Amino acid dipepetide frequency for Nocardia otitidiscaviarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.011AlaAla: 23.011 ± 0.179
0.919AlaCys: 0.919 ± 0.024
9.279AlaAsp: 9.279 ± 0.1
8.812AlaGlu: 8.812 ± 0.077
3.417AlaPhe: 3.417 ± 0.042
11.77AlaGly: 11.77 ± 0.086
2.86AlaHis: 2.86 ± 0.042
4.743AlaIle: 4.743 ± 0.053
2.464AlaLys: 2.464 ± 0.038
13.829AlaLeu: 13.829 ± 0.113
2.659AlaMet: 2.659 ± 0.043
2.2AlaAsn: 2.2 ± 0.032
6.826AlaPro: 6.826 ± 0.071
3.672AlaGln: 3.672 ± 0.052
10.166AlaArg: 10.166 ± 0.085
5.171AlaSer: 5.171 ± 0.056
7.904AlaThr: 7.904 ± 0.067
12.586AlaVal: 12.586 ± 0.104
1.743AlaTrp: 1.743 ± 0.031
2.43AlaTyr: 2.43 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.056CysAla: 1.056 ± 0.024
0.088CysCys: 0.088 ± 0.007
0.464CysAsp: 0.464 ± 0.014
0.387CysGlu: 0.387 ± 0.015
0.208CysPhe: 0.208 ± 0.009
0.883CysGly: 0.883 ± 0.023
0.182CysHis: 0.182 ± 0.009
0.2CysIle: 0.2 ± 0.01
0.105CysLys: 0.105 ± 0.008
0.667CysLeu: 0.667 ± 0.017
0.106CysMet: 0.106 ± 0.006
0.125CysAsn: 0.125 ± 0.007
0.492CysPro: 0.492 ± 0.016
0.159CysGln: 0.159 ± 0.008
0.556CysArg: 0.556 ± 0.018
0.388CysSer: 0.388 ± 0.015
0.495CysThr: 0.495 ± 0.018
0.604CysVal: 0.604 ± 0.017
0.115CysTrp: 0.115 ± 0.008
0.17CysTyr: 0.17 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.985AspAla: 7.985 ± 0.087
0.453AspCys: 0.453 ± 0.016
3.73AspAsp: 3.73 ± 0.046
3.707AspGlu: 3.707 ± 0.048
1.832AspPhe: 1.832 ± 0.029
5.776AspGly: 5.776 ± 0.063
1.492AspHis: 1.492 ± 0.026
2.65AspIle: 2.65 ± 0.039
1.075AspLys: 1.075 ± 0.027
6.231AspLeu: 6.231 ± 0.083
1.011AspMet: 1.011 ± 0.02
1.135AspAsn: 1.135 ± 0.021
4.834AspPro: 4.834 ± 0.06
1.596AspGln: 1.596 ± 0.028
5.496AspArg: 5.496 ± 0.061
2.956AspSer: 2.956 ± 0.039
3.85AspThr: 3.85 ± 0.048
4.353AspVal: 4.353 ± 0.053
0.983AspTrp: 0.983 ± 0.024
1.413AspTyr: 1.413 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.042GluAla: 6.042 ± 0.053
0.346GluCys: 0.346 ± 0.014
2.203GluAsp: 2.203 ± 0.037
2.399GluGlu: 2.399 ± 0.043
2.036GluPhe: 2.036 ± 0.03
3.239GluGly: 3.239 ± 0.04
1.644GluHis: 1.644 ± 0.028
2.743GluIle: 2.743 ± 0.035
1.126GluLys: 1.126 ± 0.028
7.392GluLeu: 7.392 ± 0.092
0.989GluMet: 0.989 ± 0.025
1.11GluAsn: 1.11 ± 0.026
3.453GluPro: 3.453 ± 0.044
2.334GluGln: 2.334 ± 0.033
5.38GluArg: 5.38 ± 0.052
2.943GluSer: 2.943 ± 0.041
2.907GluThr: 2.907 ± 0.036
4.597GluVal: 4.597 ± 0.051
0.837GluTrp: 0.837 ± 0.02
1.237GluTyr: 1.237 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.096PheAla: 4.096 ± 0.05
0.243PheCys: 0.243 ± 0.01
2.474PheAsp: 2.474 ± 0.046
1.609PheGlu: 1.609 ± 0.035
0.869PhePhe: 0.869 ± 0.023
3.422PheGly: 3.422 ± 0.042
0.652PheHis: 0.652 ± 0.017
0.883PheIle: 0.883 ± 0.025
0.376PheLys: 0.376 ± 0.014
2.533PheLeu: 2.533 ± 0.041
0.402PheMet: 0.402 ± 0.015
0.529PheAsn: 0.529 ± 0.017
1.434PhePro: 1.434 ± 0.03
0.697PheGln: 0.697 ± 0.025
1.862PheArg: 1.862 ± 0.03
1.364PheSer: 1.364 ± 0.025
2.082PheThr: 2.082 ± 0.029
2.413PheVal: 2.413 ± 0.042
0.416PheTrp: 0.416 ± 0.015
0.589PheTyr: 0.589 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
10.504GlyAla: 10.504 ± 0.094
0.822GlyCys: 0.822 ± 0.023
5.1GlyAsp: 5.1 ± 0.058
4.618GlyGlu: 4.618 ± 0.062
2.981GlyPhe: 2.981 ± 0.043
8.075GlyGly: 8.075 ± 0.093
2.009GlyHis: 2.009 ± 0.031
4.12GlyIle: 4.12 ± 0.051
2.082GlyLys: 2.082 ± 0.035
8.564GlyLeu: 8.564 ± 0.078
2.16GlyMet: 2.16 ± 0.033
1.768GlyAsn: 1.768 ± 0.032
4.632GlyPro: 4.632 ± 0.06
2.437GlyGln: 2.437 ± 0.047
6.843GlyArg: 6.843 ± 0.059
5.125GlySer: 5.125 ± 0.068
5.694GlyThr: 5.694 ± 0.057
7.43GlyVal: 7.43 ± 0.078
1.599GlyTrp: 1.599 ± 0.033
2.426GlyTyr: 2.426 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.659HisAla: 2.659 ± 0.038
0.2HisCys: 0.2 ± 0.01
1.369HisAsp: 1.369 ± 0.025
1.095HisGlu: 1.095 ± 0.024
0.641HisPhe: 0.641 ± 0.018
2.26HisGly: 2.26 ± 0.039
0.694HisHis: 0.694 ± 0.022
0.859HisIle: 0.859 ± 0.02
0.279HisLys: 0.279 ± 0.012
2.21HisLeu: 2.21 ± 0.036
0.369HisMet: 0.369 ± 0.012
0.427HisAsn: 0.427 ± 0.015
1.839HisPro: 1.839 ± 0.03
0.537HisGln: 0.537 ± 0.016
2.175HisArg: 2.175 ± 0.037
1.023HisSer: 1.023 ± 0.021
1.384HisThr: 1.384 ± 0.025
1.446HisVal: 1.446 ± 0.027
0.388HisTrp: 0.388 ± 0.014
0.518HisTyr: 0.518 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
6.265IleAla: 6.265 ± 0.06
0.297IleCys: 0.297 ± 0.012
3.162IleAsp: 3.162 ± 0.038
2.48IleGlu: 2.48 ± 0.038
0.906IlePhe: 0.906 ± 0.025
4.358IleGly: 4.358 ± 0.052
0.711IleHis: 0.711 ± 0.019
1.207IleIle: 1.207 ± 0.029
0.617IleLys: 0.617 ± 0.021
3.019IleLeu: 3.019 ± 0.039
0.579IleMet: 0.579 ± 0.017
0.773IleAsn: 0.773 ± 0.021
2.441IlePro: 2.441 ± 0.033
0.794IleGln: 0.794 ± 0.018
2.68IleArg: 2.68 ± 0.038
1.963IleSer: 1.963 ± 0.033
2.697IleThr: 2.697 ± 0.035
3.432IleVal: 3.432 ± 0.043
0.41IleTrp: 0.41 ± 0.015
0.673IleTyr: 0.673 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
2.163LysAla: 2.163 ± 0.04
0.102LysCys: 0.102 ± 0.007
0.869LysAsp: 0.869 ± 0.026
0.801LysGlu: 0.801 ± 0.022
0.514LysPhe: 0.514 ± 0.017
1.3LysGly: 1.3 ± 0.028
0.397LysHis: 0.397 ± 0.013
0.805LysIle: 0.805 ± 0.021
0.524LysLys: 0.524 ± 0.021
1.877LysLeu: 1.877 ± 0.036
0.38LysMet: 0.38 ± 0.015
0.414LysAsn: 0.414 ± 0.017
1.139LysPro: 1.139 ± 0.026
0.642LysGln: 0.642 ± 0.019
1.34LysArg: 1.34 ± 0.033
1.001LysSer: 1.001 ± 0.023
1.11LysThr: 1.11 ± 0.027
1.514LysVal: 1.514 ± 0.03
0.248LysTrp: 0.248 ± 0.01
0.422LysTyr: 0.422 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
14.865LeuAla: 14.865 ± 0.106
0.793LeuCys: 0.793 ± 0.02
6.976LeuAsp: 6.976 ± 0.084
4.781LeuGlu: 4.781 ± 0.049
2.762LeuPhe: 2.762 ± 0.041
9.027LeuGly: 9.027 ± 0.075
2.19LeuHis: 2.19 ± 0.036
3.846LeuIle: 3.846 ± 0.056
1.32LeuLys: 1.32 ± 0.03
10.801LeuLeu: 10.801 ± 0.106
1.581LeuMet: 1.581 ± 0.029
1.709LeuAsn: 1.709 ± 0.033
6.273LeuPro: 6.273 ± 0.055
1.908LeuGln: 1.908 ± 0.029
8.978LeuArg: 8.978 ± 0.076
5.402LeuSer: 5.402 ± 0.063
6.818LeuThr: 6.818 ± 0.053
8.623LeuVal: 8.623 ± 0.082
1.249LeuTrp: 1.249 ± 0.028
1.701LeuTyr: 1.701 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.304MetAla: 2.304 ± 0.037
0.139MetCys: 0.139 ± 0.008
0.88MetAsp: 0.88 ± 0.02
0.692MetGlu: 0.692 ± 0.018
0.567MetPhe: 0.567 ± 0.017
1.364MetGly: 1.364 ± 0.029
0.402MetHis: 0.402 ± 0.014
0.816MetIle: 0.816 ± 0.023
0.368MetLys: 0.368 ± 0.016
2.024MetLeu: 2.024 ± 0.031
0.349MetMet: 0.349 ± 0.015
0.51MetAsn: 0.51 ± 0.017
1.156MetPro: 1.156 ± 0.025
0.429MetGln: 0.429 ± 0.014
1.628MetArg: 1.628 ± 0.028
1.474MetSer: 1.474 ± 0.028
1.579MetThr: 1.579 ± 0.03
1.583MetVal: 1.583 ± 0.026
0.232MetTrp: 0.232 ± 0.011
0.338MetTyr: 0.338 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.286AsnAla: 2.286 ± 0.035
0.148AsnCys: 0.148 ± 0.009
0.971AsnAsp: 0.971 ± 0.021
0.818AsnGlu: 0.818 ± 0.022
0.529AsnPhe: 0.529 ± 0.017
1.84AsnGly: 1.84 ± 0.034
0.394AsnHis: 0.394 ± 0.015
0.802AsnIle: 0.802 ± 0.021
0.353AsnLys: 0.353 ± 0.016
1.92AsnLeu: 1.92 ± 0.027
0.364AsnMet: 0.364 ± 0.015
0.425AsnAsn: 0.425 ± 0.016
1.657AsnPro: 1.657 ± 0.033
0.544AsnGln: 0.544 ± 0.016
1.478AsnArg: 1.478 ± 0.029
1.032AsnSer: 1.032 ± 0.026
1.185AsnThr: 1.185 ± 0.026
1.332AsnVal: 1.332 ± 0.027
0.327AsnTrp: 0.327 ± 0.014
0.444AsnTyr: 0.444 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
8.014ProAla: 8.014 ± 0.073
0.291ProCys: 0.291 ± 0.013
4.725ProAsp: 4.725 ± 0.063
4.589ProGlu: 4.589 ± 0.049
1.552ProPhe: 1.552 ± 0.028
6.14ProGly: 6.14 ± 0.071
1.35ProHis: 1.35 ± 0.025
2.131ProIle: 2.131 ± 0.035
1.094ProLys: 1.094 ± 0.024
5.202ProLeu: 5.202 ± 0.053
1.135ProMet: 1.135 ± 0.025
1.197ProAsn: 1.197 ± 0.029
3.556ProPro: 3.556 ± 0.077
1.611ProGln: 1.611 ± 0.037
4.004ProArg: 4.004 ± 0.05
2.837ProSer: 2.837 ± 0.043
3.851ProThr: 3.851 ± 0.051
5.396ProVal: 5.396 ± 0.066
0.86ProTrp: 0.86 ± 0.022
1.11ProTyr: 1.11 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.226GlnAla: 3.226 ± 0.04
0.169GlnCys: 0.169 ± 0.009
1.066GlnAsp: 1.066 ± 0.023
1.071GlnGlu: 1.071 ± 0.026
0.725GlnPhe: 0.725 ± 0.018
1.793GlnGly: 1.793 ± 0.031
0.683GlnHis: 0.683 ± 0.019
1.152GlnIle: 1.152 ± 0.025
0.414GlnLys: 0.414 ± 0.016
3.262GlnLeu: 3.262 ± 0.041
0.468GlnMet: 0.468 ± 0.017
0.479GlnAsn: 0.479 ± 0.017
1.81GlnPro: 1.81 ± 0.041
1.218GlnGln: 1.218 ± 0.035
2.881GlnArg: 2.881 ± 0.042
1.183GlnSer: 1.183 ± 0.025
1.238GlnThr: 1.238 ± 0.025
2.424GlnVal: 2.424 ± 0.041
0.48GlnTrp: 0.48 ± 0.015
0.577GlnTyr: 0.577 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
10.056ArgAla: 10.056 ± 0.095
0.618ArgCys: 0.618 ± 0.02
4.651ArgAsp: 4.651 ± 0.051
4.65ArgGlu: 4.65 ± 0.053
2.579ArgPhe: 2.579 ± 0.038
5.665ArgGly: 5.665 ± 0.055
1.947ArgHis: 1.947 ± 0.03
3.813ArgIle: 3.813 ± 0.042
1.534ArgLys: 1.534 ± 0.034
8.413ArgLeu: 8.413 ± 0.079
2.093ArgMet: 2.093 ± 0.026
1.53ArgAsn: 1.53 ± 0.027
4.73ArgPro: 4.73 ± 0.055
2.237ArgGln: 2.237 ± 0.033
7.515ArgArg: 7.515 ± 0.088
3.981ArgSer: 3.981 ± 0.053
5.393ArgThr: 5.393 ± 0.055
6.271ArgVal: 6.271 ± 0.058
1.478ArgTrp: 1.478 ± 0.028
2.01ArgTyr: 2.01 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.787SerAla: 6.787 ± 0.063
0.38SerCys: 0.38 ± 0.015
2.999SerAsp: 2.999 ± 0.042
2.517SerGlu: 2.517 ± 0.037
1.457SerPhe: 1.457 ± 0.028
5.864SerGly: 5.864 ± 0.059
0.942SerHis: 0.942 ± 0.019
1.838SerIle: 1.838 ± 0.026
0.928SerLys: 0.928 ± 0.023
4.276SerLeu: 4.276 ± 0.054
1.163SerMet: 1.163 ± 0.027
0.935SerAsn: 0.935 ± 0.02
2.908SerPro: 2.908 ± 0.037
1.156SerGln: 1.156 ± 0.024
3.517SerArg: 3.517 ± 0.043
2.58SerSer: 2.58 ± 0.042
3.206SerThr: 3.206 ± 0.032
4.137SerVal: 4.137 ± 0.04
0.828SerTrp: 0.828 ± 0.018
1.14SerTyr: 1.14 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
9.514ThrAla: 9.514 ± 0.076
0.389ThrCys: 0.389 ± 0.015
4.031ThrAsp: 4.031 ± 0.051
3.564ThrGlu: 3.564 ± 0.046
1.667ThrPhe: 1.667 ± 0.029
6.36ThrGly: 6.36 ± 0.057
1.182ThrHis: 1.182 ± 0.022
2.249ThrIle: 2.249 ± 0.033
0.994ThrLys: 0.994 ± 0.026
5.904ThrLeu: 5.904 ± 0.062
1.079ThrMet: 1.079 ± 0.021
1.053ThrAsn: 1.053 ± 0.025
4.324ThrPro: 4.324 ± 0.054
1.293ThrGln: 1.293 ± 0.026
4.229ThrArg: 4.229 ± 0.049
2.888ThrSer: 2.888 ± 0.041
4.165ThrThr: 4.165 ± 0.056
6.467ThrVal: 6.467 ± 0.054
0.805ThrTrp: 0.805 ± 0.02
1.184ThrTyr: 1.184 ± 0.023
0.0ThrXaa: 0.0 ± 0.0
Val
11.524ValAla: 11.524 ± 0.103
0.713ValCys: 0.713 ± 0.019
5.523ValAsp: 5.523 ± 0.059
4.599ValGlu: 4.599 ± 0.051
2.518ValPhe: 2.518 ± 0.038
6.851ValGly: 6.851 ± 0.066
1.852ValHis: 1.852 ± 0.029
3.386ValIle: 3.386 ± 0.041
1.33ValLys: 1.33 ± 0.027
9.365ValLeu: 9.365 ± 0.076
1.331ValMet: 1.331 ± 0.026
1.736ValAsn: 1.736 ± 0.029
5.099ValPro: 5.099 ± 0.058
1.864ValGln: 1.864 ± 0.034
6.978ValArg: 6.978 ± 0.067
4.302ValSer: 4.302 ± 0.05
5.614ValThr: 5.614 ± 0.055
8.127ValVal: 8.127 ± 0.076
1.058ValTrp: 1.058 ± 0.022
1.601ValTyr: 1.601 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.575TrpAla: 1.575 ± 0.027
0.142TrpCys: 0.142 ± 0.008
0.759TrpAsp: 0.759 ± 0.023
0.728TrpGlu: 0.728 ± 0.017
0.522TrpPhe: 0.522 ± 0.018
0.938TrpGly: 0.938 ± 0.024
0.348TrpHis: 0.348 ± 0.013
0.617TrpIle: 0.617 ± 0.017
0.294TrpLys: 0.294 ± 0.012
1.749TrpLeu: 1.749 ± 0.032
0.318TrpMet: 0.318 ± 0.011
0.395TrpAsn: 0.395 ± 0.016
0.766TrpPro: 0.766 ± 0.019
0.585TrpGln: 0.585 ± 0.018
1.386TrpArg: 1.386 ± 0.028
0.899TrpSer: 0.899 ± 0.024
0.975TrpThr: 0.975 ± 0.024
1.096TrpVal: 1.096 ± 0.025
0.354TrpTrp: 0.354 ± 0.015
0.332TrpTyr: 0.332 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.531TyrAla: 2.531 ± 0.043
0.196TyrCys: 0.196 ± 0.01
1.329TyrAsp: 1.329 ± 0.034
1.041TyrGlu: 1.041 ± 0.024
0.665TyrPhe: 0.665 ± 0.021
2.065TyrGly: 2.065 ± 0.033
0.439TyrHis: 0.439 ± 0.013
0.607TyrIle: 0.607 ± 0.015
0.287TyrLys: 0.287 ± 0.013
2.366TyrLeu: 2.366 ± 0.031
0.296TyrMet: 0.296 ± 0.014
0.4TyrAsn: 0.4 ± 0.017
1.274TyrPro: 1.274 ± 0.029
0.605TyrGln: 0.605 ± 0.018
2.073TyrArg: 2.073 ± 0.034
1.044TyrSer: 1.044 ± 0.021
1.19TyrThr: 1.19 ± 0.024
1.538TyrVal: 1.538 ± 0.039
0.369TyrTrp: 0.369 ± 0.013
0.464TyrTyr: 0.464 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6808 proteins (2213753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski