Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA259I14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.848AlaAla: 3.848 ± 0.192
0.831AlaCys: 0.831 ± 0.082
3.358AlaAsp: 3.358 ± 0.148
5.667AlaGlu: 5.667 ± 0.2
2.237AlaPhe: 2.237 ± 0.127
4.674AlaGly: 4.674 ± 0.199
1.032AlaHis: 1.032 ± 0.076
4.462AlaIle: 4.462 ± 0.194
4.06AlaLys: 4.06 ± 0.162
5.628AlaLeu: 5.628 ± 0.173
1.461AlaMet: 1.461 ± 0.105
1.762AlaAsn: 1.762 ± 0.101
2.03AlaPro: 2.03 ± 0.13
1.45AlaGln: 1.45 ± 0.099
3.486AlaArg: 3.486 ± 0.137
3.469AlaSer: 3.469 ± 0.135
2.577AlaThr: 2.577 ± 0.136
4.306AlaVal: 4.306 ± 0.18
0.764AlaTrp: 0.764 ± 0.059
1.629AlaTyr: 1.629 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.574CysAla: 0.574 ± 0.064
0.173CysCys: 0.173 ± 0.037
0.586CysAsp: 0.586 ± 0.062
0.943CysGlu: 0.943 ± 0.087
0.452CysPhe: 0.452 ± 0.05
1.171CysGly: 1.171 ± 0.091
0.245CysHis: 0.245 ± 0.037
0.547CysIle: 0.547 ± 0.055
0.619CysLys: 0.619 ± 0.058
0.775CysLeu: 0.775 ± 0.077
0.173CysMet: 0.173 ± 0.028
0.379CysAsn: 0.379 ± 0.049
0.937CysPro: 0.937 ± 0.072
0.24CysGln: 0.24 ± 0.038
0.68CysArg: 0.68 ± 0.057
0.703CysSer: 0.703 ± 0.079
0.418CysThr: 0.418 ± 0.051
0.653CysVal: 0.653 ± 0.069
0.128CysTrp: 0.128 ± 0.028
0.357CysTyr: 0.357 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
2.984AspAla: 2.984 ± 0.153
0.541AspCys: 0.541 ± 0.064
2.833AspAsp: 2.833 ± 0.138
5.527AspGlu: 5.527 ± 0.197
2.755AspPhe: 2.755 ± 0.12
3.709AspGly: 3.709 ± 0.152
0.987AspHis: 0.987 ± 0.08
4.596AspIle: 4.596 ± 0.171
3.815AspLys: 3.815 ± 0.133
6.699AspLeu: 6.699 ± 0.215
1.216AspMet: 1.216 ± 0.082
1.673AspAsn: 1.673 ± 0.097
2.967AspPro: 2.967 ± 0.137
1.227AspGln: 1.227 ± 0.079
3.67AspArg: 3.67 ± 0.145
3.174AspSer: 3.174 ± 0.131
2.454AspThr: 2.454 ± 0.114
4.3AspVal: 4.3 ± 0.186
0.831AspTrp: 0.831 ± 0.071
2.281AspTyr: 2.281 ± 0.106
0.0AspXaa: 0.0 ± 0.0
Glu
5.617GluAla: 5.617 ± 0.225
0.87GluCys: 0.87 ± 0.077
5.717GluAsp: 5.717 ± 0.204
12.538GluGlu: 12.538 ± 0.331
3.079GluPhe: 3.079 ± 0.155
6.559GluGly: 6.559 ± 0.178
1.417GluHis: 1.417 ± 0.082
8.846GluIle: 8.846 ± 0.26
11.752GluLys: 11.752 ± 0.336
8.294GluLeu: 8.294 ± 0.225
2.331GluMet: 2.331 ± 0.11
5.276GluAsn: 5.276 ± 0.195
2.778GluPro: 2.778 ± 0.15
1.701GluGln: 1.701 ± 0.1
6.107GluArg: 6.107 ± 0.245
5.081GluSer: 5.081 ± 0.151
4.746GluThr: 4.746 ± 0.177
6.202GluVal: 6.202 ± 0.197
0.982GluTrp: 0.982 ± 0.069
2.688GluTyr: 2.688 ± 0.124
0.0GluXaa: 0.0 ± 0.0
Phe
2.03PheAla: 2.03 ± 0.132
0.608PheCys: 0.608 ± 0.066
2.727PheAsp: 2.727 ± 0.125
3.743PheGlu: 3.743 ± 0.152
1.885PhePhe: 1.885 ± 0.133
2.99PheGly: 2.99 ± 0.148
0.781PheHis: 0.781 ± 0.065
2.142PheIle: 2.142 ± 0.12
2.231PheLys: 2.231 ± 0.115
4.049PheLeu: 4.049 ± 0.182
0.803PheMet: 0.803 ± 0.074
1.249PheAsn: 1.249 ± 0.09
1.701PhePro: 1.701 ± 0.094
1.199PheGln: 1.199 ± 0.076
1.98PheArg: 1.98 ± 0.1
3.017PheSer: 3.017 ± 0.142
1.701PheThr: 1.701 ± 0.097
2.421PheVal: 2.421 ± 0.12
0.491PheTrp: 0.491 ± 0.05
1.467PheTyr: 1.467 ± 0.102
0.0PheXaa: 0.0 ± 0.0
Gly
4.228GlyAla: 4.228 ± 0.174
0.825GlyCys: 0.825 ± 0.081
3.848GlyAsp: 3.848 ± 0.136
7.223GlyGlu: 7.223 ± 0.235
3.19GlyPhe: 3.19 ± 0.157
5.433GlyGly: 5.433 ± 0.228
1.049GlyHis: 1.049 ± 0.077
5.778GlyIle: 5.778 ± 0.195
5.879GlyLys: 5.879 ± 0.189
6.191GlyLeu: 6.191 ± 0.19
1.868GlyMet: 1.868 ± 0.104
2.359GlyAsn: 2.359 ± 0.123
2.292GlyPro: 2.292 ± 0.122
1.288GlyGln: 1.288 ± 0.088
4.166GlyArg: 4.166 ± 0.172
4.462GlySer: 4.462 ± 0.144
3.369GlyThr: 3.369 ± 0.139
5.209GlyVal: 5.209 ± 0.194
0.898GlyTrp: 0.898 ± 0.077
2.37GlyTyr: 2.37 ± 0.114
0.0GlyXaa: 0.0 ± 0.0
His
0.865HisAla: 0.865 ± 0.076
0.184HisCys: 0.184 ± 0.039
0.948HisAsp: 0.948 ± 0.072
1.327HisGlu: 1.327 ± 0.09
0.658HisPhe: 0.658 ± 0.059
1.305HisGly: 1.305 ± 0.082
0.346HisHis: 0.346 ± 0.048
1.043HisIle: 1.043 ± 0.088
0.825HisLys: 0.825 ± 0.07
1.835HisLeu: 1.835 ± 0.097
0.262HisMet: 0.262 ± 0.038
0.563HisAsn: 0.563 ± 0.056
1.127HisPro: 1.127 ± 0.078
0.374HisGln: 0.374 ± 0.052
0.97HisArg: 0.97 ± 0.075
1.037HisSer: 1.037 ± 0.092
0.825HisThr: 0.825 ± 0.07
1.104HisVal: 1.104 ± 0.084
0.19HisTrp: 0.19 ± 0.033
0.614HisTyr: 0.614 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
4.741IleAla: 4.741 ± 0.183
0.736IleCys: 0.736 ± 0.067
4.323IleAsp: 4.323 ± 0.144
7.479IleGlu: 7.479 ± 0.221
2.85IlePhe: 2.85 ± 0.14
5.327IleGly: 5.327 ± 0.198
1.333IleHis: 1.333 ± 0.091
4.88IleIle: 4.88 ± 0.185
4.601IleLys: 4.601 ± 0.163
6.888IleLeu: 6.888 ± 0.213
1.277IleMet: 1.277 ± 0.092
2.683IleAsn: 2.683 ± 0.133
3.101IlePro: 3.101 ± 0.136
1.634IleGln: 1.634 ± 0.097
3.876IleArg: 3.876 ± 0.144
5.009IleSer: 5.009 ± 0.163
3.363IleThr: 3.363 ± 0.137
5.12IleVal: 5.12 ± 0.164
0.731IleTrp: 0.731 ± 0.072
1.902IleTyr: 1.902 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
4.797LysAla: 4.797 ± 0.145
0.708LysCys: 0.708 ± 0.073
4.356LysAsp: 4.356 ± 0.17
8.478LysGlu: 8.478 ± 0.229
2.778LysPhe: 2.778 ± 0.132
5.059LysGly: 5.059 ± 0.176
1.127LysHis: 1.127 ± 0.101
6.877LysIle: 6.877 ± 0.217
7.753LysLys: 7.753 ± 0.28
6.693LysLeu: 6.693 ± 0.221
1.729LysMet: 1.729 ± 0.098
3.826LysAsn: 3.826 ± 0.167
2.571LysPro: 2.571 ± 0.141
1.735LysGln: 1.735 ± 0.181
4.172LysArg: 4.172 ± 0.161
4.479LysSer: 4.479 ± 0.173
4.099LysThr: 4.099 ± 0.144
5.382LysVal: 5.382 ± 0.176
0.904LysTrp: 0.904 ± 0.064
2.382LysTyr: 2.382 ± 0.121
0.0LysXaa: 0.0 ± 0.0
Leu
6.119LeuAla: 6.119 ± 0.195
0.786LeuCys: 0.786 ± 0.067
6.102LeuAsp: 6.102 ± 0.226
9.644LeuGlu: 9.644 ± 0.294
3.33LeuPhe: 3.33 ± 0.159
6.715LeuGly: 6.715 ± 0.259
1.461LeuHis: 1.461 ± 0.088
5.756LeuIle: 5.756 ± 0.222
7.279LeuLys: 7.279 ± 0.211
7.831LeuLeu: 7.831 ± 0.272
1.947LeuMet: 1.947 ± 0.099
3.609LeuAsn: 3.609 ± 0.142
3.642LeuPro: 3.642 ± 0.147
2.214LeuGln: 2.214 ± 0.11
5.254LeuArg: 5.254 ± 0.19
6.526LeuSer: 6.526 ± 0.218
4.451LeuThr: 4.451 ± 0.175
5.516LeuVal: 5.516 ± 0.204
0.931LeuTrp: 0.931 ± 0.078
2.465LeuTyr: 2.465 ± 0.127
0.0LeuXaa: 0.0 ± 0.0
Met
1.327MetAla: 1.327 ± 0.076
0.223MetCys: 0.223 ± 0.03
1.389MetAsp: 1.389 ± 0.094
2.231MetGlu: 2.231 ± 0.119
0.563MetPhe: 0.563 ± 0.06
1.634MetGly: 1.634 ± 0.1
0.318MetHis: 0.318 ± 0.045
1.4MetIle: 1.4 ± 0.098
2.086MetLys: 2.086 ± 0.101
1.428MetLeu: 1.428 ± 0.085
0.424MetMet: 0.424 ± 0.054
1.071MetAsn: 1.071 ± 0.082
0.887MetPro: 0.887 ± 0.062
0.452MetGln: 0.452 ± 0.049
1.121MetArg: 1.121 ± 0.074
1.657MetSer: 1.657 ± 0.094
1.199MetThr: 1.199 ± 0.074
1.802MetVal: 1.802 ± 0.108
0.139MetTrp: 0.139 ± 0.024
0.435MetTyr: 0.435 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
2.108AsnAla: 2.108 ± 0.119
0.58AsnCys: 0.58 ± 0.057
1.668AsnAsp: 1.668 ± 0.099
2.805AsnGlu: 2.805 ± 0.143
1.696AsnPhe: 1.696 ± 0.103
2.343AsnGly: 2.343 ± 0.106
0.625AsnHis: 0.625 ± 0.057
2.962AsnIle: 2.962 ± 0.135
2.493AsnLys: 2.493 ± 0.14
4.624AsnLeu: 4.624 ± 0.144
0.892AsnMet: 0.892 ± 0.065
1.344AsnAsn: 1.344 ± 0.079
2.292AsnPro: 2.292 ± 0.129
1.015AsnGln: 1.015 ± 0.078
2.276AsnArg: 2.276 ± 0.122
2.37AsnSer: 2.37 ± 0.128
1.617AsnThr: 1.617 ± 0.091
2.666AsnVal: 2.666 ± 0.13
0.563AsnTrp: 0.563 ± 0.059
1.551AsnTyr: 1.551 ± 0.113
0.0AsnXaa: 0.0 ± 0.0
Pro
2.053ProAla: 2.053 ± 0.113
0.351ProCys: 0.351 ± 0.041
2.666ProAsp: 2.666 ± 0.14
4.908ProGlu: 4.908 ± 0.18
1.445ProPhe: 1.445 ± 0.098
2.889ProGly: 2.889 ± 0.148
0.753ProHis: 0.753 ± 0.063
2.555ProIle: 2.555 ± 0.12
2.744ProLys: 2.744 ± 0.166
3.341ProLeu: 3.341 ± 0.135
0.831ProMet: 0.831 ± 0.065
1.456ProAsn: 1.456 ± 0.093
2.08ProPro: 2.08 ± 0.118
0.982ProGln: 0.982 ± 0.071
1.824ProArg: 1.824 ± 0.11
2.766ProSer: 2.766 ± 0.132
1.852ProThr: 1.852 ± 0.091
3.073ProVal: 3.073 ± 0.129
0.513ProTrp: 0.513 ± 0.06
1.316ProTyr: 1.316 ± 0.091
0.0ProXaa: 0.0 ± 0.0
Gln
1.584GlnAla: 1.584 ± 0.1
0.151GlnCys: 0.151 ± 0.029
1.327GlnAsp: 1.327 ± 0.09
2.142GlnGlu: 2.142 ± 0.102
0.664GlnPhe: 0.664 ± 0.065
1.445GlnGly: 1.445 ± 0.092
0.34GlnHis: 0.34 ± 0.041
1.696GlnIle: 1.696 ± 0.104
2.287GlnLys: 2.287 ± 0.155
1.841GlnLeu: 1.841 ± 0.105
0.524GlnMet: 0.524 ± 0.048
1.032GlnAsn: 1.032 ± 0.081
0.725GlnPro: 0.725 ± 0.071
0.535GlnGln: 0.535 ± 0.059
1.467GlnArg: 1.467 ± 0.081
1.244GlnSer: 1.244 ± 0.089
1.093GlnThr: 1.093 ± 0.076
1.523GlnVal: 1.523 ± 0.096
0.19GlnTrp: 0.19 ± 0.03
0.72GlnTyr: 0.72 ± 0.072
0.0GlnXaa: 0.0 ± 0.0
Arg
3.402ArgAla: 3.402 ± 0.142
0.658ArgCys: 0.658 ± 0.062
3.408ArgAsp: 3.408 ± 0.144
6.749ArgGlu: 6.749 ± 0.195
2.147ArgPhe: 2.147 ± 0.103
3.86ArgGly: 3.86 ± 0.145
0.814ArgHis: 0.814 ± 0.066
3.904ArgIle: 3.904 ± 0.154
5.633ArgLys: 5.633 ± 0.205
4.568ArgLeu: 4.568 ± 0.164
1.394ArgMet: 1.394 ± 0.077
2.649ArgAsn: 2.649 ± 0.113
1.829ArgPro: 1.829 ± 0.109
1.088ArgGln: 1.088 ± 0.078
3.475ArgArg: 3.475 ± 0.182
3.168ArgSer: 3.168 ± 0.13
2.761ArgThr: 2.761 ± 0.136
3.631ArgVal: 3.631 ± 0.148
0.714ArgTrp: 0.714 ± 0.061
1.606ArgTyr: 1.606 ± 0.087
0.0ArgXaa: 0.0 ± 0.0
Ser
3.229SerAla: 3.229 ± 0.121
0.608SerCys: 0.608 ± 0.072
3.419SerAsp: 3.419 ± 0.155
6.347SerGlu: 6.347 ± 0.199
2.867SerPhe: 2.867 ± 0.119
4.819SerGly: 4.819 ± 0.167
1.026SerHis: 1.026 ± 0.082
4.339SerIle: 4.339 ± 0.177
5.025SerLys: 5.025 ± 0.173
5.89SerLeu: 5.89 ± 0.198
1.422SerMet: 1.422 ± 0.098
1.958SerAsn: 1.958 ± 0.102
2.627SerPro: 2.627 ± 0.125
1.668SerGln: 1.668 ± 0.109
3.581SerArg: 3.581 ± 0.166
3.921SerSer: 3.921 ± 0.176
2.772SerThr: 2.772 ± 0.134
4.178SerVal: 4.178 ± 0.179
0.736SerTrp: 0.736 ± 0.07
1.88SerTyr: 1.88 ± 0.097
0.0SerXaa: 0.0 ± 0.0
Thr
2.934ThrAla: 2.934 ± 0.125
0.535ThrCys: 0.535 ± 0.058
2.627ThrAsp: 2.627 ± 0.128
4.239ThrGlu: 4.239 ± 0.157
1.829ThrPhe: 1.829 ± 0.106
3.815ThrGly: 3.815 ± 0.152
0.809ThrHis: 0.809 ± 0.071
3.313ThrIle: 3.313 ± 0.137
2.766ThrLys: 2.766 ± 0.129
4.295ThrLeu: 4.295 ± 0.168
0.909ThrMet: 0.909 ± 0.059
1.729ThrAsn: 1.729 ± 0.097
2.298ThrPro: 2.298 ± 0.13
1.037ThrGln: 1.037 ± 0.082
2.304ThrArg: 2.304 ± 0.116
3.073ThrSer: 3.073 ± 0.124
2.17ThrThr: 2.17 ± 0.127
3.871ThrVal: 3.871 ± 0.151
0.569ThrTrp: 0.569 ± 0.06
1.366ThrTyr: 1.366 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
4.083ValAla: 4.083 ± 0.159
0.865ValCys: 0.865 ± 0.073
4.495ValAsp: 4.495 ± 0.193
6.899ValGlu: 6.899 ± 0.232
2.822ValPhe: 2.822 ± 0.138
4.958ValGly: 4.958 ± 0.173
1.082ValHis: 1.082 ± 0.074
4.116ValIle: 4.116 ± 0.159
5.176ValLys: 5.176 ± 0.184
6.425ValLeu: 6.425 ± 0.231
1.35ValMet: 1.35 ± 0.09
2.359ValAsn: 2.359 ± 0.106
2.733ValPro: 2.733 ± 0.128
1.489ValGln: 1.489 ± 0.092
3.876ValArg: 3.876 ± 0.125
4.507ValSer: 4.507 ± 0.156
3.313ValThr: 3.313 ± 0.136
4.3ValVal: 4.3 ± 0.178
0.747ValTrp: 0.747 ± 0.069
1.88ValTyr: 1.88 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.563TrpAla: 0.563 ± 0.057
0.167TrpCys: 0.167 ± 0.03
0.753TrpAsp: 0.753 ± 0.068
1.049TrpGlu: 1.049 ± 0.081
0.491TrpPhe: 0.491 ± 0.056
0.937TrpGly: 0.937 ± 0.073
0.24TrpHis: 0.24 ± 0.042
0.809TrpIle: 0.809 ± 0.073
0.954TrpLys: 0.954 ± 0.074
1.054TrpLeu: 1.054 ± 0.093
0.34TrpMet: 0.34 ± 0.046
0.491TrpAsn: 0.491 ± 0.054
0.368TrpPro: 0.368 ± 0.049
0.273TrpGln: 0.273 ± 0.036
0.97TrpArg: 0.97 ± 0.074
0.669TrpSer: 0.669 ± 0.07
0.474TrpThr: 0.474 ± 0.056
0.586TrpVal: 0.586 ± 0.066
0.173TrpTrp: 0.173 ± 0.034
0.268TrpTyr: 0.268 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.645TyrAla: 1.645 ± 0.099
0.351TyrCys: 0.351 ± 0.047
1.69TyrAsp: 1.69 ± 0.11
2.644TyrGlu: 2.644 ± 0.115
1.478TyrPhe: 1.478 ± 0.097
2.287TyrGly: 2.287 ± 0.122
0.619TyrHis: 0.619 ± 0.053
1.835TyrIle: 1.835 ± 0.098
1.924TyrLys: 1.924 ± 0.112
3.235TyrLeu: 3.235 ± 0.142
0.625TyrMet: 0.625 ± 0.054
1.021TyrAsn: 1.021 ± 0.063
1.411TyrPro: 1.411 ± 0.083
0.926TyrGln: 0.926 ± 0.081
2.203TyrArg: 2.203 ± 0.106
1.98TyrSer: 1.98 ± 0.117
1.233TyrThr: 1.233 ± 0.087
1.634TyrVal: 1.634 ± 0.095
0.435TyrTrp: 0.435 ± 0.053
1.065TyrTyr: 1.065 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 774 proteins (179292 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski