Amino acid dipepetide frequency for Thermotalea metallivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.908AlaAla: 5.908 ± 0.119	0.786AlaCys: 0.786 ± 0.033	3.279AlaAsp: 3.279 ± 0.065	4.557AlaGlu: 4.557 ± 0.075	2.993AlaPhe: 2.993 ± 0.065	5.035AlaGly: 5.035 ± 0.094	1.202AlaHis: 1.202 ± 0.035	5.993AlaIle: 5.993 ± 0.104	5.168AlaLys: 5.168 ± 0.086	6.997AlaLeu: 6.997 ± 0.112	2.314AlaMet: 2.314 ± 0.052	2.678AlaAsn: 2.678 ± 0.058	1.873AlaPro: 1.873 ± 0.055	2.115AlaGln: 2.115 ± 0.05	2.876AlaArg: 2.876 ± 0.057	3.49AlaSer: 3.49 ± 0.068	3.041AlaThr: 3.041 ± 0.06	5.621AlaVal: 5.621 ± 0.111	0.526AlaTrp: 0.526 ± 0.025	2.573AlaTyr: 2.573 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.601CysAla: 0.601 ± 0.027	0.215CysCys: 0.215 ± 0.017	0.567CysAsp: 0.567 ± 0.03	0.633CysGlu: 0.633 ± 0.028	0.459CysPhe: 0.459 ± 0.023	1.011CysGly: 1.011 ± 0.038	0.277CysHis: 0.277 ± 0.018	0.961CysIle: 0.961 ± 0.036	0.77CysLys: 0.77 ± 0.03	0.855CysLeu: 0.855 ± 0.033	0.291CysMet: 0.291 ± 0.019	0.465CysAsn: 0.465 ± 0.022	0.544CysPro: 0.544 ± 0.028	0.317CysGln: 0.317 ± 0.018	0.545CysArg: 0.545 ± 0.023	0.622CysSer: 0.622 ± 0.029	0.538CysThr: 0.538 ± 0.024	0.593CysVal: 0.593 ± 0.025	0.085CysTrp: 0.085 ± 0.009	0.381CysTyr: 0.381 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.422AspAla: 3.422 ± 0.065	0.633AspCys: 0.633 ± 0.029	2.332AspAsp: 2.332 ± 0.063	4.063AspGlu: 4.063 ± 0.073	2.49AspPhe: 2.49 ± 0.052	3.613AspGly: 3.613 ± 0.068	1.114AspHis: 1.114 ± 0.036	5.249AspIle: 5.249 ± 0.082	3.806AspLys: 3.806 ± 0.072	4.865AspLeu: 4.865 ± 0.082	1.669AspMet: 1.669 ± 0.048	1.711AspAsn: 1.711 ± 0.054	1.863AspPro: 1.863 ± 0.049	1.498AspGln: 1.498 ± 0.037	2.661AspArg: 2.661 ± 0.063	2.194AspSer: 2.194 ± 0.049	2.465AspThr: 2.465 ± 0.059	3.613AspVal: 3.613 ± 0.068	0.463AspTrp: 0.463 ± 0.024	2.344AspTyr: 2.344 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	5.278GluAla: 5.278 ± 0.089	0.547GluCys: 0.547 ± 0.026	4.048GluAsp: 4.048 ± 0.074	7.366GluGlu: 7.366 ± 0.126	2.413GluPhe: 2.413 ± 0.06	4.966GluGly: 4.966 ± 0.103	1.193GluHis: 1.193 ± 0.041	7.627GluIle: 7.627 ± 0.085	8.277GluLys: 8.277 ± 0.1	6.327GluLeu: 6.327 ± 0.094	2.522GluMet: 2.522 ± 0.057	4.34GluAsn: 4.34 ± 0.083	1.673GluPro: 1.673 ± 0.046	2.512GluGln: 2.512 ± 0.062	3.583GluArg: 3.583 ± 0.072	2.97GluSer: 2.97 ± 0.065	3.174GluThr: 3.174 ± 0.065	4.94GluVal: 4.94 ± 0.078	0.514GluTrp: 0.514 ± 0.025	2.597GluTyr: 2.597 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.646PheAla: 2.646 ± 0.066	0.522PheCys: 0.522 ± 0.023	2.29PheAsp: 2.29 ± 0.063	2.661PheGlu: 2.661 ± 0.059	1.919PhePhe: 1.919 ± 0.06	2.898PheGly: 2.898 ± 0.074	1.203PheHis: 1.203 ± 0.041	3.824PheIle: 3.824 ± 0.074	2.379PheLys: 2.379 ± 0.058	3.819PheLeu: 3.819 ± 0.085	1.204PheMet: 1.204 ± 0.036	1.58PheAsn: 1.58 ± 0.048	1.411PhePro: 1.411 ± 0.037	1.6PheGln: 1.6 ± 0.047	1.691PheArg: 1.691 ± 0.039	2.614PheSer: 2.614 ± 0.054	2.195PheThr: 2.195 ± 0.056	2.787PheVal: 2.787 ± 0.062	0.336PheTrp: 0.336 ± 0.02	1.65PheTyr: 1.65 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.83GlyAla: 4.83 ± 0.106	0.879GlyCys: 0.879 ± 0.035	3.438GlyAsp: 3.438 ± 0.077	5.062GlyGlu: 5.062 ± 0.099	3.227GlyPhe: 3.227 ± 0.076	4.836GlyGly: 4.836 ± 0.093	1.301GlyHis: 1.301 ± 0.037	7.188GlyIle: 7.188 ± 0.096	6.013GlyLys: 6.013 ± 0.097	6.249GlyLeu: 6.249 ± 0.095	2.293GlyMet: 2.293 ± 0.052	3.132GlyAsn: 3.132 ± 0.055	1.596GlyPro: 1.596 ± 0.041	2.093GlyGln: 2.093 ± 0.05	3.159GlyArg: 3.159 ± 0.061	3.533GlySer: 3.533 ± 0.073	3.776GlyThr: 3.776 ± 0.078	4.719GlyVal: 4.719 ± 0.078	0.624GlyTrp: 0.624 ± 0.028	3.014GlyTyr: 3.014 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.199HisAla: 1.199 ± 0.042	0.253HisCys: 0.253 ± 0.017	0.948HisAsp: 0.948 ± 0.039	1.4HisGlu: 1.4 ± 0.041	0.846HisPhe: 0.846 ± 0.03	1.588HisGly: 1.588 ± 0.044	0.702HisHis: 0.702 ± 0.034	1.781HisIle: 1.781 ± 0.048	1.243HisLys: 1.243 ± 0.035	1.823HisLeu: 1.823 ± 0.047	0.649HisMet: 0.649 ± 0.03	0.718HisAsn: 0.718 ± 0.031	1.047HisPro: 1.047 ± 0.037	0.752HisGln: 0.752 ± 0.031	1.18HisArg: 1.18 ± 0.038	0.968HisSer: 0.968 ± 0.033	1.014HisThr: 1.014 ± 0.034	1.309HisVal: 1.309 ± 0.036	0.215HisTrp: 0.215 ± 0.015	0.831HisTyr: 0.831 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.618IleAla: 6.618 ± 0.098	1.06IleCys: 1.06 ± 0.036	5.083IleAsp: 5.083 ± 0.076	6.825IleGlu: 6.825 ± 0.107	3.736IlePhe: 3.736 ± 0.088	6.21IleGly: 6.21 ± 0.091	2.162IleHis: 2.162 ± 0.048	6.921IleIle: 6.921 ± 0.111	6.156IleLys: 6.156 ± 0.096	8.817IleLeu: 8.817 ± 0.109	2.146IleMet: 2.146 ± 0.057	3.315IleAsn: 3.315 ± 0.078	3.781IlePro: 3.781 ± 0.075	3.206IleGln: 3.206 ± 0.067	4.231IleArg: 4.231 ± 0.063	5.115IleSer: 5.115 ± 0.086	4.331IleThr: 4.331 ± 0.079	5.888IleVal: 5.888 ± 0.089	0.635IleTrp: 0.635 ± 0.028	3.125IleTyr: 3.125 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.466LysAla: 5.466 ± 0.091	0.618LysCys: 0.618 ± 0.029	4.524LysAsp: 4.524 ± 0.073	7.64LysGlu: 7.64 ± 0.116	2.403LysPhe: 2.403 ± 0.053	5.385LysGly: 5.385 ± 0.086	1.282LysHis: 1.282 ± 0.045	7.492LysIle: 7.492 ± 0.099	6.917LysLys: 6.917 ± 0.103	6.285LysLeu: 6.285 ± 0.089	2.405LysMet: 2.405 ± 0.05	4.396LysAsn: 4.396 ± 0.068	2.317LysPro: 2.317 ± 0.054	2.419LysGln: 2.419 ± 0.058	3.351LysArg: 3.351 ± 0.066	3.503LysSer: 3.503 ± 0.073	3.754LysThr: 3.754 ± 0.067	5.129LysVal: 5.129 ± 0.093	0.568LysTrp: 0.568 ± 0.027	3.143LysTyr: 3.143 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	6.314LeuAla: 6.314 ± 0.095	0.998LeuCys: 0.998 ± 0.035	4.885LeuAsp: 4.885 ± 0.071	7.063LeuGlu: 7.063 ± 0.11	3.819LeuPhe: 3.819 ± 0.083	6.783LeuGly: 6.783 ± 0.108	1.756LeuHis: 1.756 ± 0.046	7.042LeuIle: 7.042 ± 0.096	7.656LeuLys: 7.656 ± 0.101	8.723LeuLeu: 8.723 ± 0.126	2.755LeuMet: 2.755 ± 0.062	3.989LeuAsn: 3.989 ± 0.072	3.3LeuPro: 3.3 ± 0.066	3.095LeuGln: 3.095 ± 0.066	3.934LeuArg: 3.934 ± 0.067	5.713LeuSer: 5.713 ± 0.096	4.372LeuThr: 4.372 ± 0.07	5.519LeuVal: 5.519 ± 0.084	0.843LeuTrp: 0.843 ± 0.032	3.155LeuTyr: 3.155 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.483MetAla: 2.483 ± 0.058	0.234MetCys: 0.234 ± 0.015	1.901MetAsp: 1.901 ± 0.05	2.786MetGlu: 2.786 ± 0.055	0.884MetPhe: 0.884 ± 0.034	2.32MetGly: 2.32 ± 0.058	0.53MetHis: 0.53 ± 0.027	2.572MetIle: 2.572 ± 0.057	2.756MetLys: 2.756 ± 0.063	2.626MetLeu: 2.626 ± 0.05	1.104MetMet: 1.104 ± 0.043	1.513MetAsn: 1.513 ± 0.049	1.057MetPro: 1.057 ± 0.033	0.862MetGln: 0.862 ± 0.032	1.135MetArg: 1.135 ± 0.035	1.399MetSer: 1.399 ± 0.043	1.44MetThr: 1.44 ± 0.046	1.995MetVal: 1.995 ± 0.048	0.127MetTrp: 0.127 ± 0.013	0.831MetTyr: 0.831 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.758AsnAla: 2.758 ± 0.063	0.506AsnCys: 0.506 ± 0.024	1.864AsnAsp: 1.864 ± 0.047	2.644AsnGlu: 2.644 ± 0.06	1.831AsnPhe: 1.831 ± 0.044	3.061AsnGly: 3.061 ± 0.071	1.07AsnHis: 1.07 ± 0.034	4.49AsnIle: 4.49 ± 0.069	3.161AsnLys: 3.161 ± 0.064	4.173AsnLeu: 4.173 ± 0.079	1.387AsnMet: 1.387 ± 0.042	1.917AsnAsn: 1.917 ± 0.049	2.195AsnPro: 2.195 ± 0.059	1.515AsnGln: 1.515 ± 0.047	2.301AsnArg: 2.301 ± 0.056	2.003AsnSer: 2.003 ± 0.055	2.16AsnThr: 2.16 ± 0.051	2.728AsnVal: 2.728 ± 0.055	0.398AsnTrp: 0.398 ± 0.021	1.821AsnTyr: 1.821 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.129ProAla: 2.129 ± 0.054	0.347ProCys: 0.347 ± 0.02	1.834ProAsp: 1.834 ± 0.052	2.798ProGlu: 2.798 ± 0.06	1.581ProPhe: 1.581 ± 0.044	2.361ProGly: 2.361 ± 0.06	0.775ProHis: 0.775 ± 0.031	2.706ProIle: 2.706 ± 0.063	2.409ProLys: 2.409 ± 0.056	2.964ProLeu: 2.964 ± 0.053	1.082ProMet: 1.082 ± 0.038	1.384ProAsn: 1.384 ± 0.041	1.031ProPro: 1.031 ± 0.041	1.215ProGln: 1.215 ± 0.038	1.241ProArg: 1.241 ± 0.041	1.858ProSer: 1.858 ± 0.049	1.648ProThr: 1.648 ± 0.044	2.866ProVal: 2.866 ± 0.067	0.381ProTrp: 0.381 ± 0.021	1.485ProTyr: 1.485 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.128GlnAla: 2.128 ± 0.049	0.35GlnCys: 0.35 ± 0.019	1.589GlnAsp: 1.589 ± 0.044	2.788GlnGlu: 2.788 ± 0.065	1.204GlnPhe: 1.204 ± 0.039	2.289GlnGly: 2.289 ± 0.048	0.603GlnHis: 0.603 ± 0.026	2.761GlnIle: 2.761 ± 0.064	2.801GlnLys: 2.801 ± 0.074	2.971GlnLeu: 2.971 ± 0.065	1.106GlnMet: 1.106 ± 0.038	1.545GlnAsn: 1.545 ± 0.048	1.019GlnPro: 1.019 ± 0.037	1.26GlnGln: 1.26 ± 0.051	1.623GlnArg: 1.623 ± 0.041	1.527GlnSer: 1.527 ± 0.046	1.363GlnThr: 1.363 ± 0.041	1.995GlnVal: 1.995 ± 0.046	0.423GlnTrp: 0.423 ± 0.022	1.353GlnTyr: 1.353 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.648ArgAla: 2.648 ± 0.053	0.452ArgCys: 0.452 ± 0.024	2.353ArgAsp: 2.353 ± 0.056	4.16ArgGlu: 4.16 ± 0.074	1.859ArgPhe: 1.859 ± 0.049	2.71ArgGly: 2.71 ± 0.055	0.808ArgHis: 0.808 ± 0.032	4.102ArgIle: 4.102 ± 0.073	3.965ArgLys: 3.965 ± 0.067	4.174ArgLeu: 4.174 ± 0.07	1.496ArgMet: 1.496 ± 0.044	2.155ArgAsn: 2.155 ± 0.046	1.355ArgPro: 1.355 ± 0.037	1.611ArgGln: 1.611 ± 0.046	2.23ArgArg: 2.23 ± 0.061	1.796ArgSer: 1.796 ± 0.047	1.907ArgThr: 1.907 ± 0.048	2.812ArgVal: 2.812 ± 0.063	0.44ArgTrp: 0.44 ± 0.024	1.866ArgTyr: 1.866 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.122SerAla: 3.122 ± 0.067	0.55SerCys: 0.55 ± 0.027	2.408SerAsp: 2.408 ± 0.049	2.975SerGlu: 2.975 ± 0.063	2.52SerPhe: 2.52 ± 0.05	3.792SerGly: 3.792 ± 0.075	1.083SerHis: 1.083 ± 0.037	4.745SerIle: 4.745 ± 0.079	3.81SerLys: 3.81 ± 0.062	4.974SerLeu: 4.974 ± 0.076	1.621SerMet: 1.621 ± 0.045	2.216SerAsn: 2.216 ± 0.058	1.826SerPro: 1.826 ± 0.046	1.704SerGln: 1.704 ± 0.05	2.193SerArg: 2.193 ± 0.05	2.806SerSer: 2.806 ± 0.065	2.57SerThr: 2.57 ± 0.057	3.326SerVal: 3.326 ± 0.062	0.43SerTrp: 0.43 ± 0.022	1.97SerTyr: 1.97 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	3.764ThrAla: 3.764 ± 0.076	0.468ThrCys: 0.468 ± 0.023	2.372ThrAsp: 2.372 ± 0.046	3.045ThrGlu: 3.045 ± 0.066	1.935ThrPhe: 1.935 ± 0.049	4.191ThrGly: 4.191 ± 0.072	0.913ThrHis: 0.913 ± 0.036	4.206ThrIle: 4.206 ± 0.071	3.165ThrLys: 3.165 ± 0.062	4.622ThrLeu: 4.622 ± 0.072	1.266ThrMet: 1.266 ± 0.032	1.959ThrAsn: 1.959 ± 0.051	1.995ThrPro: 1.995 ± 0.055	1.263ThrGln: 1.263 ± 0.036	1.849ThrArg: 1.849 ± 0.047	2.459ThrSer: 2.459 ± 0.049	2.468ThrThr: 2.468 ± 0.058	3.603ThrVal: 3.603 ± 0.081	0.386ThrTrp: 0.386 ± 0.024	1.858ThrTyr: 1.858 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.785ValAla: 4.785 ± 0.085	0.719ValCys: 0.719 ± 0.032	3.695ValAsp: 3.695 ± 0.064	5.083ValGlu: 5.083 ± 0.077	2.967ValPhe: 2.967 ± 0.061	4.394ValGly: 4.394 ± 0.089	1.285ValHis: 1.285 ± 0.037	5.885ValIle: 5.885 ± 0.086	5.27ValLys: 5.27 ± 0.089	6.32ValLeu: 6.32 ± 0.088	1.879ValMet: 1.879 ± 0.044	2.854ValAsn: 2.854 ± 0.058	2.444ValPro: 2.444 ± 0.052	2.002ValGln: 2.002 ± 0.05	2.652ValArg: 2.652 ± 0.057	3.742ValSer: 3.742 ± 0.067	3.315ValThr: 3.315 ± 0.071	4.973ValVal: 4.973 ± 0.09	0.527ValTrp: 0.527 ± 0.025	2.442ValTyr: 2.442 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.487TrpAla: 0.487 ± 0.024	0.088TrpCys: 0.088 ± 0.012	0.455TrpAsp: 0.455 ± 0.025	0.623TrpGlu: 0.623 ± 0.031	0.354TrpPhe: 0.354 ± 0.021	0.57TrpGly: 0.57 ± 0.027	0.186TrpHis: 0.186 ± 0.017	0.739TrpIle: 0.739 ± 0.031	0.719TrpLys: 0.719 ± 0.029	0.724TrpLeu: 0.724 ± 0.033	0.294TrpMet: 0.294 ± 0.019	0.468TrpAsn: 0.468 ± 0.026	0.218TrpPro: 0.218 ± 0.016	0.322TrpGln: 0.322 ± 0.02	0.375TrpArg: 0.375 ± 0.021	0.407TrpSer: 0.407 ± 0.022	0.413TrpThr: 0.413 ± 0.02	0.506TrpVal: 0.506 ± 0.027	0.096TrpTrp: 0.096 ± 0.01	0.299TrpTyr: 0.299 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.437TyrAla: 2.437 ± 0.045	0.503TyrCys: 0.503 ± 0.023	2.203TyrAsp: 2.203 ± 0.056	2.696TyrGlu: 2.696 ± 0.062	1.791TyrPhe: 1.791 ± 0.046	2.951TyrGly: 2.951 ± 0.06	1.018TyrHis: 1.018 ± 0.034	3.075TyrIle: 3.075 ± 0.067	2.56TyrLys: 2.56 ± 0.057	3.409TyrLeu: 3.409 ± 0.074	1.068TyrMet: 1.068 ± 0.033	1.648TyrAsn: 1.648 ± 0.043	1.548TyrPro: 1.548 ± 0.047	1.337TyrGln: 1.337 ± 0.04	2.089TyrArg: 2.089 ± 0.061	1.922TyrSer: 1.922 ± 0.042	1.845TyrThr: 1.845 ± 0.048	2.31TyrVal: 2.31 ± 0.055	0.329TyrTrp: 0.329 ± 0.02	1.607TyrTyr: 1.607 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3013 proteins (875152 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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