Amino acid dipepetide frequency for Thioalkalivibrio denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.035AlaAla: 13.035 ± 0.162	1.225AlaCys: 1.225 ± 0.037	6.007AlaAsp: 6.007 ± 0.065	7.203AlaGlu: 7.203 ± 0.108	3.597AlaPhe: 3.597 ± 0.066	9.827AlaGly: 9.827 ± 0.118	2.622AlaHis: 2.622 ± 0.057	4.646AlaIle: 4.646 ± 0.079	2.148AlaLys: 2.148 ± 0.055	13.288AlaLeu: 13.288 ± 0.141	3.045AlaMet: 3.045 ± 0.058	2.194AlaAsn: 2.194 ± 0.047	4.734AlaPro: 4.734 ± 0.079	3.702AlaGln: 3.702 ± 0.063	9.814AlaArg: 9.814 ± 0.127	4.939AlaSer: 4.939 ± 0.094	4.534AlaThr: 4.534 ± 0.067	8.653AlaVal: 8.653 ± 0.086	1.695AlaTrp: 1.695 ± 0.048	2.411AlaTyr: 2.411 ± 0.052	0.001AlaXaa: 0.001 ± 0.001
Cys	1.029CysAla: 1.029 ± 0.033	0.123CysCys: 0.123 ± 0.011	0.539CysAsp: 0.539 ± 0.021	0.576CysGlu: 0.576 ± 0.024	0.295CysPhe: 0.295 ± 0.019	0.98CysGly: 0.98 ± 0.033	0.351CysHis: 0.351 ± 0.021	0.382CysIle: 0.382 ± 0.02	0.169CysLys: 0.169 ± 0.012	0.927CysLeu: 0.927 ± 0.028	0.194CysMet: 0.194 ± 0.014	0.232CysAsn: 0.232 ± 0.015	0.599CysPro: 0.599 ± 0.031	0.255CysGln: 0.255 ± 0.014	0.764CysArg: 0.764 ± 0.033	0.436CysSer: 0.436 ± 0.022	0.414CysThr: 0.414 ± 0.022	0.685CysVal: 0.685 ± 0.028	0.09CysTrp: 0.09 ± 0.01	0.237CysTyr: 0.237 ± 0.016	0.001CysXaa: 0.001 ± 0.001
Asp	6.659AspAla: 6.659 ± 0.087	0.478AspCys: 0.478 ± 0.022	3.622AspAsp: 3.622 ± 0.073	4.241AspGlu: 4.241 ± 0.072	2.076AspPhe: 2.076 ± 0.049	4.937AspGly: 4.937 ± 0.083	1.525AspHis: 1.525 ± 0.046	2.63AspIle: 2.63 ± 0.048	1.331AspLys: 1.331 ± 0.038	6.486AspLeu: 6.486 ± 0.09	1.528AspMet: 1.528 ± 0.042	1.351AspAsn: 1.351 ± 0.035	3.841AspPro: 3.841 ± 0.064	1.638AspGln: 1.638 ± 0.039	4.822AspArg: 4.822 ± 0.069	2.516AspSer: 2.516 ± 0.053	3.136AspThr: 3.136 ± 0.061	4.251AspVal: 4.251 ± 0.069	1.009AspTrp: 1.009 ± 0.033	1.614AspTyr: 1.614 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.369GluAla: 8.369 ± 0.114	0.454GluCys: 0.454 ± 0.02	3.635GluAsp: 3.635 ± 0.058	4.049GluGlu: 4.049 ± 0.077	1.995GluPhe: 1.995 ± 0.044	5.177GluGly: 5.177 ± 0.078	1.852GluHis: 1.852 ± 0.047	3.221GluIle: 3.221 ± 0.056	1.749GluLys: 1.749 ± 0.047	6.601GluLeu: 6.601 ± 0.097	1.715GluMet: 1.715 ± 0.042	1.487GluAsn: 1.487 ± 0.042	3.325GluPro: 3.325 ± 0.08	2.993GluGln: 2.993 ± 0.058	6.502GluArg: 6.502 ± 0.105	3.169GluSer: 3.169 ± 0.062	3.49GluThr: 3.49 ± 0.065	4.789GluVal: 4.789 ± 0.074	0.796GluTrp: 0.796 ± 0.03	1.429GluTyr: 1.429 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.362PheAla: 3.362 ± 0.068	0.359PheCys: 0.359 ± 0.022	2.3PheAsp: 2.3 ± 0.055	2.285PheGlu: 2.285 ± 0.044	1.338PhePhe: 1.338 ± 0.04	2.996PheGly: 2.996 ± 0.064	0.895PheHis: 0.895 ± 0.03	1.535PheIle: 1.535 ± 0.048	0.761PheLys: 0.761 ± 0.03	3.449PheLeu: 3.449 ± 0.071	0.884PheMet: 0.884 ± 0.026	1.015PheAsn: 1.015 ± 0.031	1.581PhePro: 1.581 ± 0.042	1.028PheGln: 1.028 ± 0.03	2.634PheArg: 2.634 ± 0.046	1.974PheSer: 1.974 ± 0.045	1.881PheThr: 1.881 ± 0.042	2.677PheVal: 2.677 ± 0.055	0.552PheTrp: 0.552 ± 0.026	0.925PheTyr: 0.925 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.896GlyAla: 7.896 ± 0.111	0.939GlyCys: 0.939 ± 0.034	4.88GlyAsp: 4.88 ± 0.083	5.652GlyGlu: 5.652 ± 0.083	3.321GlyPhe: 3.321 ± 0.061	6.647GlyGly: 6.647 ± 0.107	2.204GlyHis: 2.204 ± 0.048	4.347GlyIle: 4.347 ± 0.076	2.285GlyLys: 2.285 ± 0.051	9.044GlyLeu: 9.044 ± 0.097	2.616GlyMet: 2.616 ± 0.06	2.009GlyAsn: 2.009 ± 0.046	3.332GlyPro: 3.332 ± 0.063	2.852GlyGln: 2.852 ± 0.056	6.987GlyArg: 6.987 ± 0.085	4.041GlySer: 4.041 ± 0.075	4.261GlyThr: 4.261 ± 0.071	6.608GlyVal: 6.608 ± 0.086	1.313GlyTrp: 1.313 ± 0.039	2.413GlyTyr: 2.413 ± 0.051	0.001GlyXaa: 0.001 ± 0.001
His	2.624HisAla: 2.624 ± 0.058	0.302HisCys: 0.302 ± 0.018	1.423HisAsp: 1.423 ± 0.042	1.549HisGlu: 1.549 ± 0.04	0.99HisPhe: 0.99 ± 0.033	2.42HisGly: 2.42 ± 0.055	0.826HisHis: 0.826 ± 0.03	1.06HisIle: 1.06 ± 0.031	0.499HisLys: 0.499 ± 0.019	2.635HisLeu: 2.635 ± 0.058	0.648HisMet: 0.648 ± 0.027	0.558HisAsn: 0.558 ± 0.024	1.754HisPro: 1.754 ± 0.052	0.749HisGln: 0.749 ± 0.03	2.12HisArg: 2.12 ± 0.048	1.119HisSer: 1.119 ± 0.033	1.198HisThr: 1.198 ± 0.038	1.928HisVal: 1.928 ± 0.041	0.474HisTrp: 0.474 ± 0.02	0.797HisTyr: 0.797 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.096IleAla: 5.096 ± 0.09	0.435IleCys: 0.435 ± 0.022	2.769IleAsp: 2.769 ± 0.057	3.202IleGlu: 3.202 ± 0.059	1.298IlePhe: 1.298 ± 0.045	3.821IleGly: 3.821 ± 0.078	1.218IleHis: 1.218 ± 0.035	1.955IleIle: 1.955 ± 0.059	1.102IleLys: 1.102 ± 0.037	4.451IleLeu: 4.451 ± 0.07	0.992IleMet: 0.992 ± 0.03	1.45IleAsn: 1.45 ± 0.041	2.551IlePro: 2.551 ± 0.055	1.281IleGln: 1.281 ± 0.037	3.948IleArg: 3.948 ± 0.058	2.409IleSer: 2.409 ± 0.052	2.566IleThr: 2.566 ± 0.053	3.242IleVal: 3.242 ± 0.067	0.507IleTrp: 0.507 ± 0.022	1.078IleTyr: 1.078 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.852LysAla: 2.852 ± 0.065	0.157LysCys: 0.157 ± 0.012	1.393LysAsp: 1.393 ± 0.038	1.466LysGlu: 1.466 ± 0.045	0.554LysPhe: 0.554 ± 0.026	2.042LysGly: 2.042 ± 0.048	0.584LysHis: 0.584 ± 0.025	1.018LysIle: 1.018 ± 0.041	0.953LysLys: 0.953 ± 0.073	2.33LysLeu: 2.33 ± 0.051	0.513LysMet: 0.513 ± 0.024	0.537LysAsn: 0.537 ± 0.026	1.351LysPro: 1.351 ± 0.039	0.843LysGln: 0.843 ± 0.034	2.047LysArg: 2.047 ± 0.05	1.21LysSer: 1.21 ± 0.038	1.237LysThr: 1.237 ± 0.038	1.913LysVal: 1.913 ± 0.051	0.238LysTrp: 0.238 ± 0.016	0.525LysTyr: 0.525 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.147LeuAla: 13.147 ± 0.146	0.938LeuCys: 0.938 ± 0.033	6.98LeuAsp: 6.98 ± 0.091	7.612LeuGlu: 7.612 ± 0.111	3.771LeuPhe: 3.771 ± 0.066	8.759LeuGly: 8.759 ± 0.09	2.525LeuHis: 2.525 ± 0.055	4.762LeuIle: 4.762 ± 0.079	2.926LeuLys: 2.926 ± 0.06	11.4LeuLeu: 11.4 ± 0.14	2.774LeuMet: 2.774 ± 0.058	2.647LeuAsn: 2.647 ± 0.051	5.881LeuPro: 5.881 ± 0.084	3.172LeuGln: 3.172 ± 0.063	8.634LeuArg: 8.634 ± 0.11	6.204LeuSer: 6.204 ± 0.084	5.361LeuThr: 5.361 ± 0.076	8.308LeuVal: 8.308 ± 0.108	1.43LeuTrp: 1.43 ± 0.043	2.353LeuTyr: 2.353 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.996MetAla: 2.996 ± 0.057	0.156MetCys: 0.156 ± 0.012	1.602MetAsp: 1.602 ± 0.044	1.658MetGlu: 1.658 ± 0.037	0.693MetPhe: 0.693 ± 0.028	1.997MetGly: 1.997 ± 0.058	0.584MetHis: 0.584 ± 0.025	1.137MetIle: 1.137 ± 0.034	0.88MetLys: 0.88 ± 0.028	2.596MetLeu: 2.596 ± 0.054	0.598MetMet: 0.598 ± 0.029	0.838MetAsn: 0.838 ± 0.028	1.499MetPro: 1.499 ± 0.038	0.927MetGln: 0.927 ± 0.029	2.062MetArg: 2.062 ± 0.046	1.61MetSer: 1.61 ± 0.045	1.532MetThr: 1.532 ± 0.036	1.807MetVal: 1.807 ± 0.047	0.191MetTrp: 0.191 ± 0.015	0.435MetTyr: 0.435 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.518AsnAla: 2.518 ± 0.05	0.243AsnCys: 0.243 ± 0.016	1.322AsnAsp: 1.322 ± 0.039	1.355AsnGlu: 1.355 ± 0.037	0.715AsnPhe: 0.715 ± 0.03	1.868AsnGly: 1.868 ± 0.053	0.561AsnHis: 0.561 ± 0.026	1.23AsnIle: 1.23 ± 0.041	0.498AsnLys: 0.498 ± 0.026	2.765AsnLeu: 2.765 ± 0.053	0.612AsnMet: 0.612 ± 0.025	0.606AsnAsn: 0.606 ± 0.026	1.787AsnPro: 1.787 ± 0.041	0.762AsnGln: 0.762 ± 0.028	2.156AsnArg: 2.156 ± 0.055	0.973AsnSer: 0.973 ± 0.039	1.214AsnThr: 1.214 ± 0.036	1.799AsnVal: 1.799 ± 0.047	0.317AsnTrp: 0.317 ± 0.02	0.538AsnTyr: 0.538 ± 0.025	0.001AsnXaa: 0.001 ± 0.001
Pro	5.545ProAla: 5.545 ± 0.084	0.388ProCys: 0.388 ± 0.02	4.205ProAsp: 4.205 ± 0.075	4.686ProGlu: 4.686 ± 0.087	1.803ProPhe: 1.803 ± 0.045	5.2ProGly: 5.2 ± 0.083	1.234ProHis: 1.234 ± 0.037	1.822ProIle: 1.822 ± 0.044	1.103ProLys: 1.103 ± 0.035	5.046ProLeu: 5.046 ± 0.082	1.305ProMet: 1.305 ± 0.038	1.043ProAsn: 1.043 ± 0.033	2.832ProPro: 2.832 ± 0.074	1.512ProGln: 1.512 ± 0.038	3.511ProArg: 3.511 ± 0.064	2.25ProSer: 2.25 ± 0.054	1.979ProThr: 1.979 ± 0.046	4.898ProVal: 4.898 ± 0.082	0.836ProTrp: 0.836 ± 0.033	1.158ProTyr: 1.158 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.262GlnAla: 4.262 ± 0.064	0.277GlnCys: 0.277 ± 0.017	1.605GlnAsp: 1.605 ± 0.036	1.897GlnGlu: 1.897 ± 0.046	0.971GlnPhe: 0.971 ± 0.031	2.906GlnGly: 2.906 ± 0.054	0.765GlnHis: 0.765 ± 0.029	1.434GlnIle: 1.434 ± 0.041	0.756GlnLys: 0.756 ± 0.027	3.31GlnLeu: 3.31 ± 0.06	0.868GlnMet: 0.868 ± 0.028	0.623GlnAsn: 0.623 ± 0.024	1.659GlnPro: 1.659 ± 0.045	1.287GlnGln: 1.287 ± 0.04	2.939GlnArg: 2.939 ± 0.056	1.558GlnSer: 1.558 ± 0.043	1.531GlnThr: 1.531 ± 0.041	2.931GlnVal: 2.931 ± 0.056	0.52GlnTrp: 0.52 ± 0.026	0.715GlnTyr: 0.715 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.092ArgAla: 8.092 ± 0.115	0.742ArgCys: 0.742 ± 0.028	4.923ArgAsp: 4.923 ± 0.073	6.31ArgGlu: 6.31 ± 0.094	3.421ArgPhe: 3.421 ± 0.062	5.609ArgGly: 5.609 ± 0.083	2.53ArgHis: 2.53 ± 0.05	4.458ArgIle: 4.458 ± 0.069	2.098ArgLys: 2.098 ± 0.053	9.965ArgLeu: 9.965 ± 0.116	2.31ArgMet: 2.31 ± 0.042	2.086ArgAsn: 2.086 ± 0.05	3.971ArgPro: 3.971 ± 0.069	3.045ArgGln: 3.045 ± 0.062	7.359ArgArg: 7.359 ± 0.119	3.653ArgSer: 3.653 ± 0.06	3.662ArgThr: 3.662 ± 0.066	6.456ArgVal: 6.456 ± 0.098	1.271ArgTrp: 1.271 ± 0.041	2.331ArgTyr: 2.331 ± 0.05	0.003ArgXaa: 0.003 ± 0.002
Ser	5.137SerAla: 5.137 ± 0.096	0.426SerCys: 0.426 ± 0.024	2.77SerAsp: 2.77 ± 0.048	2.965SerGlu: 2.965 ± 0.059	1.686SerPhe: 1.686 ± 0.038	5.048SerGly: 5.048 ± 0.078	1.198SerHis: 1.198 ± 0.034	2.09SerIle: 2.09 ± 0.045	1.019SerLys: 1.019 ± 0.032	5.54SerLeu: 5.54 ± 0.087	1.333SerMet: 1.333 ± 0.039	1.135SerAsn: 1.135 ± 0.038	2.662SerPro: 2.662 ± 0.055	1.399SerGln: 1.399 ± 0.038	4.058SerArg: 4.058 ± 0.072	2.203SerSer: 2.203 ± 0.057	2.336SerThr: 2.336 ± 0.052	3.815SerVal: 3.815 ± 0.062	0.607SerTrp: 0.607 ± 0.026	1.081SerTyr: 1.081 ± 0.035	0.001SerXaa: 0.001 ± 0.001
Thr	5.035ThrAla: 5.035 ± 0.065	0.423ThrCys: 0.423 ± 0.019	2.87ThrAsp: 2.87 ± 0.049	2.771ThrGlu: 2.771 ± 0.053	1.622ThrPhe: 1.622 ± 0.037	4.944ThrGly: 4.944 ± 0.08	1.221ThrHis: 1.221 ± 0.034	1.983ThrIle: 1.983 ± 0.051	0.821ThrLys: 0.821 ± 0.031	6.236ThrLeu: 6.236 ± 0.088	0.953ThrMet: 0.953 ± 0.027	0.964ThrAsn: 0.964 ± 0.035	3.165ThrPro: 3.165 ± 0.055	1.42ThrGln: 1.42 ± 0.041	3.981ThrArg: 3.981 ± 0.07	2.061ThrSer: 2.061 ± 0.051	2.342ThrThr: 2.342 ± 0.049	4.119ThrVal: 4.119 ± 0.071	0.648ThrTrp: 0.648 ± 0.025	1.05ThrTyr: 1.05 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.259ValAla: 8.259 ± 0.099	0.773ValCys: 0.773 ± 0.027	4.855ValAsp: 4.855 ± 0.073	5.161ValGlu: 5.161 ± 0.073	2.806ValPhe: 2.806 ± 0.06	5.545ValGly: 5.545 ± 0.069	1.966ValHis: 1.966 ± 0.048	4.061ValIle: 4.061 ± 0.066	1.843ValLys: 1.843 ± 0.046	8.606ValLeu: 8.606 ± 0.097	2.028ValMet: 2.028 ± 0.043	2.114ValAsn: 2.114 ± 0.047	3.903ValPro: 3.903 ± 0.07	2.381ValGln: 2.381 ± 0.053	6.234ValArg: 6.234 ± 0.088	4.329ValSer: 4.329 ± 0.059	4.142ValThr: 4.142 ± 0.06	6.497ValVal: 6.497 ± 0.091	0.968ValTrp: 0.968 ± 0.034	1.726ValTyr: 1.726 ± 0.041	0.001ValXaa: 0.001 ± 0.001
Trp	1.165TrpAla: 1.165 ± 0.037	0.164TrpCys: 0.164 ± 0.013	0.666TrpAsp: 0.666 ± 0.027	0.745TrpGlu: 0.745 ± 0.027	0.562TrpPhe: 0.562 ± 0.029	0.927TrpGly: 0.927 ± 0.034	0.405TrpHis: 0.405 ± 0.02	0.705TrpIle: 0.705 ± 0.025	0.327TrpLys: 0.327 ± 0.021	2.005TrpLeu: 2.005 ± 0.055	0.371TrpMet: 0.371 ± 0.019	0.357TrpAsn: 0.357 ± 0.02	0.71TrpPro: 0.71 ± 0.028	0.677TrpGln: 0.677 ± 0.021	1.337TrpArg: 1.337 ± 0.036	0.714TrpSer: 0.714 ± 0.026	0.608TrpThr: 0.608 ± 0.023	1.087TrpVal: 1.087 ± 0.032	0.287TrpTrp: 0.287 ± 0.019	0.324TrpTyr: 0.324 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.239TyrAla: 2.239 ± 0.042	0.278TyrCys: 0.278 ± 0.016	1.326TyrAsp: 1.326 ± 0.038	1.414TyrGlu: 1.414 ± 0.039	0.914TyrPhe: 0.914 ± 0.034	1.999TyrGly: 1.999 ± 0.048	0.605TyrHis: 0.605 ± 0.027	0.896TyrIle: 0.896 ± 0.033	0.491TyrLys: 0.491 ± 0.023	2.904TyrLeu: 2.904 ± 0.056	0.511TyrMet: 0.511 ± 0.024	0.595TyrAsn: 0.595 ± 0.028	1.219TyrPro: 1.219 ± 0.034	0.892TyrGln: 0.892 ± 0.028	2.385TyrArg: 2.385 ± 0.052	1.138TyrSer: 1.138 ± 0.035	1.206TyrThr: 1.206 ± 0.038	1.734TyrVal: 1.734 ± 0.039	0.395TyrTrp: 0.395 ± 0.019	0.705TyrTyr: 0.705 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 3346 proteins (1015271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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