Amino acid dipepetide frequency for Cuscuta australis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.41AlaAla: 7.41 ± 0.05
1.286AlaCys: 1.286 ± 0.014
3.155AlaAsp: 3.155 ± 0.02
4.303AlaGlu: 4.303 ± 0.028
2.878AlaPhe: 2.878 ± 0.024
4.538AlaGly: 4.538 ± 0.03
1.442AlaHis: 1.442 ± 0.014
3.698AlaIle: 3.698 ± 0.025
3.93AlaLys: 3.93 ± 0.024
6.805AlaLeu: 6.805 ± 0.037
1.824AlaMet: 1.824 ± 0.015
2.5AlaAsn: 2.5 ± 0.019
2.976AlaPro: 2.976 ± 0.026
2.102AlaGln: 2.102 ± 0.017
3.618AlaArg: 3.618 ± 0.019
6.124AlaSer: 6.124 ± 0.03
3.698AlaThr: 3.698 ± 0.024
5.211AlaVal: 5.211 ± 0.03
0.757AlaTrp: 0.757 ± 0.011
1.808AlaTyr: 1.808 ± 0.017
0.0AlaXaa: 0.0 ± 0.0
Cys
1.076CysAla: 1.076 ± 0.013
0.541CysCys: 0.541 ± 0.01
0.943CysAsp: 0.943 ± 0.013
0.953CysGlu: 0.953 ± 0.013
0.904CysPhe: 0.904 ± 0.012
1.484CysGly: 1.484 ± 0.017
0.512CysHis: 0.512 ± 0.008
1.013CysIle: 1.013 ± 0.013
1.148CysLys: 1.148 ± 0.014
1.936CysLeu: 1.936 ± 0.019
0.439CysMet: 0.439 ± 0.009
0.888CysAsn: 0.888 ± 0.013
0.968CysPro: 0.968 ± 0.014
0.597CysGln: 0.597 ± 0.009
1.172CysArg: 1.172 ± 0.012
1.919CysSer: 1.919 ± 0.017
0.91CysThr: 0.91 ± 0.01
1.174CysVal: 1.174 ± 0.012
0.258CysTrp: 0.258 ± 0.007
0.556CysTyr: 0.556 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
3.659AspAla: 3.659 ± 0.024
0.996AspCys: 0.996 ± 0.013
3.983AspAsp: 3.983 ± 0.033
4.177AspGlu: 4.177 ± 0.031
2.302AspPhe: 2.302 ± 0.017
4.011AspGly: 4.011 ± 0.025
1.272AspHis: 1.272 ± 0.012
2.902AspIle: 2.902 ± 0.02
2.574AspLys: 2.574 ± 0.019
5.06AspLeu: 5.06 ± 0.032
1.307AspMet: 1.307 ± 0.013
1.99AspAsn: 1.99 ± 0.017
2.691AspPro: 2.691 ± 0.019
1.571AspGln: 1.571 ± 0.015
2.485AspArg: 2.485 ± 0.021
4.193AspSer: 4.193 ± 0.025
2.159AspThr: 2.159 ± 0.015
3.601AspVal: 3.601 ± 0.025
0.711AspTrp: 0.711 ± 0.01
1.527AspTyr: 1.527 ± 0.013
0.0AspXaa: 0.0 ± 0.0
Glu
4.851GluAla: 4.851 ± 0.027
0.99GluCys: 0.99 ± 0.011
3.97GluAsp: 3.97 ± 0.03
6.456GluGlu: 6.456 ± 0.052
2.386GluPhe: 2.386 ± 0.018
3.94GluGly: 3.94 ± 0.028
1.345GluHis: 1.345 ± 0.014
3.548GluIle: 3.548 ± 0.028
4.729GluLys: 4.729 ± 0.039
5.789GluLeu: 5.789 ± 0.037
1.943GluMet: 1.943 ± 0.018
2.946GluAsn: 2.946 ± 0.023
2.137GluPro: 2.137 ± 0.017
1.939GluGln: 1.939 ± 0.021
3.557GluArg: 3.557 ± 0.025
4.624GluSer: 4.624 ± 0.03
3.018GluThr: 3.018 ± 0.023
4.053GluVal: 4.053 ± 0.025
0.76GluTrp: 0.76 ± 0.012
1.628GluTyr: 1.628 ± 0.017
0.0GluXaa: 0.0 ± 0.0
Phe
2.578PheAla: 2.578 ± 0.019
0.947PheCys: 0.947 ± 0.013
2.298PheAsp: 2.298 ± 0.02
2.328PheGlu: 2.328 ± 0.019
2.031PhePhe: 2.031 ± 0.021
3.012PheGly: 3.012 ± 0.023
1.116PheHis: 1.116 ± 0.013
2.126PheIle: 2.126 ± 0.02
2.05PheLys: 2.05 ± 0.014
4.246PheLeu: 4.246 ± 0.029
1.006PheMet: 1.006 ± 0.012
1.688PheAsn: 1.688 ± 0.016
2.232PhePro: 2.232 ± 0.018
1.517PheGln: 1.517 ± 0.016
2.164PheArg: 2.164 ± 0.019
4.017PheSer: 4.017 ± 0.025
2.004PheThr: 2.004 ± 0.018
2.795PheVal: 2.795 ± 0.022
0.55PheTrp: 0.55 ± 0.01
1.229PheTyr: 1.229 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
4.131GlyAla: 4.131 ± 0.027
1.357GlyCys: 1.357 ± 0.015
3.667GlyAsp: 3.667 ± 0.021
3.96GlyGlu: 3.96 ± 0.028
3.171GlyPhe: 3.171 ± 0.023
6.532GlyGly: 6.532 ± 0.07
1.618GlyHis: 1.618 ± 0.016
3.542GlyIle: 3.542 ± 0.026
4.178GlyLys: 4.178 ± 0.026
6.024GlyLeu: 6.024 ± 0.033
1.573GlyMet: 1.573 ± 0.016
3.103GlyAsn: 3.103 ± 0.023
2.611GlyPro: 2.611 ± 0.019
1.985GlyGln: 1.985 ± 0.019
4.09GlyArg: 4.09 ± 0.03
6.073GlySer: 6.073 ± 0.029
3.224GlyThr: 3.224 ± 0.02
4.462GlyVal: 4.462 ± 0.026
0.934GlyTrp: 0.934 ± 0.012
2.094GlyTyr: 2.094 ± 0.017
0.0GlyXaa: 0.0 ± 0.0
His
1.502HisAla: 1.502 ± 0.015
0.593HisCys: 0.593 ± 0.01
1.157HisAsp: 1.157 ± 0.012
1.276HisGlu: 1.276 ± 0.011
1.131HisPhe: 1.131 ± 0.014
1.782HisGly: 1.782 ± 0.016
1.136HisHis: 1.136 ± 0.017
1.298HisIle: 1.298 ± 0.013
1.217HisLys: 1.217 ± 0.014
2.532HisLeu: 2.532 ± 0.02
0.579HisMet: 0.579 ± 0.009
1.044HisAsn: 1.044 ± 0.011
1.495HisPro: 1.495 ± 0.017
1.032HisGln: 1.032 ± 0.012
1.503HisArg: 1.503 ± 0.015
2.153HisSer: 2.153 ± 0.018
1.097HisThr: 1.097 ± 0.012
1.53HisVal: 1.53 ± 0.014
0.309HisTrp: 0.309 ± 0.007
0.742HisTyr: 0.742 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
3.479IleAla: 3.479 ± 0.026
1.127IleCys: 1.127 ± 0.015
2.874IleAsp: 2.874 ± 0.02
3.009IleGlu: 3.009 ± 0.024
2.163IlePhe: 2.163 ± 0.02
3.284IleGly: 3.284 ± 0.023
1.35IleHis: 1.35 ± 0.015
2.607IleIle: 2.607 ± 0.019
2.797IleLys: 2.797 ± 0.02
4.996IleLeu: 4.996 ± 0.031
1.11IleMet: 1.11 ± 0.013
2.011IleAsn: 2.011 ± 0.018
2.904IlePro: 2.904 ± 0.024
1.841IleGln: 1.841 ± 0.019
2.712IleArg: 2.712 ± 0.017
4.826IleSer: 4.826 ± 0.029
2.405IleThr: 2.405 ± 0.019
3.347IleVal: 3.347 ± 0.022
0.674IleTrp: 0.674 ± 0.011
1.431IleTyr: 1.431 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
4.032LysAla: 4.032 ± 0.027
1.063LysCys: 1.063 ± 0.012
3.152LysAsp: 3.152 ± 0.023
4.399LysGlu: 4.399 ± 0.034
2.151LysPhe: 2.151 ± 0.018
3.652LysGly: 3.652 ± 0.024
1.415LysHis: 1.415 ± 0.013
2.994LysIle: 2.994 ± 0.024
4.918LysLys: 4.918 ± 0.042
5.686LysLeu: 5.686 ± 0.033
1.551LysMet: 1.551 ± 0.016
2.661LysAsn: 2.661 ± 0.021
2.774LysPro: 2.774 ± 0.025
2.166LysGln: 2.166 ± 0.019
3.712LysArg: 3.712 ± 0.024
4.574LysSer: 4.574 ± 0.027
2.825LysThr: 2.825 ± 0.021
3.651LysVal: 3.651 ± 0.027
0.785LysTrp: 0.785 ± 0.012
1.593LysTyr: 1.593 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
6.407LeuAla: 6.407 ± 0.036
1.949LeuCys: 1.949 ± 0.019
5.027LeuAsp: 5.027 ± 0.031
6.144LeuGlu: 6.144 ± 0.04
3.928LeuPhe: 3.928 ± 0.026
5.939LeuGly: 5.939 ± 0.034
2.681LeuHis: 2.681 ± 0.021
4.459LeuIle: 4.459 ± 0.025
5.897LeuLys: 5.897 ± 0.033
9.925LeuLeu: 9.925 ± 0.049
2.118LeuMet: 2.118 ± 0.018
3.859LeuAsn: 3.859 ± 0.022
5.23LeuPro: 5.23 ± 0.03
4.05LeuGln: 4.05 ± 0.028
5.554LeuArg: 5.554 ± 0.031
8.321LeuSer: 8.321 ± 0.04
4.226LeuThr: 4.226 ± 0.025
6.174LeuVal: 6.174 ± 0.037
1.125LeuTrp: 1.125 ± 0.015
2.39LeuTyr: 2.39 ± 0.02
0.0LeuXaa: 0.0 ± 0.0
Met
2.169MetAla: 2.169 ± 0.02
0.372MetCys: 0.372 ± 0.007
1.423MetAsp: 1.423 ± 0.012
2.036MetGlu: 2.036 ± 0.019
0.822MetPhe: 0.822 ± 0.012
1.666MetGly: 1.666 ± 0.015
0.558MetHis: 0.558 ± 0.009
1.152MetIle: 1.152 ± 0.015
1.65MetLys: 1.65 ± 0.015
2.111MetLeu: 2.111 ± 0.018
0.752MetMet: 0.752 ± 0.012
1.097MetAsn: 1.097 ± 0.012
1.076MetPro: 1.076 ± 0.013
0.895MetGln: 0.895 ± 0.01
1.252MetArg: 1.252 ± 0.015
1.761MetSer: 1.761 ± 0.015
1.059MetThr: 1.059 ± 0.012
1.643MetVal: 1.643 ± 0.015
0.266MetTrp: 0.266 ± 0.006
0.617MetTyr: 0.617 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.783AsnAla: 2.783 ± 0.019
0.838AsnCys: 0.838 ± 0.011
2.05AsnAsp: 2.05 ± 0.017
2.45AsnGlu: 2.45 ± 0.019
1.816AsnPhe: 1.816 ± 0.016
3.274AsnGly: 3.274 ± 0.025
1.156AsnHis: 1.156 ± 0.015
2.323AsnIle: 2.323 ± 0.017
2.321AsnLys: 2.321 ± 0.019
4.25AsnLeu: 4.25 ± 0.029
1.063AsnMet: 1.063 ± 0.013
2.387AsnAsn: 2.387 ± 0.027
2.422AsnPro: 2.422 ± 0.021
1.552AsnGln: 1.552 ± 0.017
2.13AsnArg: 2.13 ± 0.018
3.613AsnSer: 3.613 ± 0.023
1.894AsnThr: 1.894 ± 0.016
2.756AsnVal: 2.756 ± 0.022
0.536AsnTrp: 0.536 ± 0.007
1.235AsnTyr: 1.235 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
3.388ProAla: 3.388 ± 0.026
0.865ProCys: 0.865 ± 0.013
2.545ProAsp: 2.545 ± 0.02
3.147ProGlu: 3.147 ± 0.024
2.078ProPhe: 2.078 ± 0.018
3.012ProGly: 3.012 ± 0.024
1.258ProHis: 1.258 ± 0.015
2.344ProIle: 2.344 ± 0.018
2.747ProLys: 2.747 ± 0.021
4.423ProLeu: 4.423 ± 0.029
1.001ProMet: 1.001 ± 0.011
2.308ProAsn: 2.308 ± 0.022
4.561ProPro: 4.561 ± 0.063
1.76ProGln: 1.76 ± 0.019
2.571ProArg: 2.571 ± 0.023
5.154ProSer: 5.154 ± 0.031
2.723ProThr: 2.723 ± 0.02
3.075ProVal: 3.075 ± 0.021
0.604ProTrp: 0.604 ± 0.01
1.308ProTyr: 1.308 ± 0.012
0.0ProXaa: 0.0 ± 0.0
Gln
2.244GlnAla: 2.244 ± 0.018
0.603GlnCys: 0.603 ± 0.01
1.523GlnAsp: 1.523 ± 0.015
2.293GlnGlu: 2.293 ± 0.02
1.33GlnPhe: 1.33 ± 0.014
1.995GlnGly: 1.995 ± 0.017
0.908GlnHis: 0.908 ± 0.014
1.898GlnIle: 1.898 ± 0.019
2.241GlnLys: 2.241 ± 0.022
3.251GlnLeu: 3.251 ± 0.025
0.961GlnMet: 0.961 ± 0.011
1.672GlnAsn: 1.672 ± 0.016
1.767GlnPro: 1.767 ± 0.017
1.837GlnGln: 1.837 ± 0.029
2.169GlnArg: 2.169 ± 0.019
2.754GlnSer: 2.754 ± 0.021
1.673GlnThr: 1.673 ± 0.015
2.21GlnVal: 2.21 ± 0.017
0.452GlnTrp: 0.452 ± 0.009
0.884GlnTyr: 0.884 ± 0.012
0.0GlnXaa: 0.0 ± 0.0
Arg
3.634ArgAla: 3.634 ± 0.024
1.061ArgCys: 1.061 ± 0.013
2.828ArgAsp: 2.828 ± 0.022
3.587ArgGlu: 3.587 ± 0.026
2.337ArgPhe: 2.337 ± 0.018
3.603ArgGly: 3.603 ± 0.026
1.444ArgHis: 1.444 ± 0.014
2.863ArgIle: 2.863 ± 0.02
3.887ArgLys: 3.887 ± 0.03
5.14ArgLeu: 5.14 ± 0.027
1.371ArgMet: 1.371 ± 0.012
2.492ArgAsn: 2.492 ± 0.02
2.564ArgPro: 2.564 ± 0.024
1.896ArgGln: 1.896 ± 0.017
4.695ArgArg: 4.695 ± 0.033
4.599ArgSer: 4.599 ± 0.033
2.563ArgThr: 2.563 ± 0.017
3.558ArgVal: 3.558 ± 0.021
0.787ArgTrp: 0.787 ± 0.012
1.415ArgTyr: 1.415 ± 0.015
0.0ArgXaa: 0.0 ± 0.0
Ser
5.713SerAla: 5.713 ± 0.03
1.741SerCys: 1.741 ± 0.014
4.316SerAsp: 4.316 ± 0.026
4.729SerGlu: 4.729 ± 0.026
3.902SerPhe: 3.902 ± 0.024
6.128SerGly: 6.128 ± 0.035
2.176SerHis: 2.176 ± 0.018
4.35SerIle: 4.35 ± 0.031
4.767SerLys: 4.767 ± 0.03
8.496SerLeu: 8.496 ± 0.04
1.993SerMet: 1.993 ± 0.018
3.802SerAsn: 3.802 ± 0.025
4.823SerPro: 4.823 ± 0.036
2.93SerGln: 2.93 ± 0.02
4.75SerArg: 4.75 ± 0.029
11.193SerSer: 11.193 ± 0.062
4.444SerThr: 4.444 ± 0.028
5.221SerVal: 5.221 ± 0.029
1.181SerTrp: 1.181 ± 0.014
2.273SerTyr: 2.273 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
3.523ThrAla: 3.523 ± 0.025
0.925ThrCys: 0.925 ± 0.013
2.206ThrAsp: 2.206 ± 0.021
2.625ThrGlu: 2.625 ± 0.021
2.001ThrPhe: 2.001 ± 0.018
3.24ThrGly: 3.24 ± 0.025
1.107ThrHis: 1.107 ± 0.012
2.522ThrIle: 2.522 ± 0.018
2.567ThrLys: 2.567 ± 0.02
4.626ThrLeu: 4.626 ± 0.025
1.204ThrMet: 1.204 ± 0.012
1.948ThrAsn: 1.948 ± 0.018
2.718ThrPro: 2.718 ± 0.022
1.48ThrGln: 1.48 ± 0.015
2.472ThrArg: 2.472 ± 0.02
4.448ThrSer: 4.448 ± 0.026
2.846ThrThr: 2.846 ± 0.025
3.367ThrVal: 3.367 ± 0.021
0.608ThrTrp: 0.608 ± 0.009
1.412ThrTyr: 1.412 ± 0.016
0.0ThrXaa: 0.0 ± 0.0
Val
4.841ValAla: 4.841 ± 0.031
1.256ValCys: 1.256 ± 0.013
3.769ValAsp: 3.769 ± 0.023
4.403ValGlu: 4.403 ± 0.025
2.782ValPhe: 2.782 ± 0.024
4.292ValGly: 4.292 ± 0.027
1.595ValHis: 1.595 ± 0.016
3.219ValIle: 3.219 ± 0.023
3.747ValLys: 3.747 ± 0.021
6.346ValLeu: 6.346 ± 0.037
1.521ValMet: 1.521 ± 0.012
2.536ValAsn: 2.536 ± 0.02
3.216ValPro: 3.216 ± 0.022
2.213ValGln: 2.213 ± 0.02
3.383ValArg: 3.383 ± 0.023
5.416ValSer: 5.416 ± 0.031
3.107ValThr: 3.107 ± 0.021
4.957ValVal: 4.957 ± 0.03
0.803ValTrp: 0.803 ± 0.01
1.923ValTyr: 1.923 ± 0.016
0.0ValXaa: 0.0 ± 0.0
Trp
0.856TrpAla: 0.856 ± 0.012
0.248TrpCys: 0.248 ± 0.006
0.727TrpAsp: 0.727 ± 0.011
0.787TrpGlu: 0.787 ± 0.011
0.531TrpPhe: 0.531 ± 0.009
0.743TrpGly: 0.743 ± 0.013
0.287TrpHis: 0.287 ± 0.006
0.655TrpIle: 0.655 ± 0.01
0.935TrpLys: 0.935 ± 0.012
1.197TrpLeu: 1.197 ± 0.012
0.348TrpMet: 0.348 ± 0.007
0.685TrpAsn: 0.685 ± 0.01
0.488TrpPro: 0.488 ± 0.008
0.394TrpGln: 0.394 ± 0.007
0.851TrpArg: 0.851 ± 0.012
0.968TrpSer: 0.968 ± 0.012
0.624TrpThr: 0.624 ± 0.01
0.829TrpVal: 0.829 ± 0.012
0.258TrpTrp: 0.258 ± 0.006
0.325TrpTyr: 0.325 ± 0.007
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.79TyrAla: 1.79 ± 0.018
0.63TyrCys: 0.63 ± 0.009
1.557TyrAsp: 1.557 ± 0.016
1.547TyrGlu: 1.547 ± 0.015
1.29TyrPhe: 1.29 ± 0.015
2.202TyrGly: 2.202 ± 0.02
0.732TyrHis: 0.732 ± 0.011
1.437TyrIle: 1.437 ± 0.014
1.454TyrLys: 1.454 ± 0.014
2.563TyrLeu: 2.563 ± 0.02
0.711TyrMet: 0.711 ± 0.009
1.233TyrAsn: 1.233 ± 0.014
1.22TyrPro: 1.22 ± 0.013
0.91TyrGln: 0.91 ± 0.012
1.484TyrArg: 1.484 ± 0.015
2.198TyrSer: 2.198 ± 0.017
1.342TyrThr: 1.342 ± 0.014
1.713TyrVal: 1.713 ± 0.017
0.375TyrTrp: 0.375 ± 0.007
0.982TyrTyr: 0.982 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18107 proteins (7463362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski