Amino acid dipepetide frequency for Nocardioides sp. zg-579

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.542AlaAla: 21.542 ± 0.194	1.044AlaCys: 1.044 ± 0.03	8.721AlaAsp: 8.721 ± 0.098	9.049AlaGlu: 9.049 ± 0.111	3.437AlaPhe: 3.437 ± 0.058	13.598AlaGly: 13.598 ± 0.134	2.558AlaHis: 2.558 ± 0.044	3.984AlaIle: 3.984 ± 0.066	2.379AlaLys: 2.379 ± 0.061	14.05AlaLeu: 14.05 ± 0.126	2.682AlaMet: 2.682 ± 0.05	1.898AlaAsn: 1.898 ± 0.041	6.877AlaPro: 6.877 ± 0.094	3.385AlaGln: 3.385 ± 0.048	10.367AlaArg: 10.367 ± 0.127	6.118AlaSer: 6.118 ± 0.066	8.105AlaThr: 8.105 ± 0.085	12.411AlaVal: 12.411 ± 0.117	2.067AlaTrp: 2.067 ± 0.041	2.657AlaTyr: 2.657 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.898CysAla: 0.898 ± 0.029	0.08CysCys: 0.08 ± 0.008	0.445CysAsp: 0.445 ± 0.02	0.426CysGlu: 0.426 ± 0.018	0.219CysPhe: 0.219 ± 0.013	0.827CysGly: 0.827 ± 0.028	0.179CysHis: 0.179 ± 0.011	0.179CysIle: 0.179 ± 0.012	0.082CysLys: 0.082 ± 0.009	0.658CysLeu: 0.658 ± 0.022	0.1CysMet: 0.1 ± 0.009	0.128CysAsn: 0.128 ± 0.01	0.469CysPro: 0.469 ± 0.022	0.153CysGln: 0.153 ± 0.011	0.578CysArg: 0.578 ± 0.021	0.442CysSer: 0.442 ± 0.019	0.491CysThr: 0.491 ± 0.023	0.621CysVal: 0.621 ± 0.021	0.12CysTrp: 0.12 ± 0.01	0.148CysTyr: 0.148 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.026AspAla: 8.026 ± 0.087	0.361AspCys: 0.361 ± 0.018	4.166AspAsp: 4.166 ± 0.062	4.155AspGlu: 4.155 ± 0.057	1.56AspPhe: 1.56 ± 0.035	6.398AspGly: 6.398 ± 0.076	1.591AspHis: 1.591 ± 0.038	1.657AspIle: 1.657 ± 0.037	0.949AspLys: 0.949 ± 0.027	7.608AspLeu: 7.608 ± 0.085	0.807AspMet: 0.807 ± 0.024	0.785AspAsn: 0.785 ± 0.026	5.041AspPro: 5.041 ± 0.072	1.769AspGln: 1.769 ± 0.036	5.325AspArg: 5.325 ± 0.062	2.206AspSer: 2.206 ± 0.05	2.78AspThr: 2.78 ± 0.045	6.196AspVal: 6.196 ± 0.072	0.993AspTrp: 0.993 ± 0.025	1.035AspTyr: 1.035 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.756GluAla: 7.756 ± 0.112	0.335GluCys: 0.335 ± 0.016	3.5GluAsp: 3.5 ± 0.062	3.973GluGlu: 3.973 ± 0.066	1.261GluPhe: 1.261 ± 0.034	4.683GluGly: 4.683 ± 0.067	1.791GluHis: 1.791 ± 0.041	2.132GluIle: 2.132 ± 0.044	1.192GluLys: 1.192 ± 0.04	6.517GluLeu: 6.517 ± 0.069	0.983GluMet: 0.983 ± 0.033	0.89GluAsn: 0.89 ± 0.027	3.55GluPro: 3.55 ± 0.054	2.492GluGln: 2.492 ± 0.048	5.589GluArg: 5.589 ± 0.077	2.425GluSer: 2.425 ± 0.041	2.941GluThr: 2.941 ± 0.045	6.247GluVal: 6.247 ± 0.075	0.758GluTrp: 0.758 ± 0.026	0.878GluTyr: 0.878 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.473PheAla: 3.473 ± 0.058	0.251PheCys: 0.251 ± 0.014	1.927PheAsp: 1.927 ± 0.039	1.607PheGlu: 1.607 ± 0.036	0.837PhePhe: 0.837 ± 0.029	2.822PheGly: 2.822 ± 0.049	0.558PheHis: 0.558 ± 0.021	0.638PheIle: 0.638 ± 0.022	0.428PheLys: 0.428 ± 0.02	2.593PheLeu: 2.593 ± 0.054	0.374PheMet: 0.374 ± 0.019	0.521PheAsn: 0.521 ± 0.021	1.206PhePro: 1.206 ± 0.03	0.587PheGln: 0.587 ± 0.021	1.71PheArg: 1.71 ± 0.035	1.4PheSer: 1.4 ± 0.032	1.67PheThr: 1.67 ± 0.04	2.54PheVal: 2.54 ± 0.047	0.397PheTrp: 0.397 ± 0.018	0.53PheTyr: 0.53 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.247GlyAla: 11.247 ± 0.104	0.833GlyCys: 0.833 ± 0.027	5.335GlyAsp: 5.335 ± 0.068	5.523GlyGlu: 5.523 ± 0.071	2.849GlyPhe: 2.849 ± 0.053	8.702GlyGly: 8.702 ± 0.096	2.071GlyHis: 2.071 ± 0.039	3.408GlyIle: 3.408 ± 0.052	1.977GlyLys: 1.977 ± 0.05	9.824GlyLeu: 9.824 ± 0.089	1.969GlyMet: 1.969 ± 0.037	1.494GlyAsn: 1.494 ± 0.04	5.243GlyPro: 5.243 ± 0.068	2.517GlyGln: 2.517 ± 0.052	7.976GlyArg: 7.976 ± 0.085	5.435GlySer: 5.435 ± 0.079	5.992GlyThr: 5.992 ± 0.09	8.208GlyVal: 8.208 ± 0.089	1.759GlyTrp: 1.759 ± 0.037	2.043GlyTyr: 2.043 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.667HisAla: 2.667 ± 0.052	0.187HisCys: 0.187 ± 0.012	1.57HisAsp: 1.57 ± 0.037	1.308HisGlu: 1.308 ± 0.031	0.494HisPhe: 0.494 ± 0.018	2.259HisGly: 2.259 ± 0.046	0.769HisHis: 0.769 ± 0.028	0.415HisIle: 0.415 ± 0.017	0.28HisLys: 0.28 ± 0.015	2.557HisLeu: 2.557 ± 0.05	0.262HisMet: 0.262 ± 0.014	0.308HisAsn: 0.308 ± 0.016	1.642HisPro: 1.642 ± 0.041	0.631HisGln: 0.631 ± 0.02	1.96HisArg: 1.96 ± 0.041	0.752HisSer: 0.752 ± 0.023	0.965HisThr: 0.965 ± 0.029	2.129HisVal: 2.129 ± 0.043	0.304HisTrp: 0.304 ± 0.014	0.425HisTyr: 0.425 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.375IleAla: 4.375 ± 0.069	0.257IleCys: 0.257 ± 0.012	2.301IleAsp: 2.301 ± 0.043	2.161IleGlu: 2.161 ± 0.047	0.732IlePhe: 0.732 ± 0.027	3.449IleGly: 3.449 ± 0.063	0.546IleHis: 0.546 ± 0.017	0.874IleIle: 0.874 ± 0.028	0.633IleLys: 0.633 ± 0.025	2.193IleLeu: 2.193 ± 0.055	0.404IleMet: 0.404 ± 0.018	0.647IleAsn: 0.647 ± 0.026	1.518IlePro: 1.518 ± 0.038	0.643IleGln: 0.643 ± 0.024	2.036IleArg: 2.036 ± 0.04	1.584IleSer: 1.584 ± 0.038	2.034IleThr: 2.034 ± 0.038	2.786IleVal: 2.786 ± 0.054	0.325IleTrp: 0.325 ± 0.017	0.524IleTyr: 0.524 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.332LysAla: 2.332 ± 0.052	0.081LysCys: 0.081 ± 0.007	1.01LysAsp: 1.01 ± 0.028	0.891LysGlu: 0.891 ± 0.028	0.388LysPhe: 0.388 ± 0.018	1.457LysGly: 1.457 ± 0.04	0.421LysHis: 0.421 ± 0.02	0.68LysIle: 0.68 ± 0.025	0.665LysLys: 0.665 ± 0.036	1.506LysLeu: 1.506 ± 0.035	0.35LysMet: 0.35 ± 0.019	0.387LysAsn: 0.387 ± 0.021	1.149LysPro: 1.149 ± 0.034	0.618LysGln: 0.618 ± 0.025	1.285LysArg: 1.285 ± 0.034	0.879LysSer: 0.879 ± 0.03	0.991LysThr: 0.991 ± 0.035	1.913LysVal: 1.913 ± 0.048	0.185LysTrp: 0.185 ± 0.012	0.356LysTyr: 0.356 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	16.236LeuAla: 16.236 ± 0.166	0.712LeuCys: 0.712 ± 0.025	7.377LeuAsp: 7.377 ± 0.095	5.742LeuGlu: 5.742 ± 0.07	2.306LeuPhe: 2.306 ± 0.047	10.117LeuGly: 10.117 ± 0.1	2.146LeuHis: 2.146 ± 0.047	2.407LeuIle: 2.407 ± 0.055	1.504LeuLys: 1.504 ± 0.038	11.134LeuLeu: 11.134 ± 0.129	1.501LeuMet: 1.501 ± 0.033	1.426LeuAsn: 1.426 ± 0.034	6.162LeuPro: 6.162 ± 0.077	2.205LeuGln: 2.205 ± 0.04	8.109LeuArg: 8.109 ± 0.089	4.748LeuSer: 4.748 ± 0.064	6.095LeuThr: 6.095 ± 0.071	11.283LeuVal: 11.283 ± 0.123	1.244LeuTrp: 1.244 ± 0.033	1.43LeuTyr: 1.43 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.124MetAla: 2.124 ± 0.04	0.141MetCys: 0.141 ± 0.01	0.894MetAsp: 0.894 ± 0.027	0.719MetGlu: 0.719 ± 0.025	0.432MetPhe: 0.432 ± 0.018	1.36MetGly: 1.36 ± 0.032	0.359MetHis: 0.359 ± 0.018	0.614MetIle: 0.614 ± 0.024	0.398MetLys: 0.398 ± 0.018	1.751MetLeu: 1.751 ± 0.039	0.286MetMet: 0.286 ± 0.015	0.359MetAsn: 0.359 ± 0.018	1.102MetPro: 1.102 ± 0.03	0.432MetGln: 0.432 ± 0.02	1.428MetArg: 1.428 ± 0.033	1.383MetSer: 1.383 ± 0.031	1.598MetThr: 1.598 ± 0.032	1.475MetVal: 1.475 ± 0.034	0.203MetTrp: 0.203 ± 0.012	0.25MetTyr: 0.25 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.981AsnAla: 1.981 ± 0.039	0.11AsnCys: 0.11 ± 0.009	0.923AsnAsp: 0.923 ± 0.027	0.77AsnGlu: 0.77 ± 0.023	0.423AsnPhe: 0.423 ± 0.019	1.468AsnGly: 1.468 ± 0.046	0.346AsnHis: 0.346 ± 0.016	0.594AsnIle: 0.594 ± 0.024	0.336AsnLys: 0.336 ± 0.018	1.66AsnLeu: 1.66 ± 0.037	0.264AsnMet: 0.264 ± 0.016	0.33AsnAsn: 0.33 ± 0.019	1.26AsnPro: 1.26 ± 0.036	0.493AsnGln: 0.493 ± 0.022	1.07AsnArg: 1.07 ± 0.033	0.621AsnSer: 0.621 ± 0.024	0.845AsnThr: 0.845 ± 0.027	1.435AsnVal: 1.435 ± 0.038	0.192AsnTrp: 0.192 ± 0.012	0.335AsnTyr: 0.335 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.77ProAla: 8.77 ± 0.117	0.292ProCys: 0.292 ± 0.013	4.521ProAsp: 4.521 ± 0.055	4.113ProGlu: 4.113 ± 0.064	1.504ProPhe: 1.504 ± 0.034	6.208ProGly: 6.208 ± 0.078	1.23ProHis: 1.23 ± 0.034	1.441ProIle: 1.441 ± 0.037	0.96ProLys: 0.96 ± 0.033	5.158ProLeu: 5.158 ± 0.068	0.957ProMet: 0.957 ± 0.026	0.762ProAsn: 0.762 ± 0.026	3.192ProPro: 3.192 ± 0.071	1.443ProGln: 1.443 ± 0.03	3.999ProArg: 3.999 ± 0.066	2.975ProSer: 2.975 ± 0.047	3.742ProThr: 3.742 ± 0.062	5.711ProVal: 5.711 ± 0.08	0.953ProTrp: 0.953 ± 0.028	1.132ProTyr: 1.132 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.496GlnAla: 3.496 ± 0.055	0.153GlnCys: 0.153 ± 0.013	1.291GlnAsp: 1.291 ± 0.033	1.393GlnGlu: 1.393 ± 0.031	0.614GlnPhe: 0.614 ± 0.022	2.016GlnGly: 2.016 ± 0.046	0.669GlnHis: 0.669 ± 0.022	0.84GlnIle: 0.84 ± 0.03	0.506GlnLys: 0.506 ± 0.024	2.873GlnLeu: 2.873 ± 0.052	0.496GlnMet: 0.496 ± 0.018	0.402GlnAsn: 0.402 ± 0.02	1.658GlnPro: 1.658 ± 0.038	1.131GlnGln: 1.131 ± 0.032	2.421GlnArg: 2.421 ± 0.046	1.008GlnSer: 1.008 ± 0.029	1.281GlnThr: 1.281 ± 0.031	2.932GlnVal: 2.932 ± 0.045	0.427GlnTrp: 0.427 ± 0.017	0.445GlnTyr: 0.445 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.995ArgAla: 9.995 ± 0.111	0.511ArgCys: 0.511 ± 0.019	4.576ArgAsp: 4.576 ± 0.065	4.738ArgGlu: 4.738 ± 0.067	2.273ArgPhe: 2.273 ± 0.042	6.352ArgGly: 6.352 ± 0.076	1.887ArgHis: 1.887 ± 0.04	2.859ArgIle: 2.859 ± 0.046	1.333ArgLys: 1.333 ± 0.037	8.509ArgLeu: 8.509 ± 0.097	1.731ArgMet: 1.731 ± 0.037	1.178ArgAsn: 1.178 ± 0.029	4.824ArgPro: 4.824 ± 0.068	2.055ArgGln: 2.055 ± 0.041	8.121ArgArg: 8.121 ± 0.118	4.333ArgSer: 4.333 ± 0.058	5.064ArgThr: 5.064 ± 0.066	6.911ArgVal: 6.911 ± 0.075	1.441ArgTrp: 1.441 ± 0.035	1.591ArgTyr: 1.591 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.268SerAla: 6.268 ± 0.064	0.352SerCys: 0.352 ± 0.015	2.591SerAsp: 2.591 ± 0.05	2.397SerGlu: 2.397 ± 0.043	1.603SerPhe: 1.603 ± 0.032	5.276SerGly: 5.276 ± 0.063	0.901SerHis: 0.901 ± 0.028	1.664SerIle: 1.664 ± 0.037	0.776SerLys: 0.776 ± 0.025	4.842SerLeu: 4.842 ± 0.063	1.113SerMet: 1.113 ± 0.03	0.781SerAsn: 0.781 ± 0.029	2.943SerPro: 2.943 ± 0.048	1.146SerGln: 1.146 ± 0.03	3.583SerArg: 3.583 ± 0.053	2.877SerSer: 2.877 ± 0.06	3.293SerThr: 3.293 ± 0.053	4.305SerVal: 4.305 ± 0.057	0.942SerTrp: 0.942 ± 0.028	1.24SerTyr: 1.24 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.669ThrAla: 7.669 ± 0.095	0.465ThrCys: 0.465 ± 0.019	3.484ThrAsp: 3.484 ± 0.051	3.113ThrGlu: 3.113 ± 0.047	1.761ThrPhe: 1.761 ± 0.036	6.197ThrGly: 6.197 ± 0.067	1.169ThrHis: 1.169 ± 0.034	2.064ThrIle: 2.064 ± 0.044	1.019ThrLys: 1.019 ± 0.035	5.561ThrLeu: 5.561 ± 0.068	1.059ThrMet: 1.059 ± 0.031	0.99ThrAsn: 0.99 ± 0.029	3.877ThrPro: 3.877 ± 0.064	1.289ThrGln: 1.289 ± 0.031	4.157ThrArg: 4.157 ± 0.056	3.421ThrSer: 3.421 ± 0.053	4.332ThrThr: 4.332 ± 0.073	5.856ThrVal: 5.856 ± 0.082	1.074ThrTrp: 1.074 ± 0.029	1.455ThrTyr: 1.455 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	13.782ValAla: 13.782 ± 0.126	0.725ValCys: 0.725 ± 0.026	6.383ValAsp: 6.383 ± 0.074	6.07ValGlu: 6.07 ± 0.08	2.315ValPhe: 2.315 ± 0.046	8.276ValGly: 8.276 ± 0.093	2.034ValHis: 2.034 ± 0.046	2.715ValIle: 2.715 ± 0.053	1.527ValLys: 1.527 ± 0.038	11.035ValLeu: 11.035 ± 0.106	1.489ValMet: 1.489 ± 0.035	1.553ValAsn: 1.553 ± 0.038	5.625ValPro: 5.625 ± 0.068	2.094ValGln: 2.094 ± 0.04	7.699ValArg: 7.699 ± 0.093	4.431ValSer: 4.431 ± 0.059	5.85ValThr: 5.85 ± 0.075	11.724ValVal: 11.724 ± 0.139	1.158ValTrp: 1.158 ± 0.031	1.411ValTyr: 1.411 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.7TrpAla: 1.7 ± 0.039	0.195TrpCys: 0.195 ± 0.014	0.846TrpAsp: 0.846 ± 0.025	0.731TrpGlu: 0.731 ± 0.025	0.489TrpPhe: 0.489 ± 0.02	1.133TrpGly: 1.133 ± 0.024	0.334TrpHis: 0.334 ± 0.017	0.487TrpIle: 0.487 ± 0.018	0.297TrpLys: 0.297 ± 0.015	1.794TrpLeu: 1.794 ± 0.044	0.283TrpMet: 0.283 ± 0.016	0.307TrpAsn: 0.307 ± 0.016	0.758TrpPro: 0.758 ± 0.025	0.486TrpGln: 0.486 ± 0.019	1.357TrpArg: 1.357 ± 0.032	1.041TrpSer: 1.041 ± 0.028	0.997TrpThr: 0.997 ± 0.03	1.287TrpVal: 1.287 ± 0.031	0.373TrpTrp: 0.373 ± 0.017	0.306TrpTyr: 0.306 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.593TyrAla: 2.593 ± 0.049	0.161TyrCys: 0.161 ± 0.012	1.548TyrAsp: 1.548 ± 0.035	1.015TyrGlu: 1.015 ± 0.03	0.572TyrPhe: 0.572 ± 0.02	1.804TyrGly: 1.804 ± 0.04	0.325TyrHis: 0.325 ± 0.015	0.37TyrIle: 0.37 ± 0.018	0.301TyrLys: 0.301 ± 0.015	2.06TyrLeu: 2.06 ± 0.043	0.199TyrMet: 0.199 ± 0.012	0.31TyrAsn: 0.31 ± 0.015	0.967TyrPro: 0.967 ± 0.028	0.485TyrGln: 0.485 ± 0.02	1.508TyrArg: 1.508 ± 0.034	0.814TyrSer: 0.814 ± 0.025	0.946TyrThr: 0.946 ± 0.029	1.927TyrVal: 1.927 ± 0.041	0.286TyrTrp: 0.286 ± 0.015	0.366TyrTyr: 0.366 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4040 proteins (1327210 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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