Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA833F18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.287AlaAla: 5.287 ± 0.312
0.797AlaCys: 0.797 ± 0.12
3.839AlaAsp: 3.839 ± 0.254
5.911AlaGlu: 5.911 ± 0.313
2.484AlaPhe: 2.484 ± 0.173
6.057AlaGly: 6.057 ± 0.365
1.475AlaHis: 1.475 ± 0.132
5.287AlaIle: 5.287 ± 0.308
4.981AlaLys: 4.981 ± 0.286
7.93AlaLeu: 7.93 ± 0.427
1.66AlaMet: 1.66 ± 0.158
2.165AlaAsn: 2.165 ± 0.162
2.949AlaPro: 2.949 ± 0.188
1.873AlaGln: 1.873 ± 0.171
4.463AlaArg: 4.463 ± 0.236
4.477AlaSer: 4.477 ± 0.228
3.401AlaThr: 3.401 ± 0.255
4.942AlaVal: 4.942 ± 0.276
0.717AlaTrp: 0.717 ± 0.105
1.86AlaTyr: 1.86 ± 0.173
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.082
0.066CysCys: 0.066 ± 0.028
0.611CysAsp: 0.611 ± 0.089
0.863CysGlu: 0.863 ± 0.123
0.266CysPhe: 0.266 ± 0.066
1.063CysGly: 1.063 ± 0.138
0.106CysHis: 0.106 ± 0.034
0.518CysIle: 0.518 ± 0.075
0.438CysLys: 0.438 ± 0.073
0.664CysLeu: 0.664 ± 0.091
0.199CysMet: 0.199 ± 0.048
0.252CysAsn: 0.252 ± 0.059
0.598CysPro: 0.598 ± 0.083
0.266CysGln: 0.266 ± 0.065
0.452CysArg: 0.452 ± 0.074
0.425CysSer: 0.425 ± 0.076
0.558CysThr: 0.558 ± 0.093
0.651CysVal: 0.651 ± 0.111
0.133CysTrp: 0.133 ± 0.039
0.213CysTyr: 0.213 ± 0.055
0.0CysXaa: 0.0 ± 0.0
Asp
3.719AspAla: 3.719 ± 0.214
0.478AspCys: 0.478 ± 0.073
2.604AspAsp: 2.604 ± 0.21
4.822AspGlu: 4.822 ± 0.273
2.338AspPhe: 2.338 ± 0.174
3.666AspGly: 3.666 ± 0.249
0.996AspHis: 0.996 ± 0.117
3.985AspIle: 3.985 ± 0.224
2.883AspLys: 2.883 ± 0.189
6.562AspLeu: 6.562 ± 0.301
1.249AspMet: 1.249 ± 0.139
2.006AspAsn: 2.006 ± 0.317
2.949AspPro: 2.949 ± 0.222
1.581AspGln: 1.581 ± 0.139
2.471AspArg: 2.471 ± 0.175
2.976AspSer: 2.976 ± 0.221
2.365AspThr: 2.365 ± 0.169
4.503AspVal: 4.503 ± 0.255
0.81AspTrp: 0.81 ± 0.104
2.179AspTyr: 2.179 ± 0.2
0.0AspXaa: 0.0 ± 0.0
Glu
6.443GluAla: 6.443 ± 0.36
0.757GluCys: 0.757 ± 0.092
5.606GluAsp: 5.606 ± 0.335
10.986GluGlu: 10.986 ± 0.531
3.228GluPhe: 3.228 ± 0.226
5.978GluGly: 5.978 ± 0.3
1.355GluHis: 1.355 ± 0.139
7.014GluIle: 7.014 ± 0.303
7.877GluLys: 7.877 ± 0.403
9.179GluLeu: 9.179 ± 0.485
2.192GluMet: 2.192 ± 0.164
4.145GluAsn: 4.145 ± 0.319
2.816GluPro: 2.816 ± 0.213
1.82GluGln: 1.82 ± 0.153
4.795GluArg: 4.795 ± 0.219
4.769GluSer: 4.769 ± 0.302
3.959GluThr: 3.959 ± 0.225
7.147GluVal: 7.147 ± 0.347
0.784GluTrp: 0.784 ± 0.106
2.404GluTyr: 2.404 ± 0.21
0.0GluXaa: 0.0 ± 0.0
Phe
2.458PheAla: 2.458 ± 0.21
0.412PheCys: 0.412 ± 0.067
1.9PheAsp: 1.9 ± 0.179
3.002PheGlu: 3.002 ± 0.225
1.342PhePhe: 1.342 ± 0.173
2.909PheGly: 2.909 ± 0.186
0.744PheHis: 0.744 ± 0.094
2.298PheIle: 2.298 ± 0.23
2.298PheLys: 2.298 ± 0.195
3.799PheLeu: 3.799 ± 0.293
0.877PheMet: 0.877 ± 0.098
1.063PheAsn: 1.063 ± 0.117
1.289PhePro: 1.289 ± 0.114
1.116PheGln: 1.116 ± 0.126
1.66PheArg: 1.66 ± 0.148
2.179PheSer: 2.179 ± 0.188
2.006PheThr: 2.006 ± 0.191
2.418PheVal: 2.418 ± 0.195
0.345PheTrp: 0.345 ± 0.08
1.328PheTyr: 1.328 ± 0.143
0.0PheXaa: 0.0 ± 0.0
Gly
5.712GlyAla: 5.712 ± 0.415
0.624GlyCys: 0.624 ± 0.104
3.945GlyAsp: 3.945 ± 0.263
7.333GlyGlu: 7.333 ± 0.343
2.989GlyPhe: 2.989 ± 0.203
5.686GlyGly: 5.686 ± 0.322
1.235GlyHis: 1.235 ± 0.157
5.38GlyIle: 5.38 ± 0.302
5.5GlyLys: 5.5 ± 0.275
7.04GlyLeu: 7.04 ± 0.33
1.939GlyMet: 1.939 ± 0.167
2.218GlyAsn: 2.218 ± 0.171
2.378GlyPro: 2.378 ± 0.187
1.647GlyGln: 1.647 ± 0.139
4.198GlyArg: 4.198 ± 0.266
4.038GlySer: 4.038 ± 0.259
4.052GlyThr: 4.052 ± 0.247
6.376GlyVal: 6.376 ± 0.314
0.81GlyTrp: 0.81 ± 0.105
2.298GlyTyr: 2.298 ± 0.208
0.0GlyXaa: 0.0 ± 0.0
His
1.475HisAla: 1.475 ± 0.15
0.266HisCys: 0.266 ± 0.062
0.996HisAsp: 0.996 ± 0.112
1.594HisGlu: 1.594 ± 0.139
0.677HisPhe: 0.677 ± 0.099
1.435HisGly: 1.435 ± 0.153
0.359HisHis: 0.359 ± 0.072
1.209HisIle: 1.209 ± 0.142
0.757HisLys: 0.757 ± 0.101
1.833HisLeu: 1.833 ± 0.16
0.385HisMet: 0.385 ± 0.06
0.505HisAsn: 0.505 ± 0.085
1.235HisPro: 1.235 ± 0.117
0.545HisGln: 0.545 ± 0.094
0.877HisArg: 0.877 ± 0.097
1.103HisSer: 1.103 ± 0.129
0.903HisThr: 0.903 ± 0.094
1.461HisVal: 1.461 ± 0.118
0.226HisTrp: 0.226 ± 0.05
0.664HisTyr: 0.664 ± 0.084
0.0HisXaa: 0.0 ± 0.0
Ile
5.579IleAla: 5.579 ± 0.309
0.664IleCys: 0.664 ± 0.095
4.264IleAsp: 4.264 ± 0.238
6.509IleGlu: 6.509 ± 0.29
2.511IlePhe: 2.511 ± 0.2
5.739IleGly: 5.739 ± 0.35
1.554IleHis: 1.554 ± 0.143
4.915IleIle: 4.915 ± 0.3
4.251IleLys: 4.251 ± 0.257
7.001IleLeu: 7.001 ± 0.317
1.235IleMet: 1.235 ± 0.131
2.046IleAsn: 2.046 ± 0.155
3.6IlePro: 3.6 ± 0.218
1.846IleGln: 1.846 ± 0.134
3.68IleArg: 3.68 ± 0.225
5.167IleSer: 5.167 ± 0.264
4.038IleThr: 4.038 ± 0.239
4.703IleVal: 4.703 ± 0.238
0.664IleTrp: 0.664 ± 0.104
1.873IleTyr: 1.873 ± 0.169
0.0IleXaa: 0.0 ± 0.0
Lys
5.101LysAla: 5.101 ± 0.277
0.611LysCys: 0.611 ± 0.098
3.759LysAsp: 3.759 ± 0.261
6.297LysGlu: 6.297 ± 0.322
2.869LysPhe: 2.869 ± 0.175
3.945LysGly: 3.945 ± 0.24
1.156LysHis: 1.156 ± 0.135
6.243LysIle: 6.243 ± 0.267
5.619LysLys: 5.619 ± 0.411
6.881LysLeu: 6.881 ± 0.384
1.607LysMet: 1.607 ± 0.146
2.551LysAsn: 2.551 ± 0.204
2.551LysPro: 2.551 ± 0.198
1.727LysGln: 1.727 ± 0.165
3.972LysArg: 3.972 ± 0.273
4.145LysSer: 4.145 ± 0.24
3.653LysThr: 3.653 ± 0.219
4.703LysVal: 4.703 ± 0.257
0.757LysTrp: 0.757 ± 0.099
1.687LysTyr: 1.687 ± 0.139
0.0LysXaa: 0.0 ± 0.0
Leu
8.302LeuAla: 8.302 ± 0.374
0.704LeuCys: 0.704 ± 0.105
5.579LeuAsp: 5.579 ± 0.308
9.192LeuGlu: 9.192 ± 0.402
2.962LeuPhe: 2.962 ± 0.221
7.691LeuGly: 7.691 ± 0.357
1.7LeuHis: 1.7 ± 0.143
6.27LeuIle: 6.27 ± 0.349
7.333LeuLys: 7.333 ± 0.31
7.811LeuLeu: 7.811 ± 0.391
2.192LeuMet: 2.192 ± 0.184
3.427LeuAsn: 3.427 ± 0.202
4.118LeuPro: 4.118 ± 0.242
2.192LeuGln: 2.192 ± 0.181
5.686LeuArg: 5.686 ± 0.316
6.682LeuSer: 6.682 ± 0.309
5.048LeuThr: 5.048 ± 0.273
6.642LeuVal: 6.642 ± 0.325
1.049LeuTrp: 1.049 ± 0.143
2.218LeuTyr: 2.218 ± 0.191
0.0LeuXaa: 0.0 ± 0.0
Met
1.939MetAla: 1.939 ± 0.195
0.159MetCys: 0.159 ± 0.046
1.275MetAsp: 1.275 ± 0.129
1.554MetGlu: 1.554 ± 0.14
0.638MetPhe: 0.638 ± 0.111
1.86MetGly: 1.86 ± 0.16
0.438MetHis: 0.438 ± 0.065
1.833MetIle: 1.833 ± 0.169
1.674MetLys: 1.674 ± 0.138
1.926MetLeu: 1.926 ± 0.164
0.558MetMet: 0.558 ± 0.086
0.81MetAsn: 0.81 ± 0.1
1.289MetPro: 1.289 ± 0.133
0.438MetGln: 0.438 ± 0.091
1.488MetArg: 1.488 ± 0.136
1.342MetSer: 1.342 ± 0.141
1.448MetThr: 1.448 ± 0.146
1.076MetVal: 1.076 ± 0.119
0.186MetTrp: 0.186 ± 0.052
0.518MetTyr: 0.518 ± 0.097
0.0MetXaa: 0.0 ± 0.0
Asn
2.471AsnAla: 2.471 ± 0.164
0.399AsnCys: 0.399 ± 0.079
1.541AsnAsp: 1.541 ± 0.162
2.378AsnGlu: 2.378 ± 0.199
1.262AsnPhe: 1.262 ± 0.12
1.621AsnGly: 1.621 ± 0.145
0.598AsnHis: 0.598 ± 0.086
2.072AsnIle: 2.072 ± 0.166
1.727AsnLys: 1.727 ± 0.156
4.145AsnLeu: 4.145 ± 0.246
0.704AsnMet: 0.704 ± 0.1
0.983AsnAsn: 0.983 ± 0.099
2.365AsnPro: 2.365 ± 0.176
1.169AsnGln: 1.169 ± 0.12
1.9AsnArg: 1.9 ± 0.181
1.993AsnSer: 1.993 ± 0.183
1.873AsnThr: 1.873 ± 0.197
2.458AsnVal: 2.458 ± 0.197
0.478AsnTrp: 0.478 ± 0.084
1.209AsnTyr: 1.209 ± 0.128
0.0AsnXaa: 0.0 ± 0.0
Pro
2.763ProAla: 2.763 ± 0.199
0.319ProCys: 0.319 ± 0.07
2.67ProAsp: 2.67 ± 0.169
4.981ProGlu: 4.981 ± 0.31
1.302ProPhe: 1.302 ± 0.158
3.069ProGly: 3.069 ± 0.203
1.01ProHis: 1.01 ± 0.135
3.148ProIle: 3.148 ± 0.21
2.79ProLys: 2.79 ± 0.233
3.852ProLeu: 3.852 ± 0.262
0.917ProMet: 0.917 ± 0.112
1.355ProAsn: 1.355 ± 0.13
1.74ProPro: 1.74 ± 0.164
1.235ProGln: 1.235 ± 0.135
2.179ProArg: 2.179 ± 0.166
2.776ProSer: 2.776 ± 0.2
2.537ProThr: 2.537 ± 0.212
2.843ProVal: 2.843 ± 0.208
0.306ProTrp: 0.306 ± 0.062
1.528ProTyr: 1.528 ± 0.157
0.0ProXaa: 0.0 ± 0.0
Gln
1.966GlnAla: 1.966 ± 0.168
0.146GlnCys: 0.146 ± 0.044
1.328GlnAsp: 1.328 ± 0.13
2.511GlnGlu: 2.511 ± 0.207
0.677GlnPhe: 0.677 ± 0.113
2.059GlnGly: 2.059 ± 0.154
0.465GlnHis: 0.465 ± 0.082
2.258GlnIle: 2.258 ± 0.161
1.82GlnLys: 1.82 ± 0.152
2.497GlnLeu: 2.497 ± 0.165
0.717GlnMet: 0.717 ± 0.089
0.744GlnAsn: 0.744 ± 0.09
0.877GlnPro: 0.877 ± 0.118
0.624GlnGln: 0.624 ± 0.097
1.541GlnArg: 1.541 ± 0.156
1.249GlnSer: 1.249 ± 0.134
1.514GlnThr: 1.514 ± 0.144
2.072GlnVal: 2.072 ± 0.158
0.173GlnTrp: 0.173 ± 0.046
0.584GlnTyr: 0.584 ± 0.079
0.0GlnXaa: 0.0 ± 0.0
Arg
3.905ArgAla: 3.905 ± 0.214
0.412ArgCys: 0.412 ± 0.075
3.215ArgAsp: 3.215 ± 0.22
6.018ArgGlu: 6.018 ± 0.301
2.046ArgPhe: 2.046 ± 0.176
4.424ArgGly: 4.424 ± 0.287
0.677ArgHis: 0.677 ± 0.086
3.879ArgIle: 3.879 ± 0.224
4.477ArgLys: 4.477 ± 0.277
5.074ArgLeu: 5.074 ± 0.285
1.382ArgMet: 1.382 ± 0.132
1.461ArgAsn: 1.461 ± 0.173
1.767ArgPro: 1.767 ± 0.149
1.501ArgGln: 1.501 ± 0.139
3.414ArgArg: 3.414 ± 0.227
2.657ArgSer: 2.657 ± 0.203
2.205ArgThr: 2.205 ± 0.157
4.317ArgVal: 4.317 ± 0.254
0.598ArgTrp: 0.598 ± 0.086
1.554ArgTyr: 1.554 ± 0.14
0.0ArgXaa: 0.0 ± 0.0
Ser
3.706SerAla: 3.706 ± 0.237
0.478SerCys: 0.478 ± 0.071
3.56SerAsp: 3.56 ± 0.234
6.15SerGlu: 6.15 ± 0.3
2.365SerPhe: 2.365 ± 0.195
5.353SerGly: 5.353 ± 0.303
1.129SerHis: 1.129 ± 0.132
4.131SerIle: 4.131 ± 0.233
4.317SerLys: 4.317 ± 0.287
5.194SerLeu: 5.194 ± 0.315
1.355SerMet: 1.355 ± 0.131
1.727SerAsn: 1.727 ± 0.138
3.002SerPro: 3.002 ± 0.213
1.926SerGln: 1.926 ± 0.175
3.108SerArg: 3.108 ± 0.214
4.105SerSer: 4.105 ± 0.283
3.042SerThr: 3.042 ± 0.196
4.105SerVal: 4.105 ± 0.251
0.85SerTrp: 0.85 ± 0.12
1.342SerTyr: 1.342 ± 0.144
0.0SerXaa: 0.0 ± 0.0
Thr
3.627ThrAla: 3.627 ± 0.212
0.518ThrCys: 0.518 ± 0.085
2.112ThrAsp: 2.112 ± 0.202
3.653ThrGlu: 3.653 ± 0.224
1.488ThrPhe: 1.488 ± 0.135
4.41ThrGly: 4.41 ± 0.285
1.355ThrHis: 1.355 ± 0.158
4.038ThrIle: 4.038 ± 0.228
2.856ThrLys: 2.856 ± 0.212
5.008ThrLeu: 5.008 ± 0.221
1.076ThrMet: 1.076 ± 0.114
1.807ThrAsn: 1.807 ± 0.137
3.002ThrPro: 3.002 ± 0.181
1.421ThrGln: 1.421 ± 0.149
2.869ThrArg: 2.869 ± 0.206
3.361ThrSer: 3.361 ± 0.23
2.697ThrThr: 2.697 ± 0.206
3.401ThrVal: 3.401 ± 0.194
0.584ThrTrp: 0.584 ± 0.078
1.674ThrTyr: 1.674 ± 0.18
0.0ThrXaa: 0.0 ± 0.0
Val
4.716ValAla: 4.716 ± 0.328
0.731ValCys: 0.731 ± 0.105
4.238ValAsp: 4.238 ± 0.275
6.111ValGlu: 6.111 ± 0.294
2.511ValPhe: 2.511 ± 0.197
5.46ValGly: 5.46 ± 0.32
1.315ValHis: 1.315 ± 0.124
5.128ValIle: 5.128 ± 0.266
5.832ValLys: 5.832 ± 0.297
6.456ValLeu: 6.456 ± 0.311
1.554ValMet: 1.554 ± 0.158
2.723ValAsn: 2.723 ± 0.19
3.201ValPro: 3.201 ± 0.192
1.342ValGln: 1.342 ± 0.118
3.839ValArg: 3.839 ± 0.232
4.822ValSer: 4.822 ± 0.26
3.852ValThr: 3.852 ± 0.223
4.928ValVal: 4.928 ± 0.283
0.744ValTrp: 0.744 ± 0.12
1.886ValTyr: 1.886 ± 0.164
0.0ValXaa: 0.0 ± 0.0
Trp
0.704TrpAla: 0.704 ± 0.098
0.093TrpCys: 0.093 ± 0.045
0.465TrpAsp: 0.465 ± 0.072
0.81TrpGlu: 0.81 ± 0.092
0.385TrpPhe: 0.385 ± 0.097
0.651TrpGly: 0.651 ± 0.104
0.266TrpHis: 0.266 ± 0.057
0.744TrpIle: 0.744 ± 0.131
0.996TrpLys: 0.996 ± 0.139
1.036TrpLeu: 1.036 ± 0.123
0.213TrpMet: 0.213 ± 0.059
0.438TrpAsn: 0.438 ± 0.082
0.399TrpPro: 0.399 ± 0.088
0.425TrpGln: 0.425 ± 0.081
0.691TrpArg: 0.691 ± 0.093
0.81TrpSer: 0.81 ± 0.099
0.558TrpThr: 0.558 ± 0.107
0.757TrpVal: 0.757 ± 0.099
0.12TrpTrp: 0.12 ± 0.051
0.332TrpTyr: 0.332 ± 0.069
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.099TyrAla: 2.099 ± 0.171
0.292TyrCys: 0.292 ± 0.07
1.634TyrAsp: 1.634 ± 0.157
2.59TyrGlu: 2.59 ± 0.193
1.103TyrPhe: 1.103 ± 0.12
2.325TyrGly: 2.325 ± 0.211
0.571TyrHis: 0.571 ± 0.077
1.488TyrIle: 1.488 ± 0.146
1.408TyrLys: 1.408 ± 0.165
2.909TyrLeu: 2.909 ± 0.185
0.425TyrMet: 0.425 ± 0.07
0.917TyrAsn: 0.917 ± 0.105
1.196TyrPro: 1.196 ± 0.148
1.129TyrGln: 1.129 ± 0.119
1.7TyrArg: 1.7 ± 0.151
1.873TyrSer: 1.873 ± 0.184
1.249TyrThr: 1.249 ± 0.124
1.886TyrVal: 1.886 ± 0.179
0.558TyrTrp: 0.558 ± 0.106
0.85TyrTyr: 0.85 ± 0.128
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 278 proteins (75280 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski