Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)

Taxonomy: Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus; Human immunodeficiency virus 2; HIV-2 subtype A

Average proteome isoelectric point is 7.78

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 10 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P04605|TAT_HV2RO Protein Tat OS=Human immunodeficiency virus type 2 subtype A (isolate ROD) OX=11720 GN=tat PE=1 SV=1
MM1 pKa = 7.26GASGSKK7 pKa = 9.52KK8 pKa = 9.27HH9 pKa = 5.99SRR11 pKa = 11.84PPRR14 pKa = 11.84GLQEE18 pKa = 3.8RR19 pKa = 11.84LLRR22 pKa = 11.84ARR24 pKa = 11.84AGACGGYY31 pKa = 8.78WNEE34 pKa = 4.2SGGEE38 pKa = 3.8YY39 pKa = 10.48SRR41 pKa = 11.84FQEE44 pKa = 5.1GSDD47 pKa = 3.66RR48 pKa = 11.84EE49 pKa = 4.34QKK51 pKa = 10.7SPSCEE56 pKa = 3.31GRR58 pKa = 11.84QYY60 pKa = 10.61QQGDD64 pKa = 3.75FMNTPWKK71 pKa = 10.71DD72 pKa = 3.19PAAEE76 pKa = 4.09RR77 pKa = 11.84EE78 pKa = 4.23KK79 pKa = 11.22NLYY82 pKa = 8.96RR83 pKa = 11.84QQNMDD88 pKa = 4.94DD89 pKa = 3.95VDD91 pKa = 5.13SDD93 pKa = 5.15DD94 pKa = 4.77DD95 pKa = 4.07DD96 pKa = 3.72QVRR99 pKa = 11.84VSVTPKK105 pKa = 10.0VPLRR109 pKa = 11.84PMTHH113 pKa = 6.91RR114 pKa = 11.84LAIDD118 pKa = 3.26MSHH121 pKa = 7.6LIKK124 pKa = 10.16TRR126 pKa = 11.84GGLEE130 pKa = 3.66GMFYY134 pKa = 10.2SEE136 pKa = 4.72RR137 pKa = 11.84RR138 pKa = 11.84HH139 pKa = 6.26KK140 pKa = 10.39ILNIYY145 pKa = 9.03LEE147 pKa = 4.32KK148 pKa = 10.97EE149 pKa = 3.82EE150 pKa = 5.7GIIADD155 pKa = 3.76WQNYY159 pKa = 4.85THH161 pKa = 7.08GPGVRR166 pKa = 11.84YY167 pKa = 9.54PMFFGWLWKK176 pKa = 10.09LVPVDD181 pKa = 3.95VPQEE185 pKa = 4.32GEE187 pKa = 3.99DD188 pKa = 4.07TEE190 pKa = 4.72THH192 pKa = 6.35CLVHH196 pKa = 6.67PAQTSKK202 pKa = 10.91FDD204 pKa = 4.06DD205 pKa = 3.71PHH207 pKa = 8.37GEE209 pKa = 4.06TLVWEE214 pKa = 4.72FDD216 pKa = 3.49PLLAYY221 pKa = 10.32SYY223 pKa = 10.25EE224 pKa = 3.93AFIRR228 pKa = 11.84YY229 pKa = 8.95PEE231 pKa = 4.15EE232 pKa = 4.24FGHH235 pKa = 7.31KK236 pKa = 9.93SGLPEE241 pKa = 4.25EE242 pKa = 4.26EE243 pKa = 3.6WKK245 pKa = 11.05ARR247 pKa = 11.84LKK249 pKa = 11.08ARR251 pKa = 11.84GIPFSS256 pKa = 3.71

Molecular weight: 29.57 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P06938|VPR_HV2RO Protein Vpr OS=Human immunodeficiency virus type 2 subtype A (isolate ROD) OX=11720 GN=vpr PE=3 SV=1
MM1 pKa = 7.52NEE3 pKa = 3.82RR4 pKa = 11.84ADD6 pKa = 3.8EE7 pKa = 4.39EE8 pKa = 4.42GLQRR12 pKa = 11.84KK13 pKa = 8.38LRR15 pKa = 11.84LIRR18 pKa = 11.84LLHH21 pKa = 4.91QTNPYY26 pKa = 8.44PQGPGTASQRR36 pKa = 11.84RR37 pKa = 11.84NRR39 pKa = 11.84RR40 pKa = 11.84RR41 pKa = 11.84RR42 pKa = 11.84WKK44 pKa = 10.0QRR46 pKa = 11.84WRR48 pKa = 11.84QILALADD55 pKa = 3.88SIYY58 pKa = 10.61TFPDD62 pKa = 3.87PPADD66 pKa = 3.68SPLDD70 pKa = 3.29QTIQHH75 pKa = 6.05LQGLTIQEE83 pKa = 4.45LPDD86 pKa = 4.45PPTHH90 pKa = 6.53LPEE93 pKa = 4.25SQRR96 pKa = 11.84LAEE99 pKa = 4.17TT100 pKa = 3.73

Molecular weight: 11.73 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

1

10

3861

99

1464

386.1

43.94

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.371 ± 0.353

2.461 ± 0.516

3.885 ± 0.326

7.407 ± 0.635

2.668 ± 0.202

7.148 ± 0.773

2.409 ± 0.189

5.698 ± 0.7

6.501 ± 0.835

8.055 ± 0.339

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.098 ± 0.172

4.325 ± 0.556

6.268 ± 0.881

5.776 ± 0.338

6.708 ± 0.785

4.766 ± 0.553

6.346 ± 0.8

5.439 ± 0.56

2.564 ± 0.333

3.108 ± 0.496
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski