Amino acid dipepetide frequency for Catenaria anguillulae PL171

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.262AlaAla: 15.262 ± 0.111	1.49AlaCys: 1.49 ± 0.019	5.104AlaAsp: 5.104 ± 0.037	4.466AlaGlu: 4.466 ± 0.041	3.188AlaPhe: 3.188 ± 0.029	7.128AlaGly: 7.128 ± 0.056	3.055AlaHis: 3.055 ± 0.026	4.269AlaIle: 4.269 ± 0.038	4.563AlaLys: 4.563 ± 0.043	9.489AlaLeu: 9.489 ± 0.054	2.692AlaMet: 2.692 ± 0.023	3.518AlaAsn: 3.518 ± 0.024	6.565AlaPro: 6.565 ± 0.058	4.365AlaGln: 4.365 ± 0.035	6.452AlaArg: 6.452 ± 0.05	10.225AlaSer: 10.225 ± 0.071	7.419AlaThr: 7.419 ± 0.048	7.164AlaVal: 7.164 ± 0.045	1.285AlaTrp: 1.285 ± 0.018	1.99AlaTyr: 1.99 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.377CysAla: 1.377 ± 0.02	0.356CysCys: 0.356 ± 0.011	0.672CysAsp: 0.672 ± 0.013	0.538CysGlu: 0.538 ± 0.011	0.561CysPhe: 0.561 ± 0.009	1.005CysGly: 1.005 ± 0.017	0.416CysHis: 0.416 ± 0.01	0.691CysIle: 0.691 ± 0.012	0.555CysLys: 0.555 ± 0.012	1.411CysLeu: 1.411 ± 0.019	0.375CysMet: 0.375 ± 0.009	0.445CysAsn: 0.445 ± 0.01	0.978CysPro: 0.978 ± 0.017	0.478CysGln: 0.478 ± 0.01	0.988CysArg: 0.988 ± 0.015	1.092CysSer: 1.092 ± 0.018	0.943CysThr: 0.943 ± 0.016	1.042CysVal: 1.042 ± 0.015	0.211CysTrp: 0.211 ± 0.008	0.298CysTyr: 0.298 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.466AspAla: 5.466 ± 0.038	0.597AspCys: 0.597 ± 0.011	3.96AspAsp: 3.96 ± 0.051	3.55AspGlu: 3.55 ± 0.035	1.673AspPhe: 1.673 ± 0.022	3.467AspGly: 3.467 ± 0.027	1.401AspHis: 1.401 ± 0.019	1.921AspIle: 1.921 ± 0.02	2.086AspLys: 2.086 ± 0.024	5.131AspLeu: 5.131 ± 0.038	1.388AspMet: 1.388 ± 0.018	1.471AspAsn: 1.471 ± 0.02	3.648AspPro: 3.648 ± 0.029	2.02AspGln: 2.02 ± 0.026	2.911AspArg: 2.911 ± 0.025	3.743AspSer: 3.743 ± 0.032	2.543AspThr: 2.543 ± 0.025	3.78AspVal: 3.78 ± 0.033	0.858AspTrp: 0.858 ± 0.016	1.059AspTyr: 1.059 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.395GluAla: 4.395 ± 0.04	0.674GluCys: 0.674 ± 0.014	2.624GluAsp: 2.624 ± 0.028	3.0GluGlu: 3.0 ± 0.038	1.556GluPhe: 1.556 ± 0.019	2.364GluGly: 2.364 ± 0.025	1.288GluHis: 1.288 ± 0.018	1.728GluIle: 1.728 ± 0.02	1.928GluLys: 1.928 ± 0.027	4.588GluLeu: 4.588 ± 0.044	1.23GluMet: 1.23 ± 0.015	1.163GluAsn: 1.163 ± 0.016	2.163GluPro: 2.163 ± 0.024	2.194GluGln: 2.194 ± 0.025	3.171GluArg: 3.171 ± 0.029	3.489GluSer: 3.489 ± 0.028	2.238GluThr: 2.238 ± 0.025	2.999GluVal: 2.999 ± 0.029	0.92GluTrp: 0.92 ± 0.017	1.382GluTyr: 1.382 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.61PheAla: 3.61 ± 0.032	0.509PheCys: 0.509 ± 0.01	1.965PheAsp: 1.965 ± 0.02	1.446PheGlu: 1.446 ± 0.018	1.332PhePhe: 1.332 ± 0.021	2.476PheGly: 2.476 ± 0.025	0.907PheHis: 0.907 ± 0.013	1.311PheIle: 1.311 ± 0.018	1.277PheLys: 1.277 ± 0.018	3.032PheLeu: 3.032 ± 0.03	0.746PheMet: 0.746 ± 0.011	1.114PheAsn: 1.114 ± 0.017	1.928PhePro: 1.928 ± 0.019	1.036PheGln: 1.036 ± 0.016	1.744PheArg: 1.744 ± 0.019	2.529PheSer: 2.529 ± 0.026	1.962PheThr: 1.962 ± 0.023	2.468PheVal: 2.468 ± 0.027	0.404PheTrp: 0.404 ± 0.011	0.722PheTyr: 0.722 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.302GlyAla: 6.302 ± 0.044	0.93GlyCys: 0.93 ± 0.017	3.238GlyAsp: 3.238 ± 0.026	2.819GlyGlu: 2.819 ± 0.029	2.123GlyPhe: 2.123 ± 0.023	6.456GlyGly: 6.456 ± 0.062	2.049GlyHis: 2.049 ± 0.026	2.679GlyIle: 2.679 ± 0.031	2.997GlyLys: 2.997 ± 0.032	5.241GlyLeu: 5.241 ± 0.033	1.713GlyMet: 1.713 ± 0.022	2.294GlyAsn: 2.294 ± 0.025	3.255GlyPro: 3.255 ± 0.03	2.66GlyGln: 2.66 ± 0.026	3.922GlyArg: 3.922 ± 0.04	5.968GlySer: 5.968 ± 0.05	3.883GlyThr: 3.883 ± 0.033	4.331GlyVal: 4.331 ± 0.038	0.912GlyTrp: 0.912 ± 0.014	1.555GlyTyr: 1.555 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	3.103HisAla: 3.103 ± 0.032	0.436HisCys: 0.436 ± 0.009	1.459HisAsp: 1.459 ± 0.02	1.18HisGlu: 1.18 ± 0.018	0.998HisPhe: 0.998 ± 0.016	2.036HisGly: 2.036 ± 0.025	1.391HisHis: 1.391 ± 0.026	1.128HisIle: 1.128 ± 0.015	0.908HisLys: 0.908 ± 0.016	3.094HisLeu: 3.094 ± 0.029	0.669HisMet: 0.669 ± 0.012	0.751HisAsn: 0.751 ± 0.012	2.157HisPro: 2.157 ± 0.025	1.346HisGln: 1.346 ± 0.019	1.759HisArg: 1.759 ± 0.023	2.271HisSer: 2.271 ± 0.028	1.433HisThr: 1.433 ± 0.017	2.485HisVal: 2.485 ± 0.027	0.386HisTrp: 0.386 ± 0.01	0.597HisTyr: 0.597 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.117IleAla: 4.117 ± 0.033	0.567IleCys: 0.567 ± 0.011	2.352IleAsp: 2.352 ± 0.022	1.989IleGlu: 1.989 ± 0.02	1.182IlePhe: 1.182 ± 0.018	2.537IleGly: 2.537 ± 0.029	1.271IleHis: 1.271 ± 0.016	1.498IleIle: 1.498 ± 0.024	1.765IleLys: 1.765 ± 0.024	3.571IleLeu: 3.571 ± 0.034	0.904IleMet: 0.904 ± 0.013	1.278IleAsn: 1.278 ± 0.019	2.683IlePro: 2.683 ± 0.029	1.613IleGln: 1.613 ± 0.019	2.522IleArg: 2.522 ± 0.022	2.738IleSer: 2.738 ± 0.026	2.154IleThr: 2.154 ± 0.021	3.135IleVal: 3.135 ± 0.027	0.428IleTrp: 0.428 ± 0.009	0.774IleTyr: 0.774 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.69LysAla: 3.69 ± 0.036	0.622LysCys: 0.622 ± 0.012	2.066LysAsp: 2.066 ± 0.028	2.063LysGlu: 2.063 ± 0.026	1.194LysPhe: 1.194 ± 0.019	2.114LysGly: 2.114 ± 0.027	1.164LysHis: 1.164 ± 0.018	1.401LysIle: 1.401 ± 0.019	2.153LysLys: 2.153 ± 0.042	3.766LysLeu: 3.766 ± 0.035	0.884LysMet: 0.884 ± 0.015	1.074LysAsn: 1.074 ± 0.018	2.216LysPro: 2.216 ± 0.027	1.709LysGln: 1.709 ± 0.024	2.901LysArg: 2.901 ± 0.03	3.134LysSer: 3.134 ± 0.029	1.951LysThr: 1.951 ± 0.025	2.87LysVal: 2.87 ± 0.029	0.588LysTrp: 0.588 ± 0.012	1.126LysTyr: 1.126 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	11.365LeuAla: 11.365 ± 0.064	1.376LeuCys: 1.376 ± 0.019	5.633LeuAsp: 5.633 ± 0.044	4.347LeuGlu: 4.347 ± 0.042	3.209LeuPhe: 3.209 ± 0.033	5.725LeuGly: 5.725 ± 0.035	2.664LeuHis: 2.664 ± 0.026	3.494LeuIle: 3.494 ± 0.028	3.327LeuLys: 3.327 ± 0.035	8.97LeuLeu: 8.97 ± 0.062	1.997LeuMet: 1.997 ± 0.025	2.71LeuAsn: 2.71 ± 0.028	6.411LeuPro: 6.411 ± 0.044	3.312LeuGln: 3.312 ± 0.031	5.499LeuArg: 5.499 ± 0.034	7.12LeuSer: 7.12 ± 0.046	5.401LeuThr: 5.401 ± 0.034	7.468LeuVal: 7.468 ± 0.046	1.05LeuTrp: 1.05 ± 0.014	1.969LeuTyr: 1.969 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.503MetAla: 2.503 ± 0.026	0.383MetCys: 0.383 ± 0.01	1.534MetAsp: 1.534 ± 0.018	0.984MetGlu: 0.984 ± 0.016	0.824MetPhe: 0.824 ± 0.014	1.418MetGly: 1.418 ± 0.019	0.78MetHis: 0.78 ± 0.013	0.889MetIle: 0.889 ± 0.013	0.627MetLys: 0.627 ± 0.012	2.156MetLeu: 2.156 ± 0.023	0.625MetMet: 0.625 ± 0.012	0.639MetAsn: 0.639 ± 0.013	1.57MetPro: 1.57 ± 0.021	1.016MetGln: 1.016 ± 0.016	1.45MetArg: 1.45 ± 0.019	2.269MetSer: 2.269 ± 0.024	1.492MetThr: 1.492 ± 0.017	1.579MetVal: 1.579 ± 0.018	0.307MetTrp: 0.307 ± 0.007	0.712MetTyr: 0.712 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.261AsnAla: 3.261 ± 0.027	0.385AsnCys: 0.385 ± 0.01	1.565AsnAsp: 1.565 ± 0.018	1.408AsnGlu: 1.408 ± 0.018	0.786AsnPhe: 0.786 ± 0.015	2.479AsnGly: 2.479 ± 0.03	0.822AsnHis: 0.822 ± 0.014	1.119AsnIle: 1.119 ± 0.017	1.322AsnLys: 1.322 ± 0.019	2.79AsnLeu: 2.79 ± 0.027	0.714AsnMet: 0.714 ± 0.014	1.193AsnAsn: 1.193 ± 0.022	2.269AsnPro: 2.269 ± 0.026	1.253AsnGln: 1.253 ± 0.018	1.807AsnArg: 1.807 ± 0.021	2.131AsnSer: 2.131 ± 0.022	1.657AsnThr: 1.657 ± 0.017	2.337AsnVal: 2.337 ± 0.024	0.424AsnTrp: 0.424 ± 0.01	0.607AsnTyr: 0.607 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	7.745ProAla: 7.745 ± 0.062	0.81ProCys: 0.81 ± 0.014	2.906ProAsp: 2.906 ± 0.023	2.688ProGlu: 2.688 ± 0.026	1.934ProPhe: 1.934 ± 0.02	3.821ProGly: 3.821 ± 0.037	1.857ProHis: 1.857 ± 0.022	2.643ProIle: 2.643 ± 0.023	2.249ProLys: 2.249 ± 0.024	5.792ProLeu: 5.792 ± 0.042	1.522ProMet: 1.522 ± 0.02	2.188ProAsn: 2.188 ± 0.023	7.07ProPro: 7.07 ± 0.086	2.407ProGln: 2.407 ± 0.031	3.779ProArg: 3.779 ± 0.033	7.026ProSer: 7.026 ± 0.061	5.586ProThr: 5.586 ± 0.047	4.261ProVal: 4.261 ± 0.038	0.722ProTrp: 0.722 ± 0.013	1.158ProTyr: 1.158 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	4.206GlnAla: 4.206 ± 0.038	0.564GlnCys: 0.564 ± 0.013	1.792GlnAsp: 1.792 ± 0.02	1.81GlnGlu: 1.81 ± 0.026	1.369GlnPhe: 1.369 ± 0.018	2.361GlnGly: 2.361 ± 0.026	1.457GlnHis: 1.457 ± 0.021	1.348GlnIle: 1.348 ± 0.016	1.05GlnLys: 1.05 ± 0.018	4.143GlnLeu: 4.143 ± 0.034	0.869GlnMet: 0.869 ± 0.014	0.826GlnAsn: 0.826 ± 0.014	2.911GlnPro: 2.911 ± 0.04	3.575GlnGln: 3.575 ± 0.083	2.661GlnArg: 2.661 ± 0.022	3.143GlnSer: 3.143 ± 0.029	1.764GlnThr: 1.764 ± 0.019	3.354GlnVal: 3.354 ± 0.031	0.607GlnTrp: 0.607 ± 0.012	0.977GlnTyr: 0.977 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	6.105ArgAla: 6.105 ± 0.043	0.899ArgCys: 0.899 ± 0.016	3.15ArgAsp: 3.15 ± 0.029	2.95ArgGlu: 2.95 ± 0.028	2.093ArgPhe: 2.093 ± 0.019	3.679ArgGly: 3.679 ± 0.036	1.911ArgHis: 1.911 ± 0.021	2.618ArgIle: 2.618 ± 0.024	2.751ArgLys: 2.751 ± 0.03	5.596ArgLeu: 5.596 ± 0.042	1.483ArgMet: 1.483 ± 0.017	1.951ArgAsn: 1.951 ± 0.02	4.19ArgPro: 4.19 ± 0.038	2.649ArgGln: 2.649 ± 0.028	5.238ArgArg: 5.238 ± 0.055	5.006ArgSer: 5.006 ± 0.043	3.498ArgThr: 3.498 ± 0.032	4.197ArgVal: 4.197 ± 0.037	0.846ArgTrp: 0.846 ± 0.012	1.297ArgTyr: 1.297 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	9.572SerAla: 9.572 ± 0.059	1.036SerCys: 1.036 ± 0.017	3.875SerAsp: 3.875 ± 0.038	2.901SerGlu: 2.901 ± 0.027	2.569SerPhe: 2.569 ± 0.024	5.835SerGly: 5.835 ± 0.041	2.308SerHis: 2.308 ± 0.028	3.408SerIle: 3.408 ± 0.029	2.92SerLys: 2.92 ± 0.028	7.631SerLeu: 7.631 ± 0.045	1.967SerMet: 1.967 ± 0.021	2.627SerAsn: 2.627 ± 0.026	6.813SerPro: 6.813 ± 0.066	2.92SerGln: 2.92 ± 0.031	5.28SerArg: 5.28 ± 0.045	11.089SerSer: 11.089 ± 0.102	6.759SerThr: 6.759 ± 0.05	5.334SerVal: 5.334 ± 0.039	0.956SerTrp: 0.956 ± 0.015	1.367SerTyr: 1.367 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	6.596ThrAla: 6.596 ± 0.046	1.055ThrCys: 1.055 ± 0.018	2.686ThrAsp: 2.686 ± 0.026	2.112ThrGlu: 2.112 ± 0.024	2.02ThrPhe: 2.02 ± 0.022	3.865ThrGly: 3.865 ± 0.033	1.767ThrHis: 1.767 ± 0.021	2.563ThrIle: 2.563 ± 0.028	2.112ThrLys: 2.112 ± 0.025	6.065ThrLeu: 6.065 ± 0.038	1.355ThrMet: 1.355 ± 0.017	1.883ThrAsn: 1.883 ± 0.023	4.592ThrPro: 4.592 ± 0.038	2.155ThrGln: 2.155 ± 0.024	3.705ThrArg: 3.705 ± 0.03	6.292ThrSer: 6.292 ± 0.05	4.72ThrThr: 4.72 ± 0.049	3.997ThrVal: 3.997 ± 0.032	0.815ThrTrp: 0.815 ± 0.014	1.278ThrTyr: 1.278 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	7.795ValAla: 7.795 ± 0.056	1.121ValCys: 1.121 ± 0.015	4.249ValAsp: 4.249 ± 0.033	3.402ValGlu: 3.402 ± 0.029	2.475ValPhe: 2.475 ± 0.025	4.573ValGly: 4.573 ± 0.035	2.076ValHis: 2.076 ± 0.023	2.726ValIle: 2.726 ± 0.027	2.791ValLys: 2.791 ± 0.026	6.791ValLeu: 6.791 ± 0.05	1.634ValMet: 1.634 ± 0.019	2.091ValAsn: 2.091 ± 0.023	4.737ValPro: 4.737 ± 0.033	2.777ValGln: 2.777 ± 0.03	4.055ValArg: 4.055 ± 0.032	5.219ValSer: 5.219 ± 0.035	4.08ValThr: 4.08 ± 0.036	5.627ValVal: 5.627 ± 0.043	0.953ValTrp: 0.953 ± 0.017	1.695ValTyr: 1.695 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.171TrpAla: 1.171 ± 0.018	0.252TrpCys: 0.252 ± 0.006	0.714TrpAsp: 0.714 ± 0.012	0.519TrpGlu: 0.519 ± 0.012	0.523TrpPhe: 0.523 ± 0.011	0.591TrpGly: 0.591 ± 0.012	0.36TrpHis: 0.36 ± 0.009	0.768TrpIle: 0.768 ± 0.013	0.501TrpLys: 0.501 ± 0.01	1.353TrpLeu: 1.353 ± 0.02	0.428TrpMet: 0.428 ± 0.01	0.434TrpAsn: 0.434 ± 0.01	0.699TrpPro: 0.699 ± 0.013	0.486TrpGln: 0.486 ± 0.01	0.937TrpArg: 0.937 ± 0.016	1.049TrpSer: 1.049 ± 0.017	0.938TrpThr: 0.938 ± 0.015	0.957TrpVal: 0.957 ± 0.017	0.514TrpTrp: 0.514 ± 0.022	0.325TrpTyr: 0.325 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.048TyrAla: 2.048 ± 0.023	0.367TyrCys: 0.367 ± 0.009	1.129TyrAsp: 1.129 ± 0.016	0.923TyrGlu: 0.923 ± 0.014	0.91TyrPhe: 0.91 ± 0.015	1.397TyrGly: 1.397 ± 0.018	0.642TyrHis: 0.642 ± 0.012	0.878TyrIle: 0.878 ± 0.014	0.804TyrLys: 0.804 ± 0.016	2.438TyrLeu: 2.438 ± 0.024	0.563TyrMet: 0.563 ± 0.011	0.68TyrAsn: 0.68 ± 0.012	1.31TyrPro: 1.31 ± 0.02	0.813TyrGln: 0.813 ± 0.013	1.326TyrArg: 1.326 ± 0.016	1.633TyrSer: 1.633 ± 0.019	1.21TyrThr: 1.21 ± 0.016	1.481TyrVal: 1.481 ± 0.019	0.336TyrTrp: 0.336 ± 0.009	0.655TyrTyr: 0.655 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12599 proteins (4929253 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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