Amino acid dipepetide frequency for Nitrospirales bacterium LBB_01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.019AlaAla: 7.019 ± 0.149
0.719AlaCys: 0.719 ± 0.034
3.764AlaAsp: 3.764 ± 0.081
4.455AlaGlu: 4.455 ± 0.082
3.205AlaPhe: 3.205 ± 0.081
5.027AlaGly: 5.027 ± 0.096
1.36AlaHis: 1.36 ± 0.046
5.789AlaIle: 5.789 ± 0.107
4.498AlaLys: 4.498 ± 0.101
8.288AlaLeu: 8.288 ± 0.112
2.214AlaMet: 2.214 ± 0.048
2.458AlaAsn: 2.458 ± 0.07
1.859AlaPro: 1.859 ± 0.048
2.005AlaGln: 2.005 ± 0.051
2.579AlaArg: 2.579 ± 0.067
4.319AlaSer: 4.319 ± 0.088
3.075AlaThr: 3.075 ± 0.076
6.043AlaVal: 6.043 ± 0.113
0.516AlaTrp: 0.516 ± 0.034
2.499AlaTyr: 2.499 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.821CysAla: 0.821 ± 0.041
0.179CysCys: 0.179 ± 0.017
0.533CysAsp: 0.533 ± 0.032
0.601CysGlu: 0.601 ± 0.029
0.58CysPhe: 0.58 ± 0.033
0.959CysGly: 0.959 ± 0.048
0.326CysHis: 0.326 ± 0.027
0.753CysIle: 0.753 ± 0.036
0.726CysLys: 0.726 ± 0.038
1.028CysLeu: 1.028 ± 0.037
0.295CysMet: 0.295 ± 0.021
0.48CysAsn: 0.48 ± 0.029
0.602CysPro: 0.602 ± 0.032
0.281CysGln: 0.281 ± 0.023
0.519CysArg: 0.519 ± 0.03
0.789CysSer: 0.789 ± 0.037
0.562CysThr: 0.562 ± 0.03
0.695CysVal: 0.695 ± 0.033
0.118CysTrp: 0.118 ± 0.015
0.422CysTyr: 0.422 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.771AspAla: 3.771 ± 0.079
0.588AspCys: 0.588 ± 0.031
3.003AspAsp: 3.003 ± 0.078
3.826AspGlu: 3.826 ± 0.071
3.006AspPhe: 3.006 ± 0.072
3.823AspGly: 3.823 ± 0.087
0.7AspHis: 0.7 ± 0.038
5.5AspIle: 5.5 ± 0.093
4.046AspLys: 4.046 ± 0.09
4.314AspLeu: 4.314 ± 0.081
1.636AspMet: 1.636 ± 0.052
2.667AspAsn: 2.667 ± 0.075
1.578AspPro: 1.578 ± 0.047
0.675AspGln: 0.675 ± 0.033
2.112AspArg: 2.112 ± 0.059
3.5AspSer: 3.5 ± 0.074
3.382AspThr: 3.382 ± 0.078
4.231AspVal: 4.231 ± 0.086
0.468AspTrp: 0.468 ± 0.027
2.229AspTyr: 2.229 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.819GluAla: 4.819 ± 0.086
0.563GluCys: 0.563 ± 0.031
3.155GluAsp: 3.155 ± 0.077
4.129GluGlu: 4.129 ± 0.093
2.664GluPhe: 2.664 ± 0.059
3.71GluGly: 3.71 ± 0.084
1.268GluHis: 1.268 ± 0.046
5.827GluIle: 5.827 ± 0.101
5.474GluLys: 5.474 ± 0.096
6.558GluLeu: 6.558 ± 0.103
1.781GluMet: 1.781 ± 0.056
3.103GluAsn: 3.103 ± 0.07
1.909GluPro: 1.909 ± 0.054
1.922GluGln: 1.922 ± 0.063
3.29GluArg: 3.29 ± 0.074
3.801GluSer: 3.801 ± 0.088
3.91GluThr: 3.91 ± 0.075
3.823GluVal: 3.823 ± 0.091
0.4GluTrp: 0.4 ± 0.027
1.754GluTyr: 1.754 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
2.902PheAla: 2.902 ± 0.074
0.551PheCys: 0.551 ± 0.028
2.643PheAsp: 2.643 ± 0.071
2.574PheGlu: 2.574 ± 0.07
2.554PhePhe: 2.554 ± 0.074
2.789PheGly: 2.789 ± 0.067
0.797PheHis: 0.797 ± 0.037
3.902PheIle: 3.902 ± 0.088
3.182PheLys: 3.182 ± 0.063
4.846PheLeu: 4.846 ± 0.112
1.253PheMet: 1.253 ± 0.04
2.275PheAsn: 2.275 ± 0.061
1.561PhePro: 1.561 ± 0.058
1.042PheGln: 1.042 ± 0.038
1.646PheArg: 1.646 ± 0.058
3.618PheSer: 3.618 ± 0.084
2.877PheThr: 2.877 ± 0.069
3.135PheVal: 3.135 ± 0.07
0.494PheTrp: 0.494 ± 0.032
1.917PheTyr: 1.917 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
4.559GlyAla: 4.559 ± 0.09
0.916GlyCys: 0.916 ± 0.048
3.279GlyAsp: 3.279 ± 0.074
3.488GlyGlu: 3.488 ± 0.073
3.371GlyPhe: 3.371 ± 0.07
4.634GlyGly: 4.634 ± 0.115
1.316GlyHis: 1.316 ± 0.046
5.646GlyIle: 5.646 ± 0.108
5.169GlyLys: 5.169 ± 0.092
6.103GlyLeu: 6.103 ± 0.105
1.948GlyMet: 1.948 ± 0.054
2.603GlyAsn: 2.603 ± 0.078
1.294GlyPro: 1.294 ± 0.051
1.708GlyGln: 1.708 ± 0.051
2.868GlyArg: 2.868 ± 0.069
3.917GlySer: 3.917 ± 0.08
3.881GlyThr: 3.881 ± 0.086
4.948GlyVal: 4.948 ± 0.082
0.587GlyTrp: 0.587 ± 0.032
2.623GlyTyr: 2.623 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.072HisAla: 1.072 ± 0.042
0.265HisCys: 0.265 ± 0.023
0.963HisAsp: 0.963 ± 0.043
1.125HisGlu: 1.125 ± 0.041
0.901HisPhe: 0.901 ± 0.038
1.437HisGly: 1.437 ± 0.044
0.491HisHis: 0.491 ± 0.028
1.68HisIle: 1.68 ± 0.052
1.199HisLys: 1.199 ± 0.043
1.741HisLeu: 1.741 ± 0.05
0.431HisMet: 0.431 ± 0.026
0.825HisAsn: 0.825 ± 0.034
1.007HisPro: 1.007 ± 0.039
0.518HisGln: 0.518 ± 0.031
0.915HisArg: 0.915 ± 0.04
1.261HisSer: 1.261 ± 0.049
1.18HisThr: 1.18 ± 0.047
1.144HisVal: 1.144 ± 0.042
0.198HisTrp: 0.198 ± 0.02
0.725HisTyr: 0.725 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.951IleAla: 5.951 ± 0.101
0.853IleCys: 0.853 ± 0.039
4.39IleAsp: 4.39 ± 0.084
5.668IleGlu: 5.668 ± 0.1
3.472IlePhe: 3.472 ± 0.083
5.03IleGly: 5.03 ± 0.096
1.462IleHis: 1.462 ± 0.051
6.123IleIle: 6.123 ± 0.093
6.2IleLys: 6.2 ± 0.091
7.118IleLeu: 7.118 ± 0.118
1.963IleMet: 1.963 ± 0.061
3.944IleAsn: 3.944 ± 0.081
3.191IlePro: 3.191 ± 0.078
1.741IleGln: 1.741 ± 0.05
3.45IleArg: 3.45 ± 0.074
6.117IleSer: 6.117 ± 0.105
5.171IleThr: 5.171 ± 0.079
5.828IleVal: 5.828 ± 0.105
0.491IleTrp: 0.491 ± 0.025
2.731IleTyr: 2.731 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
5.052LysAla: 5.052 ± 0.094
0.675LysCys: 0.675 ± 0.034
4.722LysAsp: 4.722 ± 0.098
5.714LysGlu: 5.714 ± 0.114
2.229LysPhe: 2.229 ± 0.064
4.349LysGly: 4.349 ± 0.087
1.531LysHis: 1.531 ± 0.05
5.878LysIle: 5.878 ± 0.105
5.888LysLys: 5.888 ± 0.113
6.142LysLeu: 6.142 ± 0.101
1.906LysMet: 1.906 ± 0.059
3.558LysAsn: 3.558 ± 0.08
2.75LysPro: 2.75 ± 0.072
2.245LysGln: 2.245 ± 0.061
3.472LysArg: 3.472 ± 0.079
4.7LysSer: 4.7 ± 0.088
4.976LysThr: 4.976 ± 0.104
4.399LysVal: 4.399 ± 0.09
0.607LysTrp: 0.607 ± 0.032
2.578LysTyr: 2.578 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
6.183LeuAla: 6.183 ± 0.107
1.17LeuCys: 1.17 ± 0.044
4.724LeuAsp: 4.724 ± 0.086
5.314LeuGlu: 5.314 ± 0.092
4.454LeuPhe: 4.454 ± 0.094
5.304LeuGly: 5.304 ± 0.084
1.697LeuHis: 1.697 ± 0.052
7.727LeuIle: 7.727 ± 0.125
8.586LeuLys: 8.586 ± 0.116
8.908LeuLeu: 8.908 ± 0.143
2.563LeuMet: 2.563 ± 0.065
4.78LeuAsn: 4.78 ± 0.088
3.825LeuPro: 3.825 ± 0.088
2.579LeuGln: 2.579 ± 0.06
4.605LeuArg: 4.605 ± 0.078
8.142LeuSer: 8.142 ± 0.114
6.208LeuThr: 6.208 ± 0.106
5.425LeuVal: 5.425 ± 0.093
0.847LeuTrp: 0.847 ± 0.038
3.469LeuTyr: 3.469 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.221MetAla: 2.221 ± 0.061
0.29MetCys: 0.29 ± 0.023
1.603MetAsp: 1.603 ± 0.049
1.803MetGlu: 1.803 ± 0.05
1.214MetPhe: 1.214 ± 0.049
1.82MetGly: 1.82 ± 0.054
0.364MetHis: 0.364 ± 0.023
1.749MetIle: 1.749 ± 0.046
2.088MetLys: 2.088 ± 0.057
2.589MetLeu: 2.589 ± 0.071
0.714MetMet: 0.714 ± 0.03
1.009MetAsn: 1.009 ± 0.043
1.363MetPro: 1.363 ± 0.042
0.676MetGln: 0.676 ± 0.026
1.312MetArg: 1.312 ± 0.056
2.044MetSer: 2.044 ± 0.058
1.547MetThr: 1.547 ± 0.047
1.803MetVal: 1.803 ± 0.057
0.235MetTrp: 0.235 ± 0.02
0.756MetTyr: 0.756 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.927AsnAla: 2.927 ± 0.066
0.496AsnCys: 0.496 ± 0.027
2.407AsnAsp: 2.407 ± 0.065
2.587AsnGlu: 2.587 ± 0.071
1.895AsnPhe: 1.895 ± 0.055
2.76AsnGly: 2.76 ± 0.078
0.726AsnHis: 0.726 ± 0.033
4.098AsnIle: 4.098 ± 0.082
2.855AsnLys: 2.855 ± 0.067
4.328AsnLeu: 4.328 ± 0.095
1.291AsnMet: 1.291 ± 0.042
1.985AsnAsn: 1.985 ± 0.061
2.126AsnPro: 2.126 ± 0.062
0.987AsnGln: 0.987 ± 0.039
1.892AsnArg: 1.892 ± 0.047
2.918AsnSer: 2.918 ± 0.072
2.531AsnThr: 2.531 ± 0.066
3.098AsnVal: 3.098 ± 0.067
0.392AsnTrp: 0.392 ± 0.027
1.619AsnTyr: 1.619 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.584ProAla: 2.584 ± 0.067
0.389ProCys: 0.389 ± 0.022
2.469ProAsp: 2.469 ± 0.066
2.882ProGlu: 2.882 ± 0.071
1.985ProPhe: 1.985 ± 0.058
2.055ProGly: 2.055 ± 0.067
0.849ProHis: 0.849 ± 0.039
2.494ProIle: 2.494 ± 0.065
1.997ProLys: 1.997 ± 0.063
3.568ProLeu: 3.568 ± 0.082
0.904ProMet: 0.904 ± 0.041
1.266ProAsn: 1.266 ± 0.045
1.439ProPro: 1.439 ± 0.066
1.197ProGln: 1.197 ± 0.043
1.059ProArg: 1.059 ± 0.04
2.072ProSer: 2.072 ± 0.062
1.726ProThr: 1.726 ± 0.065
3.161ProVal: 3.161 ± 0.072
0.367ProTrp: 0.367 ± 0.023
1.454ProTyr: 1.454 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
1.834GlnAla: 1.834 ± 0.055
0.318GlnCys: 0.318 ± 0.022
1.206GlnAsp: 1.206 ± 0.043
1.395GlnGlu: 1.395 ± 0.045
0.957GlnPhe: 0.957 ± 0.041
1.472GlnGly: 1.472 ± 0.051
0.587GlnHis: 0.587 ± 0.028
1.969GlnIle: 1.969 ± 0.056
2.098GlnLys: 2.098 ± 0.058
2.425GlnLeu: 2.425 ± 0.07
0.825GlnMet: 0.825 ± 0.031
1.21GlnAsn: 1.21 ± 0.048
0.919GlnPro: 0.919 ± 0.037
0.893GlnGln: 0.893 ± 0.039
1.515GlnArg: 1.515 ± 0.046
1.845GlnSer: 1.845 ± 0.059
1.635GlnThr: 1.635 ± 0.05
1.603GlnVal: 1.603 ± 0.051
0.3GlnTrp: 0.3 ± 0.02
0.995GlnTyr: 0.995 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.992ArgAla: 2.992 ± 0.068
0.544ArgCys: 0.544 ± 0.033
2.416ArgAsp: 2.416 ± 0.064
2.967ArgGlu: 2.967 ± 0.068
2.143ArgPhe: 2.143 ± 0.064
2.736ArgGly: 2.736 ± 0.072
0.933ArgHis: 0.933 ± 0.041
3.213ArgIle: 3.213 ± 0.074
3.018ArgLys: 3.018 ± 0.062
4.401ArgLeu: 4.401 ± 0.09
1.15ArgMet: 1.15 ± 0.043
1.895ArgAsn: 1.895 ± 0.056
1.351ArgPro: 1.351 ± 0.046
1.439ArgGln: 1.439 ± 0.047
2.138ArgArg: 2.138 ± 0.075
2.185ArgSer: 2.185 ± 0.064
2.085ArgThr: 2.085 ± 0.054
3.076ArgVal: 3.076 ± 0.078
0.375ArgTrp: 0.375 ± 0.025
1.727ArgTyr: 1.727 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.986SerAla: 4.986 ± 0.095
0.75SerCys: 0.75 ± 0.038
4.021SerAsp: 4.021 ± 0.076
4.366SerGlu: 4.366 ± 0.08
3.398SerPhe: 3.398 ± 0.069
5.289SerGly: 5.289 ± 0.101
1.305SerHis: 1.305 ± 0.042
5.001SerIle: 5.001 ± 0.097
4.438SerLys: 4.438 ± 0.094
6.829SerLeu: 6.829 ± 0.108
1.803SerMet: 1.803 ± 0.052
2.554SerAsn: 2.554 ± 0.069
2.349SerPro: 2.349 ± 0.074
1.771SerGln: 1.771 ± 0.052
2.579SerArg: 2.579 ± 0.067
4.601SerSer: 4.601 ± 0.102
3.513SerThr: 3.513 ± 0.076
5.325SerVal: 5.325 ± 0.102
0.596SerTrp: 0.596 ± 0.027
2.361SerTyr: 2.361 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.772ThrAla: 4.772 ± 0.104
0.585ThrCys: 0.585 ± 0.032
3.461ThrAsp: 3.461 ± 0.079
3.903ThrGlu: 3.903 ± 0.078
2.598ThrPhe: 2.598 ± 0.066
4.794ThrGly: 4.794 ± 0.079
1.224ThrHis: 1.224 ± 0.045
4.476ThrIle: 4.476 ± 0.091
3.503ThrLys: 3.503 ± 0.078
5.925ThrLeu: 5.925 ± 0.096
1.354ThrMet: 1.354 ± 0.048
2.083ThrAsn: 2.083 ± 0.071
2.524ThrPro: 2.524 ± 0.077
1.489ThrGln: 1.489 ± 0.052
1.828ThrArg: 1.828 ± 0.052
3.568ThrSer: 3.568 ± 0.079
3.2ThrThr: 3.2 ± 0.088
4.685ThrVal: 4.685 ± 0.087
0.408ThrTrp: 0.408 ± 0.025
1.821ThrTyr: 1.821 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.358ValAla: 4.358 ± 0.09
0.835ValCys: 0.835 ± 0.036
3.673ValAsp: 3.673 ± 0.075
4.253ValGlu: 4.253 ± 0.076
3.729ValPhe: 3.729 ± 0.087
3.925ValGly: 3.925 ± 0.079
1.194ValHis: 1.194 ± 0.042
5.841ValIle: 5.841 ± 0.091
5.339ValLys: 5.339 ± 0.091
7.138ValLeu: 7.138 ± 0.109
1.908ValMet: 1.908 ± 0.053
3.092ValAsn: 3.092 ± 0.068
2.52ValPro: 2.52 ± 0.066
1.625ValGln: 1.625 ± 0.052
3.025ValArg: 3.025 ± 0.072
5.569ValSer: 5.569 ± 0.085
4.435ValThr: 4.435 ± 0.081
5.362ValVal: 5.362 ± 0.119
0.551ValTrp: 0.551 ± 0.031
2.429ValTyr: 2.429 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.615TrpAla: 0.615 ± 0.03
0.118TrpCys: 0.118 ± 0.014
0.477TrpAsp: 0.477 ± 0.03
0.486TrpGlu: 0.486 ± 0.029
0.431TrpPhe: 0.431 ± 0.031
0.537TrpGly: 0.537 ± 0.036
0.198TrpHis: 0.198 ± 0.017
0.653TrpIle: 0.653 ± 0.035
0.568TrpLys: 0.568 ± 0.028
0.874TrpLeu: 0.874 ± 0.04
0.216TrpMet: 0.216 ± 0.017
0.34TrpAsn: 0.34 ± 0.019
0.265TrpPro: 0.265 ± 0.017
0.351TrpGln: 0.351 ± 0.026
0.4TrpArg: 0.4 ± 0.026
0.507TrpSer: 0.507 ± 0.028
0.405TrpThr: 0.405 ± 0.03
0.574TrpVal: 0.574 ± 0.037
0.08TrpTrp: 0.08 ± 0.011
0.287TrpTyr: 0.287 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.253TyrAla: 2.253 ± 0.056
0.464TyrCys: 0.464 ± 0.029
2.148TyrAsp: 2.148 ± 0.06
2.323TyrGlu: 2.323 ± 0.075
1.771TyrPhe: 1.771 ± 0.053
2.411TyrGly: 2.411 ± 0.067
0.748TyrHis: 0.748 ± 0.035
2.574TyrIle: 2.574 ± 0.067
2.499TyrLys: 2.499 ± 0.072
3.387TyrLeu: 3.387 ± 0.086
1.043TyrMet: 1.043 ± 0.046
1.79TyrAsn: 1.79 ± 0.06
1.484TyrPro: 1.484 ± 0.051
0.857TyrGln: 0.857 ± 0.035
1.583TyrArg: 1.583 ± 0.049
2.361TyrSer: 2.361 ± 0.071
1.905TyrThr: 1.905 ± 0.056
2.441TyrVal: 2.441 ± 0.065
0.353TyrTrp: 0.353 ± 0.025
1.417TyrTyr: 1.417 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2708 proteins (637417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski