Amino acid dipepetide frequency for Leishmania donovani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.022AlaAla: 21.022 ± 0.187
1.789AlaCys: 1.789 ± 0.031
5.577AlaAsp: 5.577 ± 0.052
7.757AlaGlu: 7.757 ± 0.134
3.052AlaPhe: 3.052 ± 0.038
7.287AlaGly: 7.287 ± 0.061
2.761AlaHis: 2.761 ± 0.03
2.991AlaIle: 2.991 ± 0.026
3.831AlaLys: 3.831 ± 0.053
10.474AlaLeu: 10.474 ± 0.084
2.568AlaMet: 2.568 ± 0.027
2.735AlaAsn: 2.735 ± 0.038
7.104AlaPro: 7.104 ± 0.088
4.564AlaGln: 4.564 ± 0.059
7.116AlaArg: 7.116 ± 0.085
11.022AlaSer: 11.022 ± 0.092
7.873AlaThr: 7.873 ± 0.066
9.214AlaVal: 9.214 ± 0.363
1.031AlaTrp: 1.031 ± 0.016
2.284AlaTyr: 2.284 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
2.365CysAla: 2.365 ± 0.192
0.518CysCys: 0.518 ± 0.013
0.948CysAsp: 0.948 ± 0.02
0.919CysGlu: 0.919 ± 0.015
0.666CysPhe: 0.666 ± 0.012
1.64CysGly: 1.64 ± 0.041
0.438CysHis: 0.438 ± 0.01
0.715CysIle: 0.715 ± 0.013
0.486CysLys: 0.486 ± 0.011
1.532CysLeu: 1.532 ± 0.024
0.404CysMet: 0.404 ± 0.011
0.48CysAsn: 0.48 ± 0.009
0.881CysPro: 0.881 ± 0.016
0.488CysGln: 0.488 ± 0.012
1.276CysArg: 1.276 ± 0.017
1.542CysSer: 1.542 ± 0.022
1.187CysThr: 1.187 ± 0.023
1.631CysVal: 1.631 ± 0.027
0.213CysTrp: 0.213 ± 0.007
0.459CysTyr: 0.459 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.795AspAla: 6.795 ± 0.065
0.755AspCys: 0.755 ± 0.013
3.363AspAsp: 3.363 ± 0.037
3.544AspGlu: 3.544 ± 0.047
1.432AspPhe: 1.432 ± 0.019
4.234AspGly: 4.234 ± 0.04
0.947AspHis: 0.947 ± 0.014
1.727AspIle: 1.727 ± 0.02
1.496AspLys: 1.496 ± 0.027
3.654AspLeu: 3.654 ± 0.045
1.189AspMet: 1.189 ± 0.022
1.249AspAsn: 1.249 ± 0.022
2.382AspPro: 2.382 ± 0.04
1.094AspGln: 1.094 ± 0.015
2.787AspArg: 2.787 ± 0.047
3.512AspSer: 3.512 ± 0.036
2.739AspThr: 2.739 ± 0.031
4.202AspVal: 4.202 ± 0.038
0.488AspTrp: 0.488 ± 0.012
1.172AspTyr: 1.172 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
7.893GluAla: 7.893 ± 0.153
0.92GluCys: 0.92 ± 0.024
3.5GluAsp: 3.5 ± 0.048
5.777GluGlu: 5.777 ± 0.113
1.32GluPhe: 1.32 ± 0.021
3.707GluGly: 3.707 ± 0.041
1.465GluHis: 1.465 ± 0.022
1.452GluIle: 1.452 ± 0.023
2.691GluLys: 2.691 ± 0.058
5.779GluLeu: 5.779 ± 0.076
1.515GluMet: 1.515 ± 0.021
1.551GluAsn: 1.551 ± 0.023
2.255GluPro: 2.255 ± 0.042
2.689GluGln: 2.689 ± 0.05
4.78GluArg: 4.78 ± 0.081
3.797GluSer: 3.797 ± 0.035
2.799GluThr: 2.799 ± 0.049
4.448GluVal: 4.448 ± 0.038
0.744GluTrp: 0.744 ± 0.018
1.335GluTyr: 1.335 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
2.888PheAla: 2.888 ± 0.029
0.63PheCys: 0.63 ± 0.012
1.56PheAsp: 1.56 ± 0.024
1.455PheGlu: 1.455 ± 0.02
1.405PhePhe: 1.405 ± 0.023
1.934PheGly: 1.934 ± 0.031
0.82PheHis: 0.82 ± 0.015
1.09PheIle: 1.09 ± 0.021
0.856PheLys: 0.856 ± 0.017
2.956PheLeu: 2.956 ± 0.033
0.718PheMet: 0.718 ± 0.014
0.882PheAsn: 0.882 ± 0.014
1.454PhePro: 1.454 ± 0.021
1.026PheGln: 1.026 ± 0.018
1.766PheArg: 1.766 ± 0.026
2.619PheSer: 2.619 ± 0.028
1.866PheThr: 1.866 ± 0.024
2.331PheVal: 2.331 ± 0.034
0.3PheTrp: 0.3 ± 0.007
0.917PheTyr: 0.917 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
8.09GlyAla: 8.09 ± 0.071
1.3GlyCys: 1.3 ± 0.028
3.747GlyAsp: 3.747 ± 0.037
3.575GlyGlu: 3.575 ± 0.037
1.888GlyPhe: 1.888 ± 0.027
6.686GlyGly: 6.686 ± 0.073
1.559GlyHis: 1.559 ± 0.026
2.155GlyIle: 2.155 ± 0.031
2.33GlyLys: 2.33 ± 0.029
4.53GlyLeu: 4.53 ± 0.039
1.391GlyMet: 1.391 ± 0.017
1.959GlyAsn: 1.959 ± 0.023
2.532GlyPro: 2.532 ± 0.039
1.87GlyGln: 1.87 ± 0.028
4.169GlyArg: 4.169 ± 0.036
6.051GlySer: 6.051 ± 0.064
4.018GlyThr: 4.018 ± 0.036
5.054GlyVal: 5.054 ± 0.165
0.633GlyTrp: 0.633 ± 0.012
1.507GlyTyr: 1.507 ± 0.021
0.0GlyXaa: 0.0 ± 0.0
His
2.79HisAla: 2.79 ± 0.03
0.544HisCys: 0.544 ± 0.011
1.203HisAsp: 1.203 ± 0.019
1.354HisGlu: 1.354 ± 0.019
0.827HisPhe: 0.827 ± 0.014
1.841HisGly: 1.841 ± 0.028
1.041HisHis: 1.041 ± 0.016
0.923HisIle: 0.923 ± 0.016
0.752HisLys: 0.752 ± 0.015
2.443HisLeu: 2.443 ± 0.029
0.552HisMet: 0.552 ± 0.011
0.768HisAsn: 0.768 ± 0.014
1.632HisPro: 1.632 ± 0.024
1.081HisGln: 1.081 ± 0.018
2.296HisArg: 2.296 ± 0.025
2.095HisSer: 2.095 ± 0.026
1.551HisThr: 1.551 ± 0.019
1.888HisVal: 1.888 ± 0.023
0.302HisTrp: 0.302 ± 0.009
0.749HisTyr: 0.749 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.303IleAla: 3.303 ± 0.036
0.564IleCys: 0.564 ± 0.013
1.691IleAsp: 1.691 ± 0.019
1.788IleGlu: 1.788 ± 0.023
1.142IlePhe: 1.142 ± 0.023
1.966IleGly: 1.966 ± 0.025
0.777IleHis: 0.777 ± 0.012
1.22IleIle: 1.22 ± 0.024
1.015IleLys: 1.015 ± 0.021
2.577IleLeu: 2.577 ± 0.033
0.718IleMet: 0.718 ± 0.013
0.883IleAsn: 0.883 ± 0.017
1.798IlePro: 1.798 ± 0.021
1.059IleGln: 1.059 ± 0.017
1.951IleArg: 1.951 ± 0.024
2.362IleSer: 2.362 ± 0.027
1.92IleThr: 1.92 ± 0.025
2.266IleVal: 2.266 ± 0.031
0.243IleTrp: 0.243 ± 0.006
0.741IleTyr: 0.741 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
3.684LysAla: 3.684 ± 0.039
0.5LysCys: 0.5 ± 0.012
1.856LysAsp: 1.856 ± 0.028
2.625LysGlu: 2.625 ± 0.059
0.71LysPhe: 0.71 ± 0.016
2.105LysGly: 2.105 ± 0.034
0.813LysHis: 0.813 ± 0.014
0.947LysIle: 0.947 ± 0.019
1.915LysLys: 1.915 ± 0.034
2.867LysLeu: 2.867 ± 0.037
0.864LysMet: 0.864 ± 0.017
0.958LysAsn: 0.958 ± 0.019
1.693LysPro: 1.693 ± 0.027
1.418LysGln: 1.418 ± 0.026
2.752LysArg: 2.752 ± 0.033
2.304LysSer: 2.304 ± 0.032
1.828LysThr: 1.828 ± 0.025
2.185LysVal: 2.185 ± 0.028
0.373LysTrp: 0.373 ± 0.013
0.85LysTyr: 0.85 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
8.706LeuAla: 8.706 ± 0.075
2.097LeuCys: 2.097 ± 0.026
4.075LeuAsp: 4.075 ± 0.039
5.43LeuGlu: 5.43 ± 0.11
3.116LeuPhe: 3.116 ± 0.037
4.53LeuGly: 4.53 ± 0.042
3.017LeuHis: 3.017 ± 0.036
2.593LeuIle: 2.593 ± 0.031
3.029LeuLys: 3.029 ± 0.036
10.227LeuLeu: 10.227 ± 0.079
2.021LeuMet: 2.021 ± 0.024
2.347LeuAsn: 2.347 ± 0.031
5.891LeuPro: 5.891 ± 0.05
4.953LeuGln: 4.953 ± 0.052
8.339LeuArg: 8.339 ± 0.194
7.792LeuSer: 7.792 ± 0.053
4.934LeuThr: 4.934 ± 0.043
5.915LeuVal: 5.915 ± 0.16
1.135LeuTrp: 1.135 ± 0.019
2.362LeuTyr: 2.362 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
2.291MetAla: 2.291 ± 0.026
0.409MetCys: 0.409 ± 0.009
1.122MetAsp: 1.122 ± 0.017
1.56MetGlu: 1.56 ± 0.024
0.597MetPhe: 0.597 ± 0.013
1.192MetGly: 1.192 ± 0.018
0.623MetHis: 0.623 ± 0.013
0.673MetIle: 0.673 ± 0.013
0.895MetLys: 0.895 ± 0.015
2.119MetLeu: 2.119 ± 0.026
0.649MetMet: 0.649 ± 0.016
0.744MetAsn: 0.744 ± 0.019
1.428MetPro: 1.428 ± 0.02
1.134MetGln: 1.134 ± 0.016
1.768MetArg: 1.768 ± 0.02
1.867MetSer: 1.867 ± 0.024
1.274MetThr: 1.274 ± 0.02
1.299MetVal: 1.299 ± 0.019
0.283MetTrp: 0.283 ± 0.008
0.553MetTyr: 0.553 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.289AsnAla: 3.289 ± 0.044
0.48AsnCys: 0.48 ± 0.01
1.389AsnAsp: 1.389 ± 0.021
1.486AsnGlu: 1.486 ± 0.023
0.822AsnPhe: 0.822 ± 0.016
2.22AsnGly: 2.22 ± 0.027
0.578AsnHis: 0.578 ± 0.011
1.049AsnIle: 1.049 ± 0.017
0.877AsnLys: 0.877 ± 0.018
1.91AsnLeu: 1.91 ± 0.026
0.619AsnMet: 0.619 ± 0.013
0.853AsnAsn: 0.853 ± 0.014
1.459AsnPro: 1.459 ± 0.02
0.708AsnGln: 0.708 ± 0.014
1.627AsnArg: 1.627 ± 0.02
2.123AsnSer: 2.123 ± 0.026
1.737AsnThr: 1.737 ± 0.021
1.987AsnVal: 1.987 ± 0.026
0.247AsnTrp: 0.247 ± 0.006
0.726AsnTyr: 0.726 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
6.776ProAla: 6.776 ± 0.07
0.904ProCys: 0.904 ± 0.015
2.048ProAsp: 2.048 ± 0.026
2.617ProGlu: 2.617 ± 0.037
1.82ProPhe: 1.82 ± 0.027
2.855ProGly: 2.855 ± 0.034
1.692ProHis: 1.692 ± 0.022
1.52ProIle: 1.52 ± 0.021
1.573ProLys: 1.573 ± 0.027
5.966ProLeu: 5.966 ± 0.073
1.11ProMet: 1.11 ± 0.018
1.362ProAsn: 1.362 ± 0.021
5.536ProPro: 5.536 ± 0.074
2.46ProGln: 2.46 ± 0.033
3.747ProArg: 3.747 ± 0.041
6.473ProSer: 6.473 ± 0.069
3.769ProThr: 3.769 ± 0.042
3.785ProVal: 3.785 ± 0.048
0.561ProTrp: 0.561 ± 0.011
1.321ProTyr: 1.321 ± 0.02
0.0ProXaa: 0.0 ± 0.0
Gln
3.745GlnAla: 3.745 ± 0.063
0.746GlnCys: 0.746 ± 0.018
1.465GlnAsp: 1.465 ± 0.023
2.516GlnGlu: 2.516 ± 0.047
0.931GlnPhe: 0.931 ± 0.017
1.832GlnGly: 1.832 ± 0.021
1.493GlnHis: 1.493 ± 0.02
0.935GlnIle: 0.935 ± 0.02
1.351GlnLys: 1.351 ± 0.024
5.104GlnLeu: 5.104 ± 0.203
0.881GlnMet: 0.881 ± 0.016
0.922GlnAsn: 0.922 ± 0.016
2.315GlnPro: 2.315 ± 0.033
3.919GlnGln: 3.919 ± 0.398
4.476GlnArg: 4.476 ± 0.043
2.659GlnSer: 2.659 ± 0.037
1.76GlnThr: 1.76 ± 0.017
2.297GlnVal: 2.297 ± 0.026
0.56GlnTrp: 0.56 ± 0.013
1.019GlnTyr: 1.019 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
7.574ArgAla: 7.574 ± 0.218
1.638ArgCys: 1.638 ± 0.026
3.507ArgAsp: 3.507 ± 0.043
4.494ArgGlu: 4.494 ± 0.061
2.009ArgPhe: 2.009 ± 0.022
4.669ArgGly: 4.669 ± 0.05
2.403ArgHis: 2.403 ± 0.028
2.275ArgIle: 2.275 ± 0.028
2.524ArgLys: 2.524 ± 0.029
6.965ArgLeu: 6.965 ± 0.066
1.57ArgMet: 1.57 ± 0.022
1.898ArgAsn: 1.898 ± 0.023
3.279ArgPro: 3.279 ± 0.03
3.527ArgGln: 3.527 ± 0.034
7.301ArgArg: 7.301 ± 0.068
5.682ArgSer: 5.682 ± 0.051
3.782ArgThr: 3.782 ± 0.034
4.835ArgVal: 4.835 ± 0.049
0.972ArgTrp: 0.972 ± 0.016
1.896ArgTyr: 1.896 ± 0.023
0.0ArgXaa: 0.0 ± 0.0
Ser
11.009SerAla: 11.009 ± 0.101
1.501SerCys: 1.501 ± 0.024
3.741SerAsp: 3.741 ± 0.037
3.963SerGlu: 3.963 ± 0.084
2.562SerPhe: 2.562 ± 0.028
6.173SerGly: 6.173 ± 0.056
1.957SerHis: 1.957 ± 0.023
2.636SerIle: 2.636 ± 0.029
2.413SerLys: 2.413 ± 0.027
7.5SerLeu: 7.5 ± 0.052
1.851SerMet: 1.851 ± 0.025
2.149SerAsn: 2.149 ± 0.025
6.018SerPro: 6.018 ± 0.072
2.525SerGln: 2.525 ± 0.024
5.46SerArg: 5.46 ± 0.046
10.725SerSer: 10.725 ± 0.105
6.059SerThr: 6.059 ± 0.059
5.834SerVal: 5.834 ± 0.048
0.824SerTrp: 0.824 ± 0.015
1.659SerTyr: 1.659 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
8.239ThrAla: 8.239 ± 0.074
0.952ThrCys: 0.952 ± 0.017
2.52ThrAsp: 2.52 ± 0.028
3.184ThrGlu: 3.184 ± 0.037
1.718ThrPhe: 1.718 ± 0.025
3.674ThrGly: 3.674 ± 0.036
1.41ThrHis: 1.41 ± 0.018
1.812ThrIle: 1.812 ± 0.023
1.716ThrLys: 1.716 ± 0.024
5.393ThrLeu: 5.393 ± 0.048
1.239ThrMet: 1.239 ± 0.019
1.471ThrAsn: 1.471 ± 0.02
4.358ThrPro: 4.358 ± 0.049
2.025ThrGln: 2.025 ± 0.037
3.509ThrArg: 3.509 ± 0.034
5.755ThrSer: 5.755 ± 0.059
4.347ThrThr: 4.347 ± 0.054
4.365ThrVal: 4.365 ± 0.041
0.568ThrTrp: 0.568 ± 0.012
1.289ThrTyr: 1.289 ± 0.017
0.0ThrXaa: 0.0 ± 0.0
Val
8.204ValAla: 8.204 ± 0.06
1.741ValCys: 1.741 ± 0.189
3.689ValAsp: 3.689 ± 0.032
4.439ValGlu: 4.439 ± 0.06
2.28ValPhe: 2.28 ± 0.026
4.237ValGly: 4.237 ± 0.162
1.883ValHis: 1.883 ± 0.023
2.022ValIle: 2.022 ± 0.028
2.315ValLys: 2.315 ± 0.028
7.262ValLeu: 7.262 ± 0.151
1.672ValMet: 1.672 ± 0.021
1.814ValAsn: 1.814 ± 0.022
4.291ValPro: 4.291 ± 0.044
3.08ValGln: 3.08 ± 0.184
4.903ValArg: 4.903 ± 0.052
5.687ValSer: 5.687 ± 0.046
4.073ValThr: 4.073 ± 0.038
5.873ValVal: 5.873 ± 0.21
0.794ValTrp: 0.794 ± 0.013
1.821ValTyr: 1.821 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
0.987TrpAla: 0.987 ± 0.019
0.307TrpCys: 0.307 ± 0.008
0.486TrpAsp: 0.486 ± 0.01
0.573TrpGlu: 0.573 ± 0.011
0.289TrpPhe: 0.289 ± 0.008
0.627TrpGly: 0.627 ± 0.015
0.286TrpHis: 0.286 ± 0.008
0.357TrpIle: 0.357 ± 0.01
0.448TrpLys: 0.448 ± 0.01
1.045TrpLeu: 1.045 ± 0.016
0.341TrpMet: 0.341 ± 0.008
0.361TrpAsn: 0.361 ± 0.009
0.453TrpPro: 0.453 ± 0.01
0.468TrpGln: 0.468 ± 0.012
1.091TrpArg: 1.091 ± 0.019
0.856TrpSer: 0.856 ± 0.015
0.586TrpThr: 0.586 ± 0.012
0.686TrpVal: 0.686 ± 0.013
0.225TrpTrp: 0.225 ± 0.007
0.307TrpTyr: 0.307 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.403TyrAla: 2.403 ± 0.026
0.491TyrCys: 0.491 ± 0.011
1.274TyrAsp: 1.274 ± 0.02
1.36TyrGlu: 1.36 ± 0.024
0.891TyrPhe: 0.891 ± 0.018
1.636TyrGly: 1.636 ± 0.021
0.67TyrHis: 0.67 ± 0.012
0.892TyrIle: 0.892 ± 0.019
0.733TyrLys: 0.733 ± 0.013
2.205TyrLeu: 2.205 ± 0.029
0.608TyrMet: 0.608 ± 0.012
0.799TyrAsn: 0.799 ± 0.016
1.133TyrPro: 1.133 ± 0.018
0.838TyrGln: 0.838 ± 0.014
1.684TyrArg: 1.684 ± 0.02
1.637TyrSer: 1.637 ± 0.02
1.445TyrThr: 1.445 ± 0.02
1.987TyrVal: 1.987 ± 0.024
0.282TyrTrp: 0.282 ± 0.007
0.872TyrTyr: 0.872 ± 0.011
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7554 proteins (5270428 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski