Human papillomavirus 45

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 7

Average proteome isoelectric point is 6.35

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|T2A7A1|T2A7A1_HPV45 Replication protein E1 OS=Human papillomavirus 45 OX=10593 GN=E1 PE=3 SV=1
MM1 pKa = 7.44YY2 pKa = 10.3GPQATLQEE10 pKa = 4.41IVLHH14 pKa = 6.34LEE16 pKa = 4.25PQNEE20 pKa = 4.4LDD22 pKa = 5.29PVDD25 pKa = 4.29LLCYY29 pKa = 8.9EE30 pKa = 4.16QLSEE34 pKa = 4.74SEE36 pKa = 4.4EE37 pKa = 4.27EE38 pKa = 3.78NDD40 pKa = 3.45EE41 pKa = 4.31ADD43 pKa = 4.09GVSHH47 pKa = 6.67AQLPARR53 pKa = 11.84RR54 pKa = 11.84AEE56 pKa = 4.13PQRR59 pKa = 11.84HH60 pKa = 6.16NILCVCCKK68 pKa = 9.67CDD70 pKa = 3.55GRR72 pKa = 11.84IEE74 pKa = 4.18LTVEE78 pKa = 4.07SSADD82 pKa = 3.54DD83 pKa = 4.03FRR85 pKa = 11.84TLQQLFLSTLSFVCPWCATNQQ106 pKa = 3.36

Molecular weight: 12.0 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A9XFN7|A9XFN7_HPV45 Major capsid protein L1 OS=Human papillomavirus 45 OX=10593 GN=L1 PE=3 SV=1
MM1 pKa = 7.71ARR3 pKa = 11.84FDD5 pKa = 4.32DD6 pKa = 4.58PKK8 pKa = 10.52QRR10 pKa = 11.84PYY12 pKa = 11.25KK13 pKa = 10.8LPDD16 pKa = 3.26LCTEE20 pKa = 4.99LNTSLQDD27 pKa = 3.31VSIACVYY34 pKa = 10.55CKK36 pKa = 10.06ATLEE40 pKa = 4.11RR41 pKa = 11.84TEE43 pKa = 4.37VYY45 pKa = 10.39QFAFKK50 pKa = 10.42DD51 pKa = 3.35LCIVYY56 pKa = 9.55RR57 pKa = 11.84DD58 pKa = 4.32CIAYY62 pKa = 8.73AACHH66 pKa = 5.81KK67 pKa = 10.93CIDD70 pKa = 3.87FYY72 pKa = 11.79SRR74 pKa = 11.84IRR76 pKa = 11.84EE77 pKa = 3.76LRR79 pKa = 11.84YY80 pKa = 10.08YY81 pKa = 10.48SNSVYY86 pKa = 10.99GEE88 pKa = 4.09TLEE91 pKa = 5.66KK92 pKa = 9.67ITNTEE97 pKa = 4.21LYY99 pKa = 10.27NLLIRR104 pKa = 11.84CLRR107 pKa = 11.84CQKK110 pKa = 10.03PLNPAEE116 pKa = 4.45KK117 pKa = 9.69RR118 pKa = 11.84RR119 pKa = 11.84HH120 pKa = 5.72LKK122 pKa = 10.29DD123 pKa = 2.76KK124 pKa = 11.02RR125 pKa = 11.84RR126 pKa = 11.84FHH128 pKa = 7.1SIAGQYY134 pKa = 9.91RR135 pKa = 11.84GQCNTCCDD143 pKa = 3.24QARR146 pKa = 11.84QEE148 pKa = 4.0RR149 pKa = 11.84LRR151 pKa = 11.84RR152 pKa = 11.84RR153 pKa = 11.84RR154 pKa = 11.84EE155 pKa = 3.9TQVV158 pKa = 2.57

Molecular weight: 18.9 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2274

106

643

379.0

42.46

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.849 ± 0.458

2.902 ± 0.688

6.113 ± 0.565

4.661 ± 0.71

3.958 ± 0.554

5.893 ± 0.601

2.419 ± 0.278

5.321 ± 0.251

5.277 ± 0.92

7.784 ± 0.67

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.671 ± 0.224

4.529 ± 0.713

5.937 ± 1.233

4.398 ± 0.576

4.925 ± 0.795

8.223 ± 1.072

8.399 ± 0.965

6.157 ± 0.578

1.583 ± 0.265

4.002 ± 0.512
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski