Amino acid dipepetide frequency for Terriglobus roseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.274AlaAla: 13.274 ± 0.144	0.962AlaCys: 0.962 ± 0.027	5.298AlaAsp: 5.298 ± 0.062	5.872AlaGlu: 5.872 ± 0.096	3.757AlaPhe: 3.757 ± 0.052	8.224AlaGly: 8.224 ± 0.092	2.213AlaHis: 2.213 ± 0.043	5.494AlaIle: 5.494 ± 0.066	4.483AlaLys: 4.483 ± 0.074	10.504AlaLeu: 10.504 ± 0.095	2.925AlaMet: 2.925 ± 0.053	3.693AlaAsn: 3.693 ± 0.063	5.036AlaPro: 5.036 ± 0.076	4.489AlaGln: 4.489 ± 0.055	5.414AlaArg: 5.414 ± 0.069	6.807AlaSer: 6.807 ± 0.091	6.735AlaThr: 6.735 ± 0.081	7.72AlaVal: 7.72 ± 0.081	1.399AlaTrp: 1.399 ± 0.035	2.689AlaTyr: 2.689 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.856CysAla: 0.856 ± 0.024	0.154CysCys: 0.154 ± 0.01	0.444CysAsp: 0.444 ± 0.019	0.398CysGlu: 0.398 ± 0.019	0.343CysPhe: 0.343 ± 0.016	0.867CysGly: 0.867 ± 0.028	0.248CysHis: 0.248 ± 0.016	0.434CysIle: 0.434 ± 0.016	0.231CysLys: 0.231 ± 0.013	0.734CysLeu: 0.734 ± 0.023	0.213CysMet: 0.213 ± 0.012	0.267CysAsn: 0.267 ± 0.014	0.386CysPro: 0.386 ± 0.016	0.2CysGln: 0.2 ± 0.01	0.425CysArg: 0.425 ± 0.018	0.654CysSer: 0.654 ± 0.023	0.543CysThr: 0.543 ± 0.021	0.657CysVal: 0.657 ± 0.021	0.091CysTrp: 0.091 ± 0.009	0.225CysTyr: 0.225 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.958AspAla: 5.958 ± 0.075	0.41AspCys: 0.41 ± 0.018	2.631AspAsp: 2.631 ± 0.047	2.919AspGlu: 2.919 ± 0.05	2.149AspPhe: 2.149 ± 0.038	4.608AspGly: 4.608 ± 0.086	1.223AspHis: 1.223 ± 0.028	2.339AspIle: 2.339 ± 0.039	1.913AspLys: 1.913 ± 0.036	4.954AspLeu: 4.954 ± 0.063	1.001AspMet: 1.001 ± 0.025	1.552AspAsn: 1.552 ± 0.036	3.13AspPro: 3.13 ± 0.053	1.642AspGln: 1.642 ± 0.04	3.253AspArg: 3.253 ± 0.056	2.723AspSer: 2.723 ± 0.051	2.926AspThr: 2.926 ± 0.052	4.018AspVal: 4.018 ± 0.052	0.891AspTrp: 0.891 ± 0.023	1.553AspTyr: 1.553 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.599GluAla: 5.599 ± 0.087	0.357GluCys: 0.357 ± 0.017	2.613GluAsp: 2.613 ± 0.044	3.228GluGlu: 3.228 ± 0.069	1.875GluPhe: 1.875 ± 0.038	3.625GluGly: 3.625 ± 0.06	1.351GluHis: 1.351 ± 0.031	2.925GluIle: 2.925 ± 0.052	2.351GluLys: 2.351 ± 0.041	5.064GluLeu: 5.064 ± 0.073	1.437GluMet: 1.437 ± 0.033	1.69GluAsn: 1.69 ± 0.036	2.301GluPro: 2.301 ± 0.044	2.449GluGln: 2.449 ± 0.042	3.727GluArg: 3.727 ± 0.06	2.851GluSer: 2.851 ± 0.052	3.067GluThr: 3.067 ± 0.048	3.533GluVal: 3.533 ± 0.058	0.721GluTrp: 0.721 ± 0.022	1.336GluTyr: 1.336 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.329PheAla: 4.329 ± 0.066	0.362PheCys: 0.362 ± 0.016	2.368PheAsp: 2.368 ± 0.042	1.824PheGlu: 1.824 ± 0.043	1.712PhePhe: 1.712 ± 0.037	3.578PheGly: 3.578 ± 0.058	1.097PheHis: 1.097 ± 0.026	1.467PheIle: 1.467 ± 0.032	1.019PheLys: 1.019 ± 0.027	3.717PheLeu: 3.717 ± 0.065	0.71PheMet: 0.71 ± 0.022	1.433PheAsn: 1.433 ± 0.038	1.739PhePro: 1.739 ± 0.036	1.332PheGln: 1.332 ± 0.033	2.361PheArg: 2.361 ± 0.042	2.676PheSer: 2.676 ± 0.047	2.555PheThr: 2.555 ± 0.051	2.699PheVal: 2.699 ± 0.043	0.494PheTrp: 0.494 ± 0.019	1.199PheTyr: 1.199 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.293GlyAla: 7.293 ± 0.079	0.779GlyCys: 0.779 ± 0.024	3.916GlyAsp: 3.916 ± 0.063	3.84GlyGlu: 3.84 ± 0.065	3.275GlyPhe: 3.275 ± 0.057	6.783GlyGly: 6.783 ± 0.102	1.756GlyHis: 1.756 ± 0.037	4.491GlyIle: 4.491 ± 0.058	3.83GlyLys: 3.83 ± 0.056	7.129GlyLeu: 7.129 ± 0.088	2.142GlyMet: 2.142 ± 0.046	3.125GlyAsn: 3.125 ± 0.064	3.106GlyPro: 3.106 ± 0.053	2.732GlyGln: 2.732 ± 0.052	4.287GlyArg: 4.287 ± 0.057	5.362GlySer: 5.362 ± 0.076	5.784GlyThr: 5.784 ± 0.101	5.932GlyVal: 5.932 ± 0.078	1.322GlyTrp: 1.322 ± 0.037	2.672GlyTyr: 2.672 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.456HisAla: 2.456 ± 0.042	0.227HisCys: 0.227 ± 0.014	1.338HisAsp: 1.338 ± 0.03	1.191HisGlu: 1.191 ± 0.031	1.001HisPhe: 1.001 ± 0.029	2.06HisGly: 2.06 ± 0.038	0.659HisHis: 0.659 ± 0.023	1.176HisIle: 1.176 ± 0.029	0.661HisLys: 0.661 ± 0.024	2.247HisLeu: 2.247 ± 0.041	0.557HisMet: 0.557 ± 0.02	0.786HisAsn: 0.786 ± 0.023	1.49HisPro: 1.49 ± 0.034	0.728HisGln: 0.728 ± 0.021	1.428HisArg: 1.428 ± 0.034	1.364HisSer: 1.364 ± 0.031	1.355HisThr: 1.355 ± 0.029	1.649HisVal: 1.649 ± 0.032	0.401HisTrp: 0.401 ± 0.014	0.698HisTyr: 0.698 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.57IleAla: 6.57 ± 0.066	0.44IleCys: 0.44 ± 0.019	2.906IleAsp: 2.906 ± 0.047	2.695IleGlu: 2.695 ± 0.049	1.897IlePhe: 1.897 ± 0.039	4.137IleGly: 4.137 ± 0.065	1.179IleHis: 1.179 ± 0.028	1.722IleIle: 1.722 ± 0.038	1.394IleLys: 1.394 ± 0.032	4.348IleLeu: 4.348 ± 0.062	0.72IleMet: 0.72 ± 0.021	1.603IleAsn: 1.603 ± 0.04	2.726IlePro: 2.726 ± 0.042	1.635IleGln: 1.635 ± 0.034	2.933IleArg: 2.933 ± 0.04	3.144IleSer: 3.144 ± 0.052	3.432IleThr: 3.432 ± 0.057	3.82IleVal: 3.82 ± 0.061	0.519IleTrp: 0.519 ± 0.019	1.332IleTyr: 1.332 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.021LysAla: 4.021 ± 0.068	0.195LysCys: 0.195 ± 0.01	2.095LysAsp: 2.095 ± 0.043	1.982LysGlu: 1.982 ± 0.041	1.192LysPhe: 1.192 ± 0.028	2.641LysGly: 2.641 ± 0.061	0.872LysHis: 0.872 ± 0.023	1.826LysIle: 1.826 ± 0.038	1.912LysLys: 1.912 ± 0.06	3.909LysLeu: 3.909 ± 0.057	1.065LysMet: 1.065 ± 0.029	1.394LysAsn: 1.394 ± 0.032	2.467LysPro: 2.467 ± 0.048	1.732LysGln: 1.732 ± 0.035	2.351LysArg: 2.351 ± 0.042	2.239LysSer: 2.239 ± 0.044	2.548LysThr: 2.548 ± 0.042	2.595LysVal: 2.595 ± 0.045	0.498LysTrp: 0.498 ± 0.02	1.108LysTyr: 1.108 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.257LeuAla: 10.257 ± 0.094	0.947LeuCys: 0.947 ± 0.026	4.898LeuAsp: 4.898 ± 0.055	4.725LeuGlu: 4.725 ± 0.063	3.595LeuPhe: 3.595 ± 0.061	7.013LeuGly: 7.013 ± 0.072	2.549LeuHis: 2.549 ± 0.047	4.375LeuIle: 4.375 ± 0.069	3.911LeuLys: 3.911 ± 0.06	10.512LeuLeu: 10.512 ± 0.139	2.089LeuMet: 2.089 ± 0.041	3.474LeuAsn: 3.474 ± 0.053	5.736LeuPro: 5.736 ± 0.064	4.017LeuGln: 4.017 ± 0.055	6.654LeuArg: 6.654 ± 0.093	6.525LeuSer: 6.525 ± 0.073	6.207LeuThr: 6.207 ± 0.073	6.212LeuVal: 6.212 ± 0.071	1.306LeuTrp: 1.306 ± 0.038	2.372LeuTyr: 2.372 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.475MetAla: 2.475 ± 0.043	0.149MetCys: 0.149 ± 0.011	1.201MetAsp: 1.201 ± 0.032	1.202MetGlu: 1.202 ± 0.03	0.703MetPhe: 0.703 ± 0.025	1.592MetGly: 1.592 ± 0.036	0.631MetHis: 0.631 ± 0.022	1.067MetIle: 1.067 ± 0.026	1.193MetLys: 1.193 ± 0.03	2.465MetLeu: 2.465 ± 0.049	0.629MetMet: 0.629 ± 0.02	0.878MetAsn: 0.878 ± 0.023	1.49MetPro: 1.49 ± 0.034	1.164MetGln: 1.164 ± 0.03	1.699MetArg: 1.699 ± 0.038	1.551MetSer: 1.551 ± 0.034	1.548MetThr: 1.548 ± 0.032	1.484MetVal: 1.484 ± 0.028	0.244MetTrp: 0.244 ± 0.013	0.508MetTyr: 0.508 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.859AsnAla: 3.859 ± 0.062	0.329AsnCys: 0.329 ± 0.016	1.829AsnAsp: 1.829 ± 0.034	1.663AsnGlu: 1.663 ± 0.031	1.456AsnPhe: 1.456 ± 0.038	3.607AsnGly: 3.607 ± 0.061	0.773AsnHis: 0.773 ± 0.023	1.873AsnIle: 1.873 ± 0.04	1.035AsnLys: 1.035 ± 0.029	3.307AsnLeu: 3.307 ± 0.056	0.747AsnMet: 0.747 ± 0.025	1.482AsnAsn: 1.482 ± 0.044	2.27AsnPro: 2.27 ± 0.042	1.226AsnGln: 1.226 ± 0.038	1.944AsnArg: 1.944 ± 0.038	2.154AsnSer: 2.154 ± 0.052	2.289AsnThr: 2.289 ± 0.053	2.642AsnVal: 2.642 ± 0.048	0.462AsnTrp: 0.462 ± 0.018	1.188AsnTyr: 1.188 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.788ProAla: 5.788 ± 0.075	0.308ProCys: 0.308 ± 0.017	3.026ProAsp: 3.026 ± 0.049	3.419ProGlu: 3.419 ± 0.05	1.967ProPhe: 1.967 ± 0.037	4.32ProGly: 4.32 ± 0.055	1.153ProHis: 1.153 ± 0.03	2.413ProIle: 2.413 ± 0.039	2.069ProLys: 2.069 ± 0.039	4.631ProLeu: 4.631 ± 0.06	1.237ProMet: 1.237 ± 0.029	2.067ProAsn: 2.067 ± 0.043	2.485ProPro: 2.485 ± 0.061	2.273ProGln: 2.273 ± 0.047	2.508ProArg: 2.508 ± 0.039	3.463ProSer: 3.463 ± 0.052	3.326ProThr: 3.326 ± 0.06	4.052ProVal: 4.052 ± 0.045	0.685ProTrp: 0.685 ± 0.023	1.461ProTyr: 1.461 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.851GlnAla: 3.851 ± 0.058	0.216GlnCys: 0.216 ± 0.013	1.751GlnAsp: 1.751 ± 0.034	1.82GlnGlu: 1.82 ± 0.044	1.456GlnPhe: 1.456 ± 0.036	2.558GlnGly: 2.558 ± 0.046	1.0GlnHis: 1.0 ± 0.033	2.041GlnIle: 2.041 ± 0.045	1.646GlnLys: 1.646 ± 0.038	3.66GlnLeu: 3.66 ± 0.058	1.16GlnMet: 1.16 ± 0.026	1.48GlnAsn: 1.48 ± 0.041	2.298GlnPro: 2.298 ± 0.045	2.418GlnGln: 2.418 ± 0.087	2.716GlnArg: 2.716 ± 0.048	2.422GlnSer: 2.422 ± 0.043	2.495GlnThr: 2.495 ± 0.047	2.614GlnVal: 2.614 ± 0.046	0.594GlnTrp: 0.594 ± 0.021	1.076GlnTyr: 1.076 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.182ArgAla: 5.182 ± 0.066	0.44ArgCys: 0.44 ± 0.021	3.146ArgAsp: 3.146 ± 0.05	3.626ArgGlu: 3.626 ± 0.058	2.61ArgPhe: 2.61 ± 0.047	3.942ArgGly: 3.942 ± 0.057	1.324ArgHis: 1.324 ± 0.031	3.473ArgIle: 3.473 ± 0.057	2.454ArgLys: 2.454 ± 0.048	5.528ArgLeu: 5.528 ± 0.073	1.845ArgMet: 1.845 ± 0.036	2.363ArgAsn: 2.363 ± 0.044	2.63ArgPro: 2.63 ± 0.053	2.215ArgGln: 2.215 ± 0.037	3.943ArgArg: 3.943 ± 0.063	3.729ArgSer: 3.729 ± 0.055	3.585ArgThr: 3.585 ± 0.05	4.356ArgVal: 4.356 ± 0.064	0.992ArgTrp: 0.992 ± 0.025	1.925ArgTyr: 1.925 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.59SerAla: 6.59 ± 0.073	0.498SerCys: 0.498 ± 0.022	3.078SerAsp: 3.078 ± 0.043	2.887SerGlu: 2.887 ± 0.048	2.682SerPhe: 2.682 ± 0.047	5.91SerGly: 5.91 ± 0.084	1.394SerHis: 1.394 ± 0.033	3.342SerIle: 3.342 ± 0.051	2.142SerLys: 2.142 ± 0.038	6.499SerLeu: 6.499 ± 0.068	1.456SerMet: 1.456 ± 0.032	2.291SerAsn: 2.291 ± 0.052	3.352SerPro: 3.352 ± 0.047	2.299SerGln: 2.299 ± 0.045	3.478SerArg: 3.478 ± 0.055	4.574SerSer: 4.574 ± 0.083	4.161SerThr: 4.161 ± 0.078	4.776SerVal: 4.776 ± 0.065	0.766SerTrp: 0.766 ± 0.022	1.815SerTyr: 1.815 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.95ThrAla: 6.95 ± 0.096	0.561ThrCys: 0.561 ± 0.022	3.056ThrAsp: 3.056 ± 0.049	3.021ThrGlu: 3.021 ± 0.045	2.475ThrPhe: 2.475 ± 0.051	5.687ThrGly: 5.687 ± 0.086	1.405ThrHis: 1.405 ± 0.029	3.275ThrIle: 3.275 ± 0.055	2.13ThrLys: 2.13 ± 0.047	6.61ThrLeu: 6.61 ± 0.078	1.355ThrMet: 1.355 ± 0.033	2.28ThrAsn: 2.28 ± 0.054	4.174ThrPro: 4.174 ± 0.065	2.331ThrGln: 2.331 ± 0.044	3.064ThrArg: 3.064 ± 0.052	4.079ThrSer: 4.079 ± 0.078	4.156ThrThr: 4.156 ± 0.08	5.24ThrVal: 5.24 ± 0.078	0.889ThrTrp: 0.889 ± 0.026	1.753ThrTyr: 1.753 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.769ValAla: 7.769 ± 0.088	0.671ValCys: 0.671 ± 0.022	3.943ValAsp: 3.943 ± 0.053	3.788ValGlu: 3.788 ± 0.064	2.683ValPhe: 2.683 ± 0.042	5.027ValGly: 5.027 ± 0.067	1.596ValHis: 1.596 ± 0.03	3.501ValIle: 3.501 ± 0.05	2.682ValLys: 2.682 ± 0.052	7.478ValLeu: 7.478 ± 0.077	1.642ValMet: 1.642 ± 0.039	2.545ValAsn: 2.545 ± 0.046	3.855ValPro: 3.855 ± 0.052	2.653ValGln: 2.653 ± 0.044	4.349ValArg: 4.349 ± 0.061	4.881ValSer: 4.881 ± 0.067	4.984ValThr: 4.984 ± 0.073	5.635ValVal: 5.635 ± 0.065	0.893ValTrp: 0.893 ± 0.027	1.821ValTyr: 1.821 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.083TrpAla: 1.083 ± 0.03	0.113TrpCys: 0.113 ± 0.009	0.669TrpAsp: 0.669 ± 0.023	0.587TrpGlu: 0.587 ± 0.019	0.581TrpPhe: 0.581 ± 0.021	0.91TrpGly: 0.91 ± 0.027	0.403TrpHis: 0.403 ± 0.019	0.784TrpIle: 0.784 ± 0.026	0.713TrpLys: 0.713 ± 0.019	1.487TrpLeu: 1.487 ± 0.038	0.444TrpMet: 0.444 ± 0.018	0.651TrpAsn: 0.651 ± 0.024	0.579TrpPro: 0.579 ± 0.023	0.721TrpGln: 0.721 ± 0.023	0.823TrpArg: 0.823 ± 0.024	0.908TrpSer: 0.908 ± 0.027	0.912TrpThr: 0.912 ± 0.024	0.839TrpVal: 0.839 ± 0.027	0.225TrpTrp: 0.225 ± 0.013	0.38TrpTyr: 0.38 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.828TyrAla: 2.828 ± 0.039	0.252TyrCys: 0.252 ± 0.014	1.586TyrAsp: 1.586 ± 0.03	1.413TyrGlu: 1.413 ± 0.033	1.263TyrPhe: 1.263 ± 0.028	2.467TyrGly: 2.467 ± 0.04	0.643TyrHis: 0.643 ± 0.023	1.132TyrIle: 1.132 ± 0.025	0.874TyrLys: 0.874 ± 0.024	2.588TyrLeu: 2.588 ± 0.048	0.5TyrMet: 0.5 ± 0.02	1.085TyrAsn: 1.085 ± 0.035	1.398TyrPro: 1.398 ± 0.031	1.018TyrGln: 1.018 ± 0.027	1.949TyrArg: 1.949 ± 0.039	1.885TyrSer: 1.885 ± 0.044	1.882TyrThr: 1.882 ± 0.043	1.925TyrVal: 1.925 ± 0.04	0.423TyrTrp: 0.423 ± 0.018	0.842TyrTyr: 0.842 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4053 proteins (1465181 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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