Amino acid dipepetide frequency for Sparganum proliferum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.167AlaAla: 9.167 ± 0.062	1.454AlaCys: 1.454 ± 0.013	4.729AlaAsp: 4.729 ± 0.025	4.965AlaGlu: 4.965 ± 0.032	3.019AlaPhe: 3.019 ± 0.018	4.251AlaGly: 4.251 ± 0.025	1.792AlaHis: 1.792 ± 0.015	3.573AlaIle: 3.573 ± 0.022	3.127AlaLys: 3.127 ± 0.021	6.832AlaLeu: 6.832 ± 0.036	1.426AlaMet: 1.426 ± 0.012	2.905AlaAsn: 2.905 ± 0.019	4.725AlaPro: 4.725 ± 0.028	2.596AlaGln: 2.596 ± 0.021	4.678AlaArg: 4.678 ± 0.026	7.095AlaSer: 7.095 ± 0.038	5.287AlaThr: 5.287 ± 0.026	5.651AlaVal: 5.651 ± 0.028	0.906AlaTrp: 0.906 ± 0.011	2.031AlaTyr: 2.031 ± 0.015	0.004AlaXaa: 0.004 ± 0.001
Cys	1.515CysAla: 1.515 ± 0.014	0.503CysCys: 0.503 ± 0.009	1.083CysAsp: 1.083 ± 0.013	0.995CysGlu: 0.995 ± 0.013	0.7CysPhe: 0.7 ± 0.01	1.335CysGly: 1.335 ± 0.015	0.514CysHis: 0.514 ± 0.008	0.906CysIle: 0.906 ± 0.012	0.672CysLys: 0.672 ± 0.009	2.426CysLeu: 2.426 ± 0.017	0.318CysMet: 0.318 ± 0.006	0.624CysAsn: 0.624 ± 0.009	1.626CysPro: 1.626 ± 0.021	1.026CysGln: 1.026 ± 0.011	1.354CysArg: 1.354 ± 0.015	1.854CysSer: 1.854 ± 0.015	1.04CysThr: 1.04 ± 0.011	1.336CysVal: 1.336 ± 0.013	0.266CysTrp: 0.266 ± 0.006	0.41CysTyr: 0.41 ± 0.007	0.001CysXaa: 0.001 ± 0.0
Asp	4.347AspAla: 4.347 ± 0.024	1.275AspCys: 1.275 ± 0.012	5.228AspAsp: 5.228 ± 0.093	3.614AspGlu: 3.614 ± 0.024	2.23AspPhe: 2.23 ± 0.015	3.399AspGly: 3.399 ± 0.029	1.236AspHis: 1.236 ± 0.012	2.439AspIle: 2.439 ± 0.017	2.08AspLys: 2.08 ± 0.018	5.154AspLeu: 5.154 ± 0.025	0.942AspMet: 0.942 ± 0.011	1.983AspAsn: 1.983 ± 0.016	2.427AspPro: 2.427 ± 0.02	1.694AspGln: 1.694 ± 0.013	3.45AspArg: 3.45 ± 0.021	4.074AspSer: 4.074 ± 0.025	2.936AspThr: 2.936 ± 0.019	3.467AspVal: 3.467 ± 0.02	0.71AspTrp: 0.71 ± 0.008	1.332AspTyr: 1.332 ± 0.014	0.003AspXaa: 0.003 ± 0.001
Glu	4.843GluAla: 4.843 ± 0.029	0.832GluCys: 0.832 ± 0.011	3.52GluAsp: 3.52 ± 0.026	5.932GluGlu: 5.932 ± 0.069	1.791GluPhe: 1.791 ± 0.016	2.779GluGly: 2.779 ± 0.023	1.462GluHis: 1.462 ± 0.012	2.473GluIle: 2.473 ± 0.019	3.143GluLys: 3.143 ± 0.023	5.088GluLeu: 5.088 ± 0.032	1.416GluMet: 1.416 ± 0.013	2.465GluAsn: 2.465 ± 0.019	2.403GluPro: 2.403 ± 0.022	2.243GluGln: 2.243 ± 0.017	3.699GluArg: 3.699 ± 0.02	3.924GluSer: 3.924 ± 0.025	3.748GluThr: 3.748 ± 0.025	3.622GluVal: 3.622 ± 0.022	0.5GluTrp: 0.5 ± 0.008	1.086GluTyr: 1.086 ± 0.009	0.003GluXaa: 0.003 ± 0.001
Phe	2.934PheAla: 2.934 ± 0.022	0.89PheCys: 0.89 ± 0.011	2.059PheAsp: 2.059 ± 0.015	1.796PheGlu: 1.796 ± 0.016	1.684PhePhe: 1.684 ± 0.027	2.559PheGly: 2.559 ± 0.02	0.982PheHis: 0.982 ± 0.011	1.625PheIle: 1.625 ± 0.015	1.392PheLys: 1.392 ± 0.014	3.785PheLeu: 3.785 ± 0.027	0.653PheMet: 0.653 ± 0.009	1.349PheAsn: 1.349 ± 0.013	1.889PhePro: 1.889 ± 0.017	1.528PheGln: 1.528 ± 0.012	2.438PheArg: 2.438 ± 0.019	3.486PheSer: 3.486 ± 0.021	2.544PheThr: 2.544 ± 0.016	2.483PheVal: 2.483 ± 0.017	0.538PheTrp: 0.538 ± 0.007	1.208PheTyr: 1.208 ± 0.012	0.002PheXaa: 0.002 ± 0.0
Gly	3.974GlyAla: 3.974 ± 0.025	1.301GlyCys: 1.301 ± 0.015	3.124GlyAsp: 3.124 ± 0.025	3.049GlyGlu: 3.049 ± 0.031	1.902GlyPhe: 1.902 ± 0.015	5.022GlyGly: 5.022 ± 0.064	1.868GlyHis: 1.868 ± 0.014	2.626GlyIle: 2.626 ± 0.019	2.306GlyLys: 2.306 ± 0.02	5.61GlyLeu: 5.61 ± 0.027	1.028GlyMet: 1.028 ± 0.011	1.828GlyAsn: 1.828 ± 0.016	2.944GlyPro: 2.944 ± 0.047	2.185GlyGln: 2.185 ± 0.016	4.04GlyArg: 4.04 ± 0.024	4.92GlySer: 4.92 ± 0.033	3.364GlyThr: 3.364 ± 0.021	3.525GlyVal: 3.525 ± 0.022	0.532GlyTrp: 0.532 ± 0.008	1.413GlyTyr: 1.413 ± 0.014	0.004GlyXaa: 0.004 ± 0.001
His	1.682HisAla: 1.682 ± 0.013	0.902HisCys: 0.902 ± 0.013	0.971HisAsp: 0.971 ± 0.011	1.21HisGlu: 1.21 ± 0.013	1.241HisPhe: 1.241 ± 0.013	1.343HisGly: 1.343 ± 0.014	1.057HisHis: 1.057 ± 0.016	1.175HisIle: 1.175 ± 0.014	1.162HisLys: 1.162 ± 0.013	3.551HisLeu: 3.551 ± 0.022	0.579HisMet: 0.579 ± 0.009	0.87HisAsn: 0.87 ± 0.009	1.857HisPro: 1.857 ± 0.018	1.354HisGln: 1.354 ± 0.013	2.411HisArg: 2.411 ± 0.02	2.073HisSer: 2.073 ± 0.018	1.342HisThr: 1.342 ± 0.014	1.345HisVal: 1.345 ± 0.012	0.288HisTrp: 0.288 ± 0.006	0.585HisTyr: 0.585 ± 0.009	0.001HisXaa: 0.001 ± 0.0
Ile	3.445IleAla: 3.445 ± 0.019	0.95IleCys: 0.95 ± 0.011	2.387IleAsp: 2.387 ± 0.016	2.146IleGlu: 2.146 ± 0.018	1.877IlePhe: 1.877 ± 0.017	2.259IleGly: 2.259 ± 0.019	1.219IleHis: 1.219 ± 0.015	2.167IleIle: 2.167 ± 0.026	1.756IleLys: 1.756 ± 0.015	4.326IleLeu: 4.326 ± 0.029	0.808IleMet: 0.808 ± 0.01	1.911IleAsn: 1.911 ± 0.017	2.548IlePro: 2.548 ± 0.017	1.727IleGln: 1.727 ± 0.014	3.178IleArg: 3.178 ± 0.027	4.069IleSer: 4.069 ± 0.023	2.456IleThr: 2.456 ± 0.018	2.663IleVal: 2.663 ± 0.017	0.44IleTrp: 0.44 ± 0.007	1.267IleTyr: 1.267 ± 0.013	0.001IleXaa: 0.001 ± 0.0
Lys	3.99LysAla: 3.99 ± 0.025	0.868LysCys: 0.868 ± 0.011	2.165LysAsp: 2.165 ± 0.019	2.564LysGlu: 2.564 ± 0.025	1.733LysPhe: 1.733 ± 0.014	2.003LysGly: 2.003 ± 0.027	1.008LysHis: 1.008 ± 0.012	2.029LysIle: 2.029 ± 0.015	2.779LysLys: 2.779 ± 0.052	4.012LysLeu: 4.012 ± 0.025	0.93LysMet: 0.93 ± 0.01	1.588LysAsn: 1.588 ± 0.015	2.472LysPro: 2.472 ± 0.021	1.68LysGln: 1.68 ± 0.015	3.278LysArg: 3.278 ± 0.021	3.242LysSer: 3.242 ± 0.019	2.834LysThr: 2.834 ± 0.02	2.487LysVal: 2.487 ± 0.018	0.46LysTrp: 0.46 ± 0.007	0.977LysTyr: 0.977 ± 0.011	0.001LysXaa: 0.001 ± 0.0
Leu	7.45LeuAla: 7.45 ± 0.037	1.773LeuCys: 1.773 ± 0.017	4.606LeuAsp: 4.606 ± 0.027	5.231LeuGlu: 5.231 ± 0.036	3.779LeuPhe: 3.779 ± 0.021	4.706LeuGly: 4.706 ± 0.025	2.715LeuHis: 2.715 ± 0.02	3.681LeuIle: 3.681 ± 0.024	4.474LeuLys: 4.474 ± 0.03	10.911LeuLeu: 10.911 ± 0.056	1.967LeuMet: 1.967 ± 0.016	3.824LeuAsn: 3.824 ± 0.02	7.147LeuPro: 7.147 ± 0.033	4.972LeuGln: 4.972 ± 0.028	7.704LeuArg: 7.704 ± 0.033	8.554LeuSer: 8.554 ± 0.04	5.922LeuThr: 5.922 ± 0.028	5.744LeuVal: 5.744 ± 0.03	0.889LeuTrp: 0.889 ± 0.01	1.998LeuTyr: 1.998 ± 0.016	0.005LeuXaa: 0.005 ± 0.001
Met	1.576MetAla: 1.576 ± 0.014	0.286MetCys: 0.286 ± 0.006	1.217MetAsp: 1.217 ± 0.012	1.217MetGlu: 1.217 ± 0.013	0.66MetPhe: 0.66 ± 0.008	1.127MetGly: 1.127 ± 0.014	0.644MetHis: 0.644 ± 0.008	0.748MetIle: 0.748 ± 0.011	0.845MetLys: 0.845 ± 0.011	1.734MetLeu: 1.734 ± 0.016	0.512MetMet: 0.512 ± 0.016	0.655MetAsn: 0.655 ± 0.009	1.099MetPro: 1.099 ± 0.011	1.09MetGln: 1.09 ± 0.011	1.518MetArg: 1.518 ± 0.013	1.458MetSer: 1.458 ± 0.014	1.144MetThr: 1.144 ± 0.011	1.168MetVal: 1.168 ± 0.014	0.211MetTrp: 0.211 ± 0.005	0.407MetTyr: 0.407 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	2.923AsnAla: 2.923 ± 0.017	0.869AsnCys: 0.869 ± 0.01	1.879AsnAsp: 1.879 ± 0.016	1.984AsnGlu: 1.984 ± 0.017	1.739AsnPhe: 1.739 ± 0.013	2.498AsnGly: 2.498 ± 0.021	1.02AsnHis: 1.02 ± 0.01	1.609AsnIle: 1.609 ± 0.015	1.406AsnLys: 1.406 ± 0.014	3.431AsnLeu: 3.431 ± 0.021	0.666AsnMet: 0.666 ± 0.009	1.479AsnAsn: 1.479 ± 0.017	2.113AsnPro: 2.113 ± 0.015	1.438AsnGln: 1.438 ± 0.012	2.73AsnArg: 2.73 ± 0.02	3.135AsnSer: 3.135 ± 0.025	2.365AsnThr: 2.365 ± 0.017	2.118AsnVal: 2.118 ± 0.016	0.488AsnTrp: 0.488 ± 0.008	0.942AsnTyr: 0.942 ± 0.01	0.001AsnXaa: 0.001 ± 0.0
Pro	4.781ProAla: 4.781 ± 0.03	1.097ProCys: 1.097 ± 0.013	3.056ProAsp: 3.056 ± 0.022	3.26ProGlu: 3.26 ± 0.023	1.924ProPhe: 1.924 ± 0.018	3.357ProGly: 3.357 ± 0.043	1.71ProHis: 1.71 ± 0.019	2.46ProIle: 2.46 ± 0.019	2.514ProLys: 2.514 ± 0.02	5.598ProLeu: 5.598 ± 0.033	1.117ProMet: 1.117 ± 0.012	2.259ProAsn: 2.259 ± 0.015	7.137ProPro: 7.137 ± 0.062	2.557ProGln: 2.557 ± 0.023	3.628ProArg: 3.628 ± 0.022	6.638ProSer: 6.638 ± 0.044	5.274ProThr: 5.274 ± 0.028	3.754ProVal: 3.754 ± 0.026	0.493ProTrp: 0.493 ± 0.008	1.269ProTyr: 1.269 ± 0.013	0.003ProXaa: 0.003 ± 0.001
Gln	2.868GlnAla: 2.868 ± 0.023	0.747GlnCys: 0.747 ± 0.01	1.697GlnAsp: 1.697 ± 0.014	2.157GlnGlu: 2.157 ± 0.018	1.499GlnPhe: 1.499 ± 0.013	1.928GlnGly: 1.928 ± 0.02	1.318GlnHis: 1.318 ± 0.014	1.88GlnIle: 1.88 ± 0.016	1.834GlnLys: 1.834 ± 0.015	4.951GlnLeu: 4.951 ± 0.03	0.955GlnMet: 0.955 ± 0.011	1.327GlnAsn: 1.327 ± 0.013	2.827GlnPro: 2.827 ± 0.024	3.135GlnGln: 3.135 ± 0.056	3.369GlnArg: 3.369 ± 0.021	3.359GlnSer: 3.359 ± 0.022	2.432GlnThr: 2.432 ± 0.02	2.299GlnVal: 2.299 ± 0.019	0.456GlnTrp: 0.456 ± 0.007	0.798GlnTyr: 0.798 ± 0.009	0.001GlnXaa: 0.001 ± 0.0
Arg	4.178ArgAla: 4.178 ± 0.023	1.416ArgCys: 1.416 ± 0.016	2.95ArgAsp: 2.95 ± 0.02	3.471ArgGlu: 3.471 ± 0.02	2.393ArgPhe: 2.393 ± 0.017	3.419ArgGly: 3.419 ± 0.031	2.127ArgHis: 2.127 ± 0.016	3.716ArgIle: 3.716 ± 0.04	3.227ArgLys: 3.227 ± 0.021	8.014ArgLeu: 8.014 ± 0.036	1.545ArgMet: 1.545 ± 0.015	2.414ArgAsn: 2.414 ± 0.016	4.548ArgPro: 4.548 ± 0.029	3.598ArgGln: 3.598 ± 0.023	6.827ArgArg: 6.827 ± 0.042	5.597ArgSer: 5.597 ± 0.032	4.398ArgThr: 4.398 ± 0.027	3.618ArgVal: 3.618 ± 0.022	1.005ArgTrp: 1.005 ± 0.012	1.55ArgTyr: 1.55 ± 0.012	0.003ArgXaa: 0.003 ± 0.001
Ser	7.242SerAla: 7.242 ± 0.036	1.817SerCys: 1.817 ± 0.016	4.453SerAsp: 4.453 ± 0.022	4.572SerGlu: 4.572 ± 0.029	2.806SerPhe: 2.806 ± 0.021	5.389SerGly: 5.389 ± 0.033	2.143SerHis: 2.143 ± 0.016	3.38SerIle: 3.38 ± 0.024	3.517SerLys: 3.517 ± 0.021	8.087SerLeu: 8.087 ± 0.035	1.506SerMet: 1.506 ± 0.014	3.093SerAsn: 3.093 ± 0.02	6.399SerPro: 6.399 ± 0.041	3.449SerGln: 3.449 ± 0.025	5.621SerArg: 5.621 ± 0.029	11.864SerSer: 11.864 ± 0.092	6.686SerThr: 6.686 ± 0.034	5.385SerVal: 5.385 ± 0.028	0.757SerTrp: 0.757 ± 0.01	1.618SerTyr: 1.618 ± 0.014	0.004SerXaa: 0.004 ± 0.001
Thr	6.02ThrAla: 6.02 ± 0.03	1.385ThrCys: 1.385 ± 0.014	3.634ThrAsp: 3.634 ± 0.019	3.45ThrGlu: 3.45 ± 0.023	2.84ThrPhe: 2.84 ± 0.02	3.705ThrGly: 3.705 ± 0.023	1.526ThrHis: 1.526 ± 0.013	2.855ThrIle: 2.855 ± 0.018	2.557ThrLys: 2.557 ± 0.018	5.26ThrLeu: 5.26 ± 0.023	1.143ThrMet: 1.143 ± 0.011	2.578ThrAsn: 2.578 ± 0.016	4.33ThrPro: 4.33 ± 0.027	2.08ThrGln: 2.08 ± 0.017	3.334ThrArg: 3.334 ± 0.02	6.157ThrSer: 6.157 ± 0.032	5.812ThrThr: 5.812 ± 0.051	4.482ThrVal: 4.482 ± 0.025	0.698ThrTrp: 0.698 ± 0.01	1.478ThrTyr: 1.478 ± 0.014	0.003ThrXaa: 0.003 ± 0.001
Val	4.838ValAla: 4.838 ± 0.024	1.344ValCys: 1.344 ± 0.011	3.701ValAsp: 3.701 ± 0.02	3.521ValGlu: 3.521 ± 0.022	2.612ValPhe: 2.612 ± 0.02	3.608ValGly: 3.608 ± 0.021	1.733ValHis: 1.733 ± 0.014	2.716ValIle: 2.716 ± 0.02	2.606ValLys: 2.606 ± 0.017	5.904ValLeu: 5.904 ± 0.025	1.129ValMet: 1.129 ± 0.012	2.432ValAsn: 2.432 ± 0.017	3.621ValPro: 3.621 ± 0.022	2.213ValGln: 2.213 ± 0.019	3.832ValArg: 3.832 ± 0.022	5.484ValSer: 5.484 ± 0.029	3.499ValThr: 3.499 ± 0.024	4.088ValVal: 4.088 ± 0.029	0.67ValTrp: 0.67 ± 0.008	1.762ValTyr: 1.762 ± 0.016	0.003ValXaa: 0.003 ± 0.001
Trp	0.736TrpAla: 0.736 ± 0.01	0.274TrpCys: 0.274 ± 0.006	0.429TrpAsp: 0.429 ± 0.007	0.473TrpGlu: 0.473 ± 0.008	0.426TrpPhe: 0.426 ± 0.007	0.38TrpGly: 0.38 ± 0.007	0.305TrpHis: 0.305 ± 0.006	0.561TrpIle: 0.561 ± 0.009	0.57TrpLys: 0.57 ± 0.007	1.032TrpLeu: 1.032 ± 0.011	0.259TrpMet: 0.259 ± 0.006	0.481TrpAsn: 0.481 ± 0.007	0.585TrpPro: 0.585 ± 0.009	0.456TrpGln: 0.456 ± 0.008	1.06TrpArg: 1.06 ± 0.012	0.977TrpSer: 0.977 ± 0.01	0.828TrpThr: 0.828 ± 0.011	0.497TrpVal: 0.497 ± 0.007	0.126TrpTrp: 0.126 ± 0.004	0.241TrpTyr: 0.241 ± 0.005	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.699TyrAla: 1.699 ± 0.016	0.522TyrCys: 0.522 ± 0.008	1.132TyrAsp: 1.132 ± 0.012	1.36TyrGlu: 1.36 ± 0.013	0.967TyrPhe: 0.967 ± 0.011	1.496TyrGly: 1.496 ± 0.015	0.622TyrHis: 0.622 ± 0.008	0.979TyrIle: 0.979 ± 0.01	1.132TyrLys: 1.132 ± 0.013	2.339TyrLeu: 2.339 ± 0.015	0.414TyrMet: 0.414 ± 0.007	0.767TyrAsn: 0.767 ± 0.01	1.185TyrPro: 1.185 ± 0.013	0.815TyrGln: 0.815 ± 0.01	1.862TyrArg: 1.862 ± 0.015	1.824TyrSer: 1.824 ± 0.016	1.417TyrThr: 1.417 ± 0.014	1.578TyrVal: 1.578 ± 0.013	0.263TyrTrp: 0.263 ± 0.005	0.695TyrTyr: 0.695 ± 0.023	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.003XaaGlu: 0.003 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.006XaaLeu: 0.006 ± 0.001	0.003XaaMet: 0.003 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.004XaaPro: 0.004 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.003XaaArg: 0.003 ± 0.001	0.005XaaSer: 0.005 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.025XaaXaa: 0.025 ± 0.004

Statistics based on 22389 proteins (9039214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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