Amino acid dipepetide frequency for Cinara cedri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.939AlaAla: 4.939 ± 0.05	1.009AlaCys: 1.009 ± 0.029	2.798AlaAsp: 2.798 ± 0.019	3.164AlaGlu: 3.164 ± 0.02	2.007AlaPhe: 2.007 ± 0.017	2.909AlaGly: 2.909 ± 0.022	1.101AlaHis: 1.101 ± 0.011	3.436AlaIle: 3.436 ± 0.02	3.296AlaLys: 3.296 ± 0.027	4.79AlaLeu: 4.79 ± 0.026	1.301AlaMet: 1.301 ± 0.011	2.591AlaAsn: 2.591 ± 0.02	2.203AlaPro: 2.203 ± 0.024	1.848AlaGln: 1.848 ± 0.015	2.338AlaArg: 2.338 ± 0.018	3.914AlaSer: 3.914 ± 0.025	3.205AlaThr: 3.205 ± 0.022	3.883AlaVal: 3.883 ± 0.023	0.482AlaTrp: 0.482 ± 0.008	1.649AlaTyr: 1.649 ± 0.015	0.001AlaXaa: 0.001 ± 0.0
Cys	0.979CysAla: 0.979 ± 0.015	0.484CysCys: 0.484 ± 0.008	1.196CysAsp: 1.196 ± 0.016	1.125CysGlu: 1.125 ± 0.017	0.833CysPhe: 0.833 ± 0.01	1.304CysGly: 1.304 ± 0.045	0.522CysHis: 0.522 ± 0.01	1.293CysIle: 1.293 ± 0.034	1.307CysLys: 1.307 ± 0.029	1.886CysLeu: 1.886 ± 0.029	0.442CysMet: 0.442 ± 0.007	1.182CysAsn: 1.182 ± 0.021	1.009CysPro: 1.009 ± 0.04	0.804CysGln: 0.804 ± 0.024	1.033CysArg: 1.033 ± 0.038	1.789CysSer: 1.789 ± 0.04	1.153CysThr: 1.153 ± 0.027	1.27CysVal: 1.27 ± 0.029	0.217CysTrp: 0.217 ± 0.005	0.677CysTyr: 0.677 ± 0.013	0.001CysXaa: 0.001 ± 0.0
Asp	2.476AspAla: 2.476 ± 0.019	1.091AspCys: 1.091 ± 0.02	4.237AspAsp: 4.237 ± 0.034	4.226AspGlu: 4.226 ± 0.029	2.25AspPhe: 2.25 ± 0.016	3.12AspGly: 3.12 ± 0.026	1.223AspHis: 1.223 ± 0.011	3.991AspIle: 3.991 ± 0.021	3.609AspLys: 3.609 ± 0.023	4.826AspLeu: 4.826 ± 0.027	1.284AspMet: 1.284 ± 0.01	3.383AspAsn: 3.383 ± 0.025	2.264AspPro: 2.264 ± 0.041	1.976AspGln: 1.976 ± 0.015	2.389AspArg: 2.389 ± 0.021	4.319AspSer: 4.319 ± 0.028	2.925AspThr: 2.925 ± 0.02	3.414AspVal: 3.414 ± 0.019	0.617AspTrp: 0.617 ± 0.009	1.956AspTyr: 1.956 ± 0.016	0.002AspXaa: 0.002 ± 0.0
Glu	2.905GluAla: 2.905 ± 0.027	1.275GluCys: 1.275 ± 0.047	3.763GluAsp: 3.763 ± 0.027	5.078GluGlu: 5.078 ± 0.042	2.371GluPhe: 2.371 ± 0.017	2.356GluGly: 2.356 ± 0.022	1.452GluHis: 1.452 ± 0.014	4.399GluIle: 4.399 ± 0.03	5.197GluLys: 5.197 ± 0.038	5.618GluLeu: 5.618 ± 0.036	1.561GluMet: 1.561 ± 0.015	4.473GluAsn: 4.473 ± 0.03	2.339GluPro: 2.339 ± 0.025	2.521GluGln: 2.521 ± 0.022	2.789GluArg: 2.789 ± 0.024	4.398GluSer: 4.398 ± 0.028	3.617GluThr: 3.617 ± 0.026	3.416GluVal: 3.416 ± 0.028	0.652GluTrp: 0.652 ± 0.009	2.126GluTyr: 2.126 ± 0.016	0.003GluXaa: 0.003 ± 0.001
Phe	1.933PheAla: 1.933 ± 0.015	0.845PheCys: 0.845 ± 0.011	2.317PheAsp: 2.317 ± 0.014	2.375PheGlu: 2.375 ± 0.018	1.6PhePhe: 1.6 ± 0.016	2.324PheGly: 2.324 ± 0.019	0.921PheHis: 0.921 ± 0.011	2.601PheIle: 2.601 ± 0.021	2.783PheLys: 2.783 ± 0.019	3.479PheLeu: 3.479 ± 0.025	0.936PheMet: 0.936 ± 0.01	2.466PheAsn: 2.466 ± 0.017	1.587PhePro: 1.587 ± 0.014	1.486PheGln: 1.486 ± 0.013	1.73PheArg: 1.73 ± 0.015	3.113PheSer: 3.113 ± 0.02	2.204PheThr: 2.204 ± 0.014	2.534PheVal: 2.534 ± 0.017	0.452PheTrp: 0.452 ± 0.007	1.448PheTyr: 1.448 ± 0.014	0.001PheXaa: 0.001 ± 0.0
Gly	2.629GlyAla: 2.629 ± 0.024	1.037GlyCys: 1.037 ± 0.02	2.696GlyAsp: 2.696 ± 0.025	2.637GlyGlu: 2.637 ± 0.028	2.209GlyPhe: 2.209 ± 0.022	4.066GlyGly: 4.066 ± 0.055	1.381GlyHis: 1.381 ± 0.015	3.138GlyIle: 3.138 ± 0.024	3.118GlyLys: 3.118 ± 0.023	4.229GlyLeu: 4.229 ± 0.025	1.143GlyMet: 1.143 ± 0.011	2.765GlyAsn: 2.765 ± 0.023	2.174GlyPro: 2.174 ± 0.03	1.909GlyGln: 1.909 ± 0.017	2.542GlyArg: 2.542 ± 0.024	4.38GlySer: 4.38 ± 0.049	2.913GlyThr: 2.913 ± 0.025	3.064GlyVal: 3.064 ± 0.021	0.599GlyTrp: 0.599 ± 0.01	1.948GlyTyr: 1.948 ± 0.023	0.002GlyXaa: 0.002 ± 0.0
His	1.003HisAla: 1.003 ± 0.009	0.56HisCys: 0.56 ± 0.008	1.109HisAsp: 1.109 ± 0.011	1.255HisGlu: 1.255 ± 0.012	1.042HisPhe: 1.042 ± 0.011	1.242HisGly: 1.242 ± 0.012	1.155HisHis: 1.155 ± 0.018	1.579HisIle: 1.579 ± 0.012	1.545HisLys: 1.545 ± 0.014	2.292HisLeu: 2.292 ± 0.017	0.581HisMet: 0.581 ± 0.008	1.386HisAsn: 1.386 ± 0.015	1.145HisPro: 1.145 ± 0.013	1.224HisGln: 1.224 ± 0.017	1.303HisArg: 1.303 ± 0.011	1.934HisSer: 1.934 ± 0.018	1.332HisThr: 1.332 ± 0.012	1.38HisVal: 1.38 ± 0.012	0.278HisTrp: 0.278 ± 0.006	0.913HisTyr: 0.913 ± 0.011	0.001HisXaa: 0.001 ± 0.0
Ile	3.306IleAla: 3.306 ± 0.022	1.339IleCys: 1.339 ± 0.027	3.824IleAsp: 3.824 ± 0.025	4.294IleGlu: 4.294 ± 0.028	2.522IlePhe: 2.522 ± 0.018	3.149IleGly: 3.149 ± 0.025	1.518IleHis: 1.518 ± 0.012	4.576IleIle: 4.576 ± 0.03	5.072IleLys: 5.072 ± 0.031	5.849IleLeu: 5.849 ± 0.031	1.536IleMet: 1.536 ± 0.013	4.415IleAsn: 4.415 ± 0.03	3.025IlePro: 3.025 ± 0.025	2.732IleGln: 2.732 ± 0.019	2.814IleArg: 2.814 ± 0.017	5.107IleSer: 5.107 ± 0.026	3.875IleThr: 3.875 ± 0.023	4.048IleVal: 4.048 ± 0.024	0.62IleTrp: 0.62 ± 0.008	1.992IleTyr: 1.992 ± 0.016	0.004IleXaa: 0.004 ± 0.001
Lys	3.048LysAla: 3.048 ± 0.02	1.531LysCys: 1.531 ± 0.03	3.597LysAsp: 3.597 ± 0.027	4.706LysGlu: 4.706 ± 0.035	2.577LysPhe: 2.577 ± 0.016	2.633LysGly: 2.633 ± 0.028	1.745LysHis: 1.745 ± 0.016	4.912LysIle: 4.912 ± 0.029	6.439LysLys: 6.439 ± 0.052	6.616LysLeu: 6.616 ± 0.04	1.758LysMet: 1.758 ± 0.014	4.78LysAsn: 4.78 ± 0.032	3.319LysPro: 3.319 ± 0.031	2.925LysGln: 2.925 ± 0.023	3.651LysArg: 3.651 ± 0.026	5.629LysSer: 5.629 ± 0.033	4.445LysThr: 4.445 ± 0.029	3.682LysVal: 3.682 ± 0.023	0.773LysTrp: 0.773 ± 0.012	2.623LysTyr: 2.623 ± 0.018	0.004LysXaa: 0.004 ± 0.001
Leu	4.833LeuAla: 4.833 ± 0.026	1.845LeuCys: 1.845 ± 0.019	4.763LeuAsp: 4.763 ± 0.03	5.641LeuGlu: 5.641 ± 0.038	3.538LeuPhe: 3.538 ± 0.025	3.859LeuGly: 3.859 ± 0.025	2.244LeuHis: 2.244 ± 0.02	5.397LeuIle: 5.397 ± 0.031	7.057LeuLys: 7.057 ± 0.039	8.591LeuLeu: 8.591 ± 0.05	2.218LeuMet: 2.218 ± 0.016	5.692LeuAsn: 5.692 ± 0.033	4.345LeuPro: 4.345 ± 0.024	4.118LeuGln: 4.118 ± 0.029	4.23LeuArg: 4.23 ± 0.026	7.348LeuSer: 7.348 ± 0.034	4.998LeuThr: 4.998 ± 0.025	4.948LeuVal: 4.948 ± 0.026	0.936LeuTrp: 0.936 ± 0.011	2.918LeuTyr: 2.918 ± 0.02	0.004LeuXaa: 0.004 ± 0.001
Met	1.583MetAla: 1.583 ± 0.014	0.507MetCys: 0.507 ± 0.009	1.451MetAsp: 1.451 ± 0.012	1.546MetGlu: 1.546 ± 0.016	1.072MetPhe: 1.072 ± 0.011	1.033MetGly: 1.033 ± 0.013	0.524MetHis: 0.524 ± 0.007	1.391MetIle: 1.391 ± 0.013	1.638MetLys: 1.638 ± 0.015	2.104MetLeu: 2.104 ± 0.017	0.673MetMet: 0.673 ± 0.008	1.369MetAsn: 1.369 ± 0.012	1.078MetPro: 1.078 ± 0.011	0.852MetGln: 0.852 ± 0.012	1.032MetArg: 1.032 ± 0.011	2.038MetSer: 2.038 ± 0.016	1.413MetThr: 1.413 ± 0.012	1.4MetVal: 1.4 ± 0.012	0.251MetTrp: 0.251 ± 0.005	0.838MetTyr: 0.838 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.829AsnAla: 2.829 ± 0.026	1.211AsnCys: 1.211 ± 0.017	3.533AsnAsp: 3.533 ± 0.023	4.029AsnGlu: 4.029 ± 0.029	2.219AsnPhe: 2.219 ± 0.014	3.341AsnGly: 3.341 ± 0.027	1.42AsnHis: 1.42 ± 0.018	4.762AsnIle: 4.762 ± 0.032	4.5AsnLys: 4.5 ± 0.028	5.252AsnLeu: 5.252 ± 0.035	1.461AsnMet: 1.461 ± 0.013	4.947AsnAsn: 4.947 ± 0.042	2.437AsnPro: 2.437 ± 0.039	2.408AsnGln: 2.408 ± 0.021	2.601AsnArg: 2.601 ± 0.019	5.094AsnSer: 5.094 ± 0.03	3.611AsnThr: 3.611 ± 0.023	3.893AsnVal: 3.893 ± 0.024	0.591AsnTrp: 0.591 ± 0.009	2.18AsnTyr: 2.18 ± 0.019	0.003AsnXaa: 0.003 ± 0.001
Pro	2.58ProAla: 2.58 ± 0.024	0.841ProCys: 0.841 ± 0.065	2.431ProAsp: 2.431 ± 0.018	2.924ProGlu: 2.924 ± 0.028	1.63ProPhe: 1.63 ± 0.016	2.607ProGly: 2.607 ± 0.068	1.011ProHis: 1.011 ± 0.01	2.941ProIle: 2.941 ± 0.024	3.066ProLys: 3.066 ± 0.023	3.837ProLeu: 3.837 ± 0.022	1.016ProMet: 1.016 ± 0.014	2.648ProAsn: 2.648 ± 0.026	3.732ProPro: 3.732 ± 0.049	1.951ProGln: 1.951 ± 0.024	1.903ProArg: 1.903 ± 0.016	4.193ProSer: 4.193 ± 0.04	2.976ProThr: 2.976 ± 0.024	3.115ProVal: 3.115 ± 0.026	0.447ProTrp: 0.447 ± 0.007	1.571ProTyr: 1.571 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	1.891GlnAla: 1.891 ± 0.018	0.873GlnCys: 0.873 ± 0.025	1.797GlnAsp: 1.797 ± 0.015	2.359GlnGlu: 2.359 ± 0.021	1.63GlnPhe: 1.63 ± 0.017	1.592GlnGly: 1.592 ± 0.017	1.197GlnHis: 1.197 ± 0.015	2.66GlnIle: 2.66 ± 0.021	2.776GlnLys: 2.776 ± 0.021	3.886GlnLeu: 3.886 ± 0.029	1.068GlnMet: 1.068 ± 0.012	2.687GlnAsn: 2.687 ± 0.026	2.016GlnPro: 2.016 ± 0.022	3.685GlnGln: 3.685 ± 0.082	1.977GlnArg: 1.977 ± 0.02	3.144GlnSer: 3.144 ± 0.023	2.416GlnThr: 2.416 ± 0.019	2.148GlnVal: 2.148 ± 0.016	0.477GlnTrp: 0.477 ± 0.006	1.393GlnTyr: 1.393 ± 0.012	0.002GlnXaa: 0.002 ± 0.0
Arg	2.304ArgAla: 2.304 ± 0.019	0.956ArgCys: 0.956 ± 0.016	2.301ArgAsp: 2.301 ± 0.019	2.605ArgGlu: 2.605 ± 0.018	1.84ArgPhe: 1.84 ± 0.015	2.19ArgGly: 2.19 ± 0.02	1.296ArgHis: 1.296 ± 0.014	2.848ArgIle: 2.848 ± 0.02	3.528ArgLys: 3.528 ± 0.024	4.279ArgLeu: 4.279 ± 0.03	1.1ArgMet: 1.1 ± 0.011	2.614ArgAsn: 2.614 ± 0.019	2.33ArgPro: 2.33 ± 0.027	1.944ArgGln: 1.944 ± 0.017	3.279ArgArg: 3.279 ± 0.031	3.642ArgSer: 3.642 ± 0.029	2.581ArgThr: 2.581 ± 0.018	2.605ArgVal: 2.605 ± 0.02	0.562ArgTrp: 0.562 ± 0.008	1.559ArgTyr: 1.559 ± 0.013	0.002ArgXaa: 0.002 ± 0.0
Ser	4.217SerAla: 4.217 ± 0.027	1.551SerCys: 1.551 ± 0.05	4.604SerAsp: 4.604 ± 0.025	4.635SerGlu: 4.635 ± 0.025	3.049SerPhe: 3.049 ± 0.019	4.452SerGly: 4.452 ± 0.03	1.733SerHis: 1.733 ± 0.013	5.101SerIle: 5.101 ± 0.03	5.397SerLys: 5.397 ± 0.034	7.036SerLeu: 7.036 ± 0.034	1.84SerMet: 1.84 ± 0.016	5.135SerAsn: 5.135 ± 0.03	4.375SerPro: 4.375 ± 0.055	3.014SerGln: 3.014 ± 0.026	3.538SerArg: 3.538 ± 0.029	8.786SerSer: 8.786 ± 0.066	5.274SerThr: 5.274 ± 0.04	4.962SerVal: 4.962 ± 0.025	0.811SerTrp: 0.811 ± 0.009	2.579SerTyr: 2.579 ± 0.021	0.003SerXaa: 0.003 ± 0.001
Thr	3.664ThrAla: 3.664 ± 0.021	1.179ThrCys: 1.179 ± 0.025	3.236ThrAsp: 3.236 ± 0.021	3.559ThrGlu: 3.559 ± 0.025	2.28ThrPhe: 2.28 ± 0.016	3.081ThrGly: 3.081 ± 0.023	1.212ThrHis: 1.212 ± 0.014	4.033ThrIle: 4.033 ± 0.023	3.836ThrLys: 3.836 ± 0.024	5.191ThrLeu: 5.191 ± 0.027	1.35ThrMet: 1.35 ± 0.013	3.555ThrAsn: 3.555 ± 0.02	3.166ThrPro: 3.166 ± 0.025	2.076ThrGln: 2.076 ± 0.017	2.37ThrArg: 2.37 ± 0.017	5.034ThrSer: 5.034 ± 0.035	4.31ThrThr: 4.31 ± 0.042	4.053ThrVal: 4.053 ± 0.026	0.579ThrTrp: 0.579 ± 0.009	1.805ThrTyr: 1.805 ± 0.015	0.003ThrXaa: 0.003 ± 0.001
Val	3.524ValAla: 3.524 ± 0.019	1.38ValCys: 1.38 ± 0.025	3.438ValAsp: 3.438 ± 0.019	3.639ValGlu: 3.639 ± 0.025	2.492ValPhe: 2.492 ± 0.017	2.874ValGly: 2.874 ± 0.019	1.481ValHis: 1.481 ± 0.014	3.779ValIle: 3.779 ± 0.022	4.101ValLys: 4.101 ± 0.025	5.517ValLeu: 5.517 ± 0.026	1.438ValMet: 1.438 ± 0.011	3.476ValAsn: 3.476 ± 0.022	2.974ValPro: 2.974 ± 0.025	2.441ValGln: 2.441 ± 0.017	2.632ValArg: 2.632 ± 0.019	4.708ValSer: 4.708 ± 0.03	3.708ValThr: 3.708 ± 0.025	3.99ValVal: 3.99 ± 0.026	0.663ValTrp: 0.663 ± 0.008	2.026ValTyr: 2.026 ± 0.016	0.003ValXaa: 0.003 ± 0.0
Trp	0.534TrpAla: 0.534 ± 0.009	0.227TrpCys: 0.227 ± 0.005	0.558TrpAsp: 0.558 ± 0.009	0.55TrpGlu: 0.55 ± 0.007	0.462TrpPhe: 0.462 ± 0.007	0.48TrpGly: 0.48 ± 0.009	0.236TrpHis: 0.236 ± 0.005	0.693TrpIle: 0.693 ± 0.009	0.83TrpLys: 0.83 ± 0.01	1.056TrpLeu: 1.056 ± 0.012	0.28TrpMet: 0.28 ± 0.005	0.658TrpAsn: 0.658 ± 0.01	0.428TrpPro: 0.428 ± 0.006	0.403TrpGln: 0.403 ± 0.006	0.55TrpArg: 0.55 ± 0.008	0.848TrpSer: 0.848 ± 0.009	0.691TrpThr: 0.691 ± 0.009	0.538TrpVal: 0.538 ± 0.009	0.16TrpTrp: 0.16 ± 0.005	0.366TrpTyr: 0.366 ± 0.006	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.68TyrAla: 1.68 ± 0.015	0.763TyrCys: 0.763 ± 0.01	1.929TyrAsp: 1.929 ± 0.014	1.959TyrGlu: 1.959 ± 0.016	1.511TyrPhe: 1.511 ± 0.014	1.963TyrGly: 1.963 ± 0.019	0.885TyrHis: 0.885 ± 0.011	2.082TyrIle: 2.082 ± 0.018	2.294TyrLys: 2.294 ± 0.017	3.184TyrLeu: 3.184 ± 0.022	0.807TyrMet: 0.807 ± 0.01	2.099TyrAsn: 2.099 ± 0.016	1.473TyrPro: 1.473 ± 0.023	1.355TyrGln: 1.355 ± 0.014	1.666TyrArg: 1.666 ± 0.012	2.672TyrSer: 2.672 ± 0.02	1.923TyrThr: 1.923 ± 0.017	1.935TyrVal: 1.935 ± 0.014	0.385TyrTrp: 0.385 ± 0.008	1.415TyrTyr: 1.415 ± 0.014	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.005XaaIle: 0.005 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.002XaaGln: 0.002 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.004XaaSer: 0.004 ± 0.001	0.002XaaThr: 0.002 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.141XaaXaa: 0.141 ± 0.065

Statistics based on 22140 proteins (10829743 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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