.119ArgLeu: 4.119 ± 0.04
0.889ArgMet: 0.889 ± 0.019
2.241ArgAsn: 2.241 ± 0.026
2.358ArgPro: 2.358 ± 0.031
1.969ArgGln: 1.969 ± 0.029
3.55ArgArg: 3.55 ± 0.051
3.941ArgSer: 3.941 ± 0.046
2.483ArgThr: 2.483 ± 0.033
2.801ArgVal: 2.801 ± 0.033
0.479ArgTrp: 0.479 ± 0.011
1.53ArgTyr: 1.53 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
7.604SerAla: 7.604 ± 0.156
0.794SerCys: 0.794 ± 0.019
4.717SerAsp: 4.717 ± 0.071
5.535SerGlu: 5.535 ± 0.21
3.765SerPhe: 3.765 ± 0.037
6.434SerGly: 6.434 ± 0.142
2.169SerHis: 2.169 ± 0.029
5.302SerIle: 5.302 ± 0.047
5.132SerLys: 5.132 ± 0.055
8.322SerLeu: 8.322 ± 0.065
1.559SerMet: 1.559 ± 0.022
5.131SerAsn: 5.131 ± 0.067
6.063SerPro: 6.063 ± 0.073
3.944SerGln: 3.944 ± 0.049
4.298SerArg: 4.298 ± 0.044
20.607SerSer: 20.607 ± 0.834
7.956SerThr: 7.956 ± 0.108
5.688SerVal: 5.688 ± 0.085
0.772SerTrp: 0.772 ± 0.016
2.519SerTyr: 2.519 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.024ThrAla: 5.024 ± 0.061
0.598ThrCys: 0.598 ± 0.018
2.733ThrAsp: 2.733 ± 0.032
3.37ThrGlu: 3.37 ± 0.058
2.314ThrPhe: 2.314 ± 0.03
3.984ThrGly: 3.984 ± 0.078
1.258ThrHis: 1.258 ± 0.018
3.564ThrIle: 3.564 ± 0.039
3.231ThrLys: 3.231 ± 0.034
5.393ThrLeu: 5.393 ± 0.05
0.947ThrMet: 0.947 ± 0.017
3.008ThrAsn: 3.008 ± 0.034
4.543ThrPro: 4.543 ± 0.045
2.311ThrGln: 2.311 ± 0.039
2.632ThrArg: 2.632 ± 0.03
7.439ThrSer: 7.439 ± 0.09
6.538ThrThr: 6.538 ± 0.114
4.047ThrVal: 4.047 ± 0.079
0.528ThrTrp: 0.528 ± 0.013
1.589ThrTyr: 1.589 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
4.778ValAla: 4.778 ± 0.052
0.668ValCys: 0.668 ± 0.016
3.319ValAsp: 3.319 ± 0.06
3.747ValGlu: 3.747 ± 0.084
2.445ValPhe: 2.445 ± 0.032
3.307ValGly: 3.307 ± 0.045
1.244ValHis: 1.244 ± 0.02
3.195ValIle: 3.195 ± 0.035
2.97ValLys: 2.97 ± 0.033
5.236ValLeu: 5.236 ± 0.051
1.04ValMet: 1.04 ± 0.016
2.409ValAsn: 2.409 ± 0.025
3.557ValPro: 3.557 ± 0.038
2.071ValGln: 2.071 ± 0.034
2.754ValArg: 2.754 ± 0.034
5.714ValSer: 5.714 ± 0.065
3.743ValThr: 3.743 ± 0.074
4.171ValVal: 4.171 ± 0.048
0.595ValTrp: 0.595 ± 0.014
1.787ValTyr: 1.787 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
0.715TrpAla: 0.715 ± 0.015
0.117TrpCys: 0.117 ± 0.005
0.577TrpAsp: 0.577 ± 0.014
0.558TrpGlu: 0.558 ± 0.011
0.413TrpPhe: 0.413 ± 0.013
0.566TrpGly: 0.566 ± 0.012
0.245TrpHis: 0.245 ± 0.009
0.6TrpIle: 0.6 ± 0.015
0.6TrpLys: 0.6 ± 0.014
0.797TrpLeu: 0.797 ± 0.017
0.203TrpMet: 0.203 ± 0.007
0.51TrpAsn: 0.51 ± 0.011
0.329TrpPro: 0.329 ± 0.01
0.32TrpGln: 0.32 ± 0.011
0.555TrpArg: 0.555 ± 0.013
0.67TrpSer: 0.67 ± 0.013
0.593TrpThr: 0.593 ± 0.015
0.562TrpVal: 0.562 ± 0.015
0.149TrpTrp: 0.149 ± 0.007
0.327TrpTyr: 0.327 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.909TyrAla: 1.909 ± 0.026
0.376TyrCys: 0.376 ± 0.011
1.721TyrAsp: 1.721 ± 0.026
1.634TyrGlu: 1.634 ± 0.024
1.418TyrPhe: 1.418 ± 0.022
1.838TyrGly: 1.838 ± 0.025
0.833TyrHis: 0.833 ± 0.017
1.693TyrIle: 1.693 ± 0.023
1.476TyrLys: 1.476 ± 0.023
2.694TyrLeu: 2.694 ± 0.039
0.688TyrMet: 0.688 ± 0.015
1.594TyrAsn: 1.594 ± 0.022
1.448TyrPro: 1.448 ± 0.024
1.162TyrGln: 1.162 ± 0.021
1.45TyrArg: 1.45 ± 0.018
2.689TyrSer: 2.689 ± 0.032
1.788TyrThr: 1.788 ± 0.026
1.68TyrVal: 1.68 ± 0.025
0.378TyrTrp: 0.378 ± 0.015
1.187TyrTyr: 1.187 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6465 proteins (3935327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski