Amino acid dipepetide frequency for Pneumocystis jirovecii (strain SE8) (Human pneumocystis pneumonia agent)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.736AlaAla: 2.736 ± 0.068
0.856AlaCys: 0.856 ± 0.023
1.958AlaAsp: 1.958 ± 0.045
2.724AlaGlu: 2.724 ± 0.047
2.369AlaPhe: 2.369 ± 0.041
2.123AlaGly: 2.123 ± 0.052
0.994AlaHis: 0.994 ± 0.025
3.915AlaIle: 3.915 ± 0.062
3.32AlaLys: 3.32 ± 0.05
5.228AlaLeu: 5.228 ± 0.071
1.105AlaMet: 1.105 ± 0.037
2.138AlaAsn: 2.138 ± 0.038
1.609AlaPro: 1.609 ± 0.04
1.708AlaGln: 1.708 ± 0.037
2.175AlaArg: 2.175 ± 0.047
3.975AlaSer: 3.975 ± 0.057
2.374AlaThr: 2.374 ± 0.052
2.559AlaVal: 2.559 ± 0.048
0.572AlaTrp: 0.572 ± 0.024
1.714AlaTyr: 1.714 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.676CysAla: 0.676 ± 0.023
0.278CysCys: 0.278 ± 0.013
0.739CysAsp: 0.739 ± 0.023
0.812CysGlu: 0.812 ± 0.029
0.918CysPhe: 0.918 ± 0.024
0.863CysGly: 0.863 ± 0.027
0.407CysHis: 0.407 ± 0.016
1.493CysIle: 1.493 ± 0.04
1.059CysLys: 1.059 ± 0.026
1.711CysLeu: 1.711 ± 0.041
0.315CysMet: 0.315 ± 0.015
0.758CysAsn: 0.758 ± 0.025
0.609CysPro: 0.609 ± 0.024
0.52CysGln: 0.52 ± 0.02
0.662CysArg: 0.662 ± 0.024
1.345CysSer: 1.345 ± 0.035
0.761CysThr: 0.761 ± 0.024
0.798CysVal: 0.798 ± 0.023
0.162CysTrp: 0.162 ± 0.011
0.521CysTyr: 0.521 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.516AspAla: 2.516 ± 0.045
0.708AspCys: 0.708 ± 0.024
3.516AspAsp: 3.516 ± 0.079
3.895AspGlu: 3.895 ± 0.061
2.812AspPhe: 2.812 ± 0.047
2.326AspGly: 2.326 ± 0.049
1.073AspHis: 1.073 ± 0.027
5.467AspIle: 5.467 ± 0.063
3.722AspLys: 3.722 ± 0.054
5.251AspLeu: 5.251 ± 0.064
1.225AspMet: 1.225 ± 0.029
2.923AspAsn: 2.923 ± 0.058
2.169AspPro: 2.169 ± 0.037
1.72AspGln: 1.72 ± 0.037
1.983AspArg: 1.983 ± 0.045
4.312AspSer: 4.312 ± 0.062
2.834AspThr: 2.834 ± 0.043
3.054AspVal: 3.054 ± 0.046
0.621AspTrp: 0.621 ± 0.024
2.018AspTyr: 2.018 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
3.287GluAla: 3.287 ± 0.067
0.886GluCys: 0.886 ± 0.028
3.518GluAsp: 3.518 ± 0.054
5.389GluGlu: 5.389 ± 0.092
2.791GluPhe: 2.791 ± 0.043
2.487GluGly: 2.487 ± 0.043
1.424GluHis: 1.424 ± 0.032
5.763GluIle: 5.763 ± 0.076
7.155GluLys: 7.155 ± 0.107
6.111GluLeu: 6.111 ± 0.074
1.594GluMet: 1.594 ± 0.031
5.402GluAsn: 5.402 ± 0.075
1.771GluPro: 1.771 ± 0.04
2.338GluGln: 2.338 ± 0.041
3.165GluArg: 3.165 ± 0.055
4.801GluSer: 4.801 ± 0.076
3.843GluThr: 3.843 ± 0.05
2.799GluVal: 2.799 ± 0.045
0.784GluTrp: 0.784 ± 0.024
2.513GluTyr: 2.513 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
1.861PheAla: 1.861 ± 0.039
0.852PheCys: 0.852 ± 0.028
2.708PheAsp: 2.708 ± 0.042
2.929PheGlu: 2.929 ± 0.052
2.638PhePhe: 2.638 ± 0.054
2.267PheGly: 2.267 ± 0.045
1.151PheHis: 1.151 ± 0.028
3.62PheIle: 3.62 ± 0.061
3.191PheLys: 3.191 ± 0.051
4.953PheLeu: 4.953 ± 0.069
0.991PheMet: 0.991 ± 0.028
2.535PheAsn: 2.535 ± 0.042
1.963PhePro: 1.963 ± 0.038
1.984PheGln: 1.984 ± 0.043
1.96PheArg: 1.96 ± 0.036
5.135PheSer: 5.135 ± 0.068
2.097PheThr: 2.097 ± 0.04
2.468PheVal: 2.468 ± 0.047
0.57PheTrp: 0.57 ± 0.025
1.808PheTyr: 1.808 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
2.034GlyAla: 2.034 ± 0.042
0.728GlyCys: 0.728 ± 0.025
2.151GlyAsp: 2.151 ± 0.044
2.372GlyGlu: 2.372 ± 0.051
2.303GlyPhe: 2.303 ± 0.043
2.512GlyGly: 2.512 ± 0.065
1.167GlyHis: 1.167 ± 0.032
3.94GlyIle: 3.94 ± 0.055
3.538GlyLys: 3.538 ± 0.058
4.164GlyLeu: 4.164 ± 0.061
0.986GlyMet: 0.986 ± 0.031
2.347GlyAsn: 2.347 ± 0.046
1.355GlyPro: 1.355 ± 0.035
1.415GlyGln: 1.415 ± 0.034
2.18GlyArg: 2.18 ± 0.047
3.576GlySer: 3.576 ± 0.057
2.513GlyThr: 2.513 ± 0.047
2.554GlyVal: 2.554 ± 0.054
0.635GlyTrp: 0.635 ± 0.024
1.787GlyTyr: 1.787 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.072HisAla: 1.072 ± 0.026
0.368HisCys: 0.368 ± 0.015
1.188HisAsp: 1.188 ± 0.028
1.465HisGlu: 1.465 ± 0.031
1.145HisPhe: 1.145 ± 0.03
1.09HisGly: 1.09 ± 0.031
0.592HisHis: 0.592 ± 0.021
1.967HisIle: 1.967 ± 0.038
1.548HisLys: 1.548 ± 0.032
2.406HisLeu: 2.406 ± 0.041
0.488HisMet: 0.488 ± 0.016
1.195HisAsn: 1.195 ± 0.03
1.137HisPro: 1.137 ± 0.032
0.871HisGln: 0.871 ± 0.026
1.047HisArg: 1.047 ± 0.027
1.934HisSer: 1.934 ± 0.043
1.161HisThr: 1.161 ± 0.034
1.277HisVal: 1.277 ± 0.029
0.26HisTrp: 0.26 ± 0.015
0.811HisTyr: 0.811 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
3.843IleAla: 3.843 ± 0.059
1.442IleCys: 1.442 ± 0.036
4.673IleAsp: 4.673 ± 0.057
5.577IleGlu: 5.577 ± 0.082
4.074IlePhe: 4.074 ± 0.059
3.485IleGly: 3.485 ± 0.054
2.049IleHis: 2.049 ± 0.039
6.546IleIle: 6.546 ± 0.104
6.175IleLys: 6.175 ± 0.076
8.414IleLeu: 8.414 ± 0.092
1.712IleMet: 1.712 ± 0.037
4.844IleAsn: 4.844 ± 0.07
3.516IlePro: 3.516 ± 0.051
3.345IleGln: 3.345 ± 0.057
3.603IleArg: 3.603 ± 0.055
7.843IleSer: 7.843 ± 0.074
3.836IleThr: 3.836 ± 0.056
4.153IleVal: 4.153 ± 0.054
0.935IleTrp: 0.935 ± 0.03
3.201IleTyr: 3.201 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
3.524LysAla: 3.524 ± 0.064
1.023LysCys: 1.023 ± 0.031
4.565LysAsp: 4.565 ± 0.059
6.382LysGlu: 6.382 ± 0.083
2.849LysPhe: 2.849 ± 0.05
2.924LysGly: 2.924 ± 0.047
1.958LysHis: 1.958 ± 0.034
6.831LysIle: 6.831 ± 0.075
8.446LysLys: 8.446 ± 0.128
6.725LysLeu: 6.725 ± 0.07
1.795LysMet: 1.795 ± 0.035
6.242LysAsn: 6.242 ± 0.081
2.475LysPro: 2.475 ± 0.045
3.039LysGln: 3.039 ± 0.053
3.863LysArg: 3.863 ± 0.057
5.85LysSer: 5.85 ± 0.072
4.773LysThr: 4.773 ± 0.064
3.526LysVal: 3.526 ± 0.061
0.805LysTrp: 0.805 ± 0.023
3.165LysTyr: 3.165 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
4.53LeuAla: 4.53 ± 0.071
1.627LeuCys: 1.627 ± 0.035
5.461LeuAsp: 5.461 ± 0.063
7.131LeuGlu: 7.131 ± 0.096
4.575LeuPhe: 4.575 ± 0.061
4.242LeuGly: 4.242 ± 0.061
2.225LeuHis: 2.225 ± 0.042
6.733LeuIle: 6.733 ± 0.075
8.385LeuLys: 8.385 ± 0.076
9.39LeuLeu: 9.39 ± 0.112
1.856LeuMet: 1.856 ± 0.032
5.906LeuAsn: 5.906 ± 0.078
3.878LeuPro: 3.878 ± 0.058
3.907LeuGln: 3.907 ± 0.066
4.697LeuArg: 4.697 ± 0.058
9.317LeuSer: 9.317 ± 0.088
4.545LeuThr: 4.545 ± 0.064
4.609LeuVal: 4.609 ± 0.063
1.153LeuTrp: 1.153 ± 0.028
3.549LeuTyr: 3.549 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.121MetAla: 1.121 ± 0.028
0.282MetCys: 0.282 ± 0.013
1.3MetAsp: 1.3 ± 0.035
1.509MetGlu: 1.509 ± 0.035
0.924MetPhe: 0.924 ± 0.024
1.062MetGly: 1.062 ± 0.028
0.523MetHis: 0.523 ± 0.019
1.635MetIle: 1.635 ± 0.035
1.753MetLys: 1.753 ± 0.039
2.05MetLeu: 2.05 ± 0.042
0.463MetMet: 0.463 ± 0.022
1.295MetAsn: 1.295 ± 0.033
0.829MetPro: 0.829 ± 0.019
0.837MetGln: 0.837 ± 0.027
0.922MetArg: 0.922 ± 0.023
1.861MetSer: 1.861 ± 0.038
1.143MetThr: 1.143 ± 0.03
1.12MetVal: 1.12 ± 0.03
0.16MetTrp: 0.16 ± 0.011
0.623MetTyr: 0.623 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.679AsnAla: 2.679 ± 0.044
0.81AsnCys: 0.81 ± 0.026
3.525AsnAsp: 3.525 ± 0.054
4.154AsnGlu: 4.154 ± 0.06
2.73AsnPhe: 2.73 ± 0.046
2.469AsnGly: 2.469 ± 0.045
1.287AsnHis: 1.287 ± 0.03
6.224AsnIle: 6.224 ± 0.087
4.661AsnLys: 4.661 ± 0.067
5.225AsnLeu: 5.225 ± 0.068
1.453AsnMet: 1.453 ± 0.033
4.093AsnAsn: 4.093 ± 0.073
2.264AsnPro: 2.264 ± 0.048
2.145AsnGln: 2.145 ± 0.044
2.052AsnArg: 2.052 ± 0.043
5.027AsnSer: 5.027 ± 0.076
3.726AsnThr: 3.726 ± 0.067
3.047AsnVal: 3.047 ± 0.047
0.582AsnTrp: 0.582 ± 0.02
2.203AsnTyr: 2.203 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
1.482ProAla: 1.482 ± 0.035
0.528ProCys: 0.528 ± 0.02
1.954ProAsp: 1.954 ± 0.038
2.67ProGlu: 2.67 ± 0.053
1.919ProPhe: 1.919 ± 0.035
1.711ProGly: 1.711 ± 0.041
0.837ProHis: 0.837 ± 0.026
3.018ProIle: 3.018 ± 0.046
2.698ProLys: 2.698 ± 0.049
3.849ProLeu: 3.849 ± 0.055
0.702ProMet: 0.702 ± 0.023
2.009ProAsn: 2.009 ± 0.041
1.983ProPro: 1.983 ± 0.067
1.337ProGln: 1.337 ± 0.032
1.525ProArg: 1.525 ± 0.038
3.611ProSer: 3.611 ± 0.05
1.961ProThr: 1.961 ± 0.041
2.141ProVal: 2.141 ± 0.041
0.405ProTrp: 0.405 ± 0.016
1.518ProTyr: 1.518 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
1.807GlnAla: 1.807 ± 0.036
0.522GlnCys: 0.522 ± 0.022
1.851GlnAsp: 1.851 ± 0.038
2.859GlnGlu: 2.859 ± 0.048
1.51GlnPhe: 1.51 ± 0.031
1.48GlnGly: 1.48 ± 0.03
0.868GlnHis: 0.868 ± 0.026
2.915GlnIle: 2.915 ± 0.048
3.649GlnLys: 3.649 ± 0.053
3.515GlnLeu: 3.515 ± 0.055
0.806GlnMet: 0.806 ± 0.025
2.707GlnAsn: 2.707 ± 0.056
1.221GlnPro: 1.221 ± 0.033
1.738GlnGln: 1.738 ± 0.044
1.855GlnArg: 1.855 ± 0.038
2.733GlnSer: 2.733 ± 0.051
2.098GlnThr: 2.098 ± 0.041
1.704GlnVal: 1.704 ± 0.037
0.431GlnTrp: 0.431 ± 0.018
1.35GlnTyr: 1.35 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.209ArgAla: 2.209 ± 0.043
0.664ArgCys: 0.664 ± 0.019
2.174ArgAsp: 2.174 ± 0.039
2.826ArgGlu: 2.826 ± 0.049
2.068ArgPhe: 2.068 ± 0.039
1.917ArgGly: 1.917 ± 0.047
1.049ArgHis: 1.049 ± 0.029
3.752ArgIle: 3.752 ± 0.049
3.911ArgLys: 3.911 ± 0.057
4.515ArgLeu: 4.515 ± 0.063
1.003ArgMet: 1.003 ± 0.03
2.455ArgAsn: 2.455 ± 0.041
1.567ArgPro: 1.567 ± 0.034
1.83ArgGln: 1.83 ± 0.04
2.722ArgArg: 2.722 ± 0.05
3.342ArgSer: 3.342 ± 0.066
2.227ArgThr: 2.227 ± 0.047
2.319ArgVal: 2.319 ± 0.045
0.534ArgTrp: 0.534 ± 0.022
1.625ArgTyr: 1.625 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
3.599SerAla: 3.599 ± 0.054
1.298SerCys: 1.298 ± 0.03
4.469SerAsp: 4.469 ± 0.069
5.618SerGlu: 5.618 ± 0.069
4.49SerPhe: 4.49 ± 0.063
4.002SerGly: 4.002 ± 0.063
1.855SerHis: 1.855 ± 0.041
7.107SerIle: 7.107 ± 0.09
6.749SerLys: 6.749 ± 0.081
8.892SerLeu: 8.892 ± 0.094
1.736SerMet: 1.736 ± 0.033
5.097SerAsn: 5.097 ± 0.082
3.335SerPro: 3.335 ± 0.069
3.29SerGln: 3.29 ± 0.057
3.727SerArg: 3.727 ± 0.059
8.746SerSer: 8.746 ± 0.11
4.641SerThr: 4.641 ± 0.056
4.411SerVal: 4.411 ± 0.06
0.878SerTrp: 0.878 ± 0.028
3.034SerTyr: 3.034 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
2.479ThrAla: 2.479 ± 0.042
0.846ThrCys: 0.846 ± 0.028
2.552ThrAsp: 2.552 ± 0.044
3.187ThrGlu: 3.187 ± 0.048
2.515ThrPhe: 2.515 ± 0.042
2.568ThrGly: 2.568 ± 0.052
1.252ThrHis: 1.252 ± 0.028
4.194ThrIle: 4.194 ± 0.066
3.698ThrLys: 3.698 ± 0.062
5.355ThrLeu: 5.355 ± 0.068
1.05ThrMet: 1.05 ± 0.027
2.955ThrAsn: 2.955 ± 0.053
2.37ThrPro: 2.37 ± 0.046
1.968ThrGln: 1.968 ± 0.036
2.182ThrArg: 2.182 ± 0.039
4.878ThrSer: 4.878 ± 0.07
2.678ThrThr: 2.678 ± 0.049
2.876ThrVal: 2.876 ± 0.052
0.538ThrTrp: 0.538 ± 0.016
1.891ThrTyr: 1.891 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
2.49ValAla: 2.49 ± 0.041
0.875ValCys: 0.875 ± 0.028
2.887ValAsp: 2.887 ± 0.052
3.293ValGlu: 3.293 ± 0.051
2.765ValPhe: 2.765 ± 0.043
2.269ValGly: 2.269 ± 0.044
1.133ValHis: 1.133 ± 0.03
3.896ValIle: 3.896 ± 0.052
3.532ValLys: 3.532 ± 0.052
5.392ValLeu: 5.392 ± 0.073
1.007ValMet: 1.007 ± 0.029
2.626ValAsn: 2.626 ± 0.043
2.119ValPro: 2.119 ± 0.038
1.874ValGln: 1.874 ± 0.04
2.176ValArg: 2.176 ± 0.045
4.743ValSer: 4.743 ± 0.068
2.366ValThr: 2.366 ± 0.043
2.852ValVal: 2.852 ± 0.059
0.565ValTrp: 0.565 ± 0.019
1.871ValTyr: 1.871 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.541TrpAla: 0.541 ± 0.019
0.19TrpCys: 0.19 ± 0.012
0.74TrpAsp: 0.74 ± 0.024
0.7TrpGlu: 0.7 ± 0.024
0.441TrpPhe: 0.441 ± 0.019
0.529TrpGly: 0.529 ± 0.022
0.24TrpHis: 0.24 ± 0.014
0.996TrpIle: 0.996 ± 0.03
1.002TrpLys: 1.002 ± 0.028
0.928TrpLeu: 0.928 ± 0.028
0.266TrpMet: 0.266 ± 0.013
0.69TrpAsn: 0.69 ± 0.022
0.329TrpPro: 0.329 ± 0.017
0.357TrpGln: 0.357 ± 0.017
0.57TrpArg: 0.57 ± 0.02
0.851TrpSer: 0.851 ± 0.023
0.561TrpThr: 0.561 ± 0.02
0.622TrpVal: 0.622 ± 0.022
0.152TrpTrp: 0.152 ± 0.011
0.36TrpTyr: 0.36 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.667TyrAla: 1.667 ± 0.033
0.626TyrCys: 0.626 ± 0.022
2.213TyrAsp: 2.213 ± 0.038
2.33TyrGlu: 2.33 ± 0.046
1.842TyrPhe: 1.842 ± 0.037
1.934TyrGly: 1.934 ± 0.04
0.937TyrHis: 0.937 ± 0.026
3.256TyrIle: 3.256 ± 0.051
2.568TyrLys: 2.568 ± 0.043
3.643TyrLeu: 3.643 ± 0.059
0.857TyrMet: 0.857 ± 0.025
2.141TyrAsn: 2.141 ± 0.045
1.357TyrPro: 1.357 ± 0.033
1.395TyrGln: 1.395 ± 0.033
1.643TyrArg: 1.643 ± 0.036
3.096TyrSer: 3.096 ± 0.052
1.895TyrThr: 1.895 ± 0.039
1.842TyrVal: 1.842 ± 0.037
0.322TyrTrp: 0.322 ± 0.015
1.46TyrTyr: 1.46 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3419 proteins (1381820 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski