Amino acid dipepetide frequency for Candidatus Prometheoarchaeum syntrophicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.54AlaAla: 2.54 ± 0.06	0.502AlaCys: 0.502 ± 0.023	2.258AlaAsp: 2.258 ± 0.047	3.027AlaGlu: 3.027 ± 0.049	2.458AlaPhe: 2.458 ± 0.052	2.9AlaGly: 2.9 ± 0.056	0.857AlaHis: 0.857 ± 0.028	4.894AlaIle: 4.894 ± 0.071	3.733AlaLys: 3.733 ± 0.068	4.85AlaLeu: 4.85 ± 0.067	1.131AlaMet: 1.131 ± 0.032	2.206AlaAsn: 2.206 ± 0.043	1.437AlaPro: 1.437 ± 0.043	1.62AlaGln: 1.62 ± 0.037	1.851AlaArg: 1.851 ± 0.038	2.792AlaSer: 2.792 ± 0.046	2.23AlaThr: 2.23 ± 0.044	2.583AlaVal: 2.583 ± 0.053	0.51AlaTrp: 0.51 ± 0.021	1.716AlaTyr: 1.716 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.484CysAla: 0.484 ± 0.022	0.149CysCys: 0.149 ± 0.013	0.503CysAsp: 0.503 ± 0.021	0.612CysGlu: 0.612 ± 0.025	0.491CysPhe: 0.491 ± 0.021	0.99CysGly: 0.99 ± 0.039	0.216CysHis: 0.216 ± 0.013	0.888CysIle: 0.888 ± 0.023	0.751CysLys: 0.751 ± 0.028	0.879CysLeu: 0.879 ± 0.026	0.222CysMet: 0.222 ± 0.013	0.497CysAsn: 0.497 ± 0.022	0.691CysPro: 0.691 ± 0.026	0.319CysGln: 0.319 ± 0.015	0.365CysArg: 0.365 ± 0.018	0.783CysSer: 0.783 ± 0.027	0.494CysThr: 0.494 ± 0.021	0.539CysVal: 0.539 ± 0.022	0.106CysTrp: 0.106 ± 0.009	0.408CysTyr: 0.408 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.271AspAla: 2.271 ± 0.056	0.51AspCys: 0.51 ± 0.022	2.75AspAsp: 2.75 ± 0.098	3.998AspGlu: 3.998 ± 0.066	3.484AspPhe: 3.484 ± 0.05	2.97AspGly: 2.97 ± 0.141	0.972AspHis: 0.972 ± 0.027	5.343AspIle: 5.343 ± 0.068	3.559AspLys: 3.559 ± 0.059	6.007AspLeu: 6.007 ± 0.082	1.156AspMet: 1.156 ± 0.027	2.709AspAsn: 2.709 ± 0.057	2.436AspPro: 2.436 ± 0.068	1.624AspGln: 1.624 ± 0.031	1.733AspArg: 1.733 ± 0.036	3.287AspSer: 3.287 ± 0.077	2.215AspThr: 2.215 ± 0.056	2.744AspVal: 2.744 ± 0.052	0.687AspTrp: 0.687 ± 0.025	2.581AspTyr: 2.581 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	2.878GluAla: 2.878 ± 0.062	0.55GluCys: 0.55 ± 0.021	3.63GluAsp: 3.63 ± 0.055	5.653GluGlu: 5.653 ± 0.105	3.722GluPhe: 3.722 ± 0.063	3.213GluGly: 3.213 ± 0.056	1.025GluHis: 1.025 ± 0.029	8.295GluIle: 8.295 ± 0.086	7.575GluLys: 7.575 ± 0.116	6.228GluLeu: 6.228 ± 0.087	1.816GluMet: 1.816 ± 0.038	5.222GluAsn: 5.222 ± 0.084	1.655GluPro: 1.655 ± 0.044	2.01GluGln: 2.01 ± 0.06	2.411GluArg: 2.411 ± 0.054	3.903GluSer: 3.903 ± 0.061	3.102GluThr: 3.102 ± 0.05	3.074GluVal: 3.074 ± 0.054	0.717GluTrp: 0.717 ± 0.022	2.632GluTyr: 2.632 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.546PheAla: 2.546 ± 0.052	0.686PheCys: 0.686 ± 0.029	3.049PheAsp: 3.049 ± 0.053	3.443PheGlu: 3.443 ± 0.051	3.413PhePhe: 3.413 ± 0.07	3.332PheGly: 3.332 ± 0.056	1.052PheHis: 1.052 ± 0.03	5.328PheIle: 5.328 ± 0.084	3.767PheLys: 3.767 ± 0.057	6.098PheLeu: 6.098 ± 0.094	1.202PheMet: 1.202 ± 0.029	3.282PheAsn: 3.282 ± 0.059	2.252PhePro: 2.252 ± 0.045	2.062PheGln: 2.062 ± 0.045	1.864PheArg: 1.864 ± 0.04	4.674PheSer: 4.674 ± 0.068	2.799PheThr: 2.799 ± 0.053	2.532PheVal: 2.532 ± 0.048	0.712PheTrp: 0.712 ± 0.025	2.419PheTyr: 2.419 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	2.944GlyAla: 2.944 ± 0.059	0.676GlyCys: 0.676 ± 0.025	3.047GlyAsp: 3.047 ± 0.08	3.243GlyGlu: 3.243 ± 0.062	3.352GlyPhe: 3.352 ± 0.051	3.473GlyGly: 3.473 ± 0.074	0.962GlyHis: 0.962 ± 0.031	6.198GlyIle: 6.198 ± 0.091	4.641GlyLys: 4.641 ± 0.069	5.397GlyLeu: 5.397 ± 0.081	1.394GlyMet: 1.394 ± 0.034	2.988GlyAsn: 2.988 ± 0.057	1.487GlyPro: 1.487 ± 0.041	1.411GlyGln: 1.411 ± 0.032	1.867GlyArg: 1.867 ± 0.041	3.52GlySer: 3.52 ± 0.068	2.997GlyThr: 2.997 ± 0.055	3.219GlyVal: 3.219 ± 0.052	0.695GlyTrp: 0.695 ± 0.027	2.441GlyTyr: 2.441 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.799HisAla: 0.799 ± 0.027	0.259HisCys: 0.259 ± 0.015	0.88HisAsp: 0.88 ± 0.031	1.089HisGlu: 1.089 ± 0.028	1.079HisPhe: 1.079 ± 0.03	1.071HisGly: 1.071 ± 0.03	0.462HisHis: 0.462 ± 0.018	1.562HisIle: 1.562 ± 0.035	1.201HisLys: 1.201 ± 0.03	1.9HisLeu: 1.9 ± 0.047	0.352HisMet: 0.352 ± 0.015	0.952HisAsn: 0.952 ± 0.027	0.971HisPro: 0.971 ± 0.026	0.672HisGln: 0.672 ± 0.025	0.693HisArg: 0.693 ± 0.022	1.187HisSer: 1.187 ± 0.025	0.812HisThr: 0.812 ± 0.024	0.79HisVal: 0.79 ± 0.027	0.208HisTrp: 0.208 ± 0.012	0.816HisTyr: 0.816 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.153IleAla: 5.153 ± 0.074	1.147IleCys: 1.147 ± 0.029	5.285IleAsp: 5.285 ± 0.068	7.04IleGlu: 7.04 ± 0.09	6.096IlePhe: 6.096 ± 0.107	6.085IleGly: 6.085 ± 0.087	1.762IleHis: 1.762 ± 0.04	10.226IleIle: 10.226 ± 0.146	7.668IleLys: 7.668 ± 0.102	10.648IleLeu: 10.648 ± 0.13	2.095IleMet: 2.095 ± 0.042	5.599IleAsn: 5.599 ± 0.078	4.569IlePro: 4.569 ± 0.06	3.515IleGln: 3.515 ± 0.051	3.515IleArg: 3.515 ± 0.058	7.921IleSer: 7.921 ± 0.084	5.013IleThr: 5.013 ± 0.066	4.949IleVal: 4.949 ± 0.076	1.029IleTrp: 1.029 ± 0.031	3.828IleTyr: 3.828 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	3.366LysAla: 3.366 ± 0.058	0.779LysCys: 0.779 ± 0.027	4.179LysAsp: 4.179 ± 0.062	6.651LysGlu: 6.651 ± 0.107	4.161LysPhe: 4.161 ± 0.057	3.574LysGly: 3.574 ± 0.059	1.311LysHis: 1.311 ± 0.03	10.225LysIle: 10.225 ± 0.136	10.593LysLys: 10.593 ± 0.162	7.171LysLeu: 7.171 ± 0.1	2.33LysMet: 2.33 ± 0.047	6.363LysAsn: 6.363 ± 0.087	2.476LysPro: 2.476 ± 0.047	2.472LysGln: 2.472 ± 0.045	3.081LysArg: 3.081 ± 0.066	5.384LysSer: 5.384 ± 0.083	4.17LysThr: 4.17 ± 0.062	3.471LysVal: 3.471 ± 0.058	0.94LysTrp: 0.94 ± 0.025	3.511LysTyr: 3.511 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	4.594LeuAla: 4.594 ± 0.069	0.951LeuCys: 0.951 ± 0.032	5.303LeuAsp: 5.303 ± 0.073	6.958LeuGlu: 6.958 ± 0.093	5.228LeuPhe: 5.228 ± 0.087	5.638LeuGly: 5.638 ± 0.075	1.648LeuHis: 1.648 ± 0.039	9.857LeuIle: 9.857 ± 0.128	8.92LeuLys: 8.92 ± 0.118	9.127LeuLeu: 9.127 ± 0.134	2.228LeuMet: 2.228 ± 0.037	6.303LeuAsn: 6.303 ± 0.077	3.552LeuPro: 3.552 ± 0.061	3.093LeuGln: 3.093 ± 0.05	3.457LeuArg: 3.457 ± 0.058	6.92LeuSer: 6.92 ± 0.087	4.927LeuThr: 4.927 ± 0.068	4.536LeuVal: 4.536 ± 0.066	0.987LeuTrp: 0.987 ± 0.029	3.356LeuTyr: 3.356 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.401MetAla: 1.401 ± 0.036	0.218MetCys: 0.218 ± 0.014	1.325MetAsp: 1.325 ± 0.034	1.604MetGlu: 1.604 ± 0.033	0.968MetPhe: 0.968 ± 0.029	1.552MetGly: 1.552 ± 0.031	0.386MetHis: 0.386 ± 0.017	2.273MetIle: 2.273 ± 0.04	2.258MetLys: 2.258 ± 0.047	1.821MetLeu: 1.821 ± 0.039	0.593MetMet: 0.593 ± 0.026	1.458MetAsn: 1.458 ± 0.034	0.75MetPro: 0.75 ± 0.028	0.704MetGln: 0.704 ± 0.025	0.791MetArg: 0.791 ± 0.025	1.398MetSer: 1.398 ± 0.034	1.089MetThr: 1.089 ± 0.032	1.423MetVal: 1.423 ± 0.035	0.208MetTrp: 0.208 ± 0.013	0.645MetTyr: 0.645 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.525AsnAla: 2.525 ± 0.045	0.697AsnCys: 0.697 ± 0.03	2.793AsnAsp: 2.793 ± 0.063	3.95AsnGlu: 3.95 ± 0.064	3.801AsnPhe: 3.801 ± 0.05	2.792AsnGly: 2.792 ± 0.059	1.196AsnHis: 1.196 ± 0.032	5.932AsnIle: 5.932 ± 0.07	4.349AsnLys: 4.349 ± 0.071	6.976AsnLeu: 6.976 ± 0.104	1.229AsnMet: 1.229 ± 0.035	3.543AsnAsn: 3.543 ± 0.082	3.021AsnPro: 3.021 ± 0.045	2.423AsnGln: 2.423 ± 0.05	2.179AsnArg: 2.179 ± 0.045	4.228AsnSer: 4.228 ± 0.065	2.612AsnThr: 2.612 ± 0.063	2.826AsnVal: 2.826 ± 0.056	0.773AsnTrp: 0.773 ± 0.025	2.819AsnTyr: 2.819 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.514ProAla: 1.514 ± 0.04	0.269ProCys: 0.269 ± 0.016	2.221ProAsp: 2.221 ± 0.041	3.066ProGlu: 3.066 ± 0.052	2.002ProPhe: 2.002 ± 0.04	1.915ProGly: 1.915 ± 0.04	0.684ProHis: 0.684 ± 0.023	3.712ProIle: 3.712 ± 0.068	3.32ProLys: 3.32 ± 0.054	3.266ProLeu: 3.266 ± 0.051	0.711ProMet: 0.711 ± 0.025	2.379ProAsn: 2.379 ± 0.059	1.401ProPro: 1.401 ± 0.043	1.138ProGln: 1.138 ± 0.03	1.16ProArg: 1.16 ± 0.031	2.491ProSer: 2.491 ± 0.049	2.008ProThr: 2.008 ± 0.042	1.882ProVal: 1.882 ± 0.047	0.389ProTrp: 0.389 ± 0.018	1.509ProTyr: 1.509 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.445GlnAla: 1.445 ± 0.033	0.261GlnCys: 0.261 ± 0.016	1.732GlnAsp: 1.732 ± 0.036	2.305GlnGlu: 2.305 ± 0.049	1.772GlnPhe: 1.772 ± 0.038	1.471GlnGly: 1.471 ± 0.036	0.511GlnHis: 0.511 ± 0.021	3.707GlnIle: 3.707 ± 0.058	3.467GlnLys: 3.467 ± 0.076	2.843GlnLeu: 2.843 ± 0.05	0.815GlnMet: 0.815 ± 0.025	2.334GlnAsn: 2.334 ± 0.044	0.875GlnPro: 0.875 ± 0.029	1.062GlnGln: 1.062 ± 0.034	1.221GlnArg: 1.221 ± 0.043	1.844GlnSer: 1.844 ± 0.034	1.529GlnThr: 1.529 ± 0.037	1.453GlnVal: 1.453 ± 0.035	0.338GlnTrp: 0.338 ± 0.018	1.302GlnTyr: 1.302 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	1.559ArgAla: 1.559 ± 0.04	0.355ArgCys: 0.355 ± 0.019	1.909ArgAsp: 1.909 ± 0.04	2.559ArgGlu: 2.559 ± 0.055	1.891ArgPhe: 1.891 ± 0.041	1.827ArgGly: 1.827 ± 0.043	0.558ArgHis: 0.558 ± 0.023	3.58ArgIle: 3.58 ± 0.057	3.721ArgLys: 3.721 ± 0.069	3.09ArgLeu: 3.09 ± 0.053	0.864ArgMet: 0.864 ± 0.028	2.366ArgAsn: 2.366 ± 0.046	1.022ArgPro: 1.022 ± 0.031	0.948ArgGln: 0.948 ± 0.029	1.507ArgArg: 1.507 ± 0.041	2.081ArgSer: 2.081 ± 0.044	1.696ArgThr: 1.696 ± 0.039	1.799ArgVal: 1.799 ± 0.039	0.388ArgTrp: 0.388 ± 0.017	1.43ArgTyr: 1.43 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	2.854SerAla: 2.854 ± 0.056	0.602SerCys: 0.602 ± 0.022	3.775SerAsp: 3.775 ± 0.112	4.606SerGlu: 4.606 ± 0.058	3.748SerPhe: 3.748 ± 0.057	3.954SerGly: 3.954 ± 0.067	1.255SerHis: 1.255 ± 0.032	6.877SerIle: 6.877 ± 0.085	5.65SerLys: 5.65 ± 0.083	6.741SerLeu: 6.741 ± 0.074	1.542SerMet: 1.542 ± 0.035	3.945SerAsn: 3.945 ± 0.072	2.462SerPro: 2.462 ± 0.045	2.423SerGln: 2.423 ± 0.042	2.252SerArg: 2.252 ± 0.047	4.948SerSer: 4.948 ± 0.072	3.308SerThr: 3.308 ± 0.062	3.403SerVal: 3.403 ± 0.057	0.814SerTrp: 0.814 ± 0.03	2.563SerTyr: 2.563 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	2.321ThrAla: 2.321 ± 0.048	0.474ThrCys: 0.474 ± 0.019	2.555ThrAsp: 2.555 ± 0.099	2.983ThrGlu: 2.983 ± 0.052	2.688ThrPhe: 2.688 ± 0.04	3.132ThrGly: 3.132 ± 0.062	0.958ThrHis: 0.958 ± 0.03	4.828ThrIle: 4.828 ± 0.071	3.584ThrLys: 3.584 ± 0.067	4.714ThrLeu: 4.714 ± 0.075	1.045ThrMet: 1.045 ± 0.032	2.599ThrAsn: 2.599 ± 0.053	2.187ThrPro: 2.187 ± 0.046	1.641ThrGln: 1.641 ± 0.036	1.618ThrArg: 1.618 ± 0.035	3.181ThrSer: 3.181 ± 0.058	2.642ThrThr: 2.642 ± 0.059	2.347ThrVal: 2.347 ± 0.053	0.557ThrTrp: 0.557 ± 0.025	1.958ThrTyr: 1.958 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	2.478ValAla: 2.478 ± 0.046	0.616ValCys: 0.616 ± 0.027	2.794ValAsp: 2.794 ± 0.06	3.279ValGlu: 3.279 ± 0.061	2.957ValPhe: 2.957 ± 0.052	3.0ValGly: 3.0 ± 0.058	0.861ValHis: 0.861 ± 0.025	4.752ValIle: 4.752 ± 0.082	3.948ValLys: 3.948 ± 0.06	4.779ValLeu: 4.779 ± 0.071	1.08ValMet: 1.08 ± 0.03	2.656ValAsn: 2.656 ± 0.047	1.936ValPro: 1.936 ± 0.045	1.382ValGln: 1.382 ± 0.036	1.667ValArg: 1.667 ± 0.042	3.54ValSer: 3.54 ± 0.062	2.012ValThr: 2.012 ± 0.05	2.714ValVal: 2.714 ± 0.056	0.507ValTrp: 0.507 ± 0.024	1.85ValTyr: 1.85 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.589TrpAla: 0.589 ± 0.022	0.088TrpCys: 0.088 ± 0.009	0.799TrpAsp: 0.799 ± 0.031	0.78TrpGlu: 0.78 ± 0.027	0.543TrpPhe: 0.543 ± 0.022	0.773TrpGly: 0.773 ± 0.023	0.186TrpHis: 0.186 ± 0.011	1.193TrpIle: 1.193 ± 0.038	0.878TrpLys: 0.878 ± 0.028	0.936TrpLeu: 0.936 ± 0.029	0.327TrpMet: 0.327 ± 0.018	0.793TrpAsn: 0.793 ± 0.031	0.261TrpPro: 0.261 ± 0.016	0.351TrpGln: 0.351 ± 0.015	0.387TrpArg: 0.387 ± 0.018	0.598TrpSer: 0.598 ± 0.024	0.514TrpThr: 0.514 ± 0.025	0.692TrpVal: 0.692 ± 0.027	0.166TrpTrp: 0.166 ± 0.013	0.43TrpTyr: 0.43 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.834TyrAla: 1.834 ± 0.04	0.597TyrCys: 0.597 ± 0.025	2.248TyrAsp: 2.248 ± 0.055	2.468TyrGlu: 2.468 ± 0.053	2.658TyrPhe: 2.658 ± 0.052	2.289TyrGly: 2.289 ± 0.046	0.892TyrHis: 0.892 ± 0.021	3.473TyrIle: 3.473 ± 0.052	2.625TyrLys: 2.625 ± 0.048	4.112TyrLeu: 4.112 ± 0.065	0.735TyrMet: 0.735 ± 0.024	2.471TyrAsn: 2.471 ± 0.058	1.594TyrPro: 1.594 ± 0.038	1.417TyrGln: 1.417 ± 0.036	1.53TyrArg: 1.53 ± 0.032	3.039TyrSer: 3.039 ± 0.063	1.841TyrThr: 1.841 ± 0.062	1.835TyrVal: 1.835 ± 0.045	0.552TyrTrp: 0.552 ± 0.019	1.982TyrTyr: 1.982 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3933 proteins (1304535 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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