Amino acid dipepetide frequency for Tychonema bourrellyi FEM_GT703

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.69AlaAla: 7.69 ± 0.092	0.804AlaCys: 0.804 ± 0.027	4.445AlaAsp: 4.445 ± 0.062	5.828AlaGlu: 5.828 ± 0.079	2.814AlaPhe: 2.814 ± 0.049	5.755AlaGly: 5.755 ± 0.088	1.164AlaHis: 1.164 ± 0.034	7.64AlaIle: 7.64 ± 0.095	4.545AlaLys: 4.545 ± 0.063	8.363AlaLeu: 8.363 ± 0.099	1.7AlaMet: 1.7 ± 0.041	3.534AlaAsn: 3.534 ± 0.072	2.904AlaPro: 2.904 ± 0.062	3.922AlaGln: 3.922 ± 0.07	3.64AlaArg: 3.64 ± 0.057	4.888AlaSer: 4.888 ± 0.066	4.818AlaThr: 4.818 ± 0.066	5.963AlaVal: 5.963 ± 0.082	1.015AlaTrp: 1.015 ± 0.029	2.164AlaTyr: 2.164 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.675CysAla: 0.675 ± 0.023	0.188CysCys: 0.188 ± 0.013	0.704CysAsp: 0.704 ± 0.019	0.573CysGlu: 0.573 ± 0.022	0.452CysPhe: 0.452 ± 0.019	0.868CysGly: 0.868 ± 0.026	0.29CysHis: 0.29 ± 0.017	0.581CysIle: 0.581 ± 0.021	0.375CysLys: 0.375 ± 0.018	1.188CysLeu: 1.188 ± 0.031	0.153CysMet: 0.153 ± 0.01	0.372CysAsn: 0.372 ± 0.015	0.535CysPro: 0.535 ± 0.025	0.626CysGln: 0.626 ± 0.024	0.548CysArg: 0.548 ± 0.022	0.614CysSer: 0.614 ± 0.023	0.472CysThr: 0.472 ± 0.021	0.594CysVal: 0.594 ± 0.023	0.143CysTrp: 0.143 ± 0.011	0.419CysTyr: 0.419 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.952AspAla: 3.952 ± 0.058	0.605AspCys: 0.605 ± 0.026	2.426AspAsp: 2.426 ± 0.051	3.257AspGlu: 3.257 ± 0.061	2.537AspPhe: 2.537 ± 0.049	3.46AspGly: 3.46 ± 0.075	0.59AspHis: 0.59 ± 0.024	3.392AspIle: 3.392 ± 0.056	2.394AspLys: 2.394 ± 0.052	5.897AspLeu: 5.897 ± 0.075	0.879AspMet: 0.879 ± 0.028	1.973AspAsn: 1.973 ± 0.047	2.256AspPro: 2.256 ± 0.049	1.475AspGln: 1.475 ± 0.033	4.599AspArg: 4.599 ± 0.072	3.312AspSer: 3.312 ± 0.059	2.47AspThr: 2.47 ± 0.051	3.12AspVal: 3.12 ± 0.047	0.92AspTrp: 0.92 ± 0.026	1.81AspTyr: 1.81 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.695GluAla: 5.695 ± 0.082	0.574GluCys: 0.574 ± 0.025	2.772GluAsp: 2.772 ± 0.054	4.088GluGlu: 4.088 ± 0.07	2.713GluPhe: 2.713 ± 0.05	3.456GluGly: 3.456 ± 0.058	0.961GluHis: 0.961 ± 0.026	5.169GluIle: 5.169 ± 0.073	3.707GluLys: 3.707 ± 0.062	7.538GluLeu: 7.538 ± 0.084	1.577GluMet: 1.577 ± 0.035	2.876GluAsn: 2.876 ± 0.047	2.556GluPro: 2.556 ± 0.051	3.39GluGln: 3.39 ± 0.06	3.194GluArg: 3.194 ± 0.057	4.01GluSer: 4.01 ± 0.064	3.76GluThr: 3.76 ± 0.049	4.547GluVal: 4.547 ± 0.06	0.862GluTrp: 0.862 ± 0.023	1.909GluTyr: 1.909 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.202PheAla: 3.202 ± 0.051	0.544PheCys: 0.544 ± 0.022	2.394PheAsp: 2.394 ± 0.04	2.287PheGlu: 2.287 ± 0.04	1.55PhePhe: 1.55 ± 0.041	2.958PheGly: 2.958 ± 0.054	0.662PheHis: 0.662 ± 0.022	2.145PheIle: 2.145 ± 0.042	1.676PheLys: 1.676 ± 0.035	4.097PheLeu: 4.097 ± 0.065	0.734PheMet: 0.734 ± 0.025	1.616PheAsn: 1.616 ± 0.032	1.842PhePro: 1.842 ± 0.043	1.764PheGln: 1.764 ± 0.037	1.854PheArg: 1.854 ± 0.037	2.797PheSer: 2.797 ± 0.049	2.197PheThr: 2.197 ± 0.037	2.652PheVal: 2.652 ± 0.048	0.715PheTrp: 0.715 ± 0.027	1.351PheTyr: 1.351 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.015GlyAla: 5.015 ± 0.095	0.815GlyCys: 0.815 ± 0.026	3.835GlyAsp: 3.835 ± 0.076	4.317GlyGlu: 4.317 ± 0.067	2.934GlyPhe: 2.934 ± 0.055	5.141GlyGly: 5.141 ± 0.116	1.183GlyHis: 1.183 ± 0.038	5.177GlyIle: 5.177 ± 0.07	4.341GlyLys: 4.341 ± 0.06	6.857GlyLeu: 6.857 ± 0.087	1.616GlyMet: 1.616 ± 0.036	3.286GlyAsn: 3.286 ± 0.078	1.533GlyPro: 1.533 ± 0.037	2.846GlyGln: 2.846 ± 0.047	3.315GlyArg: 3.315 ± 0.049	4.15GlySer: 4.15 ± 0.062	3.875GlyThr: 3.875 ± 0.07	4.62GlyVal: 4.62 ± 0.071	1.163GlyTrp: 1.163 ± 0.034	2.225GlyTyr: 2.225 ± 0.044	0.001GlyXaa: 0.001 ± 0.001
His	0.964HisAla: 0.964 ± 0.03	0.259HisCys: 0.259 ± 0.013	0.658HisAsp: 0.658 ± 0.027	0.861HisGlu: 0.861 ± 0.027	0.736HisPhe: 0.736 ± 0.024	1.031HisGly: 1.031 ± 0.029	0.484HisHis: 0.484 ± 0.021	0.963HisIle: 0.963 ± 0.029	0.774HisLys: 0.774 ± 0.026	2.06HisLeu: 2.06 ± 0.048	0.244HisMet: 0.244 ± 0.014	0.724HisAsn: 0.724 ± 0.025	1.225HisPro: 1.225 ± 0.035	0.964HisGln: 0.964 ± 0.031	1.021HisArg: 1.021 ± 0.03	1.179HisSer: 1.179 ± 0.029	0.796HisThr: 0.796 ± 0.029	0.745HisVal: 0.745 ± 0.025	0.357HisTrp: 0.357 ± 0.017	0.614HisTyr: 0.614 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.277IleAla: 7.277 ± 0.088	0.785IleCys: 0.785 ± 0.024	4.001IleAsp: 4.001 ± 0.056	4.564IleGlu: 4.564 ± 0.071	2.59IlePhe: 2.59 ± 0.054	4.801IleGly: 4.801 ± 0.07	1.13IleHis: 1.13 ± 0.032	3.496IleIle: 3.496 ± 0.059	2.994IleLys: 2.994 ± 0.052	6.682IleLeu: 6.682 ± 0.085	0.888IleMet: 0.888 ± 0.027	2.741IleAsn: 2.741 ± 0.057	3.596IlePro: 3.596 ± 0.06	2.846IleGln: 2.846 ± 0.05	3.101IleArg: 3.101 ± 0.055	4.559IleSer: 4.559 ± 0.071	3.159IleThr: 3.159 ± 0.055	4.631IleVal: 4.631 ± 0.06	0.874IleTrp: 0.874 ± 0.03	1.907IleTyr: 1.907 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.12LysAla: 4.12 ± 0.067	0.373LysCys: 0.373 ± 0.018	2.326LysAsp: 2.326 ± 0.052	2.845LysGlu: 2.845 ± 0.053	1.89LysPhe: 1.89 ± 0.035	2.954LysGly: 2.954 ± 0.051	0.837LysHis: 0.837 ± 0.025	3.797LysIle: 3.797 ± 0.059	2.524LysLys: 2.524 ± 0.055	5.543LysLeu: 5.543 ± 0.081	1.18LysMet: 1.18 ± 0.03	2.261LysAsn: 2.261 ± 0.043	2.567LysPro: 2.567 ± 0.045	2.665LysGln: 2.665 ± 0.045	2.415LysArg: 2.415 ± 0.044	3.423LysSer: 3.423 ± 0.059	3.109LysThr: 3.109 ± 0.051	3.26LysVal: 3.26 ± 0.053	0.553LysTrp: 0.553 ± 0.021	1.505LysTyr: 1.505 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	9.5LeuAla: 9.5 ± 0.104	1.028LeuCys: 1.028 ± 0.034	5.527LeuAsp: 5.527 ± 0.061	7.563LeuGlu: 7.563 ± 0.107	3.689LeuPhe: 3.689 ± 0.066	7.712LeuGly: 7.712 ± 0.084	1.727LeuHis: 1.727 ± 0.039	6.587LeuIle: 6.587 ± 0.076	5.607LeuLys: 5.607 ± 0.069	10.671LeuLeu: 10.671 ± 0.102	2.144LeuMet: 2.144 ± 0.039	4.549LeuAsn: 4.549 ± 0.071	5.525LeuPro: 5.525 ± 0.084	5.153LeuGln: 5.153 ± 0.076	5.582LeuArg: 5.582 ± 0.073	7.516LeuSer: 7.516 ± 0.091	6.217LeuThr: 6.217 ± 0.074	6.953LeuVal: 6.953 ± 0.078	1.401LeuTrp: 1.401 ± 0.035	2.607LeuTyr: 2.607 ± 0.048	0.001LeuXaa: 0.001 ± 0.001
Met	1.852MetAla: 1.852 ± 0.037	0.126MetCys: 0.126 ± 0.009	0.771MetAsp: 0.771 ± 0.028	1.127MetGlu: 1.127 ± 0.031	0.594MetPhe: 0.594 ± 0.024	1.463MetGly: 1.463 ± 0.034	0.252MetHis: 0.252 ± 0.013	1.046MetIle: 1.046 ± 0.029	1.011MetLys: 1.011 ± 0.031	2.05MetLeu: 2.05 ± 0.044	0.475MetMet: 0.475 ± 0.022	0.9MetAsn: 0.9 ± 0.029	1.139MetPro: 1.139 ± 0.031	0.943MetGln: 0.943 ± 0.025	1.017MetArg: 1.017 ± 0.03	1.437MetSer: 1.437 ± 0.034	1.434MetThr: 1.434 ± 0.033	1.338MetVal: 1.338 ± 0.032	0.171MetTrp: 0.171 ± 0.011	0.37MetTyr: 0.37 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.979AsnAla: 2.979 ± 0.049	0.529AsnCys: 0.529 ± 0.02	1.819AsnAsp: 1.819 ± 0.062	1.814AsnGlu: 1.814 ± 0.039	1.935AsnPhe: 1.935 ± 0.04	2.612AsnGly: 2.612 ± 0.057	0.722AsnHis: 0.722 ± 0.027	2.56AsnIle: 2.56 ± 0.06	1.763AsnLys: 1.763 ± 0.041	5.649AsnLeu: 5.649 ± 0.095	0.682AsnMet: 0.682 ± 0.024	1.843AsnAsn: 1.843 ± 0.052	2.997AsnPro: 2.997 ± 0.052	2.507AsnGln: 2.507 ± 0.046	2.48AsnArg: 2.48 ± 0.046	3.22AsnSer: 3.22 ± 0.054	2.097AsnThr: 2.097 ± 0.049	2.24AsnVal: 2.24 ± 0.044	0.818AsnTrp: 0.818 ± 0.027	1.495AsnTyr: 1.495 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.659ProAla: 3.659 ± 0.064	0.358ProCys: 0.358 ± 0.017	3.106ProAsp: 3.106 ± 0.055	4.101ProGlu: 4.101 ± 0.067	1.652ProPhe: 1.652 ± 0.036	3.003ProGly: 3.003 ± 0.055	0.824ProHis: 0.824 ± 0.023	3.003ProIle: 3.003 ± 0.043	2.445ProLys: 2.445 ± 0.048	4.462ProLeu: 4.462 ± 0.068	0.865ProMet: 0.865 ± 0.027	2.234ProAsn: 2.234 ± 0.047	2.385ProPro: 2.385 ± 0.057	2.395ProGln: 2.395 ± 0.047	1.775ProArg: 1.775 ± 0.043	2.835ProSer: 2.835 ± 0.057	3.054ProThr: 3.054 ± 0.082	3.431ProVal: 3.431 ± 0.054	0.563ProTrp: 0.563 ± 0.019	1.243ProTyr: 1.243 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.325GlnAla: 4.325 ± 0.067	0.347GlnCys: 0.347 ± 0.018	1.97GlnAsp: 1.97 ± 0.038	3.336GlnGlu: 3.336 ± 0.065	1.769GlnPhe: 1.769 ± 0.038	2.952GlnGly: 2.952 ± 0.064	0.803GlnHis: 0.803 ± 0.027	3.607GlnIle: 3.607 ± 0.057	2.799GlnLys: 2.799 ± 0.053	5.725GlnLeu: 5.725 ± 0.085	1.039GlnMet: 1.039 ± 0.031	2.201GlnAsn: 2.201 ± 0.047	2.336GlnPro: 2.336 ± 0.048	3.425GlnGln: 3.425 ± 0.076	2.644GlnArg: 2.644 ± 0.054	2.901GlnSer: 2.901 ± 0.053	2.74GlnThr: 2.74 ± 0.051	3.495GlnVal: 3.495 ± 0.049	0.546GlnTrp: 0.546 ± 0.023	1.102GlnTyr: 1.102 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.572ArgAla: 3.572 ± 0.056	0.575ArgCys: 0.575 ± 0.022	2.818ArgAsp: 2.818 ± 0.054	3.627ArgGlu: 3.627 ± 0.058	2.115ArgPhe: 2.115 ± 0.036	3.176ArgGly: 3.176 ± 0.057	0.98ArgHis: 0.98 ± 0.029	3.385ArgIle: 3.385 ± 0.047	2.448ArgLys: 2.448 ± 0.047	5.864ArgLeu: 5.864 ± 0.079	1.038ArgMet: 1.038 ± 0.031	2.17ArgAsn: 2.17 ± 0.037	2.088ArgPro: 2.088 ± 0.047	3.132ArgGln: 3.132 ± 0.055	3.028ArgArg: 3.028 ± 0.06	3.64ArgSer: 3.64 ± 0.049	2.716ArgThr: 2.716 ± 0.05	3.427ArgVal: 3.427 ± 0.054	0.774ArgTrp: 0.774 ± 0.028	1.751ArgTyr: 1.751 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	5.077SerAla: 5.077 ± 0.066	0.716SerCys: 0.716 ± 0.025	3.379SerAsp: 3.379 ± 0.05	4.303SerGlu: 4.303 ± 0.059	2.502SerPhe: 2.502 ± 0.047	4.986SerGly: 4.986 ± 0.069	1.203SerHis: 1.203 ± 0.029	3.896SerIle: 3.896 ± 0.051	2.853SerLys: 2.853 ± 0.053	6.967SerLeu: 6.967 ± 0.08	1.247SerMet: 1.247 ± 0.032	2.61SerAsn: 2.61 ± 0.057	3.646SerPro: 3.646 ± 0.071	3.726SerGln: 3.726 ± 0.056	3.422SerArg: 3.422 ± 0.053	4.319SerSer: 4.319 ± 0.076	3.319SerThr: 3.319 ± 0.061	4.199SerVal: 4.199 ± 0.053	0.846SerTrp: 0.846 ± 0.027	1.748SerTyr: 1.748 ± 0.037	0.001SerXaa: 0.001 ± 0.001
Thr	4.959ThrAla: 4.959 ± 0.077	0.481ThrCys: 0.481 ± 0.021	2.755ThrAsp: 2.755 ± 0.052	3.403ThrGlu: 3.403 ± 0.055	2.049ThrPhe: 2.049 ± 0.038	4.414ThrGly: 4.414 ± 0.076	0.943ThrHis: 0.943 ± 0.026	3.653ThrIle: 3.653 ± 0.064	2.388ThrLys: 2.388 ± 0.041	5.855ThrLeu: 5.855 ± 0.067	0.836ThrMet: 0.836 ± 0.026	2.239ThrAsn: 2.239 ± 0.049	3.381ThrPro: 3.381 ± 0.085	2.586ThrGln: 2.586 ± 0.055	2.347ThrArg: 2.347 ± 0.044	3.251ThrSer: 3.251 ± 0.052	3.067ThrThr: 3.067 ± 0.065	4.197ThrVal: 4.197 ± 0.062	0.619ThrTrp: 0.619 ± 0.022	1.524ThrTyr: 1.524 ± 0.035	0.001ThrXaa: 0.001 ± 0.001
Val	6.107ValAla: 6.107 ± 0.071	0.72ValCys: 0.72 ± 0.024	3.463ValAsp: 3.463 ± 0.059	4.736ValGlu: 4.736 ± 0.07	2.607ValPhe: 2.607 ± 0.045	4.594ValGly: 4.594 ± 0.073	1.011ValHis: 1.011 ± 0.033	4.106ValIle: 4.106 ± 0.057	3.581ValLys: 3.581 ± 0.055	6.652ValLeu: 6.652 ± 0.078	1.45ValMet: 1.45 ± 0.034	2.859ValAsn: 2.859 ± 0.049	2.959ValPro: 2.959 ± 0.055	2.779ValGln: 2.779 ± 0.045	3.49ValArg: 3.49 ± 0.051	4.364ValSer: 4.364 ± 0.062	3.662ValThr: 3.662 ± 0.059	4.556ValVal: 4.556 ± 0.068	0.9ValTrp: 0.9 ± 0.029	1.874ValTyr: 1.874 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.962TrpAla: 0.962 ± 0.035	0.151TrpCys: 0.151 ± 0.01	0.681TrpAsp: 0.681 ± 0.026	1.028TrpGlu: 1.028 ± 0.032	0.571TrpPhe: 0.571 ± 0.023	0.941TrpGly: 0.941 ± 0.027	0.302TrpHis: 0.302 ± 0.018	0.843TrpIle: 0.843 ± 0.026	0.663TrpLys: 0.663 ± 0.023	1.785TrpLeu: 1.785 ± 0.042	0.364TrpMet: 0.364 ± 0.019	0.581TrpAsn: 0.581 ± 0.024	0.413TrpPro: 0.413 ± 0.018	1.025TrpGln: 1.025 ± 0.031	0.83TrpArg: 0.83 ± 0.028	0.712TrpSer: 0.712 ± 0.021	0.577TrpThr: 0.577 ± 0.022	0.917TrpVal: 0.917 ± 0.03	0.212TrpTrp: 0.212 ± 0.013	0.392TrpTyr: 0.392 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.016TyrAla: 2.016 ± 0.039	0.391TyrCys: 0.391 ± 0.018	1.478TyrAsp: 1.478 ± 0.035	1.697TyrGlu: 1.697 ± 0.04	1.34TyrPhe: 1.34 ± 0.035	1.968TyrGly: 1.968 ± 0.037	0.591TyrHis: 0.591 ± 0.022	1.577TyrIle: 1.577 ± 0.041	1.261TyrLys: 1.261 ± 0.037	3.353TyrLeu: 3.353 ± 0.051	0.4TyrMet: 0.4 ± 0.019	1.195TyrAsn: 1.195 ± 0.036	1.507TyrPro: 1.507 ± 0.032	1.89TyrGln: 1.89 ± 0.04	2.023TyrArg: 2.023 ± 0.043	1.836TyrSer: 1.836 ± 0.034	1.405TyrThr: 1.405 ± 0.033	1.583TyrVal: 1.583 ± 0.036	0.5TyrTrp: 0.5 ± 0.02	0.981TyrTyr: 0.981 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4322 proteins (1342800 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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