Amino acid dipepetide frequency for Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.692AlaAla: 10.692 ± 0.07	1.317AlaCys: 1.317 ± 0.015	5.101AlaAsp: 5.101 ± 0.035	5.49AlaGlu: 5.49 ± 0.046	3.412AlaPhe: 3.412 ± 0.028	6.179AlaGly: 6.179 ± 0.045	2.512AlaHis: 2.512 ± 0.022	4.06AlaIle: 4.06 ± 0.029	4.038AlaLys: 4.038 ± 0.036	9.616AlaLeu: 9.616 ± 0.046	2.175AlaMet: 2.175 ± 0.02	2.837AlaAsn: 2.837 ± 0.026	6.788AlaPro: 6.788 ± 0.053	3.807AlaGln: 3.807 ± 0.029	6.85AlaArg: 6.85 ± 0.045	8.463AlaSer: 8.463 ± 0.053	5.72AlaThr: 5.72 ± 0.034	5.807AlaVal: 5.807 ± 0.034	1.274AlaTrp: 1.274 ± 0.016	2.59AlaTyr: 2.59 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.283CysAla: 1.283 ± 0.015	0.245CysCys: 0.245 ± 0.007	0.752CysAsp: 0.752 ± 0.013	0.64CysGlu: 0.64 ± 0.011	0.492CysPhe: 0.492 ± 0.01	0.954CysGly: 0.954 ± 0.014	0.357CysHis: 0.357 ± 0.009	0.657CysIle: 0.657 ± 0.011	0.512CysLys: 0.512 ± 0.01	1.279CysLeu: 1.279 ± 0.017	0.308CysMet: 0.308 ± 0.008	0.394CysAsn: 0.394 ± 0.009	0.87CysPro: 0.87 ± 0.012	0.42CysGln: 0.42 ± 0.008	0.882CysArg: 0.882 ± 0.014	0.979CysSer: 0.979 ± 0.014	0.807CysThr: 0.807 ± 0.011	0.862CysVal: 0.862 ± 0.013	0.194CysTrp: 0.194 ± 0.006	0.344CysTyr: 0.344 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.299AspAla: 6.299 ± 0.042	0.683AspCys: 0.683 ± 0.011	4.702AspAsp: 4.702 ± 0.043	4.801AspGlu: 4.801 ± 0.037	2.169AspPhe: 2.169 ± 0.022	4.233AspGly: 4.233 ± 0.032	1.213AspHis: 1.213 ± 0.016	2.873AspIle: 2.873 ± 0.023	2.135AspLys: 2.135 ± 0.025	5.212AspLeu: 5.212 ± 0.034	1.343AspMet: 1.343 ± 0.015	1.605AspAsn: 1.605 ± 0.018	3.488AspPro: 3.488 ± 0.027	1.514AspGln: 1.514 ± 0.018	3.057AspArg: 3.057 ± 0.025	3.887AspSer: 3.887 ± 0.03	2.985AspThr: 2.985 ± 0.023	4.268AspVal: 4.268 ± 0.025	0.941AspTrp: 0.941 ± 0.015	1.58AspTyr: 1.58 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.579GluAla: 5.579 ± 0.045	0.689GluCys: 0.689 ± 0.011	4.447GluAsp: 4.447 ± 0.035	5.542GluGlu: 5.542 ± 0.06	1.74GluPhe: 1.74 ± 0.017	4.157GluGly: 4.157 ± 0.032	1.51GluHis: 1.51 ± 0.015	2.573GluIle: 2.573 ± 0.026	2.914GluLys: 2.914 ± 0.028	5.317GluLeu: 5.317 ± 0.037	1.341GluMet: 1.341 ± 0.014	1.707GluAsn: 1.707 ± 0.016	2.857GluPro: 2.857 ± 0.023	2.249GluGln: 2.249 ± 0.021	4.542GluArg: 4.542 ± 0.038	3.565GluSer: 3.565 ± 0.025	2.898GluThr: 2.898 ± 0.024	3.736GluVal: 3.736 ± 0.026	0.912GluTrp: 0.912 ± 0.014	1.653GluTyr: 1.653 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.327PheAla: 3.327 ± 0.024	0.539PheCys: 0.539 ± 0.008	2.348PheAsp: 2.348 ± 0.018	1.908PheGlu: 1.908 ± 0.019	1.443PhePhe: 1.443 ± 0.018	2.529PheGly: 2.529 ± 0.029	0.821PheHis: 0.821 ± 0.012	1.576PheIle: 1.576 ± 0.018	1.289PheLys: 1.289 ± 0.017	3.203PheLeu: 3.203 ± 0.027	0.755PheMet: 0.755 ± 0.012	1.152PheAsn: 1.152 ± 0.014	2.041PhePro: 2.041 ± 0.022	1.025PheGln: 1.025 ± 0.013	1.934PheArg: 1.934 ± 0.019	2.65PheSer: 2.65 ± 0.023	2.028PheThr: 2.028 ± 0.021	2.492PheVal: 2.492 ± 0.021	0.55PheTrp: 0.55 ± 0.01	1.02PheTyr: 1.02 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.943GlyAla: 5.943 ± 0.039	0.873GlyCys: 0.873 ± 0.012	3.65GlyAsp: 3.65 ± 0.024	3.722GlyGlu: 3.722 ± 0.029	2.325GlyPhe: 2.325 ± 0.025	5.593GlyGly: 5.593 ± 0.06	1.65GlyHis: 1.65 ± 0.019	2.869GlyIle: 2.869 ± 0.024	3.215GlyLys: 3.215 ± 0.032	5.556GlyLeu: 5.556 ± 0.035	1.539GlyMet: 1.539 ± 0.02	1.965GlyAsn: 1.965 ± 0.022	3.451GlyPro: 3.451 ± 0.03	2.272GlyGln: 2.272 ± 0.021	4.362GlyArg: 4.362 ± 0.036	5.254GlySer: 5.254 ± 0.04	3.728GlyThr: 3.728 ± 0.03	4.27GlyVal: 4.27 ± 0.033	1.121GlyTrp: 1.121 ± 0.014	1.915GlyTyr: 1.915 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.459HisAla: 2.459 ± 0.02	0.404HisCys: 0.404 ± 0.009	1.436HisAsp: 1.436 ± 0.016	1.319HisGlu: 1.319 ± 0.015	0.93HisPhe: 0.93 ± 0.014	1.651HisGly: 1.651 ± 0.017	0.842HisHis: 0.842 ± 0.016	1.263HisIle: 1.263 ± 0.017	0.868HisLys: 0.868 ± 0.013	2.545HisLeu: 2.545 ± 0.024	0.47HisMet: 0.47 ± 0.009	0.743HisAsn: 0.743 ± 0.012	1.935HisPro: 1.935 ± 0.019	0.803HisGln: 0.803 ± 0.011	1.771HisArg: 1.771 ± 0.022	1.833HisSer: 1.833 ± 0.019	1.421HisThr: 1.421 ± 0.015	1.701HisVal: 1.701 ± 0.018	0.377HisTrp: 0.377 ± 0.008	0.711HisTyr: 0.711 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.231IleAla: 4.231 ± 0.027	0.707IleCys: 0.707 ± 0.012	2.676IleAsp: 2.676 ± 0.021	2.444IleGlu: 2.444 ± 0.02	1.676IlePhe: 1.676 ± 0.019	2.639IleGly: 2.639 ± 0.024	1.095IleHis: 1.095 ± 0.015	2.058IleIle: 2.058 ± 0.023	1.691IleLys: 1.691 ± 0.019	4.015IleLeu: 4.015 ± 0.032	0.916IleMet: 0.916 ± 0.012	1.326IleAsn: 1.326 ± 0.017	2.927IlePro: 2.927 ± 0.021	1.506IleGln: 1.506 ± 0.016	2.7IleArg: 2.7 ± 0.025	3.21IleSer: 3.21 ± 0.023	2.458IleThr: 2.458 ± 0.021	3.067IleVal: 3.067 ± 0.027	0.648IleTrp: 0.648 ± 0.012	1.23IleTyr: 1.23 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.225LysAla: 4.225 ± 0.039	0.45LysCys: 0.45 ± 0.009	2.476LysAsp: 2.476 ± 0.022	2.926LysGlu: 2.926 ± 0.031	1.199LysPhe: 1.199 ± 0.016	2.725LysGly: 2.725 ± 0.027	1.03LysHis: 1.03 ± 0.015	1.731LysIle: 1.731 ± 0.019	2.65LysLys: 2.65 ± 0.032	3.561LysLeu: 3.561 ± 0.028	0.825LysMet: 0.825 ± 0.014	1.27LysAsn: 1.27 ± 0.016	2.475LysPro: 2.475 ± 0.025	1.508LysGln: 1.508 ± 0.017	3.448LysArg: 3.448 ± 0.031	2.674LysSer: 2.674 ± 0.026	2.359LysThr: 2.359 ± 0.026	2.479LysVal: 2.479 ± 0.023	0.587LysTrp: 0.587 ± 0.008	1.22LysTyr: 1.22 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	9.083LeuAla: 9.083 ± 0.051	1.331LeuCys: 1.331 ± 0.016	5.436LeuAsp: 5.436 ± 0.035	5.464LeuGlu: 5.464 ± 0.04	3.176LeuPhe: 3.176 ± 0.028	5.398LeuGly: 5.398 ± 0.035	2.546LeuHis: 2.546 ± 0.023	3.491LeuIle: 3.491 ± 0.028	3.731LeuLys: 3.731 ± 0.027	8.55LeuLeu: 8.55 ± 0.062	1.716LeuMet: 1.716 ± 0.018	2.776LeuAsn: 2.776 ± 0.022	6.449LeuPro: 6.449 ± 0.042	3.598LeuGln: 3.598 ± 0.027	6.934LeuArg: 6.934 ± 0.042	7.204LeuSer: 7.204 ± 0.044	5.168LeuThr: 5.168 ± 0.035	5.679LeuVal: 5.679 ± 0.036	1.248LeuTrp: 1.248 ± 0.015	2.407LeuTyr: 2.407 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.98MetAla: 1.98 ± 0.018	0.253MetCys: 0.253 ± 0.006	1.257MetAsp: 1.257 ± 0.015	1.161MetGlu: 1.161 ± 0.014	0.697MetPhe: 0.697 ± 0.011	1.308MetGly: 1.308 ± 0.018	0.605MetHis: 0.605 ± 0.011	0.83MetIle: 0.83 ± 0.013	0.879MetLys: 0.879 ± 0.013	1.925MetLeu: 1.925 ± 0.02	0.504MetMet: 0.504 ± 0.011	0.685MetAsn: 0.685 ± 0.011	1.431MetPro: 1.431 ± 0.016	0.883MetGln: 0.883 ± 0.013	1.534MetArg: 1.534 ± 0.017	1.941MetSer: 1.941 ± 0.019	1.213MetThr: 1.213 ± 0.015	1.157MetVal: 1.157 ± 0.013	0.265MetTrp: 0.265 ± 0.008	0.577MetTyr: 0.577 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.202AsnAla: 3.202 ± 0.022	0.368AsnCys: 0.368 ± 0.008	1.685AsnAsp: 1.685 ± 0.018	1.633AsnGlu: 1.633 ± 0.018	1.11AsnPhe: 1.11 ± 0.014	2.341AsnGly: 2.341 ± 0.024	0.671AsnHis: 0.671 ± 0.011	1.537AsnIle: 1.537 ± 0.017	1.212AsnLys: 1.212 ± 0.015	2.737AsnLeu: 2.737 ± 0.027	0.695AsnMet: 0.695 ± 0.013	1.034AsnAsn: 1.034 ± 0.016	1.968AsnPro: 1.968 ± 0.018	0.879AsnGln: 0.879 ± 0.013	1.579AsnArg: 1.579 ± 0.02	2.01AsnSer: 2.01 ± 0.019	1.777AsnThr: 1.777 ± 0.019	2.181AsnVal: 2.181 ± 0.021	0.459AsnTrp: 0.459 ± 0.009	0.823AsnTyr: 0.823 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	6.842ProAla: 6.842 ± 0.052	0.641ProCys: 0.641 ± 0.011	3.508ProAsp: 3.508 ± 0.026	3.821ProGlu: 3.821 ± 0.027	2.166ProPhe: 2.166 ± 0.019	3.866ProGly: 3.866 ± 0.033	1.649ProHis: 1.649 ± 0.021	2.502ProIle: 2.502 ± 0.024	2.406ProLys: 2.406 ± 0.023	5.493ProLeu: 5.493 ± 0.036	1.201ProMet: 1.201 ± 0.016	1.959ProAsn: 1.959 ± 0.018	7.215ProPro: 7.215 ± 0.085	2.401ProGln: 2.401 ± 0.027	4.331ProArg: 4.331 ± 0.037	7.15ProSer: 7.15 ± 0.055	4.503ProThr: 4.503 ± 0.037	3.808ProVal: 3.808 ± 0.029	0.782ProTrp: 0.782 ± 0.011	1.689ProTyr: 1.689 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.635GlnAla: 3.635 ± 0.031	0.466GlnCys: 0.466 ± 0.01	1.883GlnAsp: 1.883 ± 0.02	2.09GlnGlu: 2.09 ± 0.02	1.075GlnPhe: 1.075 ± 0.014	2.065GlnGly: 2.065 ± 0.02	1.02GlnHis: 1.02 ± 0.013	1.506GlnIle: 1.506 ± 0.017	1.446GlnLys: 1.446 ± 0.018	3.264GlnLeu: 3.264 ± 0.023	0.781GlnMet: 0.781 ± 0.013	1.084GlnAsn: 1.084 ± 0.016	2.498GlnPro: 2.498 ± 0.033	1.969GlnGln: 1.969 ± 0.041	2.737GlnArg: 2.737 ± 0.02	2.597GlnSer: 2.597 ± 0.026	2.046GlnThr: 2.046 ± 0.02	2.057GlnVal: 2.057 ± 0.021	0.56GlnTrp: 0.56 ± 0.01	1.046GlnTyr: 1.046 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	6.877ArgAla: 6.877 ± 0.046	0.917ArgCys: 0.917 ± 0.013	3.704ArgAsp: 3.704 ± 0.028	4.204ArgGlu: 4.204 ± 0.034	2.19ArgPhe: 2.19 ± 0.022	4.022ArgGly: 4.022 ± 0.03	1.803ArgHis: 1.803 ± 0.019	2.956ArgIle: 2.956 ± 0.026	3.31ArgLys: 3.31 ± 0.028	6.308ArgLeu: 6.308 ± 0.044	1.486ArgMet: 1.486 ± 0.015	1.893ArgAsn: 1.893 ± 0.018	4.228ArgPro: 4.228 ± 0.036	2.547ArgGln: 2.547 ± 0.022	6.329ArgArg: 6.329 ± 0.055	5.19ArgSer: 5.19 ± 0.041	3.925ArgThr: 3.925 ± 0.031	4.121ArgVal: 4.121 ± 0.034	1.075ArgTrp: 1.075 ± 0.014	1.736ArgTyr: 1.736 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.843SerAla: 7.843 ± 0.049	0.952SerCys: 0.952 ± 0.013	4.264SerAsp: 4.264 ± 0.03	3.725SerGlu: 3.725 ± 0.023	2.701SerPhe: 2.701 ± 0.023	5.259SerGly: 5.259 ± 0.039	1.873SerHis: 1.873 ± 0.016	3.317SerIle: 3.317 ± 0.03	2.918SerLys: 2.918 ± 0.026	7.147SerLeu: 7.147 ± 0.046	1.642SerMet: 1.642 ± 0.018	2.231SerAsn: 2.231 ± 0.021	6.175SerPro: 6.175 ± 0.06	2.7SerGln: 2.7 ± 0.029	5.27SerArg: 5.27 ± 0.037	8.874SerSer: 8.874 ± 0.078	5.615SerThr: 5.615 ± 0.045	4.659SerVal: 4.659 ± 0.031	1.012SerTrp: 1.012 ± 0.014	1.949SerTyr: 1.949 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.437ThrAla: 5.437 ± 0.033	0.789ThrCys: 0.789 ± 0.011	2.859ThrAsp: 2.859 ± 0.024	2.77ThrGlu: 2.77 ± 0.023	2.199ThrPhe: 2.199 ± 0.019	3.643ThrGly: 3.643 ± 0.03	1.502ThrHis: 1.502 ± 0.014	2.774ThrIle: 2.774 ± 0.023	2.187ThrLys: 2.187 ± 0.022	5.752ThrLeu: 5.752 ± 0.04	1.19ThrMet: 1.19 ± 0.015	1.733ThrAsn: 1.733 ± 0.019	4.726ThrPro: 4.726 ± 0.04	1.904ThrGln: 1.904 ± 0.018	3.626ThrArg: 3.626 ± 0.027	5.392ThrSer: 5.392 ± 0.042	4.049ThrThr: 4.049 ± 0.035	3.741ThrVal: 3.741 ± 0.027	0.802ThrTrp: 0.802 ± 0.012	1.614ThrTyr: 1.614 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.951ValAla: 5.951 ± 0.033	0.974ValCys: 0.974 ± 0.013	4.102ValAsp: 4.102 ± 0.029	3.85ValGlu: 3.85 ± 0.029	2.38ValPhe: 2.38 ± 0.024	3.845ValGly: 3.845 ± 0.03	1.692ValHis: 1.692 ± 0.019	2.72ValIle: 2.72 ± 0.027	2.693ValLys: 2.693 ± 0.026	6.11ValLeu: 6.11 ± 0.036	1.241ValMet: 1.241 ± 0.015	2.007ValAsn: 2.007 ± 0.02	4.071ValPro: 4.071 ± 0.027	2.391ValGln: 2.391 ± 0.021	4.102ValArg: 4.102 ± 0.031	4.373ValSer: 4.373 ± 0.029	3.367ValThr: 3.367 ± 0.025	4.501ValVal: 4.501 ± 0.033	0.949ValTrp: 0.949 ± 0.015	1.884ValTyr: 1.884 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.237TrpAla: 1.237 ± 0.014	0.202TrpCys: 0.202 ± 0.006	0.909TrpAsp: 0.909 ± 0.014	0.866TrpGlu: 0.866 ± 0.011	0.513TrpPhe: 0.513 ± 0.009	0.886TrpGly: 0.886 ± 0.015	0.363TrpHis: 0.363 ± 0.008	0.645TrpIle: 0.645 ± 0.011	0.703TrpLys: 0.703 ± 0.011	1.306TrpLeu: 1.306 ± 0.017	0.347TrpMet: 0.347 ± 0.008	0.528TrpAsn: 0.528 ± 0.01	0.696TrpPro: 0.696 ± 0.013	0.555TrpGln: 0.555 ± 0.01	1.146TrpArg: 1.146 ± 0.015	1.01TrpSer: 1.01 ± 0.013	0.954TrpThr: 0.954 ± 0.014	0.848TrpVal: 0.848 ± 0.013	0.264TrpTrp: 0.264 ± 0.007	0.443TrpTyr: 0.443 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.604TyrAla: 2.604 ± 0.019	0.431TyrCys: 0.431 ± 0.01	1.792TyrAsp: 1.792 ± 0.018	1.553TyrGlu: 1.553 ± 0.016	1.038TyrPhe: 1.038 ± 0.014	1.98TyrGly: 1.98 ± 0.026	0.726TyrHis: 0.726 ± 0.011	1.284TyrIle: 1.284 ± 0.017	1.021TyrLys: 1.021 ± 0.014	2.486TyrLeu: 2.486 ± 0.024	0.611TyrMet: 0.611 ± 0.012	0.973TyrAsn: 0.973 ± 0.012	1.645TyrPro: 1.645 ± 0.019	0.891TyrGln: 0.891 ± 0.012	1.687TyrArg: 1.687 ± 0.02	1.871TyrSer: 1.871 ± 0.018	1.667TyrThr: 1.667 ± 0.016	1.771TyrVal: 1.771 ± 0.017	0.402TyrTrp: 0.402 ± 0.01	0.874TyrTyr: 0.874 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13128 proteins (5882520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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