Amino acid dipepetide frequency for Rhizoctonia solani 123E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.03AlaAla: 8.03 ± 0.05
1.137AlaCys: 1.137 ± 0.017
3.779AlaAsp: 3.779 ± 0.026
4.599AlaGlu: 4.599 ± 0.033
3.151AlaPhe: 3.151 ± 0.028
5.653AlaGly: 5.653 ± 0.038
2.161AlaHis: 2.161 ± 0.018
4.321AlaIle: 4.321 ± 0.035
3.848AlaLys: 3.848 ± 0.035
8.419AlaLeu: 8.419 ± 0.048
1.852AlaMet: 1.852 ± 0.017
2.946AlaAsn: 2.946 ± 0.028
5.528AlaPro: 5.528 ± 0.048
3.453AlaGln: 3.453 ± 0.027
5.387AlaArg: 5.387 ± 0.033
7.487AlaSer: 7.487 ± 0.046
5.415AlaThr: 5.415 ± 0.034
5.01AlaVal: 5.01 ± 0.031
1.168AlaTrp: 1.168 ± 0.016
2.328AlaTyr: 2.328 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
0.956CysAla: 0.956 ± 0.014
0.215CysCys: 0.215 ± 0.007
0.691CysAsp: 0.691 ± 0.014
0.594CysGlu: 0.594 ± 0.011
0.497CysPhe: 0.497 ± 0.01
0.928CysGly: 0.928 ± 0.015
0.351CysHis: 0.351 ± 0.008
0.736CysIle: 0.736 ± 0.012
0.509CysLys: 0.509 ± 0.009
1.191CysLeu: 1.191 ± 0.015
0.261CysMet: 0.261 ± 0.007
0.444CysAsn: 0.444 ± 0.01
0.725CysPro: 0.725 ± 0.014
0.447CysGln: 0.447 ± 0.01
0.699CysArg: 0.699 ± 0.011
0.986CysSer: 0.986 ± 0.016
0.791CysThr: 0.791 ± 0.012
0.886CysVal: 0.886 ± 0.014
0.221CysTrp: 0.221 ± 0.006
0.362CysTyr: 0.362 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
4.544AspAla: 4.544 ± 0.034
0.582AspCys: 0.582 ± 0.011
3.655AspAsp: 3.655 ± 0.033
4.142AspGlu: 4.142 ± 0.037
1.91AspPhe: 1.91 ± 0.018
3.923AspGly: 3.923 ± 0.034
1.241AspHis: 1.241 ± 0.016
2.966AspIle: 2.966 ± 0.024
2.239AspLys: 2.239 ± 0.023
4.931AspLeu: 4.931 ± 0.032
1.245AspMet: 1.245 ± 0.016
1.76AspAsn: 1.76 ± 0.016
3.436AspPro: 3.436 ± 0.026
1.824AspGln: 1.824 ± 0.022
2.92AspArg: 2.92 ± 0.027
4.147AspSer: 4.147 ± 0.031
2.992AspThr: 2.992 ± 0.026
3.542AspVal: 3.542 ± 0.029
0.856AspTrp: 0.856 ± 0.012
1.531AspTyr: 1.531 ± 0.019
0.0AspXaa: 0.0 ± 0.0
Glu
4.784GluAla: 4.784 ± 0.033
0.707GluCys: 0.707 ± 0.013
3.708GluAsp: 3.708 ± 0.034
4.65GluGlu: 4.65 ± 0.051
1.878GluPhe: 1.878 ± 0.019
3.542GluGly: 3.542 ± 0.03
1.53GluHis: 1.53 ± 0.017
2.81GluIle: 2.81 ± 0.025
2.951GluLys: 2.951 ± 0.032
5.586GluLeu: 5.586 ± 0.038
1.279GluMet: 1.279 ± 0.016
1.892GluAsn: 1.892 ± 0.02
3.023GluPro: 3.023 ± 0.033
2.317GluGln: 2.317 ± 0.021
3.918GluArg: 3.918 ± 0.037
4.239GluSer: 4.239 ± 0.033
3.083GluThr: 3.083 ± 0.026
3.372GluVal: 3.372 ± 0.03
0.981GluTrp: 0.981 ± 0.013
1.69GluTyr: 1.69 ± 0.019
0.0GluXaa: 0.0 ± 0.0
Phe
2.928PheAla: 2.928 ± 0.024
0.491PheCys: 0.491 ± 0.01
2.153PheAsp: 2.153 ± 0.02
2.007PheGlu: 2.007 ± 0.02
1.358PhePhe: 1.358 ± 0.017
2.819PheGly: 2.819 ± 0.031
0.837PheHis: 0.837 ± 0.012
1.782PheIle: 1.782 ± 0.019
1.562PheLys: 1.562 ± 0.016
3.097PheLeu: 3.097 ± 0.025
0.761PheMet: 0.761 ± 0.012
1.428PheAsn: 1.428 ± 0.02
1.873PhePro: 1.873 ± 0.02
1.251PheGln: 1.251 ± 0.015
1.85PheArg: 1.85 ± 0.018
3.023PheSer: 3.023 ± 0.029
2.124PheThr: 2.124 ± 0.023
2.377PheVal: 2.377 ± 0.022
0.569PheTrp: 0.569 ± 0.012
0.98PheTyr: 0.98 ± 0.012
0.0PheXaa: 0.0 ± 0.0
Gly
5.416GlyAla: 5.416 ± 0.041
0.881GlyCys: 0.881 ± 0.015
3.413GlyAsp: 3.413 ± 0.027
3.451GlyGlu: 3.451 ± 0.03
2.472GlyPhe: 2.472 ± 0.022
5.424GlyGly: 5.424 ± 0.057
1.878GlyHis: 1.878 ± 0.024
3.293GlyIle: 3.293 ± 0.029
3.273GlyLys: 3.273 ± 0.027
5.909GlyLeu: 5.909 ± 0.039
1.572GlyMet: 1.572 ± 0.023
2.457GlyAsn: 2.457 ± 0.026
3.525GlyPro: 3.525 ± 0.03
2.488GlyGln: 2.488 ± 0.025
3.978GlyArg: 3.978 ± 0.032
6.016GlySer: 6.016 ± 0.047
4.386GlyThr: 4.386 ± 0.031
4.438GlyVal: 4.438 ± 0.03
1.126GlyTrp: 1.126 ± 0.017
2.049GlyTyr: 2.049 ± 0.022
0.0GlyXaa: 0.0 ± 0.0
His
2.14HisAla: 2.14 ± 0.022
0.317HisCys: 0.317 ± 0.007
1.317HisAsp: 1.317 ± 0.017
1.373HisGlu: 1.373 ± 0.018
0.947HisPhe: 0.947 ± 0.013
1.622HisGly: 1.622 ± 0.019
0.784HisHis: 0.784 ± 0.015
1.469HisIle: 1.469 ± 0.016
0.941HisLys: 0.941 ± 0.014
2.418HisLeu: 2.418 ± 0.022
0.527HisMet: 0.527 ± 0.01
0.861HisAsn: 0.861 ± 0.012
2.028HisPro: 2.028 ± 0.027
0.94HisGln: 0.94 ± 0.012
1.545HisArg: 1.545 ± 0.016
2.208HisSer: 2.208 ± 0.023
1.723HisThr: 1.723 ± 0.019
1.585HisVal: 1.585 ± 0.02
0.375HisTrp: 0.375 ± 0.008
0.74HisTyr: 0.74 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
4.287IleAla: 4.287 ± 0.03
0.722IleCys: 0.722 ± 0.012
2.882IleAsp: 2.882 ± 0.023
2.904IleGlu: 2.904 ± 0.027
1.757IlePhe: 1.757 ± 0.019
3.143IleGly: 3.143 ± 0.029
1.339IleHis: 1.339 ± 0.016
2.536IleIle: 2.536 ± 0.025
2.229IleLys: 2.229 ± 0.02
4.371IleLeu: 4.371 ± 0.036
1.001IleMet: 1.001 ± 0.016
1.807IleAsn: 1.807 ± 0.019
3.265IlePro: 3.265 ± 0.026
2.025IleGln: 2.025 ± 0.02
2.989IleArg: 2.989 ± 0.029
3.956IleSer: 3.956 ± 0.029
2.948IleThr: 2.948 ± 0.021
3.304IleVal: 3.304 ± 0.027
0.812IleTrp: 0.812 ± 0.013
1.415IleTyr: 1.415 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
3.991LysAla: 3.991 ± 0.034
0.531LysCys: 0.531 ± 0.01
2.478LysAsp: 2.478 ± 0.024
2.893LysGlu: 2.893 ± 0.033
1.405LysPhe: 1.405 ± 0.018
2.769LysGly: 2.769 ± 0.026
1.17LysHis: 1.17 ± 0.015
2.043LysIle: 2.043 ± 0.021
2.6LysLys: 2.6 ± 0.036
4.106LysLeu: 4.106 ± 0.03
0.861LysMet: 0.861 ± 0.012
1.562LysAsn: 1.562 ± 0.019
2.708LysPro: 2.708 ± 0.026
1.713LysGln: 1.713 ± 0.019
3.225LysArg: 3.225 ± 0.031
3.441LysSer: 3.441 ± 0.026
2.559LysThr: 2.559 ± 0.022
2.666LysVal: 2.666 ± 0.028
0.643LysTrp: 0.643 ± 0.013
1.319LysTyr: 1.319 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
8.605LeuAla: 8.605 ± 0.054
1.273LeuCys: 1.273 ± 0.017
5.268LeuAsp: 5.268 ± 0.033
5.475LeuGlu: 5.475 ± 0.038
3.23LeuPhe: 3.23 ± 0.03
6.357LeuGly: 6.357 ± 0.041
2.376LeuHis: 2.376 ± 0.021
3.964LeuIle: 3.964 ± 0.031
4.105LeuLys: 4.105 ± 0.033
8.143LeuLeu: 8.143 ± 0.057
1.719LeuMet: 1.719 ± 0.018
3.25LeuAsn: 3.25 ± 0.023
5.843LeuPro: 5.843 ± 0.035
3.426LeuGln: 3.426 ± 0.028
5.676LeuArg: 5.676 ± 0.043
7.568LeuSer: 7.568 ± 0.044
5.139LeuThr: 5.139 ± 0.032
6.022LeuVal: 6.022 ± 0.044
1.256LeuTrp: 1.256 ± 0.017
2.328LeuTyr: 2.328 ± 0.021
0.0LeuXaa: 0.0 ± 0.0
Met
1.849MetAla: 1.849 ± 0.018
0.254MetCys: 0.254 ± 0.008
1.169MetAsp: 1.169 ± 0.015
1.166MetGlu: 1.166 ± 0.016
0.76MetPhe: 0.76 ± 0.012
1.346MetGly: 1.346 ± 0.022
0.541MetHis: 0.541 ± 0.009
0.995MetIle: 0.995 ± 0.013
0.896MetLys: 0.896 ± 0.012
1.902MetLeu: 1.902 ± 0.019
0.503MetMet: 0.503 ± 0.012
0.824MetAsn: 0.824 ± 0.013
1.208MetPro: 1.208 ± 0.017
0.755MetGln: 0.755 ± 0.011
1.311MetArg: 1.311 ± 0.013
2.02MetSer: 2.02 ± 0.024
1.24MetThr: 1.24 ± 0.014
1.283MetVal: 1.283 ± 0.016
0.295MetTrp: 0.295 ± 0.008
0.518MetTyr: 0.518 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.123AsnAla: 3.123 ± 0.024
0.42AsnCys: 0.42 ± 0.009
1.834AsnAsp: 1.834 ± 0.022
1.927AsnGlu: 1.927 ± 0.018
1.177AsnPhe: 1.177 ± 0.015
2.707AsnGly: 2.707 ± 0.028
0.87AsnHis: 0.87 ± 0.011
2.0AsnIle: 2.0 ± 0.019
1.542AsnLys: 1.542 ± 0.017
3.289AsnLeu: 3.289 ± 0.027
0.8AsnMet: 0.8 ± 0.012
1.472AsnAsn: 1.472 ± 0.018
2.566AsnPro: 2.566 ± 0.022
1.337AsnGln: 1.337 ± 0.016
1.867AsnArg: 1.867 ± 0.021
2.847AsnSer: 2.847 ± 0.023
2.338AsnThr: 2.338 ± 0.021
2.337AsnVal: 2.337 ± 0.021
0.55AsnTrp: 0.55 ± 0.011
1.045AsnTyr: 1.045 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
5.551ProAla: 5.551 ± 0.053
0.528ProCys: 0.528 ± 0.012
3.598ProAsp: 3.598 ± 0.034
3.91ProGlu: 3.91 ± 0.029
2.042ProPhe: 2.042 ± 0.022
4.217ProGly: 4.217 ± 0.038
1.617ProHis: 1.617 ± 0.02
2.953ProIle: 2.953 ± 0.026
2.69ProLys: 2.69 ± 0.026
5.167ProLeu: 5.167 ± 0.036
1.104ProMet: 1.104 ± 0.015
2.517ProAsn: 2.517 ± 0.021
6.06ProPro: 6.06 ± 0.085
2.33ProGln: 2.33 ± 0.03
3.727ProArg: 3.727 ± 0.036
6.545ProSer: 6.545 ± 0.052
4.84ProThr: 4.84 ± 0.042
4.025ProVal: 4.025 ± 0.033
0.685ProTrp: 0.685 ± 0.012
1.578ProTyr: 1.578 ± 0.019
0.0ProXaa: 0.0 ± 0.0
Gln
3.428GlnAla: 3.428 ± 0.029
0.456GlnCys: 0.456 ± 0.009
1.878GlnAsp: 1.878 ± 0.019
2.063GlnGlu: 2.063 ± 0.022
1.288GlnPhe: 1.288 ± 0.015
2.219GlnGly: 2.219 ± 0.023
1.049GlnHis: 1.049 ± 0.016
1.827GlnIle: 1.827 ± 0.018
1.537GlnLys: 1.537 ± 0.019
3.748GlnLeu: 3.748 ± 0.029
0.797GlnMet: 0.797 ± 0.012
1.343GlnAsn: 1.343 ± 0.018
2.564GlnPro: 2.564 ± 0.034
1.836GlnGln: 1.836 ± 0.038
2.445GlnArg: 2.445 ± 0.023
3.07GlnSer: 3.07 ± 0.024
2.376GlnThr: 2.376 ± 0.024
2.366GlnVal: 2.366 ± 0.024
0.546GlnTrp: 0.546 ± 0.009
1.108GlnTyr: 1.108 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
5.381ArgAla: 5.381 ± 0.033
0.782ArgCys: 0.782 ± 0.013
3.111ArgAsp: 3.111 ± 0.029
3.602ArgGlu: 3.602 ± 0.033
2.184ArgPhe: 2.184 ± 0.026
3.626ArgGly: 3.626 ± 0.031
1.546ArgHis: 1.546 ± 0.02
3.104ArgIle: 3.104 ± 0.025
2.99ArgLys: 2.99 ± 0.027
5.708ArgLeu: 5.708 ± 0.033
1.357ArgMet: 1.357 ± 0.015
2.095ArgAsn: 2.095 ± 0.02
3.768ArgPro: 3.768 ± 0.036
2.303ArgGln: 2.303 ± 0.022
4.745ArgArg: 4.745 ± 0.042
5.09ArgSer: 5.09 ± 0.046
3.622ArgThr: 3.622 ± 0.029
3.836ArgVal: 3.836 ± 0.026
0.941ArgTrp: 0.941 ± 0.011
1.689ArgTyr: 1.689 ± 0.02
0.0ArgXaa: 0.0 ± 0.0
Ser
6.822SerAla: 6.822 ± 0.043
0.918SerCys: 0.918 ± 0.016
4.361SerAsp: 4.361 ± 0.029
4.201SerGlu: 4.201 ± 0.034
2.927SerPhe: 2.927 ± 0.025
5.9SerGly: 5.9 ± 0.04
2.227SerHis: 2.227 ± 0.026
4.196SerIle: 4.196 ± 0.03
3.558SerLys: 3.558 ± 0.03
7.444SerLeu: 7.444 ± 0.044
1.693SerMet: 1.693 ± 0.018
3.131SerAsn: 3.131 ± 0.025
6.282SerPro: 6.282 ± 0.063
3.236SerGln: 3.236 ± 0.024
5.314SerArg: 5.314 ± 0.043
8.847SerSer: 8.847 ± 0.068
6.131SerThr: 6.131 ± 0.044
5.126SerVal: 5.126 ± 0.036
1.047SerTrp: 1.047 ± 0.015
2.186SerTyr: 2.186 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
4.919ThrAla: 4.919 ± 0.037
0.795ThrCys: 0.795 ± 0.013
2.802ThrAsp: 2.802 ± 0.022
2.998ThrGlu: 2.998 ± 0.025
2.24ThrPhe: 2.24 ± 0.022
4.428ThrGly: 4.428 ± 0.037
1.635ThrHis: 1.635 ± 0.02
3.304ThrIle: 3.304 ± 0.026
2.543ThrLys: 2.543 ± 0.023
5.778ThrLeu: 5.778 ± 0.038
1.2ThrMet: 1.2 ± 0.013
2.254ThrAsn: 2.254 ± 0.021
5.066ThrPro: 5.066 ± 0.045
2.24ThrGln: 2.24 ± 0.023
3.769ThrArg: 3.769 ± 0.028
5.712ThrSer: 5.712 ± 0.04
4.459ThrThr: 4.459 ± 0.041
3.711ThrVal: 3.711 ± 0.029
0.894ThrTrp: 0.894 ± 0.013
1.708ThrTyr: 1.708 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
5.474ValAla: 5.474 ± 0.032
0.879ValCys: 0.879 ± 0.015
3.568ValAsp: 3.568 ± 0.025
3.672ValGlu: 3.672 ± 0.032
2.39ValPhe: 2.39 ± 0.024
3.982ValGly: 3.982 ± 0.03
1.623ValHis: 1.623 ± 0.018
3.144ValIle: 3.144 ± 0.025
2.83ValLys: 2.83 ± 0.028
5.942ValLeu: 5.942 ± 0.038
1.276ValMet: 1.276 ± 0.015
2.201ValAsn: 2.201 ± 0.02
4.031ValPro: 4.031 ± 0.034
2.457ValGln: 2.457 ± 0.021
3.606ValArg: 3.606 ± 0.027
4.954ValSer: 4.954 ± 0.034
3.61ValThr: 3.61 ± 0.026
4.533ValVal: 4.533 ± 0.033
1.064ValTrp: 1.064 ± 0.016
1.842ValTyr: 1.842 ± 0.019
0.0ValXaa: 0.0 ± 0.0
Trp
1.155TrpAla: 1.155 ± 0.014
0.221TrpCys: 0.221 ± 0.006
1.071TrpAsp: 1.071 ± 0.015
0.823TrpGlu: 0.823 ± 0.014
0.558TrpPhe: 0.558 ± 0.01
0.927TrpGly: 0.927 ± 0.015
0.357TrpHis: 0.357 ± 0.008
0.779TrpIle: 0.779 ± 0.011
0.752TrpLys: 0.752 ± 0.013
1.288TrpLeu: 1.288 ± 0.017
0.409TrpMet: 0.409 ± 0.01
0.68TrpAsn: 0.68 ± 0.013
0.602TrpPro: 0.602 ± 0.012
0.466TrpGln: 0.466 ± 0.01
0.925TrpArg: 0.925 ± 0.015
1.179TrpSer: 1.179 ± 0.014
0.934TrpThr: 0.934 ± 0.014
0.958TrpVal: 0.958 ± 0.014
0.267TrpTrp: 0.267 ± 0.007
0.406TrpTyr: 0.406 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.289TyrAla: 2.289 ± 0.021
0.379TyrCys: 0.379 ± 0.009
1.65TyrAsp: 1.65 ± 0.017
1.491TyrGlu: 1.491 ± 0.017
1.099TyrPhe: 1.099 ± 0.015
1.913TyrGly: 1.913 ± 0.022
0.727TyrHis: 0.727 ± 0.01
1.472TyrIle: 1.472 ± 0.016
1.089TyrLys: 1.089 ± 0.015
2.589TyrLeu: 2.589 ± 0.023
0.616TyrMet: 0.616 ± 0.012
1.124TyrAsn: 1.124 ± 0.015
1.585TyrPro: 1.585 ± 0.019
1.099TyrGln: 1.099 ± 0.015
1.583TyrArg: 1.583 ± 0.02
2.211TyrSer: 2.211 ± 0.023
1.744TyrThr: 1.744 ± 0.02
1.702TyrVal: 1.702 ± 0.017
0.458TyrTrp: 0.458 ± 0.01
0.879TyrTyr: 0.879 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10990 proteins (5600857 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski