Amino acid dipepetide frequency for Cadophora sp. DSE1049

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.978AlaAla: 7.978 ± 0.042	1.141AlaCys: 1.141 ± 0.012	3.831AlaAsp: 3.831 ± 0.022	4.767AlaGlu: 4.767 ± 0.03	3.266AlaPhe: 3.266 ± 0.022	5.585AlaGly: 5.585 ± 0.031	1.558AlaHis: 1.558 ± 0.013	4.482AlaIle: 4.482 ± 0.025	4.03AlaLys: 4.03 ± 0.024	7.463AlaLeu: 7.463 ± 0.035	1.913AlaMet: 1.913 ± 0.015	2.938AlaAsn: 2.938 ± 0.017	4.239AlaPro: 4.239 ± 0.025	2.969AlaGln: 2.969 ± 0.02	4.374AlaArg: 4.374 ± 0.022	6.853AlaSer: 6.853 ± 0.029	5.143AlaThr: 5.143 ± 0.026	5.181AlaVal: 5.181 ± 0.028	1.205AlaTrp: 1.205 ± 0.012	2.176AlaTyr: 2.176 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.966CysAla: 0.966 ± 0.01	0.311CysCys: 0.311 ± 0.007	0.74CysAsp: 0.74 ± 0.01	0.676CysGlu: 0.676 ± 0.01	0.621CysPhe: 0.621 ± 0.009	1.071CysGly: 1.071 ± 0.015	0.367CysHis: 0.367 ± 0.007	0.854CysIle: 0.854 ± 0.01	0.641CysLys: 0.641 ± 0.008	1.398CysLeu: 1.398 ± 0.014	0.303CysMet: 0.303 ± 0.006	0.495CysAsn: 0.495 ± 0.008	0.744CysPro: 0.744 ± 0.011	0.521CysGln: 0.521 ± 0.008	0.81CysArg: 0.81 ± 0.01	1.104CysSer: 1.104 ± 0.014	0.808CysThr: 0.808 ± 0.01	0.851CysVal: 0.851 ± 0.01	0.26CysTrp: 0.26 ± 0.006	0.416CysTyr: 0.416 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.214AspAla: 4.214 ± 0.025	0.713AspCys: 0.713 ± 0.009	3.696AspAsp: 3.696 ± 0.026	4.13AspGlu: 4.13 ± 0.022	2.355AspPhe: 2.355 ± 0.016	4.103AspGly: 4.103 ± 0.023	1.168AspHis: 1.168 ± 0.011	3.222AspIle: 3.222 ± 0.019	2.283AspLys: 2.283 ± 0.019	4.998AspLeu: 4.998 ± 0.023	1.262AspMet: 1.262 ± 0.012	1.832AspAsn: 1.832 ± 0.015	3.11AspPro: 3.11 ± 0.019	1.758AspGln: 1.758 ± 0.015	2.783AspArg: 2.783 ± 0.02	3.978AspSer: 3.978 ± 0.023	2.93AspThr: 2.93 ± 0.02	3.597AspVal: 3.597 ± 0.022	0.932AspTrp: 0.932 ± 0.01	1.549AspTyr: 1.549 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.968GluAla: 4.968 ± 0.027	0.709GluCys: 0.709 ± 0.01	4.092GluAsp: 4.092 ± 0.028	5.244GluGlu: 5.244 ± 0.041	2.036GluPhe: 2.036 ± 0.015	3.963GluGly: 3.963 ± 0.023	1.323GluHis: 1.323 ± 0.013	3.275GluIle: 3.275 ± 0.022	3.84GluLys: 3.84 ± 0.028	5.036GluLeu: 5.036 ± 0.024	1.518GluMet: 1.518 ± 0.013	2.379GluAsn: 2.379 ± 0.017	2.504GluPro: 2.504 ± 0.018	2.237GluGln: 2.237 ± 0.016	3.791GluArg: 3.791 ± 0.027	4.266GluSer: 4.266 ± 0.024	3.368GluThr: 3.368 ± 0.019	3.738GluVal: 3.738 ± 0.023	0.938GluTrp: 0.938 ± 0.012	1.714GluTyr: 1.714 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	3.167PheAla: 3.167 ± 0.02	0.657PheCys: 0.657 ± 0.01	2.343PheAsp: 2.343 ± 0.017	2.331PheGlu: 2.331 ± 0.016	1.742PhePhe: 1.742 ± 0.017	3.085PheGly: 3.085 ± 0.023	0.939PheHis: 0.939 ± 0.011	2.008PheIle: 2.008 ± 0.016	1.719PheLys: 1.719 ± 0.016	3.679PheLeu: 3.679 ± 0.02	0.856PheMet: 0.856 ± 0.01	1.581PheAsn: 1.581 ± 0.013	2.101PhePro: 2.101 ± 0.017	1.488PheGln: 1.488 ± 0.013	1.994PheArg: 1.994 ± 0.015	3.23PheSer: 3.23 ± 0.019	2.325PheThr: 2.325 ± 0.018	2.515PheVal: 2.515 ± 0.018	0.738PheTrp: 0.738 ± 0.01	1.177PheTyr: 1.177 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	5.05GlyAla: 5.05 ± 0.028	1.019GlyCys: 1.019 ± 0.011	3.562GlyAsp: 3.562 ± 0.021	3.807GlyGlu: 3.807 ± 0.021	3.019GlyPhe: 3.019 ± 0.018	5.877GlyGly: 5.877 ± 0.041	1.614GlyHis: 1.614 ± 0.015	3.902GlyIle: 3.902 ± 0.024	3.787GlyLys: 3.787 ± 0.024	6.15GlyLeu: 6.15 ± 0.03	1.734GlyMet: 1.734 ± 0.015	2.753GlyAsn: 2.753 ± 0.019	3.165GlyPro: 3.165 ± 0.021	2.389GlyGln: 2.389 ± 0.019	3.952GlyArg: 3.952 ± 0.025	5.776GlySer: 5.776 ± 0.033	4.173GlyThr: 4.173 ± 0.026	4.49GlyVal: 4.49 ± 0.027	1.285GlyTrp: 1.285 ± 0.013	2.258GlyTyr: 2.258 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.617HisAla: 1.617 ± 0.013	0.374HisCys: 0.374 ± 0.006	1.212HisAsp: 1.212 ± 0.013	1.258HisGlu: 1.258 ± 0.014	0.967HisPhe: 0.967 ± 0.01	1.64HisGly: 1.64 ± 0.015	0.773HisHis: 0.773 ± 0.01	1.269HisIle: 1.269 ± 0.01	0.94HisLys: 0.94 ± 0.01	2.206HisLeu: 2.206 ± 0.018	0.497HisMet: 0.497 ± 0.008	0.839HisAsn: 0.839 ± 0.011	1.558HisPro: 1.558 ± 0.014	0.952HisGln: 0.952 ± 0.01	1.376HisArg: 1.376 ± 0.013	1.803HisSer: 1.803 ± 0.015	1.296HisThr: 1.296 ± 0.012	1.356HisVal: 1.356 ± 0.014	0.366HisTrp: 0.366 ± 0.006	0.678HisTyr: 0.678 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	4.438IleAla: 4.438 ± 0.024	0.892IleCys: 0.892 ± 0.012	2.936IleAsp: 2.936 ± 0.022	3.068IleGlu: 3.068 ± 0.019	2.31IlePhe: 2.31 ± 0.021	3.516IleGly: 3.516 ± 0.026	1.272IleHis: 1.272 ± 0.012	2.868IleIle: 2.868 ± 0.024	2.376IleLys: 2.376 ± 0.017	5.038IleLeu: 5.038 ± 0.027	1.112IleMet: 1.112 ± 0.011	1.99IleAsn: 1.99 ± 0.015	3.318IlePro: 3.318 ± 0.017	2.043IleGln: 2.043 ± 0.016	2.831IleArg: 2.831 ± 0.018	4.328IleSer: 4.328 ± 0.023	3.159IleThr: 3.159 ± 0.021	3.355IleVal: 3.355 ± 0.02	0.858IleTrp: 0.858 ± 0.01	1.627IleTyr: 1.627 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.282LysAla: 4.282 ± 0.027	0.614LysCys: 0.614 ± 0.008	2.888LysAsp: 2.888 ± 0.02	3.503LysGlu: 3.503 ± 0.024	1.671LysPhe: 1.671 ± 0.015	3.203LysGly: 3.203 ± 0.025	1.155LysHis: 1.155 ± 0.012	2.577LysIle: 2.577 ± 0.017	3.387LysLys: 3.387 ± 0.033	4.234LysLeu: 4.234 ± 0.02	1.12LysMet: 1.12 ± 0.011	1.855LysAsn: 1.855 ± 0.016	2.632LysPro: 2.632 ± 0.02	1.757LysGln: 1.757 ± 0.014	3.286LysArg: 3.286 ± 0.023	3.808LysSer: 3.808 ± 0.021	3.005LysThr: 3.005 ± 0.019	3.062LysVal: 3.062 ± 0.019	0.777LysTrp: 0.777 ± 0.011	1.51LysTyr: 1.51 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.566LeuAla: 7.566 ± 0.033	1.322LeuCys: 1.322 ± 0.012	5.025LeuAsp: 5.025 ± 0.025	5.524LeuGlu: 5.524 ± 0.027	3.449LeuPhe: 3.449 ± 0.022	6.104LeuGly: 6.104 ± 0.028	2.212LeuHis: 2.212 ± 0.017	4.255LeuIle: 4.255 ± 0.022	4.486LeuLys: 4.486 ± 0.024	8.455LeuLeu: 8.455 ± 0.035	1.837LeuMet: 1.837 ± 0.015	3.259LeuAsn: 3.259 ± 0.017	5.467LeuPro: 5.467 ± 0.025	3.796LeuGln: 3.796 ± 0.022	5.403LeuArg: 5.403 ± 0.029	7.372LeuSer: 7.372 ± 0.027	4.888LeuThr: 4.888 ± 0.026	5.412LeuVal: 5.412 ± 0.026	1.323LeuTrp: 1.323 ± 0.015	2.465LeuTyr: 2.465 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.17MetAla: 2.17 ± 0.015	0.276MetCys: 0.276 ± 0.006	1.259MetAsp: 1.259 ± 0.012	1.32MetGlu: 1.32 ± 0.013	0.835MetPhe: 0.835 ± 0.009	1.521MetGly: 1.521 ± 0.014	0.487MetHis: 0.487 ± 0.008	1.113MetIle: 1.113 ± 0.011	1.142MetLys: 1.142 ± 0.012	1.905MetLeu: 1.905 ± 0.016	0.622MetMet: 0.622 ± 0.008	0.853MetAsn: 0.853 ± 0.01	1.257MetPro: 1.257 ± 0.013	0.838MetGln: 0.838 ± 0.01	1.256MetArg: 1.256 ± 0.011	1.972MetSer: 1.972 ± 0.017	1.324MetThr: 1.324 ± 0.012	1.342MetVal: 1.342 ± 0.012	0.305MetTrp: 0.305 ± 0.005	0.567MetTyr: 0.567 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.101AsnAla: 3.101 ± 0.019	0.527AsnCys: 0.527 ± 0.008	1.947AsnAsp: 1.947 ± 0.014	2.021AsnGlu: 2.021 ± 0.014	1.557AsnPhe: 1.557 ± 0.013	3.194AsnGly: 3.194 ± 0.023	0.873AsnHis: 0.873 ± 0.011	2.306AsnIle: 2.306 ± 0.017	1.574AsnLys: 1.574 ± 0.012	3.423AsnLeu: 3.423 ± 0.02	0.878AsnMet: 0.878 ± 0.011	1.581AsnAsn: 1.581 ± 0.015	2.501AsnPro: 2.501 ± 0.018	1.352AsnGln: 1.352 ± 0.011	1.924AsnArg: 1.924 ± 0.016	3.031AsnSer: 3.031 ± 0.021	2.408AsnThr: 2.408 ± 0.016	2.331AsnVal: 2.331 ± 0.016	0.612AsnTrp: 0.612 ± 0.008	1.12AsnTyr: 1.12 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	4.608ProAla: 4.608 ± 0.025	0.571ProCys: 0.571 ± 0.009	2.953ProAsp: 2.953 ± 0.019	3.581ProGlu: 3.581 ± 0.022	2.091ProPhe: 2.091 ± 0.014	3.761ProGly: 3.761 ± 0.026	1.224ProHis: 1.224 ± 0.012	2.74ProIle: 2.74 ± 0.017	2.754ProLys: 2.754 ± 0.018	4.656ProLeu: 4.656 ± 0.024	1.06ProMet: 1.06 ± 0.012	2.275ProAsn: 2.275 ± 0.018	4.464ProPro: 4.464 ± 0.042	2.254ProGln: 2.254 ± 0.022	3.128ProArg: 3.128 ± 0.021	5.694ProSer: 5.694 ± 0.033	3.958ProThr: 3.958 ± 0.025	3.354ProVal: 3.354 ± 0.022	0.768ProTrp: 0.768 ± 0.01	1.533ProTyr: 1.533 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.175GlnAla: 3.175 ± 0.025	0.491GlnCys: 0.491 ± 0.007	1.994GlnAsp: 1.994 ± 0.015	2.253GlnGlu: 2.253 ± 0.019	1.339GlnPhe: 1.339 ± 0.014	2.272GlnGly: 2.272 ± 0.018	0.993GlnHis: 0.993 ± 0.011	1.983GlnIle: 1.983 ± 0.015	1.968GlnLys: 1.968 ± 0.014	3.228GlnLeu: 3.228 ± 0.018	0.869GlnMet: 0.869 ± 0.01	1.632GlnAsn: 1.632 ± 0.014	2.219GlnPro: 2.219 ± 0.019	2.015GlnGln: 2.015 ± 0.03	2.399GlnArg: 2.399 ± 0.018	3.01GlnSer: 3.01 ± 0.024	2.305GlnThr: 2.305 ± 0.016	2.156GlnVal: 2.156 ± 0.017	0.566GlnTrp: 0.566 ± 0.008	1.177GlnTyr: 1.177 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.158ArgAla: 4.158 ± 0.023	0.775ArgCys: 0.775 ± 0.009	3.134ArgAsp: 3.134 ± 0.02	3.656ArgGlu: 3.656 ± 0.024	2.121ArgPhe: 2.121 ± 0.015	3.649ArgGly: 3.649 ± 0.023	1.42ArgHis: 1.42 ± 0.013	2.969ArgIle: 2.969 ± 0.02	3.402ArgLys: 3.402 ± 0.025	5.186ArgLeu: 5.186 ± 0.023	1.294ArgMet: 1.294 ± 0.011	2.257ArgAsn: 2.257 ± 0.015	3.068ArgPro: 3.068 ± 0.024	2.354ArgGln: 2.354 ± 0.018	4.415ArgArg: 4.415 ± 0.031	4.47ArgSer: 4.47 ± 0.026	3.197ArgThr: 3.197 ± 0.018	3.183ArgVal: 3.183 ± 0.018	0.962ArgTrp: 0.962 ± 0.011	1.675ArgTyr: 1.675 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	6.25SerAla: 6.25 ± 0.028	1.058SerCys: 1.058 ± 0.011	4.08SerAsp: 4.08 ± 0.024	4.185SerGlu: 4.185 ± 0.023	3.248SerPhe: 3.248 ± 0.019	5.6SerGly: 5.6 ± 0.028	1.871SerHis: 1.871 ± 0.017	4.455SerIle: 4.455 ± 0.027	4.009SerLys: 4.009 ± 0.023	7.274SerLeu: 7.274 ± 0.028	1.775SerMet: 1.775 ± 0.016	3.299SerAsn: 3.299 ± 0.021	5.287SerPro: 5.287 ± 0.038	3.272SerGln: 3.272 ± 0.025	4.784SerArg: 4.784 ± 0.029	8.835SerSer: 8.835 ± 0.058	5.965SerThr: 5.965 ± 0.032	4.521SerVal: 4.521 ± 0.027	1.257SerTrp: 1.257 ± 0.01	2.21SerTyr: 2.21 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	5.058ThrAla: 5.058 ± 0.026	0.894ThrCys: 0.894 ± 0.012	2.74ThrAsp: 2.74 ± 0.017	3.051ThrGlu: 3.051 ± 0.019	2.572ThrPhe: 2.572 ± 0.016	4.214ThrGly: 4.214 ± 0.023	1.26ThrHis: 1.26 ± 0.012	3.478ThrIle: 3.478 ± 0.023	2.804ThrLys: 2.804 ± 0.019	5.435ThrLeu: 5.435 ± 0.024	1.246ThrMet: 1.246 ± 0.013	2.312ThrAsn: 2.312 ± 0.019	4.179ThrPro: 4.179 ± 0.028	2.029ThrGln: 2.029 ± 0.013	3.026ThrArg: 3.026 ± 0.02	5.803ThrSer: 5.803 ± 0.034	4.459ThrThr: 4.459 ± 0.035	3.735ThrVal: 3.735 ± 0.022	0.947ThrTrp: 0.947 ± 0.01	1.775ThrTyr: 1.775 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	5.018ValAla: 5.018 ± 0.025	0.888ValCys: 0.888 ± 0.011	3.611ValAsp: 3.611 ± 0.022	3.99ValGlu: 3.99 ± 0.023	2.56ValPhe: 2.56 ± 0.017	4.188ValGly: 4.188 ± 0.023	1.339ValHis: 1.339 ± 0.013	3.108ValIle: 3.108 ± 0.02	3.054ValLys: 3.054 ± 0.02	5.659ValLeu: 5.659 ± 0.029	1.398ValMet: 1.398 ± 0.012	2.24ValAsn: 2.24 ± 0.015	3.428ValPro: 3.428 ± 0.019	2.28ValGln: 2.28 ± 0.017	3.236ValArg: 3.236 ± 0.02	4.555ValSer: 4.555 ± 0.03	3.514ValThr: 3.514 ± 0.024	4.397ValVal: 4.397 ± 0.029	0.977ValTrp: 0.977 ± 0.012	1.789ValTyr: 1.789 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	1.17TrpAla: 1.17 ± 0.012	0.229TrpCys: 0.229 ± 0.005	0.938TrpAsp: 0.938 ± 0.011	0.951TrpGlu: 0.951 ± 0.011	0.597TrpPhe: 0.597 ± 0.009	1.065TrpGly: 1.065 ± 0.011	0.372TrpHis: 0.372 ± 0.007	0.921TrpIle: 0.921 ± 0.01	0.935TrpLys: 0.935 ± 0.01	1.41TrpLeu: 1.41 ± 0.013	0.422TrpMet: 0.422 ± 0.006	0.706TrpAsn: 0.706 ± 0.009	0.66TrpPro: 0.66 ± 0.009	0.569TrpGln: 0.569 ± 0.008	0.983TrpArg: 0.983 ± 0.011	1.146TrpSer: 1.146 ± 0.011	1.03TrpThr: 1.03 ± 0.012	0.983TrpVal: 0.983 ± 0.011	0.303TrpTrp: 0.303 ± 0.006	0.497TrpTyr: 0.497 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.135TyrAla: 2.135 ± 0.014	0.497TyrCys: 0.497 ± 0.008	1.632TyrAsp: 1.632 ± 0.014	1.623TyrGlu: 1.623 ± 0.013	1.32TyrPhe: 1.32 ± 0.01	2.151TyrGly: 2.151 ± 0.017	0.757TyrHis: 0.757 ± 0.009	1.55TyrIle: 1.55 ± 0.015	1.194TyrLys: 1.194 ± 0.012	2.789TyrLeu: 2.789 ± 0.02	0.646TyrMet: 0.646 ± 0.008	1.186TyrAsn: 1.186 ± 0.011	1.525TyrPro: 1.525 ± 0.014	1.171TyrGln: 1.171 ± 0.013	1.597TyrArg: 1.597 ± 0.013	2.203TyrSer: 2.203 ± 0.017	1.762TyrThr: 1.762 ± 0.012	1.667TyrVal: 1.667 ± 0.015	0.506TyrTrp: 0.506 ± 0.008	0.966TyrTyr: 0.966 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.007

Statistics based on 22755 proteins (9288616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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