Amino acid dipepetide frequency for Endogone sp. FLAS-F59071

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.864AlaAla: 7.864 ± 0.076	1.005AlaCys: 1.005 ± 0.016	3.887AlaAsp: 3.887 ± 0.036	4.86AlaGlu: 4.86 ± 0.049	2.875AlaPhe: 2.875 ± 0.03	4.793AlaGly: 4.793 ± 0.043	1.719AlaHis: 1.719 ± 0.024	4.124AlaIle: 4.124 ± 0.036	4.027AlaLys: 4.027 ± 0.041	7.085AlaLeu: 7.085 ± 0.05	1.82AlaMet: 1.82 ± 0.024	3.009AlaAsn: 3.009 ± 0.033	4.072AlaPro: 4.072 ± 0.047	3.058AlaGln: 3.058 ± 0.034	4.589AlaArg: 4.589 ± 0.041	6.399AlaSer: 6.399 ± 0.049	5.207AlaThr: 5.207 ± 0.052	5.098AlaVal: 5.098 ± 0.046	0.896AlaTrp: 0.896 ± 0.017	1.958AlaTyr: 1.958 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.917CysAla: 0.917 ± 0.017	0.292CysCys: 0.292 ± 0.011	0.708CysAsp: 0.708 ± 0.016	0.684CysGlu: 0.684 ± 0.016	0.612CysPhe: 0.612 ± 0.013	0.981CysGly: 0.981 ± 0.022	0.368CysHis: 0.368 ± 0.01	0.755CysIle: 0.755 ± 0.016	0.593CysLys: 0.593 ± 0.013	1.331CysLeu: 1.331 ± 0.022	0.271CysMet: 0.271 ± 0.008	0.506CysAsn: 0.506 ± 0.012	0.704CysPro: 0.704 ± 0.016	0.45CysGln: 0.45 ± 0.012	0.823CysArg: 0.823 ± 0.017	1.015CysSer: 1.015 ± 0.019	0.741CysThr: 0.741 ± 0.016	0.9CysVal: 0.9 ± 0.016	0.2CysTrp: 0.2 ± 0.008	0.412CysTyr: 0.412 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.114AspAla: 4.114 ± 0.04	0.629AspCys: 0.629 ± 0.015	4.477AspAsp: 4.477 ± 0.061	4.619AspGlu: 4.619 ± 0.052	2.187AspPhe: 2.187 ± 0.03	3.647AspGly: 3.647 ± 0.035	1.257AspHis: 1.257 ± 0.021	3.196AspIle: 3.196 ± 0.032	2.502AspLys: 2.502 ± 0.03	4.956AspLeu: 4.956 ± 0.042	1.223AspMet: 1.223 ± 0.019	2.186AspAsn: 2.186 ± 0.028	3.045AspPro: 3.045 ± 0.027	1.781AspGln: 1.781 ± 0.024	2.984AspArg: 2.984 ± 0.038	3.791AspSer: 3.791 ± 0.038	3.008AspThr: 3.008 ± 0.03	3.821AspVal: 3.821 ± 0.031	0.723AspTrp: 0.723 ± 0.015	1.611AspTyr: 1.611 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	4.893GluAla: 4.893 ± 0.051	0.703GluCys: 0.703 ± 0.014	4.229GluAsp: 4.229 ± 0.045	6.826GluGlu: 6.826 ± 0.1	2.197GluPhe: 2.197 ± 0.024	3.761GluGly: 3.761 ± 0.04	1.345GluHis: 1.345 ± 0.019	3.374GluIle: 3.374 ± 0.032	3.992GluLys: 3.992 ± 0.041	5.584GluLeu: 5.584 ± 0.049	1.647GluMet: 1.647 ± 0.022	2.628GluAsn: 2.628 ± 0.027	2.487GluPro: 2.487 ± 0.034	2.59GluGln: 2.59 ± 0.032	4.258GluArg: 4.258 ± 0.053	4.019GluSer: 4.019 ± 0.035	3.413GluThr: 3.413 ± 0.035	3.999GluVal: 3.999 ± 0.043	0.821GluTrp: 0.821 ± 0.017	1.791GluTyr: 1.791 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	2.978PheAla: 2.978 ± 0.033	0.622PheCys: 0.622 ± 0.014	2.412PheAsp: 2.412 ± 0.027	2.274PheGlu: 2.274 ± 0.026	1.794PhePhe: 1.794 ± 0.025	2.639PheGly: 2.639 ± 0.036	0.983PheHis: 0.983 ± 0.017	1.994PheIle: 1.994 ± 0.025	1.706PheLys: 1.706 ± 0.021	3.848PheLeu: 3.848 ± 0.037	0.803PheMet: 0.803 ± 0.015	1.572PheAsn: 1.572 ± 0.021	2.026PhePro: 2.026 ± 0.027	1.374PheGln: 1.374 ± 0.019	2.016PheArg: 2.016 ± 0.027	3.127PheSer: 3.127 ± 0.034	2.264PheThr: 2.264 ± 0.028	2.721PheVal: 2.721 ± 0.026	0.563PheTrp: 0.563 ± 0.011	1.226PheTyr: 1.226 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	4.414GlyAla: 4.414 ± 0.042	0.832GlyCys: 0.832 ± 0.019	3.309GlyAsp: 3.309 ± 0.03	3.873GlyGlu: 3.873 ± 0.038	2.462GlyPhe: 2.462 ± 0.028	5.391GlyGly: 5.391 ± 0.073	1.427GlyHis: 1.427 ± 0.02	3.22GlyIle: 3.22 ± 0.03	3.409GlyLys: 3.409 ± 0.038	5.062GlyLeu: 5.062 ± 0.041	1.538GlyMet: 1.538 ± 0.024	2.414GlyAsn: 2.414 ± 0.025	2.527GlyPro: 2.527 ± 0.03	2.099GlyGln: 2.099 ± 0.028	3.731GlyArg: 3.731 ± 0.039	4.835GlySer: 4.835 ± 0.047	3.597GlyThr: 3.597 ± 0.038	4.149GlyVal: 4.149 ± 0.039	0.937GlyTrp: 0.937 ± 0.016	1.942GlyTyr: 1.942 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.748HisAla: 1.748 ± 0.026	0.353HisCys: 0.353 ± 0.01	1.253HisAsp: 1.253 ± 0.021	1.224HisGlu: 1.224 ± 0.017	1.008HisPhe: 1.008 ± 0.015	1.475HisGly: 1.475 ± 0.021	1.037HisHis: 1.037 ± 0.019	1.345HisIle: 1.345 ± 0.018	1.014HisLys: 1.014 ± 0.017	2.449HisLeu: 2.449 ± 0.03	0.474HisMet: 0.474 ± 0.009	0.928HisAsn: 0.928 ± 0.016	1.65HisPro: 1.65 ± 0.022	1.058HisGln: 1.058 ± 0.019	1.541HisArg: 1.541 ± 0.025	1.933HisSer: 1.933 ± 0.022	1.441HisThr: 1.441 ± 0.021	1.579HisVal: 1.579 ± 0.02	0.291HisTrp: 0.291 ± 0.009	0.791HisTyr: 0.791 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.089IleAla: 4.089 ± 0.031	0.786IleCys: 0.786 ± 0.016	3.033IleAsp: 3.033 ± 0.032	3.169IleGlu: 3.169 ± 0.032	2.199IlePhe: 2.199 ± 0.029	3.003IleGly: 3.003 ± 0.032	1.276IleHis: 1.276 ± 0.02	2.92IleIle: 2.92 ± 0.036	2.61IleLys: 2.61 ± 0.033	5.035IleLeu: 5.035 ± 0.042	1.097IleMet: 1.097 ± 0.016	2.064IleAsn: 2.064 ± 0.026	3.214IlePro: 3.214 ± 0.03	1.9IleGln: 1.9 ± 0.021	2.899IleArg: 2.899 ± 0.026	4.037IleSer: 4.037 ± 0.033	3.273IleThr: 3.273 ± 0.031	3.767IleVal: 3.767 ± 0.04	0.592IleTrp: 0.592 ± 0.012	1.611IleTyr: 1.611 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.837LysAla: 3.837 ± 0.039	0.583LysCys: 0.583 ± 0.013	2.852LysAsp: 2.852 ± 0.032	3.915LysGlu: 3.915 ± 0.043	1.711LysPhe: 1.711 ± 0.025	2.824LysGly: 2.824 ± 0.029	1.197LysHis: 1.197 ± 0.018	2.661LysIle: 2.661 ± 0.03	3.891LysLys: 3.891 ± 0.053	4.429LysLeu: 4.429 ± 0.039	1.155LysMet: 1.155 ± 0.018	2.083LysAsn: 2.083 ± 0.027	2.547LysPro: 2.547 ± 0.029	1.999LysGln: 1.999 ± 0.026	3.637LysArg: 3.637 ± 0.04	3.462LysSer: 3.462 ± 0.033	2.754LysThr: 2.754 ± 0.026	3.203LysVal: 3.203 ± 0.032	0.616LysTrp: 0.616 ± 0.013	1.52LysTyr: 1.52 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.367LeuAla: 7.367 ± 0.044	1.41LeuCys: 1.41 ± 0.023	5.096LeuAsp: 5.096 ± 0.044	5.64LeuGlu: 5.64 ± 0.046	3.704LeuPhe: 3.704 ± 0.039	5.118LeuGly: 5.118 ± 0.048	2.366LeuHis: 2.366 ± 0.023	4.325LeuIle: 4.325 ± 0.041	4.583LeuLys: 4.583 ± 0.049	9.011LeuLeu: 9.011 ± 0.067	1.852LeuMet: 1.852 ± 0.025	3.59LeuAsn: 3.59 ± 0.038	5.513LeuPro: 5.513 ± 0.044	3.726LeuGln: 3.726 ± 0.039	5.72LeuArg: 5.72 ± 0.047	7.349LeuSer: 7.349 ± 0.052	5.424LeuThr: 5.424 ± 0.042	5.905LeuVal: 5.905 ± 0.053	1.085LeuTrp: 1.085 ± 0.02	2.609LeuTyr: 2.609 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.952MetAla: 1.952 ± 0.022	0.285MetCys: 0.285 ± 0.009	1.295MetAsp: 1.295 ± 0.02	1.5MetGlu: 1.5 ± 0.022	0.793MetPhe: 0.793 ± 0.014	1.308MetGly: 1.308 ± 0.025	0.49MetHis: 0.49 ± 0.012	1.086MetIle: 1.086 ± 0.018	1.046MetLys: 1.046 ± 0.017	1.968MetLeu: 1.968 ± 0.024	0.621MetMet: 0.621 ± 0.014	0.918MetAsn: 0.918 ± 0.017	1.192MetPro: 1.192 ± 0.018	0.899MetGln: 0.899 ± 0.017	1.318MetArg: 1.318 ± 0.022	1.822MetSer: 1.822 ± 0.022	1.368MetThr: 1.368 ± 0.02	1.428MetVal: 1.428 ± 0.02	0.261MetTrp: 0.261 ± 0.008	0.577MetTyr: 0.577 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.011AsnAla: 3.011 ± 0.034	0.532AsnCys: 0.532 ± 0.015	2.287AsnAsp: 2.287 ± 0.029	2.367AsnGlu: 2.367 ± 0.026	1.608AsnPhe: 1.608 ± 0.025	2.772AsnGly: 2.772 ± 0.032	0.954AsnHis: 0.954 ± 0.014	2.432AsnIle: 2.432 ± 0.03	1.833AsnLys: 1.833 ± 0.022	3.67AsnLeu: 3.67 ± 0.038	0.931AsnMet: 0.931 ± 0.017	1.899AsnAsn: 1.899 ± 0.028	2.543AsnPro: 2.543 ± 0.027	1.434AsnGln: 1.434 ± 0.021	2.033AsnArg: 2.033 ± 0.028	3.058AsnSer: 3.058 ± 0.032	2.443AsnThr: 2.443 ± 0.026	2.674AsnVal: 2.674 ± 0.03	0.487AsnTrp: 0.487 ± 0.011	1.204AsnTyr: 1.204 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	4.599ProAla: 4.599 ± 0.046	0.569ProCys: 0.569 ± 0.013	2.689ProAsp: 2.689 ± 0.027	3.141ProGlu: 3.141 ± 0.034	2.149ProPhe: 2.149 ± 0.026	2.943ProGly: 2.943 ± 0.036	1.414ProHis: 1.414 ± 0.024	2.846ProIle: 2.846 ± 0.029	2.55ProLys: 2.55 ± 0.033	4.882ProLeu: 4.882 ± 0.039	1.047ProMet: 1.047 ± 0.018	2.346ProAsn: 2.346 ± 0.025	5.253ProPro: 5.253 ± 0.081	2.303ProGln: 2.303 ± 0.039	3.035ProArg: 3.035 ± 0.039	5.982ProSer: 5.982 ± 0.067	4.451ProThr: 4.451 ± 0.047	3.595ProVal: 3.595 ± 0.039	0.532ProTrp: 0.532 ± 0.012	1.522ProTyr: 1.522 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.949GlnAla: 2.949 ± 0.035	0.475GlnCys: 0.475 ± 0.014	1.825GlnAsp: 1.825 ± 0.024	2.37GlnGlu: 2.37 ± 0.029	1.421GlnPhe: 1.421 ± 0.021	2.036GlnGly: 2.036 ± 0.028	1.159GlnHis: 1.159 ± 0.021	1.992GlnIle: 1.992 ± 0.02	1.949GlnLys: 1.949 ± 0.028	3.654GlnLeu: 3.654 ± 0.037	0.843GlnMet: 0.843 ± 0.015	1.592GlnAsn: 1.592 ± 0.02	2.303GlnPro: 2.303 ± 0.04	3.353GlnGln: 3.353 ± 0.124	2.563GlnArg: 2.563 ± 0.031	2.835GlnSer: 2.835 ± 0.032	2.229GlnThr: 2.229 ± 0.028	2.132GlnVal: 2.132 ± 0.023	0.498GlnTrp: 0.498 ± 0.012	1.276GlnTyr: 1.276 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.379ArgAla: 4.379 ± 0.043	0.804ArgCys: 0.804 ± 0.018	3.201ArgAsp: 3.201 ± 0.041	3.997ArgGlu: 3.997 ± 0.048	2.287ArgPhe: 2.287 ± 0.026	3.483ArgGly: 3.483 ± 0.042	1.602ArgHis: 1.602 ± 0.023	3.058ArgIle: 3.058 ± 0.031	3.526ArgLys: 3.526 ± 0.034	5.445ArgLeu: 5.445 ± 0.043	1.371ArgMet: 1.371 ± 0.022	2.369ArgAsn: 2.369 ± 0.027	3.158ArgPro: 3.158 ± 0.032	2.388ArgGln: 2.388 ± 0.029	4.944ArgArg: 4.944 ± 0.055	4.582ArgSer: 4.582 ± 0.051	3.296ArgThr: 3.296 ± 0.03	3.69ArgVal: 3.69 ± 0.036	0.807ArgTrp: 0.807 ± 0.014	1.717ArgTyr: 1.717 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.181SerAla: 6.181 ± 0.053	0.926SerCys: 0.926 ± 0.019	3.989SerAsp: 3.989 ± 0.036	4.026SerGlu: 4.026 ± 0.036	3.156SerPhe: 3.156 ± 0.032	4.782SerGly: 4.782 ± 0.043	1.908SerHis: 1.908 ± 0.025	4.036SerIle: 4.036 ± 0.035	3.64SerLys: 3.64 ± 0.038	7.412SerLeu: 7.412 ± 0.048	1.639SerMet: 1.639 ± 0.019	3.214SerAsn: 3.214 ± 0.034	5.57SerPro: 5.57 ± 0.073	2.898SerGln: 2.898 ± 0.032	4.539SerArg: 4.539 ± 0.045	9.14SerSer: 9.14 ± 0.11	5.871SerThr: 5.871 ± 0.056	4.793SerVal: 4.793 ± 0.038	0.894SerTrp: 0.894 ± 0.015	2.058SerTyr: 2.058 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	4.946ThrAla: 4.946 ± 0.049	0.766ThrCys: 0.766 ± 0.018	2.973ThrAsp: 2.973 ± 0.03	3.287ThrGlu: 3.287 ± 0.036	2.414ThrPhe: 2.414 ± 0.031	3.618ThrGly: 3.618 ± 0.037	1.457ThrHis: 1.457 ± 0.021	3.502ThrIle: 3.502 ± 0.034	2.864ThrLys: 2.864 ± 0.037	5.755ThrLeu: 5.755 ± 0.044	1.321ThrMet: 1.321 ± 0.02	2.451ThrAsn: 2.451 ± 0.027	4.451ThrPro: 4.451 ± 0.049	2.095ThrGln: 2.095 ± 0.026	3.211ThrArg: 3.211 ± 0.034	5.662ThrSer: 5.662 ± 0.053	5.021ThrThr: 5.021 ± 0.063	3.971ThrVal: 3.971 ± 0.039	0.721ThrTrp: 0.721 ± 0.014	1.621ThrTyr: 1.621 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.344ValAla: 5.344 ± 0.047	0.981ValCys: 0.981 ± 0.016	3.788ValAsp: 3.788 ± 0.031	4.42ValGlu: 4.42 ± 0.037	2.52ValPhe: 2.52 ± 0.035	4.013ValGly: 4.013 ± 0.037	1.5ValHis: 1.5 ± 0.02	3.38ValIle: 3.38 ± 0.036	3.194ValLys: 3.194 ± 0.034	5.843ValLeu: 5.843 ± 0.045	1.51ValMet: 1.51 ± 0.018	2.51ValAsn: 2.51 ± 0.03	3.597ValPro: 3.597 ± 0.036	2.415ValGln: 2.415 ± 0.027	3.716ValArg: 3.716 ± 0.034	4.698ValSer: 4.698 ± 0.035	3.908ValThr: 3.908 ± 0.037	4.984ValVal: 4.984 ± 0.046	0.82ValTrp: 0.82 ± 0.016	1.834ValTyr: 1.834 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.785TrpAla: 0.785 ± 0.016	0.225TrpCys: 0.225 ± 0.008	0.764TrpAsp: 0.764 ± 0.015	0.773TrpGlu: 0.773 ± 0.015	0.51TrpPhe: 0.51 ± 0.011	0.725TrpGly: 0.725 ± 0.013	0.319TrpHis: 0.319 ± 0.011	0.691TrpIle: 0.691 ± 0.015	0.675TrpLys: 0.675 ± 0.013	1.106TrpLeu: 1.106 ± 0.019	0.328TrpMet: 0.328 ± 0.009	0.608TrpAsn: 0.608 ± 0.012	0.47TrpPro: 0.47 ± 0.011	0.459TrpGln: 0.459 ± 0.012	0.897TrpArg: 0.897 ± 0.016	0.905TrpSer: 0.905 ± 0.015	0.731TrpThr: 0.731 ± 0.016	0.767TrpVal: 0.767 ± 0.016	0.237TrpTrp: 0.237 ± 0.009	0.378TrpTyr: 0.378 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.981TyrAla: 1.981 ± 0.025	0.485TyrCys: 0.485 ± 0.012	1.691TyrAsp: 1.691 ± 0.024	1.59TyrGlu: 1.59 ± 0.021	1.334TyrPhe: 1.334 ± 0.023	1.858TyrGly: 1.858 ± 0.026	0.815TyrHis: 0.815 ± 0.014	1.637TyrIle: 1.637 ± 0.021	1.271TyrLys: 1.271 ± 0.018	2.867TyrLeu: 2.867 ± 0.036	0.635TyrMet: 0.635 ± 0.013	1.286TyrAsn: 1.286 ± 0.02	1.524TyrPro: 1.524 ± 0.025	1.174TyrGln: 1.174 ± 0.02	1.648TyrArg: 1.648 ± 0.023	2.022TyrSer: 2.022 ± 0.028	1.669TyrThr: 1.669 ± 0.021	1.8TyrVal: 1.8 ± 0.02	0.371TyrTrp: 0.371 ± 0.01	1.071TyrTyr: 1.071 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9431 proteins (3895637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---