Amino acid dipepetide frequency for Aciduliprofundum boonei (strain DSM 19572 / T469)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.256AlaAla: 4.256 ± 0.123
0.409AlaCys: 0.409 ± 0.03
2.734AlaAsp: 2.734 ± 0.086
4.138AlaGlu: 4.138 ± 0.113
2.68AlaPhe: 2.68 ± 0.078
4.224AlaGly: 4.224 ± 0.114
1.244AlaHis: 1.244 ± 0.049
6.23AlaIle: 6.23 ± 0.139
5.442AlaLys: 5.442 ± 0.129
6.819AlaLeu: 6.819 ± 0.167
2.036AlaMet: 2.036 ± 0.065
2.291AlaAsn: 2.291 ± 0.079
2.152AlaPro: 2.152 ± 0.069
1.514AlaGln: 1.514 ± 0.061
3.408AlaArg: 3.408 ± 0.101
3.417AlaSer: 3.417 ± 0.098
3.042AlaThr: 3.042 ± 0.092
4.314AlaVal: 4.314 ± 0.101
0.707AlaTrp: 0.707 ± 0.043
2.862AlaTyr: 2.862 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
0.332CysAla: 0.332 ± 0.027
0.058CysCys: 0.058 ± 0.011
0.392CysAsp: 0.392 ± 0.029
0.46CysGlu: 0.46 ± 0.033
0.173CysPhe: 0.173 ± 0.019
0.927CysGly: 0.927 ± 0.049
0.161CysHis: 0.161 ± 0.017
0.458CysIle: 0.458 ± 0.035
0.505CysLys: 0.505 ± 0.032
0.413CysLeu: 0.413 ± 0.033
0.135CysMet: 0.135 ± 0.016
0.33CysAsn: 0.33 ± 0.029
0.698CysPro: 0.698 ± 0.045
0.109CysGln: 0.109 ± 0.015
0.319CysArg: 0.319 ± 0.027
0.437CysSer: 0.437 ± 0.045
0.351CysThr: 0.351 ± 0.03
0.383CysVal: 0.383 ± 0.032
0.086CysTrp: 0.086 ± 0.011
0.201CysTyr: 0.201 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.368AspAla: 3.368 ± 0.102
0.31AspCys: 0.31 ± 0.029
2.287AspAsp: 2.287 ± 0.082
4.605AspGlu: 4.605 ± 0.132
2.61AspPhe: 2.61 ± 0.072
3.411AspGly: 3.411 ± 0.102
0.561AspHis: 0.561 ± 0.039
5.423AspIle: 5.423 ± 0.121
3.524AspLys: 3.524 ± 0.091
4.28AspLeu: 4.28 ± 0.11
1.751AspMet: 1.751 ± 0.066
1.918AspAsn: 1.918 ± 0.083
1.867AspPro: 1.867 ± 0.075
0.39AspGln: 0.39 ± 0.03
2.154AspArg: 2.154 ± 0.07
2.561AspSer: 2.561 ± 0.083
2.1AspThr: 2.1 ± 0.078
4.207AspVal: 4.207 ± 0.097
0.629AspTrp: 0.629 ± 0.038
2.64AspTyr: 2.64 ± 0.085
0.0AspXaa: 0.0 ± 0.0
Glu
4.168GluAla: 4.168 ± 0.103
0.403GluCys: 0.403 ± 0.03
4.661GluAsp: 4.661 ± 0.112
8.204GluGlu: 8.204 ± 0.199
2.997GluPhe: 2.997 ± 0.076
4.691GluGly: 4.691 ± 0.1
1.347GluHis: 1.347 ± 0.051
8.32GluIle: 8.32 ± 0.16
7.962GluLys: 7.962 ± 0.182
6.954GluLeu: 6.954 ± 0.181
2.434GluMet: 2.434 ± 0.077
4.65GluAsn: 4.65 ± 0.118
2.06GluPro: 2.06 ± 0.074
1.107GluGln: 1.107 ± 0.058
4.38GluArg: 4.38 ± 0.127
3.081GluSer: 3.081 ± 0.087
2.13GluThr: 2.13 ± 0.072
4.993GluVal: 4.993 ± 0.118
0.826GluTrp: 0.826 ± 0.041
3.209GluTyr: 3.209 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.892PheAla: 2.892 ± 0.088
0.242PheCys: 0.242 ± 0.022
1.946PheAsp: 1.946 ± 0.057
2.907PheGlu: 2.907 ± 0.071
2.042PhePhe: 2.042 ± 0.084
3.246PheGly: 3.246 ± 0.095
0.788PheHis: 0.788 ± 0.042
3.578PheIle: 3.578 ± 0.114
2.997PheLys: 2.997 ± 0.079
4.406PheLeu: 4.406 ± 0.128
1.154PheMet: 1.154 ± 0.059
1.676PheAsn: 1.676 ± 0.066
1.625PhePro: 1.625 ± 0.065
0.856PheGln: 0.856 ± 0.049
1.668PheArg: 1.668 ± 0.062
2.753PheSer: 2.753 ± 0.084
1.995PheThr: 1.995 ± 0.068
3.079PheVal: 3.079 ± 0.086
0.529PheTrp: 0.529 ± 0.037
2.017PheTyr: 2.017 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.601GlyAla: 4.601 ± 0.126
0.552GlyCys: 0.552 ± 0.04
3.777GlyAsp: 3.777 ± 0.101
5.183GlyGlu: 5.183 ± 0.122
3.032GlyPhe: 3.032 ± 0.087
5.076GlyGly: 5.076 ± 0.146
1.197GlyHis: 1.197 ± 0.05
7.476GlyIle: 7.476 ± 0.147
6.616GlyLys: 6.616 ± 0.141
5.387GlyLeu: 5.387 ± 0.121
2.188GlyMet: 2.188 ± 0.081
3.28GlyAsn: 3.28 ± 0.129
1.738GlyPro: 1.738 ± 0.066
0.955GlyGln: 0.955 ± 0.047
2.955GlyArg: 2.955 ± 0.09
3.605GlySer: 3.605 ± 0.105
3.353GlyThr: 3.353 ± 0.104
5.014GlyVal: 5.014 ± 0.115
0.991GlyTrp: 0.991 ± 0.048
3.565GlyTyr: 3.565 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
1.1HisAla: 1.1 ± 0.053
0.165HisCys: 0.165 ± 0.021
0.707HisAsp: 0.707 ± 0.049
0.951HisGlu: 0.951 ± 0.051
0.814HisPhe: 0.814 ± 0.043
1.257HisGly: 1.257 ± 0.054
0.411HisHis: 0.411 ± 0.028
1.636HisIle: 1.636 ± 0.061
1.163HisLys: 1.163 ± 0.046
1.67HisLeu: 1.67 ± 0.057
0.473HisMet: 0.473 ± 0.034
0.762HisAsn: 0.762 ± 0.038
1.088HisPro: 1.088 ± 0.048
0.315HisGln: 0.315 ± 0.028
0.88HisArg: 0.88 ± 0.042
0.976HisSer: 0.976 ± 0.042
1.053HisThr: 1.053 ± 0.054
1.019HisVal: 1.019 ± 0.049
0.214HisTrp: 0.214 ± 0.021
0.852HisTyr: 0.852 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.768IleAla: 6.768 ± 0.138
0.617IleCys: 0.617 ± 0.037
4.505IleAsp: 4.505 ± 0.112
7.307IleGlu: 7.307 ± 0.15
4.22IlePhe: 4.22 ± 0.13
6.342IleGly: 6.342 ± 0.149
1.334IleHis: 1.334 ± 0.049
8.131IleIle: 8.131 ± 0.186
7.408IleLys: 7.408 ± 0.144
8.842IleLeu: 8.842 ± 0.167
2.428IleMet: 2.428 ± 0.097
3.764IleAsn: 3.764 ± 0.109
4.019IlePro: 4.019 ± 0.09
1.531IleGln: 1.531 ± 0.06
4.049IleArg: 4.049 ± 0.1
5.665IleSer: 5.665 ± 0.148
4.35IleThr: 4.35 ± 0.11
6.806IleVal: 6.806 ± 0.148
0.929IleTrp: 0.929 ± 0.045
4.171IleTyr: 4.171 ± 0.107
0.0IleXaa: 0.0 ± 0.0
Lys
4.545LysAla: 4.545 ± 0.105
0.668LysCys: 0.668 ± 0.044
4.958LysAsp: 4.958 ± 0.113
8.206LysGlu: 8.206 ± 0.203
3.055LysPhe: 3.055 ± 0.089
5.033LysGly: 5.033 ± 0.11
1.199LysHis: 1.199 ± 0.05
8.842LysIle: 8.842 ± 0.158
7.934LysLys: 7.934 ± 0.163
6.494LysLeu: 6.494 ± 0.129
2.616LysMet: 2.616 ± 0.077
4.601LysAsn: 4.601 ± 0.114
2.398LysPro: 2.398 ± 0.076
0.966LysGln: 0.966 ± 0.045
4.393LysArg: 4.393 ± 0.142
3.605LysSer: 3.605 ± 0.087
2.704LysThr: 2.704 ± 0.079
5.537LysVal: 5.537 ± 0.114
0.85LysTrp: 0.85 ± 0.05
4.066LysTyr: 4.066 ± 0.092
0.0LysXaa: 0.0 ± 0.0
Leu
6.286LeuAla: 6.286 ± 0.124
0.507LeuCys: 0.507 ± 0.035
4.273LeuAsp: 4.273 ± 0.114
6.401LeuGlu: 6.401 ± 0.145
3.796LeuPhe: 3.796 ± 0.129
6.367LeuGly: 6.367 ± 0.135
1.756LeuHis: 1.756 ± 0.061
7.686LeuIle: 7.686 ± 0.161
8.253LeuLys: 8.253 ± 0.179
8.418LeuLeu: 8.418 ± 0.208
2.516LeuMet: 2.516 ± 0.073
4.149LeuAsn: 4.149 ± 0.1
3.582LeuPro: 3.582 ± 0.091
2.083LeuGln: 2.083 ± 0.079
4.59LeuArg: 4.59 ± 0.105
5.93LeuSer: 5.93 ± 0.118
3.942LeuThr: 3.942 ± 0.106
5.327LeuVal: 5.327 ± 0.107
1.06LeuTrp: 1.06 ± 0.045
3.7LeuTyr: 3.7 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
1.961MetAla: 1.961 ± 0.068
0.18MetCys: 0.18 ± 0.021
1.773MetAsp: 1.773 ± 0.068
2.368MetGlu: 2.368 ± 0.067
0.955MetPhe: 0.955 ± 0.053
2.353MetGly: 2.353 ± 0.08
0.608MetHis: 0.608 ± 0.035
2.034MetIle: 2.034 ± 0.067
2.537MetLys: 2.537 ± 0.076
2.74MetLeu: 2.74 ± 0.082
0.754MetMet: 0.754 ± 0.043
1.469MetAsn: 1.469 ± 0.051
1.126MetPro: 1.126 ± 0.048
0.711MetGln: 0.711 ± 0.041
1.775MetArg: 1.775 ± 0.068
1.571MetSer: 1.571 ± 0.048
0.933MetThr: 0.933 ± 0.052
1.801MetVal: 1.801 ± 0.058
0.265MetTrp: 0.265 ± 0.027
0.923MetTyr: 0.923 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.25AsnAla: 3.25 ± 0.093
0.381AsnCys: 0.381 ± 0.035
1.912AsnAsp: 1.912 ± 0.069
3.128AsnGlu: 3.128 ± 0.099
2.165AsnPhe: 2.165 ± 0.077
3.434AsnGly: 3.434 ± 0.109
0.591AsnHis: 0.591 ± 0.036
4.158AsnIle: 4.158 ± 0.112
2.892AsnLys: 2.892 ± 0.089
4.528AsnLeu: 4.528 ± 0.108
1.327AsnMet: 1.327 ± 0.058
2.066AsnAsn: 2.066 ± 0.166
2.37AsnPro: 2.37 ± 0.076
0.621AsnGln: 0.621 ± 0.041
1.741AsnArg: 1.741 ± 0.062
2.565AsnSer: 2.565 ± 0.118
2.09AsnThr: 2.09 ± 0.094
3.7AsnVal: 3.7 ± 0.109
0.495AsnTrp: 0.495 ± 0.036
2.488AsnTyr: 2.488 ± 0.091
0.0AsnXaa: 0.0 ± 0.0
Pro
1.912ProAla: 1.912 ± 0.067
0.3ProCys: 0.3 ± 0.025
1.865ProAsp: 1.865 ± 0.068
3.181ProGlu: 3.181 ± 0.086
1.687ProPhe: 1.687 ± 0.058
2.325ProGly: 2.325 ± 0.078
0.891ProHis: 0.891 ± 0.044
2.993ProIle: 2.993 ± 0.075
2.914ProLys: 2.914 ± 0.087
3.376ProLeu: 3.376 ± 0.083
0.953ProMet: 0.953 ± 0.047
1.612ProAsn: 1.612 ± 0.067
1.801ProPro: 1.801 ± 0.072
1.13ProGln: 1.13 ± 0.052
1.64ProArg: 1.64 ± 0.063
2.31ProSer: 2.31 ± 0.066
1.895ProThr: 1.895 ± 0.067
2.74ProVal: 2.74 ± 0.07
0.522ProTrp: 0.522 ± 0.037
2.053ProTyr: 2.053 ± 0.073
0.0ProXaa: 0.0 ± 0.0
Gln
1.205GlnAla: 1.205 ± 0.053
0.133GlnCys: 0.133 ± 0.016
0.944GlnAsp: 0.944 ± 0.041
1.407GlnGlu: 1.407 ± 0.057
0.7GlnPhe: 0.7 ± 0.042
1.355GlnGly: 1.355 ± 0.055
0.364GlnHis: 0.364 ± 0.03
1.666GlnIle: 1.666 ± 0.06
1.49GlnLys: 1.49 ± 0.056
1.458GlnLeu: 1.458 ± 0.069
0.572GlnMet: 0.572 ± 0.032
0.989GlnAsn: 0.989 ± 0.061
0.612GlnPro: 0.612 ± 0.037
0.469GlnGln: 0.469 ± 0.04
1.026GlnArg: 1.026 ± 0.053
0.946GlnSer: 0.946 ± 0.058
0.816GlnThr: 0.816 ± 0.049
1.195GlnVal: 1.195 ± 0.045
0.214GlnTrp: 0.214 ± 0.02
0.801GlnTyr: 0.801 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
3.119ArgAla: 3.119 ± 0.095
0.456ArgCys: 0.456 ± 0.035
2.736ArgAsp: 2.736 ± 0.085
4.8ArgGlu: 4.8 ± 0.132
1.91ArgPhe: 1.91 ± 0.063
3.481ArgGly: 3.481 ± 0.098
0.754ArgHis: 0.754 ± 0.04
4.607ArgIle: 4.607 ± 0.105
4.59ArgLys: 4.59 ± 0.13
3.295ArgLeu: 3.295 ± 0.093
1.482ArgMet: 1.482 ± 0.062
2.205ArgAsn: 2.205 ± 0.076
1.184ArgPro: 1.184 ± 0.054
0.717ArgGln: 0.717 ± 0.042
3.107ArgArg: 3.107 ± 0.115
1.794ArgSer: 1.794 ± 0.074
1.661ArgThr: 1.661 ± 0.068
3.348ArgVal: 3.348 ± 0.088
0.514ArgTrp: 0.514 ± 0.033
2.105ArgTyr: 2.105 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
3.177SerAla: 3.177 ± 0.089
0.37SerCys: 0.37 ± 0.028
2.077SerAsp: 2.077 ± 0.071
3.226SerGlu: 3.226 ± 0.088
2.479SerPhe: 2.479 ± 0.081
4.123SerGly: 4.123 ± 0.126
0.993SerHis: 0.993 ± 0.048
4.988SerIle: 4.988 ± 0.12
4.044SerLys: 4.044 ± 0.099
5.594SerLeu: 5.594 ± 0.133
1.747SerMet: 1.747 ± 0.057
2.434SerAsn: 2.434 ± 0.144
2.299SerPro: 2.299 ± 0.068
1.336SerGln: 1.336 ± 0.059
2.132SerArg: 2.132 ± 0.071
3.892SerSer: 3.892 ± 0.154
2.734SerThr: 2.734 ± 0.106
3.503SerVal: 3.503 ± 0.1
0.766SerTrp: 0.766 ± 0.044
2.501SerTyr: 2.501 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
2.92ThrAla: 2.92 ± 0.083
0.289ThrCys: 0.289 ± 0.026
1.702ThrAsp: 1.702 ± 0.067
2.263ThrGlu: 2.263 ± 0.079
1.762ThrPhe: 1.762 ± 0.069
3.513ThrGly: 3.513 ± 0.087
0.929ThrHis: 0.929 ± 0.047
3.969ThrIle: 3.969 ± 0.109
2.79ThrLys: 2.79 ± 0.085
4.554ThrLeu: 4.554 ± 0.119
1.004ThrMet: 1.004 ± 0.045
1.831ThrAsn: 1.831 ± 0.089
2.227ThrPro: 2.227 ± 0.073
0.97ThrGln: 0.97 ± 0.049
1.751ThrArg: 1.751 ± 0.063
2.451ThrSer: 2.451 ± 0.093
2.323ThrThr: 2.323 ± 0.096
3.01ThrVal: 3.01 ± 0.116
0.484ThrTrp: 0.484 ± 0.035
2.051ThrTyr: 2.051 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
4.472ValAla: 4.472 ± 0.114
0.505ValCys: 0.505 ± 0.032
4.205ValAsp: 4.205 ± 0.11
5.626ValGlu: 5.626 ± 0.135
2.79ValPhe: 2.79 ± 0.069
4.836ValGly: 4.836 ± 0.114
1.295ValHis: 1.295 ± 0.051
6.164ValIle: 6.164 ± 0.125
5.603ValLys: 5.603 ± 0.112
6.005ValLeu: 6.005 ± 0.123
1.831ValMet: 1.831 ± 0.059
3.07ValAsn: 3.07 ± 0.087
2.925ValPro: 2.925 ± 0.079
1.357ValGln: 1.357 ± 0.053
3.171ValArg: 3.171 ± 0.085
3.578ValSer: 3.578 ± 0.109
2.633ValThr: 2.633 ± 0.095
5.132ValVal: 5.132 ± 0.124
0.837ValTrp: 0.837 ± 0.044
3.017ValTyr: 3.017 ± 0.112
0.0ValXaa: 0.0 ± 0.0
Trp
0.636TrpAla: 0.636 ± 0.037
0.066TrpCys: 0.066 ± 0.012
0.743TrpAsp: 0.743 ± 0.049
0.831TrpGlu: 0.831 ± 0.046
0.439TrpPhe: 0.439 ± 0.033
0.85TrpGly: 0.85 ± 0.046
0.253TrpHis: 0.253 ± 0.021
0.996TrpIle: 0.996 ± 0.057
1.041TrpLys: 1.041 ± 0.048
1.066TrpLeu: 1.066 ± 0.051
0.315TrpMet: 0.315 ± 0.022
0.711TrpAsn: 0.711 ± 0.042
0.274TrpPro: 0.274 ± 0.029
0.31TrpGln: 0.31 ± 0.026
0.587TrpArg: 0.587 ± 0.034
0.627TrpSer: 0.627 ± 0.039
0.417TrpThr: 0.417 ± 0.04
0.773TrpVal: 0.773 ± 0.04
0.24TrpTrp: 0.24 ± 0.024
0.514TrpTyr: 0.514 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.95TyrAla: 2.95 ± 0.089
0.317TyrCys: 0.317 ± 0.029
2.4TyrAsp: 2.4 ± 0.076
3.385TyrGlu: 3.385 ± 0.093
2.092TyrPhe: 2.092 ± 0.08
3.695TyrGly: 3.695 ± 0.088
0.831TyrHis: 0.831 ± 0.049
3.828TyrIle: 3.828 ± 0.094
2.965TyrLys: 2.965 ± 0.077
4.323TyrLeu: 4.323 ± 0.106
1.12TyrMet: 1.12 ± 0.05
2.092TyrAsn: 2.092 ± 0.088
2.057TyrPro: 2.057 ± 0.073
0.914TyrGln: 0.914 ± 0.047
2.141TyrArg: 2.141 ± 0.072
2.653TyrSer: 2.653 ± 0.085
2.269TyrThr: 2.269 ± 0.091
3.173TyrVal: 3.173 ± 0.092
0.529TyrTrp: 0.529 ± 0.034
2.308TyrTyr: 2.308 ± 0.09
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1539 proteins (467080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski