Human papillomavirus 201

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 27

Average proteome isoelectric point is 6.12

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A0H4LQV7|A0A0H4LQV7_9PAPI Major capsid protein L1 OS=Human papillomavirus 201 OX=1682340 GN=L1 PE=3 SV=1
MM1 pKa = 7.59IGVEE5 pKa = 3.93PTIADD10 pKa = 3.47IEE12 pKa = 4.53LDD14 pKa = 3.74LQEE17 pKa = 5.55LVLPSNLLSNEE28 pKa = 3.92EE29 pKa = 4.07SLEE32 pKa = 4.04EE33 pKa = 3.88QVEE36 pKa = 4.44EE37 pKa = 4.24EE38 pKa = 3.8QQEE41 pKa = 4.77YY42 pKa = 10.44YY43 pKa = 10.71RR44 pKa = 11.84IDD46 pKa = 3.86TRR48 pKa = 11.84CHH50 pKa = 5.43TCGTGVRR57 pKa = 11.84CCVSATSFGIRR68 pKa = 11.84QLEE71 pKa = 3.82LLLIHH76 pKa = 6.72EE77 pKa = 6.0GISFCCPGCSRR88 pKa = 11.84RR89 pKa = 11.84RR90 pKa = 11.84SFHH93 pKa = 6.54HH94 pKa = 6.91GRR96 pKa = 11.84LQQ98 pKa = 3.32

Molecular weight: 11.14 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A0H4M3P8|A0A0H4M3P8_9PAPI Regulatory protein E2 OS=Human papillomavirus 201 OX=1682340 GN=E2 PE=3 SV=1
MM1 pKa = 7.71EE2 pKa = 5.0EE3 pKa = 3.62LTRR6 pKa = 11.84RR7 pKa = 11.84FDD9 pKa = 3.57VLQDD13 pKa = 3.1QLMRR17 pKa = 11.84HH18 pKa = 5.61YY19 pKa = 10.29EE20 pKa = 4.14SEE22 pKa = 4.45SKK24 pKa = 10.79SLQDD28 pKa = 4.46QINYY32 pKa = 9.14WEE34 pKa = 4.56TIRR37 pKa = 11.84KK38 pKa = 8.76EE39 pKa = 4.18SALLHH44 pKa = 5.73YY45 pKa = 10.3ARR47 pKa = 11.84QQGISKK53 pKa = 10.5LGLQPVPALVVSEE66 pKa = 4.43YY67 pKa = 10.61NGKK70 pKa = 8.79QAISISLTLQSLLKK84 pKa = 10.77SPFGKK89 pKa = 8.4EE90 pKa = 3.28TWTLPEE96 pKa = 4.16TSAEE100 pKa = 4.46LINTEE105 pKa = 4.71PKK107 pKa = 9.31NTLKK111 pKa = 10.82KK112 pKa = 10.06HH113 pKa = 5.16GFTVTVWFDD122 pKa = 3.39HH123 pKa = 6.17EE124 pKa = 4.58KK125 pKa = 9.93QNAMQYY131 pKa = 8.47TNWNNIYY138 pKa = 10.13YY139 pKa = 9.79QDD141 pKa = 4.43YY142 pKa = 10.51DD143 pKa = 4.2NVWHH147 pKa = 6.38KK148 pKa = 11.39VKK150 pKa = 11.26GEE152 pKa = 3.51VDD154 pKa = 3.52YY155 pKa = 11.8NGLYY159 pKa = 8.66FTEE162 pKa = 4.56PSGDD166 pKa = 2.99RR167 pKa = 11.84AYY169 pKa = 11.04FKK171 pKa = 10.67IFAQDD176 pKa = 2.85AEE178 pKa = 4.78MYY180 pKa = 10.31SKK182 pKa = 9.52TGEE185 pKa = 3.98WTVHH189 pKa = 4.94YY190 pKa = 7.95KK191 pKa = 10.06TYY193 pKa = 10.21TISPPSGFSSASSSYY208 pKa = 11.32SRR210 pKa = 11.84TTEE213 pKa = 3.32ISTSATTRR221 pKa = 11.84HH222 pKa = 5.65TSPEE226 pKa = 3.86KK227 pKa = 10.62ASTSNEE233 pKa = 3.66QQRR236 pKa = 11.84VLRR239 pKa = 11.84SPPRR243 pKa = 11.84LRR245 pKa = 11.84AASVSPPQPSSTTEE259 pKa = 3.67TPEE262 pKa = 3.69RR263 pKa = 11.84EE264 pKa = 3.62RR265 pKa = 11.84VQRR268 pKa = 11.84RR269 pKa = 11.84RR270 pKa = 11.84RR271 pKa = 11.84RR272 pKa = 11.84EE273 pKa = 3.72QGEE276 pKa = 4.2SRR278 pKa = 11.84PRR280 pKa = 11.84EE281 pKa = 4.03ATPKK285 pKa = 9.96RR286 pKa = 11.84RR287 pKa = 11.84RR288 pKa = 11.84TEE290 pKa = 3.9DD291 pKa = 2.97SGGRR295 pKa = 11.84AGRR298 pKa = 11.84GGGGRR303 pKa = 11.84GAPSPEE309 pKa = 3.64AVGQRR314 pKa = 11.84HH315 pKa = 5.63RR316 pKa = 11.84SVEE319 pKa = 4.28TKK321 pKa = 10.26GLSRR325 pKa = 11.84LRR327 pKa = 11.84ALQEE331 pKa = 3.86EE332 pKa = 4.57ARR334 pKa = 11.84DD335 pKa = 3.65PPVIIIRR342 pKa = 11.84GGANALKK349 pKa = 10.18CFRR352 pKa = 11.84YY353 pKa = 9.99RR354 pKa = 11.84KK355 pKa = 6.75THH357 pKa = 5.99SSSKK361 pKa = 10.66HH362 pKa = 5.16LFLCISSVFKK372 pKa = 10.59WVGDD376 pKa = 3.85CTATSGSRR384 pKa = 11.84MLVSFKK390 pKa = 10.59DD391 pKa = 3.55VKK393 pKa = 9.86QRR395 pKa = 11.84EE396 pKa = 4.02MFIRR400 pKa = 11.84HH401 pKa = 3.96TTFPKK406 pKa = 9.54GSEE409 pKa = 4.2YY410 pKa = 10.74FLGQLNSLL418 pKa = 4.16

Molecular weight: 47.69 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2471

98

608

353.0

40.04

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.261 ± 0.467

2.388 ± 0.837

5.828 ± 0.732

6.92 ± 0.867

4.937 ± 0.717

5.585 ± 0.479

2.185 ± 0.4

5.706 ± 0.748

5.261 ± 0.838

8.822 ± 0.83

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.538 ± 0.389

5.059 ± 0.782

6.192 ± 0.866

4.775 ± 0.188

5.949 ± 0.892

7.487 ± 0.933

6.516 ± 0.787

5.221 ± 0.31

1.214 ± 0.247

3.157 ± 0.422
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski