Amino acid dipepetide frequency for Thalassiosira pseudonana (Marine diatom) (Cyclotella nana)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.797AlaAla: 7.797 ± 0.064
1.177AlaCys: 1.177 ± 0.017
3.946AlaAsp: 3.946 ± 0.034
4.427AlaGlu: 4.427 ± 0.038
2.834AlaPhe: 2.834 ± 0.027
4.465AlaGly: 4.465 ± 0.034
1.356AlaHis: 1.356 ± 0.018
3.905AlaIle: 3.905 ± 0.031
4.38AlaLys: 4.38 ± 0.032
6.937AlaLeu: 6.937 ± 0.046
2.179AlaMet: 2.179 ± 0.018
3.35AlaAsn: 3.35 ± 0.026
3.442AlaPro: 3.442 ± 0.044
2.36AlaGln: 2.36 ± 0.023
3.667AlaArg: 3.667 ± 0.027
7.685AlaSer: 7.685 ± 0.045
5.384AlaThr: 5.384 ± 0.036
5.191AlaVal: 5.191 ± 0.031
0.778AlaTrp: 0.778 ± 0.015
1.808AlaTyr: 1.808 ± 0.018
0.0AlaXaa: 0.0 ± 0.0
Cys
1.076CysAla: 1.076 ± 0.015
0.49CysCys: 0.49 ± 0.013
0.997CysAsp: 0.997 ± 0.016
0.871CysGlu: 0.871 ± 0.014
0.64CysPhe: 0.64 ± 0.011
1.279CysGly: 1.279 ± 0.018
0.417CysHis: 0.417 ± 0.008
0.904CysIle: 0.904 ± 0.013
0.745CysLys: 0.745 ± 0.013
1.431CysLeu: 1.431 ± 0.017
0.338CysMet: 0.338 ± 0.008
0.763CysAsn: 0.763 ± 0.012
0.812CysPro: 0.812 ± 0.016
0.545CysGln: 0.545 ± 0.01
0.856CysArg: 0.856 ± 0.014
1.36CysSer: 1.36 ± 0.017
0.949CysThr: 0.949 ± 0.013
1.043CysVal: 1.043 ± 0.015
0.194CysTrp: 0.194 ± 0.006
0.47CysTyr: 0.47 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.298AspAla: 5.298 ± 0.034
0.945AspCys: 0.945 ± 0.016
6.351AspAsp: 6.351 ± 0.058
5.748AspGlu: 5.748 ± 0.045
2.095AspPhe: 2.095 ± 0.024
5.361AspGly: 5.361 ± 0.039
1.104AspHis: 1.104 ± 0.014
3.042AspIle: 3.042 ± 0.028
2.667AspLys: 2.667 ± 0.023
4.49AspLeu: 4.49 ± 0.031
1.412AspMet: 1.412 ± 0.017
2.769AspAsn: 2.769 ± 0.022
2.5AspPro: 2.5 ± 0.024
1.565AspGln: 1.565 ± 0.016
2.542AspArg: 2.542 ± 0.026
4.599AspSer: 4.599 ± 0.041
3.33AspThr: 3.33 ± 0.031
4.702AspVal: 4.702 ± 0.033
0.719AspTrp: 0.719 ± 0.013
1.614AspTyr: 1.614 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
5.046GluAla: 5.046 ± 0.038
1.034GluCys: 1.034 ± 0.016
4.68GluAsp: 4.68 ± 0.04
7.057GluGlu: 7.057 ± 0.067
1.942GluPhe: 1.942 ± 0.019
4.471GluGly: 4.471 ± 0.029
1.305GluHis: 1.305 ± 0.015
2.915GluIle: 2.915 ± 0.024
3.896GluLys: 3.896 ± 0.035
5.396GluLeu: 5.396 ± 0.039
1.853GluMet: 1.853 ± 0.019
2.535GluAsn: 2.535 ± 0.023
1.963GluPro: 1.963 ± 0.022
2.483GluGln: 2.483 ± 0.025
3.821GluArg: 3.821 ± 0.034
5.028GluSer: 5.028 ± 0.037
3.328GluThr: 3.328 ± 0.029
4.115GluVal: 4.115 ± 0.029
0.802GluTrp: 0.802 ± 0.012
1.9GluTyr: 1.9 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.756PheAla: 2.756 ± 0.024
0.657PheCys: 0.657 ± 0.014
2.528PheAsp: 2.528 ± 0.026
2.038PheGlu: 2.038 ± 0.022
1.465PhePhe: 1.465 ± 0.022
2.884PheGly: 2.884 ± 0.033
0.909PheHis: 0.909 ± 0.014
1.624PheIle: 1.624 ± 0.02
1.358PheLys: 1.358 ± 0.016
3.19PheLeu: 3.19 ± 0.029
0.798PheMet: 0.798 ± 0.012
1.45PheAsn: 1.45 ± 0.018
1.555PhePro: 1.555 ± 0.016
1.266PheGln: 1.266 ± 0.014
1.659PheArg: 1.659 ± 0.016
2.826PheSer: 2.826 ± 0.028
1.885PheThr: 1.885 ± 0.02
2.612PheVal: 2.612 ± 0.026
0.391PheTrp: 0.391 ± 0.009
1.02PheTyr: 1.02 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
4.727GlyAla: 4.727 ± 0.037
1.203GlyCys: 1.203 ± 0.017
4.653GlyAsp: 4.653 ± 0.035
4.41GlyGlu: 4.41 ± 0.028
2.396GlyPhe: 2.396 ± 0.024
8.181GlyGly: 8.181 ± 0.085
1.325GlyHis: 1.325 ± 0.015
3.398GlyIle: 3.398 ± 0.027
3.983GlyLys: 3.983 ± 0.03
5.002GlyLeu: 5.002 ± 0.033
1.964GlyMet: 1.964 ± 0.023
3.118GlyAsn: 3.118 ± 0.027
1.853GlyPro: 1.853 ± 0.022
1.868GlyGln: 1.868 ± 0.022
3.787GlyArg: 3.787 ± 0.032
6.158GlySer: 6.158 ± 0.047
3.781GlyThr: 3.781 ± 0.03
4.848GlyVal: 4.848 ± 0.035
0.93GlyTrp: 0.93 ± 0.014
1.986GlyTyr: 1.986 ± 0.022
0.0GlyXaa: 0.0 ± 0.0
His
1.555HisAla: 1.555 ± 0.017
0.445HisCys: 0.445 ± 0.009
1.323HisAsp: 1.323 ± 0.014
1.258HisGlu: 1.258 ± 0.016
0.849HisPhe: 0.849 ± 0.014
1.518HisGly: 1.518 ± 0.02
1.133HisHis: 1.133 ± 0.02
1.027HisIle: 1.027 ± 0.013
0.943HisLys: 0.943 ± 0.014
2.041HisLeu: 2.041 ± 0.022
0.43HisMet: 0.43 ± 0.009
1.015HisAsn: 1.015 ± 0.014
1.506HisPro: 1.506 ± 0.016
1.164HisGln: 1.164 ± 0.018
1.476HisArg: 1.476 ± 0.018
1.958HisSer: 1.958 ± 0.022
1.115HisThr: 1.115 ± 0.015
1.388HisVal: 1.388 ± 0.017
0.28HisTrp: 0.28 ± 0.007
0.723HisTyr: 0.723 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
3.907IleAla: 3.907 ± 0.028
0.813IleCys: 0.813 ± 0.013
3.183IleAsp: 3.183 ± 0.026
2.934IleGlu: 2.934 ± 0.024
1.578IlePhe: 1.578 ± 0.018
3.283IleGly: 3.283 ± 0.027
1.202IleHis: 1.202 ± 0.015
2.299IleIle: 2.299 ± 0.022
2.193IleLys: 2.193 ± 0.021
4.232IleLeu: 4.232 ± 0.033
1.073IleMet: 1.073 ± 0.016
2.061IleAsn: 2.061 ± 0.022
2.469IlePro: 2.469 ± 0.025
1.876IleGln: 1.876 ± 0.02
2.389IleArg: 2.389 ± 0.022
4.004IleSer: 4.004 ± 0.029
2.714IleThr: 2.714 ± 0.027
3.396IleVal: 3.396 ± 0.026
0.441IleTrp: 0.441 ± 0.011
1.114IleTyr: 1.114 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
4.06LysAla: 4.06 ± 0.033
0.782LysCys: 0.782 ± 0.012
3.024LysAsp: 3.024 ± 0.028
4.193LysGlu: 4.193 ± 0.038
1.552LysPhe: 1.552 ± 0.017
3.246LysGly: 3.246 ± 0.031
1.224LysHis: 1.224 ± 0.016
2.262LysIle: 2.262 ± 0.022
4.503LysLys: 4.503 ± 0.042
4.354LysLeu: 4.354 ± 0.033
1.362LysMet: 1.362 ± 0.016
2.205LysAsn: 2.205 ± 0.021
2.197LysPro: 2.197 ± 0.028
2.409LysGln: 2.409 ± 0.026
3.702LysArg: 3.702 ± 0.035
4.652LysSer: 4.652 ± 0.038
2.75LysThr: 2.75 ± 0.025
3.071LysVal: 3.071 ± 0.025
0.604LysTrp: 0.604 ± 0.012
1.518LysTyr: 1.518 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
6.534LeuAla: 6.534 ± 0.036
1.459LeuCys: 1.459 ± 0.021
4.943LeuAsp: 4.943 ± 0.034
5.356LeuGlu: 5.356 ± 0.039
3.231LeuPhe: 3.231 ± 0.028
5.247LeuGly: 5.247 ± 0.038
2.13LeuHis: 2.13 ± 0.021
3.642LeuIle: 3.642 ± 0.029
4.36LeuLys: 4.36 ± 0.034
8.491LeuLeu: 8.491 ± 0.056
2.085LeuMet: 2.085 ± 0.02
3.438LeuAsn: 3.438 ± 0.024
4.572LeuPro: 4.572 ± 0.032
3.616LeuGln: 3.616 ± 0.03
4.822LeuArg: 4.822 ± 0.032
7.803LeuSer: 7.803 ± 0.051
4.489LeuThr: 4.489 ± 0.032
5.331LeuVal: 5.331 ± 0.038
0.896LeuTrp: 0.896 ± 0.015
2.166LeuTyr: 2.166 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
2.03MetAla: 2.03 ± 0.02
0.388MetCys: 0.388 ± 0.01
1.47MetAsp: 1.47 ± 0.016
1.798MetGlu: 1.798 ± 0.021
0.789MetPhe: 0.789 ± 0.014
1.644MetGly: 1.644 ± 0.02
0.572MetHis: 0.572 ± 0.011
1.179MetIle: 1.179 ± 0.014
1.663MetLys: 1.663 ± 0.018
2.038MetLeu: 2.038 ± 0.018
0.936MetMet: 0.936 ± 0.017
1.277MetAsn: 1.277 ± 0.016
1.163MetPro: 1.163 ± 0.019
1.011MetGln: 1.011 ± 0.016
1.209MetArg: 1.209 ± 0.015
2.194MetSer: 2.194 ± 0.018
1.46MetThr: 1.46 ± 0.016
1.406MetVal: 1.406 ± 0.016
0.246MetTrp: 0.246 ± 0.007
0.644MetTyr: 0.644 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.778AsnAla: 3.778 ± 0.026
0.619AsnCys: 0.619 ± 0.011
3.405AsnAsp: 3.405 ± 0.025
3.167AsnGlu: 3.167 ± 0.026
1.37AsnPhe: 1.37 ± 0.018
3.496AsnGly: 3.496 ± 0.03
1.017AsnHis: 1.017 ± 0.015
2.125AsnIle: 2.125 ± 0.017
2.207AsnLys: 2.207 ± 0.024
3.155AsnLeu: 3.155 ± 0.027
0.96AsnMet: 0.96 ± 0.012
3.359AsnAsn: 3.359 ± 0.042
2.169AsnPro: 2.169 ± 0.021
1.575AsnGln: 1.575 ± 0.018
1.996AsnArg: 1.996 ± 0.02
3.736AsnSer: 3.736 ± 0.028
2.788AsnThr: 2.788 ± 0.024
2.967AsnVal: 2.967 ± 0.023
0.453AsnTrp: 0.453 ± 0.009
1.156AsnTyr: 1.156 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
2.93ProAla: 2.93 ± 0.029
0.563ProCys: 0.563 ± 0.011
2.246ProAsp: 2.246 ± 0.023
2.406ProGlu: 2.406 ± 0.021
1.746ProPhe: 1.746 ± 0.018
2.282ProGly: 2.282 ± 0.024
1.108ProHis: 1.108 ± 0.016
2.258ProIle: 2.258 ± 0.021
2.36ProLys: 2.36 ± 0.023
4.052ProLeu: 4.052 ± 0.03
1.105ProMet: 1.105 ± 0.016
2.118ProAsn: 2.118 ± 0.022
4.071ProPro: 4.071 ± 0.05
1.714ProGln: 1.714 ± 0.023
2.176ProArg: 2.176 ± 0.024
6.056ProSer: 6.056 ± 0.132
3.894ProThr: 3.894 ± 0.047
2.688ProVal: 2.688 ± 0.026
0.488ProTrp: 0.488 ± 0.011
1.172ProTyr: 1.172 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
2.335GlnAla: 2.335 ± 0.021
0.618GlnCys: 0.618 ± 0.013
1.635GlnAsp: 1.635 ± 0.016
1.999GlnGlu: 1.999 ± 0.02
1.255GlnPhe: 1.255 ± 0.016
1.754GlnGly: 1.754 ± 0.02
1.263GlnHis: 1.263 ± 0.018
1.633GlnIle: 1.633 ± 0.016
1.933GlnLys: 1.933 ± 0.02
3.504GlnLeu: 3.504 ± 0.024
1.053GlnMet: 1.053 ± 0.017
1.457GlnAsn: 1.457 ± 0.018
2.011GlnPro: 2.011 ± 0.031
3.468GlnGln: 3.468 ± 0.059
2.635GlnArg: 2.635 ± 0.026
3.63GlnSer: 3.63 ± 0.031
2.083GlnThr: 2.083 ± 0.021
1.868GlnVal: 1.868 ± 0.02
0.487GlnTrp: 0.487 ± 0.01
1.206GlnTyr: 1.206 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
3.615ArgAla: 3.615 ± 0.032
0.877ArgCys: 0.877 ± 0.014
2.886ArgAsp: 2.886 ± 0.023
3.408ArgGlu: 3.408 ± 0.031
1.771ArgPhe: 1.771 ± 0.018
3.688ArgGly: 3.688 ± 0.036
1.428ArgHis: 1.428 ± 0.019
2.523ArgIle: 2.523 ± 0.025
3.276ArgLys: 3.276 ± 0.029
4.582ArgLeu: 4.582 ± 0.031
1.445ArgMet: 1.445 ± 0.018
2.286ArgAsn: 2.286 ± 0.021
2.17ArgPro: 2.17 ± 0.021
2.262ArgGln: 2.262 ± 0.022
4.56ArgArg: 4.56 ± 0.052
4.537ArgSer: 4.537 ± 0.035
2.598ArgThr: 2.598 ± 0.025
3.201ArgVal: 3.201 ± 0.025
0.67ArgTrp: 0.67 ± 0.011
1.531ArgTyr: 1.531 ± 0.019
0.0ArgXaa: 0.0 ± 0.0
Ser
6.681SerAla: 6.681 ± 0.044
1.365SerCys: 1.365 ± 0.016
5.191SerAsp: 5.191 ± 0.045
4.592SerGlu: 4.592 ± 0.039
3.539SerPhe: 3.539 ± 0.032
6.002SerGly: 6.002 ± 0.051
1.951SerHis: 1.951 ± 0.021
4.587SerIle: 4.587 ± 0.034
4.788SerLys: 4.788 ± 0.034
7.872SerLeu: 7.872 ± 0.047
2.194SerMet: 2.194 ± 0.02
4.669SerAsn: 4.669 ± 0.034
4.941SerPro: 4.941 ± 0.063
3.046SerGln: 3.046 ± 0.03
4.33SerArg: 4.33 ± 0.037
12.838SerSer: 12.838 ± 0.108
6.563SerThr: 6.563 ± 0.041
5.44SerVal: 5.44 ± 0.035
0.94SerTrp: 0.94 ± 0.013
2.297SerTyr: 2.297 ± 0.02
0.0SerXaa: 0.0 ± 0.0
Thr
4.822ThrAla: 4.822 ± 0.035
0.932ThrCys: 0.932 ± 0.013
3.13ThrAsp: 3.13 ± 0.022
3.049ThrGlu: 3.049 ± 0.025
2.052ThrPhe: 2.052 ± 0.02
3.436ThrGly: 3.436 ± 0.032
1.208ThrHis: 1.208 ± 0.014
3.15ThrIle: 3.15 ± 0.024
3.299ThrLys: 3.299 ± 0.025
5.082ThrLeu: 5.082 ± 0.037
1.475ThrMet: 1.475 ± 0.017
3.033ThrAsn: 3.033 ± 0.022
3.483ThrPro: 3.483 ± 0.032
1.927ThrGln: 1.927 ± 0.021
2.576ThrArg: 2.576 ± 0.021
6.419ThrSer: 6.419 ± 0.039
5.347ThrThr: 5.347 ± 0.046
3.713ThrVal: 3.713 ± 0.028
0.592ThrTrp: 0.592 ± 0.011
1.362ThrTyr: 1.362 ± 0.015
0.0ThrXaa: 0.0 ± 0.0
Val
5.533ValAla: 5.533 ± 0.038
1.05ValCys: 1.05 ± 0.014
4.561ValAsp: 4.561 ± 0.033
4.389ValGlu: 4.389 ± 0.031
2.232ValPhe: 2.232 ± 0.022
4.611ValGly: 4.611 ± 0.031
1.467ValHis: 1.467 ± 0.017
2.945ValIle: 2.945 ± 0.023
3.188ValLys: 3.188 ± 0.026
5.495ValLeu: 5.495 ± 0.038
1.539ValMet: 1.539 ± 0.014
2.658ValAsn: 2.658 ± 0.021
3.0ValPro: 3.0 ± 0.028
2.238ValGln: 2.238 ± 0.018
3.021ValArg: 3.021 ± 0.024
5.343ValSer: 5.343 ± 0.032
3.543ValThr: 3.543 ± 0.03
5.071ValVal: 5.071 ± 0.037
0.715ValTrp: 0.715 ± 0.013
1.691ValTyr: 1.691 ± 0.016
0.0ValXaa: 0.0 ± 0.0
Trp
0.684TrpAla: 0.684 ± 0.012
0.218TrpCys: 0.218 ± 0.007
0.718TrpAsp: 0.718 ± 0.012
0.721TrpGlu: 0.721 ± 0.01
0.408TrpPhe: 0.408 ± 0.009
0.767TrpGly: 0.767 ± 0.013
0.245TrpHis: 0.245 ± 0.007
0.589TrpIle: 0.589 ± 0.01
0.775TrpLys: 0.775 ± 0.013
0.924TrpLeu: 0.924 ± 0.014
0.378TrpMet: 0.378 ± 0.008
0.604TrpAsn: 0.604 ± 0.011
0.341TrpPro: 0.341 ± 0.008
0.355TrpGln: 0.355 ± 0.008
0.702TrpArg: 0.702 ± 0.012
0.868TrpSer: 0.868 ± 0.013
0.641TrpThr: 0.641 ± 0.011
0.635TrpVal: 0.635 ± 0.012
0.191TrpTrp: 0.191 ± 0.006
0.384TrpTyr: 0.384 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.906TyrAla: 1.906 ± 0.018
0.544TyrCys: 0.544 ± 0.009
1.983TyrAsp: 1.983 ± 0.023
1.749TyrGlu: 1.749 ± 0.02
1.128TyrPhe: 1.128 ± 0.015
1.957TyrGly: 1.957 ± 0.019
0.783TyrHis: 0.783 ± 0.012
1.152TyrIle: 1.152 ± 0.015
1.153TyrLys: 1.153 ± 0.014
2.343TyrLeu: 2.343 ± 0.027
0.537TyrMet: 0.537 ± 0.011
1.333TyrAsn: 1.333 ± 0.017
1.214TyrPro: 1.214 ± 0.017
1.079TyrGln: 1.079 ± 0.014
1.387TyrArg: 1.387 ± 0.017
2.132TyrSer: 2.132 ± 0.019
1.446TyrThr: 1.446 ± 0.016
1.604TyrVal: 1.604 ± 0.019
0.33TyrTrp: 0.33 ± 0.008
1.002TyrTyr: 1.002 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11718 proteins (5824029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski