Amino acid dipepetide frequency for Macleaya cordata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.836AlaAla: 5.836 ± 0.039	1.225AlaCys: 1.225 ± 0.012	2.969AlaAsp: 2.969 ± 0.021	3.997AlaGlu: 3.997 ± 0.026	2.647AlaPhe: 2.647 ± 0.019	4.036AlaGly: 4.036 ± 0.024	1.258AlaHis: 1.258 ± 0.013	3.752AlaIle: 3.752 ± 0.024	3.683AlaLys: 3.683 ± 0.022	6.372AlaLeu: 6.372 ± 0.032	1.746AlaMet: 1.746 ± 0.016	2.452AlaAsn: 2.452 ± 0.015	2.616AlaPro: 2.616 ± 0.021	1.989AlaGln: 1.989 ± 0.015	3.241AlaArg: 3.241 ± 0.019	5.58AlaSer: 5.58 ± 0.027	3.418AlaThr: 3.418 ± 0.02	4.539AlaVal: 4.539 ± 0.024	0.772AlaTrp: 0.772 ± 0.01	1.731AlaTyr: 1.731 ± 0.014	0.001AlaXaa: 0.001 ± 0.0
Cys	0.956CysAla: 0.956 ± 0.01	0.488CysCys: 0.488 ± 0.008	0.796CysAsp: 0.796 ± 0.013	0.88CysGlu: 0.88 ± 0.01	0.867CysPhe: 0.867 ± 0.01	1.379CysGly: 1.379 ± 0.015	0.423CysHis: 0.423 ± 0.007	1.024CysIle: 1.024 ± 0.01	1.162CysLys: 1.162 ± 0.012	1.77CysLeu: 1.77 ± 0.015	0.449CysMet: 0.449 ± 0.007	0.872CysAsn: 0.872 ± 0.01	0.905CysPro: 0.905 ± 0.013	0.574CysGln: 0.574 ± 0.008	1.064CysArg: 1.064 ± 0.012	1.836CysSer: 1.836 ± 0.016	0.87CysThr: 0.87 ± 0.011	1.001CysVal: 1.001 ± 0.012	0.255CysTrp: 0.255 ± 0.006	0.544CysTyr: 0.544 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.234AspAla: 3.234 ± 0.019	0.938AspCys: 0.938 ± 0.012	3.677AspAsp: 3.677 ± 0.025	4.103AspGlu: 4.103 ± 0.029	2.355AspPhe: 2.355 ± 0.018	3.849AspGly: 3.849 ± 0.022	1.358AspHis: 1.358 ± 0.014	2.924AspIle: 2.924 ± 0.019	2.614AspLys: 2.614 ± 0.02	5.183AspLeu: 5.183 ± 0.025	1.328AspMet: 1.328 ± 0.012	1.996AspAsn: 1.996 ± 0.014	2.721AspPro: 2.721 ± 0.019	1.922AspGln: 1.922 ± 0.016	2.465AspArg: 2.465 ± 0.024	4.224AspSer: 4.224 ± 0.026	2.188AspThr: 2.188 ± 0.017	3.528AspVal: 3.528 ± 0.023	0.706AspTrp: 0.706 ± 0.011	1.557AspTyr: 1.557 ± 0.016	0.001AspXaa: 0.001 ± 0.0
Glu	4.653GluAla: 4.653 ± 0.025	0.87GluCys: 0.87 ± 0.011	4.057GluAsp: 4.057 ± 0.028	6.729GluGlu: 6.729 ± 0.048	2.446GluPhe: 2.446 ± 0.016	3.849GluGly: 3.849 ± 0.026	1.206GluHis: 1.206 ± 0.013	3.915GluIle: 3.915 ± 0.022	4.909GluLys: 4.909 ± 0.04	5.909GluLeu: 5.909 ± 0.036	1.895GluMet: 1.895 ± 0.019	3.131GluAsn: 3.131 ± 0.018	2.2GluPro: 2.2 ± 0.018	2.181GluGln: 2.181 ± 0.019	3.494GluArg: 3.494 ± 0.025	4.596GluSer: 4.596 ± 0.03	3.125GluThr: 3.125 ± 0.019	4.274GluVal: 4.274 ± 0.024	0.735GluTrp: 0.735 ± 0.009	1.587GluTyr: 1.587 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	2.418PheAla: 2.418 ± 0.017	0.896PheCys: 0.896 ± 0.011	2.401PheAsp: 2.401 ± 0.019	2.379PheGlu: 2.379 ± 0.017	2.048PhePhe: 2.048 ± 0.02	3.082PheGly: 3.082 ± 0.022	1.094PheHis: 1.094 ± 0.011	2.211PheIle: 2.211 ± 0.019	2.129PheLys: 2.129 ± 0.014	4.262PheLeu: 4.262 ± 0.027	0.998PheMet: 0.998 ± 0.009	1.812PheAsn: 1.812 ± 0.015	2.03PhePro: 2.03 ± 0.015	1.555PheGln: 1.555 ± 0.012	2.116PheArg: 2.116 ± 0.014	4.161PheSer: 4.161 ± 0.025	2.047PheThr: 2.047 ± 0.017	2.767PheVal: 2.767 ± 0.02	0.604PheTrp: 0.604 ± 0.009	1.293PheTyr: 1.293 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	3.733GlyAla: 3.733 ± 0.022	1.329GlyCys: 1.329 ± 0.015	3.385GlyAsp: 3.385 ± 0.021	3.721GlyGlu: 3.721 ± 0.021	3.325GlyPhe: 3.325 ± 0.023	5.794GlyGly: 5.794 ± 0.048	1.515GlyHis: 1.515 ± 0.014	3.74GlyIle: 3.74 ± 0.023	4.058GlyLys: 4.058 ± 0.023	6.09GlyLeu: 6.09 ± 0.029	1.505GlyMet: 1.505 ± 0.014	3.05GlyAsn: 3.05 ± 0.023	2.4GlyPro: 2.4 ± 0.021	2.013GlyGln: 2.013 ± 0.016	3.791GlyArg: 3.791 ± 0.027	6.105GlySer: 6.105 ± 0.031	3.294GlyThr: 3.294 ± 0.02	4.253GlyVal: 4.253 ± 0.027	0.966GlyTrp: 0.966 ± 0.011	2.097GlyTyr: 2.097 ± 0.018	0.001GlyXaa: 0.001 ± 0.0
His	1.289HisAla: 1.289 ± 0.015	0.483HisCys: 0.483 ± 0.008	1.125HisAsp: 1.125 ± 0.013	1.303HisGlu: 1.303 ± 0.013	1.048HisPhe: 1.048 ± 0.01	1.714HisGly: 1.714 ± 0.015	1.102HisHis: 1.102 ± 0.019	1.2HisIle: 1.2 ± 0.013	1.129HisLys: 1.129 ± 0.01	2.402HisLeu: 2.402 ± 0.018	0.526HisMet: 0.526 ± 0.008	0.96HisAsn: 0.96 ± 0.01	1.382HisPro: 1.382 ± 0.014	1.128HisGln: 1.128 ± 0.012	1.332HisArg: 1.332 ± 0.013	1.859HisSer: 1.859 ± 0.014	0.957HisThr: 0.957 ± 0.011	1.475HisVal: 1.475 ± 0.013	0.319HisTrp: 0.319 ± 0.005	0.709HisTyr: 0.709 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.44IleAla: 3.44 ± 0.024	1.128IleCys: 1.128 ± 0.012	2.982IleAsp: 2.982 ± 0.018	3.364IleGlu: 3.364 ± 0.021	2.385IlePhe: 2.385 ± 0.02	3.436IleGly: 3.436 ± 0.023	1.387IleHis: 1.387 ± 0.013	2.927IleIle: 2.927 ± 0.021	3.056IleLys: 3.056 ± 0.019	5.37IleLeu: 5.37 ± 0.031	1.17IleMet: 1.17 ± 0.011	2.358IleAsn: 2.358 ± 0.018	3.044IlePro: 3.044 ± 0.022	2.07IleGln: 2.07 ± 0.016	2.838IleArg: 2.838 ± 0.019	5.267IleSer: 5.267 ± 0.025	2.769IleThr: 2.769 ± 0.019	3.433IleVal: 3.433 ± 0.018	0.799IleTrp: 0.799 ± 0.013	1.562IleTyr: 1.562 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.84LysAla: 3.84 ± 0.024	0.98LysCys: 0.98 ± 0.009	3.322LysAsp: 3.322 ± 0.024	4.756LysGlu: 4.756 ± 0.035	2.194LysPhe: 2.194 ± 0.017	3.563LysGly: 3.563 ± 0.022	1.269LysHis: 1.269 ± 0.014	3.344LysIle: 3.344 ± 0.021	4.946LysLys: 4.946 ± 0.041	5.783LysLeu: 5.783 ± 0.032	1.572LysMet: 1.572 ± 0.014	2.828LysAsn: 2.828 ± 0.02	2.793LysPro: 2.793 ± 0.023	2.295LysGln: 2.295 ± 0.018	3.542LysArg: 3.542 ± 0.022	4.701LysSer: 4.701 ± 0.027	2.951LysThr: 2.951 ± 0.018	3.809LysVal: 3.809 ± 0.025	0.793LysTrp: 0.793 ± 0.011	1.617LysTyr: 1.617 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	6.217LeuAla: 6.217 ± 0.031	1.787LeuCys: 1.787 ± 0.016	5.037LeuAsp: 5.037 ± 0.023	6.292LeuGlu: 6.292 ± 0.036	3.91LeuPhe: 3.91 ± 0.024	5.941LeuGly: 5.941 ± 0.032	2.514LeuHis: 2.514 ± 0.018	4.948LeuIle: 4.948 ± 0.031	6.091LeuLys: 6.091 ± 0.028	9.906LeuLeu: 9.906 ± 0.055	2.233LeuMet: 2.233 ± 0.017	4.027LeuAsn: 4.027 ± 0.023	5.03LeuPro: 5.03 ± 0.03	4.303LeuGln: 4.303 ± 0.024	5.269LeuArg: 5.269 ± 0.024	8.392LeuSer: 8.392 ± 0.042	4.373LeuThr: 4.373 ± 0.027	6.334LeuVal: 6.334 ± 0.03	1.171LeuTrp: 1.171 ± 0.012	2.448LeuTyr: 2.448 ± 0.017	0.001LeuXaa: 0.001 ± 0.0
Met	2.1MetAla: 2.1 ± 0.014	0.303MetCys: 0.303 ± 0.005	1.493MetAsp: 1.493 ± 0.012	2.08MetGlu: 2.08 ± 0.017	0.841MetPhe: 0.841 ± 0.009	1.763MetGly: 1.763 ± 0.015	0.51MetHis: 0.51 ± 0.007	1.32MetIle: 1.32 ± 0.013	1.712MetLys: 1.712 ± 0.015	2.101MetLeu: 2.101 ± 0.016	0.733MetMet: 0.733 ± 0.01	1.071MetAsn: 1.071 ± 0.011	1.015MetPro: 1.015 ± 0.011	0.896MetGln: 0.896 ± 0.01	1.175MetArg: 1.175 ± 0.012	1.713MetSer: 1.713 ± 0.013	1.039MetThr: 1.039 ± 0.011	1.751MetVal: 1.751 ± 0.014	0.266MetTrp: 0.266 ± 0.006	0.621MetTyr: 0.621 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.499AsnAla: 2.499 ± 0.016	0.874AsnCys: 0.874 ± 0.011	2.028AsnAsp: 2.028 ± 0.014	2.519AsnGlu: 2.519 ± 0.019	1.955AsnPhe: 1.955 ± 0.016	3.333AsnGly: 3.333 ± 0.024	1.106AsnHis: 1.106 ± 0.011	2.498AsnIle: 2.498 ± 0.018	2.447AsnLys: 2.447 ± 0.019	4.656AsnLeu: 4.656 ± 0.029	1.081AsnMet: 1.081 ± 0.011	2.545AsnAsn: 2.545 ± 0.027	2.564AsnPro: 2.564 ± 0.017	1.768AsnGln: 1.768 ± 0.016	2.164AsnArg: 2.164 ± 0.016	4.209AsnSer: 4.209 ± 0.028	2.059AsnThr: 2.059 ± 0.016	2.707AsnVal: 2.707 ± 0.02	0.6AsnTrp: 0.6 ± 0.01	1.325AsnTyr: 1.325 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	2.783ProAla: 2.783 ± 0.022	0.758ProCys: 0.758 ± 0.012	2.474ProAsp: 2.474 ± 0.018	3.085ProGlu: 3.085 ± 0.02	1.978ProPhe: 1.978 ± 0.018	2.654ProGly: 2.654 ± 0.023	1.08ProHis: 1.08 ± 0.015	2.499ProIle: 2.499 ± 0.021	2.77ProLys: 2.77 ± 0.023	4.276ProLeu: 4.276 ± 0.023	0.977ProMet: 0.977 ± 0.012	2.406ProAsn: 2.406 ± 0.018	4.132ProPro: 4.132 ± 0.064	1.759ProGln: 1.759 ± 0.017	2.313ProArg: 2.313 ± 0.019	5.152ProSer: 5.152 ± 0.033	2.83ProThr: 2.83 ± 0.018	3.105ProVal: 3.105 ± 0.02	0.635ProTrp: 0.635 ± 0.01	1.328ProTyr: 1.328 ± 0.016	0.001ProXaa: 0.001 ± 0.0
Gln	2.298GlnAla: 2.298 ± 0.019	0.56GlnCys: 0.56 ± 0.009	1.641GlnAsp: 1.641 ± 0.016	2.444GlnGlu: 2.444 ± 0.02	1.408GlnPhe: 1.408 ± 0.013	2.122GlnGly: 2.122 ± 0.018	0.909GlnHis: 0.909 ± 0.012	2.133GlnIle: 2.133 ± 0.017	2.342GlnLys: 2.342 ± 0.019	3.558GlnLeu: 3.558 ± 0.021	0.993GlnMet: 0.993 ± 0.011	1.847GlnAsn: 1.847 ± 0.016	1.732GlnPro: 1.732 ± 0.019	2.34GlnGln: 2.34 ± 0.045	2.096GlnArg: 2.096 ± 0.017	2.85GlnSer: 2.85 ± 0.02	1.8GlnThr: 1.8 ± 0.014	2.394GlnVal: 2.394 ± 0.016	0.472GlnTrp: 0.472 ± 0.007	0.889GlnTyr: 0.889 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	3.135ArgAla: 3.135 ± 0.022	0.948ArgCys: 0.948 ± 0.011	2.723ArgAsp: 2.723 ± 0.017	3.458ArgGlu: 3.458 ± 0.024	2.258ArgPhe: 2.258 ± 0.016	3.26ArgGly: 3.26 ± 0.027	1.195ArgHis: 1.195 ± 0.013	3.017ArgIle: 3.017 ± 0.019	3.751ArgLys: 3.751 ± 0.023	4.985ArgLeu: 4.985 ± 0.025	1.329ArgMet: 1.329 ± 0.013	2.52ArgAsn: 2.52 ± 0.017	2.287ArgPro: 2.287 ± 0.019	1.801ArgGln: 1.801 ± 0.015	3.941ArgArg: 3.941 ± 0.027	4.511ArgSer: 4.511 ± 0.03	2.551ArgThr: 2.551 ± 0.017	3.41ArgVal: 3.41 ± 0.02	0.781ArgTrp: 0.781 ± 0.009	1.412ArgTyr: 1.412 ± 0.013	0.001ArgXaa: 0.001 ± 0.0
Ser	5.09SerAla: 5.09 ± 0.025	1.667SerCys: 1.667 ± 0.014	4.418SerAsp: 4.418 ± 0.03	4.903SerGlu: 4.903 ± 0.031	3.965SerPhe: 3.965 ± 0.024	5.858SerGly: 5.858 ± 0.031	1.938SerHis: 1.938 ± 0.017	4.851SerIle: 4.851 ± 0.026	5.043SerLys: 5.043 ± 0.024	8.625SerLeu: 8.625 ± 0.039	2.173SerMet: 2.173 ± 0.015	4.192SerAsn: 4.192 ± 0.026	4.535SerPro: 4.535 ± 0.039	2.961SerGln: 2.961 ± 0.022	4.533SerArg: 4.533 ± 0.027	12.168SerSer: 12.168 ± 0.065	5.006SerThr: 5.006 ± 0.026	5.394SerVal: 5.394 ± 0.027	1.27SerTrp: 1.27 ± 0.013	2.282SerTyr: 2.282 ± 0.017	0.001SerXaa: 0.001 ± 0.0
Thr	3.276ThrAla: 3.276 ± 0.023	0.911ThrCys: 0.911 ± 0.01	2.383ThrAsp: 2.383 ± 0.018	2.952ThrGlu: 2.952 ± 0.02	2.057ThrPhe: 2.057 ± 0.015	3.372ThrGly: 3.372 ± 0.023	1.071ThrHis: 1.071 ± 0.009	2.805ThrIle: 2.805 ± 0.02	2.714ThrLys: 2.714 ± 0.017	4.62ThrLeu: 4.62 ± 0.023	1.162ThrMet: 1.162 ± 0.012	2.185ThrAsn: 2.185 ± 0.018	2.626ThrPro: 2.626 ± 0.023	1.611ThrGln: 1.611 ± 0.014	2.348ThrArg: 2.348 ± 0.016	4.777ThrSer: 4.777 ± 0.025	3.456ThrThr: 3.456 ± 0.027	3.441ThrVal: 3.441 ± 0.021	0.671ThrTrp: 0.671 ± 0.009	1.395ThrTyr: 1.395 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	4.566ValAla: 4.566 ± 0.026	1.122ValCys: 1.122 ± 0.011	3.764ValAsp: 3.764 ± 0.024	4.457ValGlu: 4.457 ± 0.025	2.712ValPhe: 2.712 ± 0.02	4.324ValGly: 4.324 ± 0.024	1.509ValHis: 1.509 ± 0.013	3.475ValIle: 3.475 ± 0.02	3.804ValLys: 3.804 ± 0.025	6.434ValLeu: 6.434 ± 0.034	1.545ValMet: 1.545 ± 0.013	2.597ValAsn: 2.597 ± 0.018	3.249ValPro: 3.249 ± 0.023	2.306ValGln: 2.306 ± 0.016	3.185ValArg: 3.185 ± 0.021	5.429ValSer: 5.429 ± 0.027	3.176ValThr: 3.176 ± 0.02	5.078ValVal: 5.078 ± 0.027	0.808ValTrp: 0.808 ± 0.01	1.846ValTyr: 1.846 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.795TrpAla: 0.795 ± 0.01	0.248TrpCys: 0.248 ± 0.006	0.718TrpAsp: 0.718 ± 0.01	0.792TrpGlu: 0.792 ± 0.009	0.586TrpPhe: 0.586 ± 0.009	0.775TrpGly: 0.775 ± 0.011	0.293TrpHis: 0.293 ± 0.005	0.755TrpIle: 0.755 ± 0.009	0.977TrpLys: 0.977 ± 0.011	1.218TrpLeu: 1.218 ± 0.013	0.365TrpMet: 0.365 ± 0.007	0.78TrpAsn: 0.78 ± 0.012	0.476TrpPro: 0.476 ± 0.007	0.436TrpGln: 0.436 ± 0.007	0.885TrpArg: 0.885 ± 0.011	1.035TrpSer: 1.035 ± 0.013	0.657TrpThr: 0.657 ± 0.009	0.923TrpVal: 0.923 ± 0.011	0.266TrpTrp: 0.266 ± 0.006	0.341TrpTyr: 0.341 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.701TyrAla: 1.701 ± 0.017	0.6TyrCys: 0.6 ± 0.008	1.481TyrAsp: 1.481 ± 0.016	1.548TyrGlu: 1.548 ± 0.016	1.318TyrPhe: 1.318 ± 0.013	2.064TyrGly: 2.064 ± 0.016	0.703TyrHis: 0.703 ± 0.01	1.449TyrIle: 1.449 ± 0.014	1.56TyrLys: 1.56 ± 0.021	2.698TyrLeu: 2.698 ± 0.021	0.721TyrMet: 0.721 ± 0.009	1.309TyrAsn: 1.309 ± 0.014	1.258TyrPro: 1.258 ± 0.012	0.922TyrGln: 0.922 ± 0.011	1.479TyrArg: 1.479 ± 0.013	2.309TyrSer: 2.309 ± 0.017	1.27TyrThr: 1.27 ± 0.014	1.767TyrVal: 1.767 ± 0.015	0.429TyrTrp: 0.429 ± 0.008	0.989TyrTyr: 0.989 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.029XaaXaa: 0.029 ± 0.012

Statistics based on 21697 proteins (9115806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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