Amino acid dipepetide frequency for Conexivisphaera calida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.796AlaAla: 12.796 ± 0.236	0.612AlaCys: 0.612 ± 0.043	4.297AlaAsp: 4.297 ± 0.114	6.026AlaGlu: 6.026 ± 0.129	3.367AlaPhe: 3.367 ± 0.105	8.457AlaGly: 8.457 ± 0.162	1.582AlaHis: 1.582 ± 0.058	5.433AlaIle: 5.433 ± 0.128	3.117AlaLys: 3.117 ± 0.098	12.544AlaLeu: 12.544 ± 0.238	2.926AlaMet: 2.926 ± 0.09	1.827AlaAsn: 1.827 ± 0.067	4.068AlaPro: 4.068 ± 0.096	2.098AlaGln: 2.098 ± 0.066	8.152AlaArg: 8.152 ± 0.168	7.284AlaSer: 7.284 ± 0.159	4.103AlaThr: 4.103 ± 0.113	8.804AlaVal: 8.804 ± 0.152	1.181AlaTrp: 1.181 ± 0.058	3.177AlaTyr: 3.177 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	0.623CysAla: 0.623 ± 0.038	0.064CysCys: 0.064 ± 0.013	0.328CysAsp: 0.328 ± 0.029	0.388CysGlu: 0.388 ± 0.033	0.128CysPhe: 0.128 ± 0.018	1.041CysGly: 1.041 ± 0.069	0.096CysHis: 0.096 ± 0.015	0.22CysIle: 0.22 ± 0.026	0.151CysLys: 0.151 ± 0.02	0.333CysLeu: 0.333 ± 0.028	0.149CysMet: 0.149 ± 0.022	0.162CysAsn: 0.162 ± 0.02	0.725CysPro: 0.725 ± 0.05	0.128CysGln: 0.128 ± 0.018	0.554CysArg: 0.554 ± 0.037	0.507CysSer: 0.507 ± 0.035	0.371CysThr: 0.371 ± 0.031	0.444CysVal: 0.444 ± 0.032	0.06CysTrp: 0.06 ± 0.012	0.19CysTyr: 0.19 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.732AspAla: 5.732 ± 0.129	0.267AspCys: 0.267 ± 0.029	2.378AspAsp: 2.378 ± 0.091	3.96AspGlu: 3.96 ± 0.101	1.638AspPhe: 1.638 ± 0.065	4.54AspGly: 4.54 ± 0.102	0.847AspHis: 0.847 ± 0.039	2.079AspIle: 2.079 ± 0.058	1.166AspLys: 1.166 ± 0.057	5.578AspLeu: 5.578 ± 0.133	1.169AspMet: 1.169 ± 0.052	0.759AspAsn: 0.759 ± 0.04	3.838AspPro: 3.838 ± 0.102	0.879AspGln: 0.879 ± 0.05	3.563AspArg: 3.563 ± 0.093	2.659AspSer: 2.659 ± 0.078	1.39AspThr: 1.39 ± 0.052	5.857AspVal: 5.857 ± 0.11	0.537AspTrp: 0.537 ± 0.039	1.687AspTyr: 1.687 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	6.712GluAla: 6.712 ± 0.153	0.352GluCys: 0.352 ± 0.027	4.013GluAsp: 4.013 ± 0.103	6.393GluGlu: 6.393 ± 0.148	2.318GluPhe: 2.318 ± 0.079	5.553GluGly: 5.553 ± 0.126	1.137GluHis: 1.137 ± 0.05	3.755GluIle: 3.755 ± 0.105	2.228GluLys: 2.228 ± 0.091	8.312GluLeu: 8.312 ± 0.158	1.77GluMet: 1.77 ± 0.055	1.363GluAsn: 1.363 ± 0.061	2.659GluPro: 2.659 ± 0.069	0.987GluGln: 0.987 ± 0.05	5.597GluArg: 5.597 ± 0.129	3.727GluSer: 3.727 ± 0.09	1.893GluThr: 1.893 ± 0.069	6.657GluVal: 6.657 ± 0.147	0.738GluTrp: 0.738 ± 0.044	2.247GluTyr: 2.247 ± 0.083	0.0GluXaa: 0.0 ± 0.0
Phe	2.949PheAla: 2.949 ± 0.089	0.215PheCys: 0.215 ± 0.021	1.522PheAsp: 1.522 ± 0.061	1.817PheGlu: 1.817 ± 0.06	0.981PhePhe: 0.981 ± 0.059	2.589PheGly: 2.589 ± 0.079	0.512PheHis: 0.512 ± 0.034	1.505PheIle: 1.505 ± 0.065	0.787PheLys: 0.787 ± 0.041	3.403PheLeu: 3.403 ± 0.092	0.889PheMet: 0.889 ± 0.042	0.885PheAsn: 0.885 ± 0.051	1.493PhePro: 1.493 ± 0.065	0.638PheGln: 0.638 ± 0.039	2.284PheArg: 2.284 ± 0.073	2.501PheSer: 2.501 ± 0.076	1.667PheThr: 1.667 ± 0.064	2.781PheVal: 2.781 ± 0.081	0.394PheTrp: 0.394 ± 0.032	1.256PheTyr: 1.256 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	8.924GlyAla: 8.924 ± 0.178	0.778GlyCys: 0.778 ± 0.039	4.435GlyAsp: 4.435 ± 0.104	5.16GlyGlu: 5.16 ± 0.128	3.175GlyPhe: 3.175 ± 0.08	7.883GlyGly: 7.883 ± 0.177	1.537GlyHis: 1.537 ± 0.055	6.049GlyIle: 6.049 ± 0.147	3.262GlyLys: 3.262 ± 0.08	8.602GlyLeu: 8.602 ± 0.136	2.793GlyMet: 2.793 ± 0.093	2.145GlyAsn: 2.145 ± 0.076	3.868GlyPro: 3.868 ± 0.095	1.584GlyGln: 1.584 ± 0.058	7.691GlyArg: 7.691 ± 0.151	6.655GlySer: 6.655 ± 0.156	4.173GlyThr: 4.173 ± 0.126	7.57GlyVal: 7.57 ± 0.132	1.256GlyTrp: 1.256 ± 0.056	3.361GlyTyr: 3.361 ± 0.097	0.0GlyXaa: 0.0 ± 0.0
His	1.525HisAla: 1.525 ± 0.062	0.154HisCys: 0.154 ± 0.016	0.751HisAsp: 0.751 ± 0.043	1.098HisGlu: 1.098 ± 0.049	0.463HisPhe: 0.463 ± 0.028	1.757HisGly: 1.757 ± 0.065	0.311HisHis: 0.311 ± 0.027	0.674HisIle: 0.674 ± 0.038	0.341HisLys: 0.341 ± 0.027	1.488HisLeu: 1.488 ± 0.063	0.512HisMet: 0.512 ± 0.033	0.348HisAsn: 0.348 ± 0.027	1.098HisPro: 1.098 ± 0.051	0.275HisGln: 0.275 ± 0.022	1.296HisArg: 1.296 ± 0.059	0.887HisSer: 0.887 ± 0.046	0.633HisThr: 0.633 ± 0.031	1.719HisVal: 1.719 ± 0.066	0.232HisTrp: 0.232 ± 0.021	0.527HisTyr: 0.527 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.744IleAla: 5.744 ± 0.133	0.405IleCys: 0.405 ± 0.029	2.535IleAsp: 2.535 ± 0.077	3.039IleGlu: 3.039 ± 0.079	1.687IlePhe: 1.687 ± 0.062	4.418IleGly: 4.418 ± 0.11	0.783IleHis: 0.783 ± 0.043	2.48IleIle: 2.48 ± 0.099	1.535IleLys: 1.535 ± 0.065	4.802IleLeu: 4.802 ± 0.113	1.328IleMet: 1.328 ± 0.056	1.034IleAsn: 1.034 ± 0.051	3.017IlePro: 3.017 ± 0.076	0.812IleGln: 0.812 ± 0.046	3.606IleArg: 3.606 ± 0.092	4.693IleSer: 4.693 ± 0.12	2.367IleThr: 2.367 ± 0.073	4.987IleVal: 4.987 ± 0.114	0.625IleTrp: 0.625 ± 0.034	2.002IleTyr: 2.002 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	2.648LysAla: 2.648 ± 0.08	0.29LysCys: 0.29 ± 0.029	1.702LysAsp: 1.702 ± 0.077	2.422LysGlu: 2.422 ± 0.096	1.087LysPhe: 1.087 ± 0.055	2.695LysGly: 2.695 ± 0.089	0.386LysHis: 0.386 ± 0.034	1.646LysIle: 1.646 ± 0.07	0.981LysLys: 0.981 ± 0.061	3.373LysLeu: 3.373 ± 0.095	0.819LysMet: 0.819 ± 0.043	0.618LysAsn: 0.618 ± 0.038	1.516LysPro: 1.516 ± 0.071	0.493LysGln: 0.493 ± 0.038	2.056LysArg: 2.056 ± 0.078	1.872LysSer: 1.872 ± 0.066	1.006LysThr: 1.006 ± 0.049	3.305LysVal: 3.305 ± 0.087	0.441LysTrp: 0.441 ± 0.032	1.456LysTyr: 1.456 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	10.527LeuAla: 10.527 ± 0.18	0.448LeuCys: 0.448 ± 0.039	5.209LeuAsp: 5.209 ± 0.115	7.625LeuGlu: 7.625 ± 0.16	2.42LeuPhe: 2.42 ± 0.084	9.625LeuGly: 9.625 ± 0.163	1.529LeuHis: 1.529 ± 0.064	4.572LeuIle: 4.572 ± 0.115	3.154LeuLys: 3.154 ± 0.099	9.77LeuLeu: 9.77 ± 0.19	3.017LeuMet: 3.017 ± 0.09	2.224LeuAsn: 2.224 ± 0.073	4.578LeuPro: 4.578 ± 0.102	1.891LeuGln: 1.891 ± 0.065	9.781LeuArg: 9.781 ± 0.181	7.885LeuSer: 7.885 ± 0.134	4.277LeuThr: 4.277 ± 0.1	8.672LeuVal: 8.672 ± 0.142	1.087LeuTrp: 1.087 ± 0.049	3.166LeuTyr: 3.166 ± 0.087	0.0LeuXaa: 0.0 ± 0.0
Met	2.902MetAla: 2.902 ± 0.081	0.158MetCys: 0.158 ± 0.018	1.853MetAsp: 1.853 ± 0.063	2.079MetGlu: 2.079 ± 0.076	0.755MetPhe: 0.755 ± 0.045	2.849MetGly: 2.849 ± 0.078	0.458MetHis: 0.458 ± 0.029	1.427MetIle: 1.427 ± 0.057	0.964MetLys: 0.964 ± 0.053	2.529MetLeu: 2.529 ± 0.078	0.783MetMet: 0.783 ± 0.051	0.71MetAsn: 0.71 ± 0.04	1.456MetPro: 1.456 ± 0.05	0.399MetGln: 0.399 ± 0.032	2.265MetArg: 2.265 ± 0.068	2.252MetSer: 2.252 ± 0.073	1.213MetThr: 1.213 ± 0.053	2.092MetVal: 2.092 ± 0.066	0.226MetTrp: 0.226 ± 0.022	0.719MetTyr: 0.719 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.318AsnAla: 2.318 ± 0.074	0.143AsnCys: 0.143 ± 0.018	0.904AsnAsp: 0.904 ± 0.049	1.081AsnGlu: 1.081 ± 0.05	0.751AsnPhe: 0.751 ± 0.042	2.179AsnGly: 2.179 ± 0.094	0.249AsnHis: 0.249 ± 0.024	1.141AsnIle: 1.141 ± 0.061	0.533AsnLys: 0.533 ± 0.039	2.096AsnLeu: 2.096 ± 0.07	0.646AsnMet: 0.646 ± 0.043	0.51AsnAsn: 0.51 ± 0.046	1.808AsnPro: 1.808 ± 0.07	0.407AsnGln: 0.407 ± 0.035	1.356AsnArg: 1.356 ± 0.057	1.495AsnSer: 1.495 ± 0.064	1.058AsnThr: 1.058 ± 0.051	2.459AsnVal: 2.459 ± 0.086	0.284AsnTrp: 0.284 ± 0.025	0.994AsnTyr: 0.994 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	4.243ProAla: 4.243 ± 0.105	0.331ProCys: 0.331 ± 0.026	2.798ProAsp: 2.798 ± 0.093	3.979ProGlu: 3.979 ± 0.099	1.618ProPhe: 1.618 ± 0.056	5.256ProGly: 5.256 ± 0.138	0.917ProHis: 0.917 ± 0.044	2.028ProIle: 2.028 ± 0.066	1.352ProLys: 1.352 ± 0.059	4.7ProLeu: 4.7 ± 0.107	1.299ProMet: 1.299 ± 0.051	1.151ProAsn: 1.151 ± 0.055	3.16ProPro: 3.16 ± 0.097	1.111ProGln: 1.111 ± 0.054	4.145ProArg: 4.145 ± 0.102	3.732ProSer: 3.732 ± 0.098	2.39ProThr: 2.39 ± 0.09	4.124ProVal: 4.124 ± 0.112	0.723ProTrp: 0.723 ± 0.045	1.864ProTyr: 1.864 ± 0.073	0.0ProXaa: 0.0 ± 0.0
Gln	1.601GlnAla: 1.601 ± 0.062	0.119GlnCys: 0.119 ± 0.016	0.829GlnAsp: 0.829 ± 0.049	1.235GlnGlu: 1.235 ± 0.052	0.652GlnPhe: 0.652 ± 0.037	1.527GlnGly: 1.527 ± 0.059	0.245GlnHis: 0.245 ± 0.023	0.857GlnIle: 0.857 ± 0.045	0.561GlnLys: 0.561 ± 0.04	2.06GlnLeu: 2.06 ± 0.065	0.603GlnMet: 0.603 ± 0.034	0.458GlnAsn: 0.458 ± 0.038	0.874GlnPro: 0.874 ± 0.043	0.507GlnGln: 0.507 ± 0.039	1.397GlnArg: 1.397 ± 0.061	1.171GlnSer: 1.171 ± 0.054	0.74GlnThr: 0.74 ± 0.047	1.77GlnVal: 1.77 ± 0.069	0.247GlnTrp: 0.247 ± 0.022	0.697GlnTyr: 0.697 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	8.209ArgAla: 8.209 ± 0.161	0.714ArgCys: 0.714 ± 0.042	4.297ArgAsp: 4.297 ± 0.109	5.994ArgGlu: 5.994 ± 0.136	2.209ArgPhe: 2.209 ± 0.067	7.429ArgGly: 7.429 ± 0.168	1.226ArgHis: 1.226 ± 0.051	5.047ArgIle: 5.047 ± 0.112	2.832ArgLys: 2.832 ± 0.083	7.523ArgLeu: 7.523 ± 0.149	2.318ArgMet: 2.318 ± 0.077	1.868ArgAsn: 1.868 ± 0.075	3.742ArgPro: 3.742 ± 0.091	1.119ArgGln: 1.119 ± 0.047	8.312ArgArg: 8.312 ± 0.183	5.553ArgSer: 5.553 ± 0.125	3.16ArgThr: 3.16 ± 0.077	5.87ArgVal: 5.87 ± 0.125	1.09ArgTrp: 1.09 ± 0.05	2.525ArgTyr: 2.525 ± 0.08	0.0ArgXaa: 0.0 ± 0.0
Ser	7.12SerAla: 7.12 ± 0.141	0.467SerCys: 0.467 ± 0.037	3.017SerAsp: 3.017 ± 0.082	3.909SerGlu: 3.909 ± 0.096	2.296SerPhe: 2.296 ± 0.077	7.405SerGly: 7.405 ± 0.173	1.1SerHis: 1.1 ± 0.054	3.793SerIle: 3.793 ± 0.104	2.275SerLys: 2.275 ± 0.078	6.542SerLeu: 6.542 ± 0.155	2.36SerMet: 2.36 ± 0.068	1.465SerAsn: 1.465 ± 0.07	3.791SerPro: 3.791 ± 0.105	1.39SerGln: 1.39 ± 0.062	5.627SerArg: 5.627 ± 0.11	6.156SerSer: 6.156 ± 0.196	3.448SerThr: 3.448 ± 0.114	5.593SerVal: 5.593 ± 0.137	1.024SerTrp: 1.024 ± 0.056	2.501SerTyr: 2.501 ± 0.092	0.0SerXaa: 0.0 ± 0.0
Thr	4.032ThrAla: 4.032 ± 0.106	0.377ThrCys: 0.377 ± 0.03	1.655ThrAsp: 1.655 ± 0.064	1.966ThrGlu: 1.966 ± 0.068	1.544ThrPhe: 1.544 ± 0.066	4.269ThrGly: 4.269 ± 0.115	0.712ThrHis: 0.712 ± 0.042	2.335ThrIle: 2.335 ± 0.082	1.277ThrLys: 1.277 ± 0.054	4.051ThrLeu: 4.051 ± 0.106	1.166ThrMet: 1.166 ± 0.056	1.139ThrAsn: 1.139 ± 0.061	2.501ThrPro: 2.501 ± 0.083	0.742ThrGln: 0.742 ± 0.043	2.582ThrArg: 2.582 ± 0.076	3.145ThrSer: 3.145 ± 0.097	2.075ThrThr: 2.075 ± 0.072	3.947ThrVal: 3.947 ± 0.126	0.691ThrTrp: 0.691 ± 0.047	1.723ThrTyr: 1.723 ± 0.078	0.0ThrXaa: 0.0 ± 0.0
Val	8.751ValAla: 8.751 ± 0.169	0.484ValCys: 0.484 ± 0.032	5.819ValAsp: 5.819 ± 0.116	7.316ValGlu: 7.316 ± 0.135	2.405ValPhe: 2.405 ± 0.075	7.154ValGly: 7.154 ± 0.131	1.689ValHis: 1.689 ± 0.075	4.621ValIle: 4.621 ± 0.096	3.175ValLys: 3.175 ± 0.106	8.971ValLeu: 8.971 ± 0.163	2.158ValMet: 2.158 ± 0.07	2.412ValAsn: 2.412 ± 0.081	4.384ValPro: 4.384 ± 0.11	1.821ValGln: 1.821 ± 0.068	6.736ValArg: 6.736 ± 0.127	5.48ValSer: 5.48 ± 0.127	3.723ValThr: 3.723 ± 0.113	8.388ValVal: 8.388 ± 0.172	0.797ValTrp: 0.797 ± 0.046	2.817ValTyr: 2.817 ± 0.077	0.0ValXaa: 0.0 ± 0.0
Trp	1.137TrpAla: 1.137 ± 0.054	0.058TrpCys: 0.058 ± 0.012	0.514TrpAsp: 0.514 ± 0.035	0.772TrpGlu: 0.772 ± 0.043	0.431TrpPhe: 0.431 ± 0.03	1.011TrpGly: 1.011 ± 0.049	0.196TrpHis: 0.196 ± 0.025	0.829TrpIle: 0.829 ± 0.041	0.362TrpLys: 0.362 ± 0.026	1.258TrpLeu: 1.258 ± 0.048	0.371TrpMet: 0.371 ± 0.033	0.371TrpAsn: 0.371 ± 0.033	0.452TrpPro: 0.452 ± 0.033	0.2TrpGln: 0.2 ± 0.022	1.309TrpArg: 1.309 ± 0.057	0.964TrpSer: 0.964 ± 0.059	0.561TrpThr: 0.561 ± 0.04	0.857TrpVal: 0.857 ± 0.042	0.213TrpTrp: 0.213 ± 0.021	0.456TrpTyr: 0.456 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.358TyrAla: 3.358 ± 0.088	0.226TyrCys: 0.226 ± 0.023	1.665TyrAsp: 1.665 ± 0.061	2.154TyrGlu: 2.154 ± 0.077	1.143TyrPhe: 1.143 ± 0.058	3.267TyrGly: 3.267 ± 0.098	0.576TyrHis: 0.576 ± 0.037	1.409TyrIle: 1.409 ± 0.063	0.759TyrLys: 0.759 ± 0.045	3.527TyrLeu: 3.527 ± 0.086	1.009TyrMet: 1.009 ± 0.048	0.962TyrAsn: 0.962 ± 0.061	1.889TyrPro: 1.889 ± 0.065	0.67TyrGln: 0.67 ± 0.035	2.727TyrArg: 2.727 ± 0.077	2.663TyrSer: 2.663 ± 0.085	1.68TyrThr: 1.68 ± 0.067	3.205TyrVal: 3.205 ± 0.094	0.476TyrTrp: 0.476 ± 0.028	1.723TyrTyr: 1.723 ± 0.073	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1603 proteins (468978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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