Amino acid dipepetide frequency for Diaporthe helianthi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.776AlaAla: 10.776 ± 0.067	1.101AlaCys: 1.101 ± 0.015	4.778AlaAsp: 4.778 ± 0.027	5.406AlaGlu: 5.406 ± 0.034	3.179AlaPhe: 3.179 ± 0.022	6.893AlaGly: 6.893 ± 0.042	1.915AlaHis: 1.915 ± 0.021	4.004AlaIle: 4.004 ± 0.03	4.051AlaLys: 4.051 ± 0.028	7.851AlaLeu: 7.851 ± 0.04	2.075AlaMet: 2.075 ± 0.019	3.088AlaAsn: 3.088 ± 0.025	5.28AlaPro: 5.28 ± 0.037	3.702AlaGln: 3.702 ± 0.03	5.393AlaArg: 5.393 ± 0.033	7.636AlaSer: 7.636 ± 0.044	5.638AlaThr: 5.638 ± 0.034	5.939AlaVal: 5.939 ± 0.031	1.296AlaTrp: 1.296 ± 0.016	2.187AlaTyr: 2.187 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.014	0.247CysCys: 0.247 ± 0.008	0.654CysAsp: 0.654 ± 0.011	0.579CysGlu: 0.579 ± 0.01	0.5CysPhe: 0.5 ± 0.01	0.973CysGly: 0.973 ± 0.014	0.314CysHis: 0.314 ± 0.007	0.64CysIle: 0.64 ± 0.011	0.474CysLys: 0.474 ± 0.009	1.195CysLeu: 1.195 ± 0.015	0.256CysMet: 0.256 ± 0.006	0.415CysAsn: 0.415 ± 0.009	0.684CysPro: 0.684 ± 0.011	0.424CysGln: 0.424 ± 0.008	0.718CysArg: 0.718 ± 0.012	0.882CysSer: 0.882 ± 0.014	0.68CysThr: 0.68 ± 0.012	0.815CysVal: 0.815 ± 0.011	0.207CysTrp: 0.207 ± 0.006	0.333CysTyr: 0.333 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.036AspAla: 5.036 ± 0.03	0.625AspCys: 0.625 ± 0.011	4.736AspAsp: 4.736 ± 0.038	4.631AspGlu: 4.631 ± 0.034	2.252AspPhe: 2.252 ± 0.02	4.672AspGly: 4.672 ± 0.036	1.307AspHis: 1.307 ± 0.014	2.772AspIle: 2.772 ± 0.023	2.535AspLys: 2.535 ± 0.025	5.076AspLeu: 5.076 ± 0.035	1.359AspMet: 1.359 ± 0.016	1.915AspAsn: 1.915 ± 0.018	3.462AspPro: 3.462 ± 0.026	1.945AspGln: 1.945 ± 0.018	3.141AspArg: 3.141 ± 0.03	4.136AspSer: 4.136 ± 0.029	2.952AspThr: 2.952 ± 0.022	3.814AspVal: 3.814 ± 0.026	0.925AspTrp: 0.925 ± 0.013	1.573AspTyr: 1.573 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.691GluAla: 5.691 ± 0.035	0.575GluCys: 0.575 ± 0.01	4.249GluAsp: 4.249 ± 0.033	4.83GluGlu: 4.83 ± 0.044	1.862GluPhe: 1.862 ± 0.02	3.813GluGly: 3.813 ± 0.026	1.367GluHis: 1.367 ± 0.016	2.686GluIle: 2.686 ± 0.018	3.308GluLys: 3.308 ± 0.028	5.025GluLeu: 5.025 ± 0.035	1.414GluMet: 1.414 ± 0.016	2.096GluAsn: 2.096 ± 0.02	2.95GluPro: 2.95 ± 0.027	2.471GluGln: 2.471 ± 0.025	3.768GluArg: 3.768 ± 0.034	3.896GluSer: 3.896 ± 0.029	3.302GluThr: 3.302 ± 0.026	3.568GluVal: 3.568 ± 0.023	0.878GluTrp: 0.878 ± 0.012	1.557GluTyr: 1.557 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.048PheAla: 3.048 ± 0.022	0.538PheCys: 0.538 ± 0.01	2.31PheAsp: 2.31 ± 0.018	2.085PheGlu: 2.085 ± 0.02	1.549PhePhe: 1.549 ± 0.02	2.95PheGly: 2.95 ± 0.025	0.866PheHis: 0.866 ± 0.012	1.655PheIle: 1.655 ± 0.018	1.466PheLys: 1.466 ± 0.017	3.282PheLeu: 3.282 ± 0.026	0.808PheMet: 0.808 ± 0.013	1.417PheAsn: 1.417 ± 0.015	1.919PhePro: 1.919 ± 0.019	1.332PheGln: 1.332 ± 0.017	1.934PheArg: 1.934 ± 0.017	2.864PheSer: 2.864 ± 0.024	2.084PheThr: 2.084 ± 0.02	2.454PheVal: 2.454 ± 0.02	0.659PheTrp: 0.659 ± 0.01	1.063PheTyr: 1.063 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	6.209GlyAla: 6.209 ± 0.039	0.906GlyCys: 0.906 ± 0.013	4.165GlyAsp: 4.165 ± 0.029	3.819GlyGlu: 3.819 ± 0.028	2.884GlyPhe: 2.884 ± 0.025	7.199GlyGly: 7.199 ± 0.06	1.875GlyHis: 1.875 ± 0.02	3.421GlyIle: 3.421 ± 0.026	3.374GlyLys: 3.374 ± 0.027	6.453GlyLeu: 6.453 ± 0.038	1.65GlyMet: 1.65 ± 0.015	2.652GlyAsn: 2.652 ± 0.023	3.996GlyPro: 3.996 ± 0.034	2.913GlyGln: 2.913 ± 0.027	4.543GlyArg: 4.543 ± 0.035	6.252GlySer: 6.252 ± 0.035	4.308GlyThr: 4.308 ± 0.03	4.623GlyVal: 4.623 ± 0.031	1.244GlyTrp: 1.244 ± 0.016	2.096GlyTyr: 2.096 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.915HisAla: 1.915 ± 0.019	0.332HisCys: 0.332 ± 0.007	1.387HisAsp: 1.387 ± 0.018	1.356HisGlu: 1.356 ± 0.016	0.894HisPhe: 0.894 ± 0.012	1.858HisGly: 1.858 ± 0.02	0.939HisHis: 0.939 ± 0.016	1.078HisIle: 1.078 ± 0.015	0.948HisLys: 0.948 ± 0.014	2.115HisLeu: 2.115 ± 0.019	0.507HisMet: 0.507 ± 0.01	0.834HisAsn: 0.834 ± 0.012	1.621HisPro: 1.621 ± 0.016	1.021HisGln: 1.021 ± 0.014	1.505HisArg: 1.505 ± 0.018	1.769HisSer: 1.769 ± 0.019	1.207HisThr: 1.207 ± 0.014	1.513HisVal: 1.513 ± 0.015	0.338HisTrp: 0.338 ± 0.007	0.652HisTyr: 0.652 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.863IleAla: 3.863 ± 0.026	0.676IleCys: 0.676 ± 0.01	2.639IleAsp: 2.639 ± 0.019	2.509IleGlu: 2.509 ± 0.022	1.814IlePhe: 1.814 ± 0.02	3.004IleGly: 3.004 ± 0.026	1.061IleHis: 1.061 ± 0.014	2.239IleIle: 2.239 ± 0.024	1.989IleLys: 1.989 ± 0.021	4.091IleLeu: 4.091 ± 0.033	1.02IleMet: 1.02 ± 0.014	1.668IleAsn: 1.668 ± 0.017	2.771IlePro: 2.771 ± 0.022	1.71IleGln: 1.71 ± 0.019	2.567IleArg: 2.567 ± 0.021	3.503IleSer: 3.503 ± 0.026	2.69IleThr: 2.69 ± 0.023	2.936IleVal: 2.936 ± 0.024	0.697IleTrp: 0.697 ± 0.011	1.267IleTyr: 1.267 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.335LysAla: 4.335 ± 0.033	0.463LysCys: 0.463 ± 0.009	2.718LysAsp: 2.718 ± 0.024	2.99LysGlu: 2.99 ± 0.029	1.403LysPhe: 1.403 ± 0.015	3.003LysGly: 3.003 ± 0.025	1.071LysHis: 1.071 ± 0.011	2.031LysIle: 2.031 ± 0.021	3.116LysLys: 3.116 ± 0.04	3.806LysLeu: 3.806 ± 0.029	0.998LysMet: 0.998 ± 0.016	1.586LysAsn: 1.586 ± 0.019	2.66LysPro: 2.66 ± 0.024	1.78LysGln: 1.78 ± 0.016	3.163LysArg: 3.163 ± 0.026	3.224LysSer: 3.224 ± 0.025	2.798LysThr: 2.798 ± 0.023	2.715LysVal: 2.715 ± 0.023	0.659LysTrp: 0.659 ± 0.01	1.286LysTyr: 1.286 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.229LeuAla: 8.229 ± 0.042	1.155LeuCys: 1.155 ± 0.016	5.188LeuAsp: 5.188 ± 0.031	5.17LeuGlu: 5.17 ± 0.037	3.165LeuPhe: 3.165 ± 0.026	6.254LeuGly: 6.254 ± 0.031	2.065LeuHis: 2.065 ± 0.019	3.552LeuIle: 3.552 ± 0.027	3.877LeuLys: 3.877 ± 0.029	7.872LeuLeu: 7.872 ± 0.055	1.754LeuMet: 1.754 ± 0.017	2.926LeuAsn: 2.926 ± 0.022	5.363LeuPro: 5.363 ± 0.03	3.556LeuGln: 3.556 ± 0.027	5.704LeuArg: 5.704 ± 0.039	6.873LeuSer: 6.873 ± 0.039	4.674LeuThr: 4.674 ± 0.031	5.624LeuVal: 5.624 ± 0.035	1.241LeuTrp: 1.241 ± 0.015	2.186LeuTyr: 2.186 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.418MetAla: 2.418 ± 0.018	0.241MetCys: 0.241 ± 0.007	1.278MetAsp: 1.278 ± 0.015	1.233MetGlu: 1.233 ± 0.015	0.75MetPhe: 0.75 ± 0.013	1.536MetGly: 1.536 ± 0.017	0.477MetHis: 0.477 ± 0.009	0.946MetIle: 0.946 ± 0.013	0.933MetLys: 0.933 ± 0.012	1.845MetLeu: 1.845 ± 0.017	0.598MetMet: 0.598 ± 0.01	0.744MetAsn: 0.744 ± 0.011	1.34MetPro: 1.34 ± 0.017	0.847MetGln: 0.847 ± 0.012	1.32MetArg: 1.32 ± 0.015	1.905MetSer: 1.905 ± 0.017	1.317MetThr: 1.317 ± 0.016	1.334MetVal: 1.334 ± 0.015	0.287MetTrp: 0.287 ± 0.007	0.532MetTyr: 0.532 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.043AsnAla: 3.043 ± 0.023	0.421AsnCys: 0.421 ± 0.009	1.868AsnAsp: 1.868 ± 0.019	1.868AsnGlu: 1.868 ± 0.018	1.375AsnPhe: 1.375 ± 0.015	3.073AsnGly: 3.073 ± 0.03	0.816AsnHis: 0.816 ± 0.012	1.864AsnIle: 1.864 ± 0.019	1.538AsnLys: 1.538 ± 0.019	3.078AsnLeu: 3.078 ± 0.021	0.865AsnMet: 0.865 ± 0.014	1.601AsnAsn: 1.601 ± 0.023	2.336AsnPro: 2.336 ± 0.02	1.273AsnGln: 1.273 ± 0.017	1.805AsnArg: 1.805 ± 0.018	2.69AsnSer: 2.69 ± 0.022	2.158AsnThr: 2.158 ± 0.021	2.286AsnVal: 2.286 ± 0.02	0.55AsnTrp: 0.55 ± 0.01	1.027AsnTyr: 1.027 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.033ProAla: 6.033 ± 0.045	0.511ProCys: 0.511 ± 0.008	3.413ProAsp: 3.413 ± 0.023	3.837ProGlu: 3.837 ± 0.027	2.021ProPhe: 2.021 ± 0.021	4.648ProGly: 4.648 ± 0.04	1.337ProHis: 1.337 ± 0.015	2.316ProIle: 2.316 ± 0.021	2.586ProLys: 2.586 ± 0.027	4.634ProLeu: 4.634 ± 0.03	1.105ProMet: 1.105 ± 0.014	2.134ProAsn: 2.134 ± 0.02	5.561ProPro: 5.561 ± 0.065	2.563ProGln: 2.563 ± 0.031	3.724ProArg: 3.724 ± 0.031	5.904ProSer: 5.904 ± 0.046	4.002ProThr: 4.002 ± 0.029	3.742ProVal: 3.742 ± 0.031	0.801ProTrp: 0.801 ± 0.012	1.456ProTyr: 1.456 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.775GlnAla: 3.775 ± 0.031	0.438GlnCys: 0.438 ± 0.009	2.238GlnAsp: 2.238 ± 0.021	2.284GlnGlu: 2.284 ± 0.024	1.226GlnPhe: 1.226 ± 0.015	2.671GlnGly: 2.671 ± 0.023	1.136GlnHis: 1.136 ± 0.015	1.696GlnIle: 1.696 ± 0.017	1.822GlnLys: 1.822 ± 0.02	3.347GlnLeu: 3.347 ± 0.025	0.877GlnMet: 0.877 ± 0.012	1.46GlnAsn: 1.46 ± 0.017	2.761GlnPro: 2.761 ± 0.029	2.764GlnGln: 2.764 ± 0.044	2.656GlnArg: 2.656 ± 0.022	2.927GlnSer: 2.927 ± 0.023	2.209GlnThr: 2.209 ± 0.019	2.296GlnVal: 2.296 ± 0.019	0.576GlnTrp: 0.576 ± 0.01	1.125GlnTyr: 1.125 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.084ArgAla: 5.084 ± 0.033	0.704ArgCys: 0.704 ± 0.011	3.623ArgAsp: 3.623 ± 0.03	3.682ArgGlu: 3.682 ± 0.03	2.109ArgPhe: 2.109 ± 0.018	4.026ArgGly: 4.026 ± 0.033	1.638ArgHis: 1.638 ± 0.017	2.624ArgIle: 2.624 ± 0.021	3.231ArgLys: 3.231 ± 0.028	5.516ArgLeu: 5.516 ± 0.035	1.326ArgMet: 1.326 ± 0.015	2.18ArgAsn: 2.18 ± 0.018	3.83ArgPro: 3.83 ± 0.033	2.716ArgGln: 2.716 ± 0.024	5.247ArgArg: 5.247 ± 0.041	4.721ArgSer: 4.721 ± 0.035	3.241ArgThr: 3.241 ± 0.026	3.431ArgVal: 3.431 ± 0.023	0.977ArgTrp: 0.977 ± 0.012	1.559ArgTyr: 1.559 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.999SerAla: 6.999 ± 0.043	0.859SerCys: 0.859 ± 0.015	4.164SerAsp: 4.164 ± 0.028	3.935SerGlu: 3.935 ± 0.027	2.896SerPhe: 2.896 ± 0.023	6.047SerGly: 6.047 ± 0.037	1.868SerHis: 1.868 ± 0.02	3.607SerIle: 3.607 ± 0.027	3.484SerLys: 3.484 ± 0.027	6.814SerLeu: 6.814 ± 0.034	1.731SerMet: 1.731 ± 0.016	2.862SerAsn: 2.862 ± 0.024	5.59SerPro: 5.59 ± 0.052	3.201SerGln: 3.201 ± 0.023	4.988SerArg: 4.988 ± 0.033	8.911SerSer: 8.911 ± 0.067	5.408SerThr: 5.408 ± 0.045	4.549SerVal: 4.549 ± 0.028	1.144SerTrp: 1.144 ± 0.015	1.956SerTyr: 1.956 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	5.641ThrAla: 5.641 ± 0.036	0.749ThrCys: 0.749 ± 0.011	2.859ThrAsp: 2.859 ± 0.023	2.939ThrGlu: 2.939 ± 0.022	2.19ThrPhe: 2.19 ± 0.022	4.495ThrGly: 4.495 ± 0.031	1.242ThrHis: 1.242 ± 0.016	2.839ThrIle: 2.839 ± 0.023	2.489ThrLys: 2.489 ± 0.021	4.917ThrLeu: 4.917 ± 0.031	1.218ThrMet: 1.218 ± 0.016	2.077ThrAsn: 2.077 ± 0.019	4.31ThrPro: 4.31 ± 0.034	2.071ThrGln: 2.071 ± 0.02	3.23ThrArg: 3.23 ± 0.025	5.252ThrSer: 5.252 ± 0.038	4.46ThrThr: 4.46 ± 0.043	3.826ThrVal: 3.826 ± 0.027	0.904ThrTrp: 0.904 ± 0.014	1.568ThrTyr: 1.568 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.724ValAla: 5.724 ± 0.032	0.823ValCys: 0.823 ± 0.011	3.931ValAsp: 3.931 ± 0.03	3.837ValGlu: 3.837 ± 0.026	2.495ValPhe: 2.495 ± 0.023	4.36ValGly: 4.36 ± 0.031	1.398ValHis: 1.398 ± 0.012	2.807ValIle: 2.807 ± 0.022	2.774ValLys: 2.774 ± 0.024	5.651ValLeu: 5.651 ± 0.034	1.342ValMet: 1.342 ± 0.015	2.171ValAsn: 2.171 ± 0.02	3.805ValPro: 3.805 ± 0.028	2.381ValGln: 2.381 ± 0.017	3.552ValArg: 3.552 ± 0.022	4.678ValSer: 4.678 ± 0.03	3.645ValThr: 3.645 ± 0.028	4.676ValVal: 4.676 ± 0.035	0.925ValTrp: 0.925 ± 0.013	1.738ValTyr: 1.738 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.291TrpAla: 1.291 ± 0.016	0.204TrpCys: 0.204 ± 0.006	1.0TrpAsp: 1.0 ± 0.013	0.851TrpGlu: 0.851 ± 0.011	0.566TrpPhe: 0.566 ± 0.011	1.006TrpGly: 1.006 ± 0.015	0.364TrpHis: 0.364 ± 0.008	0.689TrpIle: 0.689 ± 0.012	0.761TrpLys: 0.761 ± 0.011	1.411TrpLeu: 1.411 ± 0.014	0.376TrpMet: 0.376 ± 0.008	0.622TrpAsn: 0.622 ± 0.011	0.671TrpPro: 0.671 ± 0.012	0.578TrpGln: 0.578 ± 0.01	0.973TrpArg: 0.973 ± 0.013	1.069TrpSer: 1.069 ± 0.013	0.965TrpThr: 0.965 ± 0.012	0.956TrpVal: 0.956 ± 0.013	0.302TrpTrp: 0.302 ± 0.007	0.426TrpTyr: 0.426 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.111TyrAla: 2.111 ± 0.02	0.388TyrCys: 0.388 ± 0.009	1.665TyrAsp: 1.665 ± 0.017	1.466TyrGlu: 1.466 ± 0.016	1.153TyrPhe: 1.153 ± 0.013	2.102TyrGly: 2.102 ± 0.022	0.732TyrHis: 0.732 ± 0.01	1.247TyrIle: 1.247 ± 0.017	1.05TyrLys: 1.05 ± 0.014	2.451TyrLeu: 2.451 ± 0.022	0.603TyrMet: 0.603 ± 0.01	1.086TyrAsn: 1.086 ± 0.013	1.419TyrPro: 1.419 ± 0.016	1.034TyrGln: 1.034 ± 0.016	1.535TyrArg: 1.535 ± 0.016	1.923TyrSer: 1.923 ± 0.019	1.536TyrThr: 1.536 ± 0.02	1.616TyrVal: 1.616 ± 0.018	0.472TyrTrp: 0.472 ± 0.009	0.906TyrTyr: 0.906 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.022XaaXaa: 0.022 ± 0.009

Statistics based on 13137 proteins (6232127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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