Amino acid dipepetide frequency for Natronomonas sp. CBA1123

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.097AlaAla: 13.097 ± 0.182	0.745AlaCys: 0.745 ± 0.03	9.225AlaAsp: 9.225 ± 0.105	9.101AlaGlu: 9.101 ± 0.11	4.131AlaPhe: 4.131 ± 0.075	9.285AlaGly: 9.285 ± 0.122	1.749AlaHis: 1.749 ± 0.044	4.804AlaIle: 4.804 ± 0.074	1.84AlaLys: 1.84 ± 0.045	10.237AlaLeu: 10.237 ± 0.128	2.075AlaMet: 2.075 ± 0.051	2.358AlaAsn: 2.358 ± 0.05	3.931AlaPro: 3.931 ± 0.064	2.014AlaGln: 2.014 ± 0.048	5.758AlaArg: 5.758 ± 0.084	5.07AlaSer: 5.07 ± 0.081	6.67AlaThr: 6.67 ± 0.092	10.893AlaVal: 10.893 ± 0.165	1.065AlaTrp: 1.065 ± 0.036	2.712AlaTyr: 2.712 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.622CysAla: 0.622 ± 0.024	0.091CysCys: 0.091 ± 0.01	0.627CysAsp: 0.627 ± 0.027	0.609CysGlu: 0.609 ± 0.027	0.214CysPhe: 0.214 ± 0.014	0.887CysGly: 0.887 ± 0.035	0.178CysHis: 0.178 ± 0.014	0.29CysIle: 0.29 ± 0.017	0.12CysLys: 0.12 ± 0.012	0.58CysLeu: 0.58 ± 0.027	0.112CysMet: 0.112 ± 0.012	0.21CysAsn: 0.21 ± 0.015	0.526CysPro: 0.526 ± 0.029	0.162CysGln: 0.162 ± 0.013	0.499CysArg: 0.499 ± 0.024	0.483CysSer: 0.483 ± 0.024	0.409CysThr: 0.409 ± 0.021	0.544CysVal: 0.544 ± 0.023	0.094CysTrp: 0.094 ± 0.01	0.192CysTyr: 0.192 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.374AspAla: 9.374 ± 0.1	0.769AspCys: 0.769 ± 0.035	7.96AspAsp: 7.96 ± 0.112	7.2AspGlu: 7.2 ± 0.11	2.129AspPhe: 2.129 ± 0.046	8.289AspGly: 8.289 ± 0.111	1.742AspHis: 1.742 ± 0.042	4.247AspIle: 4.247 ± 0.069	0.912AspLys: 0.912 ± 0.036	6.353AspLeu: 6.353 ± 0.102	1.198AspMet: 1.198 ± 0.039	1.424AspAsn: 1.424 ± 0.041	4.467AspPro: 4.467 ± 0.066	1.326AspGln: 1.326 ± 0.037	6.055AspArg: 6.055 ± 0.082	4.353AspSer: 4.353 ± 0.084	4.436AspThr: 4.436 ± 0.073	6.73AspVal: 6.73 ± 0.089	0.798AspTrp: 0.798 ± 0.028	1.974AspTyr: 1.974 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	9.679GluAla: 9.679 ± 0.113	0.558GluCys: 0.558 ± 0.025	5.765GluAsp: 5.765 ± 0.096	7.944GluGlu: 7.944 ± 0.138	3.129GluPhe: 3.129 ± 0.057	5.95GluGly: 5.95 ± 0.083	1.922GluHis: 1.922 ± 0.046	3.573GluIle: 3.573 ± 0.076	2.035GluLys: 2.035 ± 0.065	8.228GluLeu: 8.228 ± 0.097	1.88GluMet: 1.88 ± 0.043	2.46GluAsn: 2.46 ± 0.053	3.765GluPro: 3.765 ± 0.063	2.685GluGln: 2.685 ± 0.06	7.202GluArg: 7.202 ± 0.108	5.391GluSer: 5.391 ± 0.087	6.763GluThr: 6.763 ± 0.113	6.06GluVal: 6.06 ± 0.093	1.296GluTrp: 1.296 ± 0.04	2.748GluTyr: 2.748 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.716PheAla: 3.716 ± 0.073	0.315PheCys: 0.315 ± 0.019	3.286PheAsp: 3.286 ± 0.058	3.669PheGlu: 3.669 ± 0.067	1.029PhePhe: 1.029 ± 0.039	3.566PheGly: 3.566 ± 0.067	0.651PheHis: 0.651 ± 0.027	1.178PheIle: 1.178 ± 0.039	0.51PheLys: 0.51 ± 0.024	2.99PheLeu: 2.99 ± 0.065	0.539PheMet: 0.539 ± 0.026	0.733PheAsn: 0.733 ± 0.028	1.377PhePro: 1.377 ± 0.039	0.788PheGln: 0.788 ± 0.027	1.891PheArg: 1.891 ± 0.045	1.741PheSer: 1.741 ± 0.051	1.93PheThr: 1.93 ± 0.052	3.419PheVal: 3.419 ± 0.071	0.372PheTrp: 0.372 ± 0.024	0.884PheTyr: 0.884 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.974GlyAla: 7.974 ± 0.131	0.72GlyCys: 0.72 ± 0.029	6.637GlyAsp: 6.637 ± 0.097	7.411GlyGlu: 7.411 ± 0.099	3.358GlyPhe: 3.358 ± 0.068	7.666GlyGly: 7.666 ± 0.113	1.741GlyHis: 1.741 ± 0.042	4.393GlyIle: 4.393 ± 0.073	1.818GlyLys: 1.818 ± 0.059	7.477GlyLeu: 7.477 ± 0.1	1.68GlyMet: 1.68 ± 0.044	2.206GlyAsn: 2.206 ± 0.059	3.365GlyPro: 3.365 ± 0.063	1.993GlyGln: 1.993 ± 0.042	4.812GlyArg: 4.812 ± 0.072	4.974GlySer: 4.974 ± 0.079	5.933GlyThr: 5.933 ± 0.094	7.951GlyVal: 7.951 ± 0.115	1.16GlyTrp: 1.16 ± 0.037	2.819GlyTyr: 2.819 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.937HisAla: 1.937 ± 0.048	0.172HisCys: 0.172 ± 0.014	1.85HisAsp: 1.85 ± 0.042	1.705HisGlu: 1.705 ± 0.04	0.56HisPhe: 0.56 ± 0.023	1.924HisGly: 1.924 ± 0.046	0.549HisHis: 0.549 ± 0.028	0.782HisIle: 0.782 ± 0.032	0.301HisLys: 0.301 ± 0.02	1.687HisLeu: 1.687 ± 0.042	0.275HisMet: 0.275 ± 0.017	0.433HisAsn: 0.433 ± 0.02	1.186HisPro: 1.186 ± 0.041	0.455HisGln: 0.455 ± 0.021	1.272HisArg: 1.272 ± 0.035	0.877HisSer: 0.877 ± 0.03	1.083HisThr: 1.083 ± 0.034	1.797HisVal: 1.797 ± 0.041	0.212HisTrp: 0.212 ± 0.013	0.574HisTyr: 0.574 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.861IleAla: 4.861 ± 0.07	0.253IleCys: 0.253 ± 0.015	4.119IleAsp: 4.119 ± 0.069	4.68IleGlu: 4.68 ± 0.084	0.911IlePhe: 0.911 ± 0.033	3.731IleGly: 3.731 ± 0.073	0.868IleHis: 0.868 ± 0.032	1.468IleIle: 1.468 ± 0.045	0.685IleLys: 0.685 ± 0.034	2.989IleLeu: 2.989 ± 0.057	0.464IleMet: 0.464 ± 0.024	1.034IleAsn: 1.034 ± 0.034	2.083IlePro: 2.083 ± 0.055	1.077IleGln: 1.077 ± 0.033	2.64IleArg: 2.64 ± 0.059	2.104IleSer: 2.104 ± 0.052	2.315IleThr: 2.315 ± 0.053	3.679IleVal: 3.679 ± 0.066	0.278IleTrp: 0.278 ± 0.019	0.911IleTyr: 0.911 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	1.933LysAla: 1.933 ± 0.051	0.128LysCys: 0.128 ± 0.013	1.053LysAsp: 1.053 ± 0.039	1.463LysGlu: 1.463 ± 0.05	0.527LysPhe: 0.527 ± 0.025	1.316LysGly: 1.316 ± 0.046	0.483LysHis: 0.483 ± 0.026	0.734LysIle: 0.734 ± 0.031	0.521LysLys: 0.521 ± 0.029	1.702LysLeu: 1.702 ± 0.049	0.374LysMet: 0.374 ± 0.023	0.577LysAsn: 0.577 ± 0.028	0.943LysPro: 0.943 ± 0.029	0.777LysGln: 0.777 ± 0.026	1.737LysArg: 1.737 ± 0.05	1.103LysSer: 1.103 ± 0.036	1.319LysThr: 1.319 ± 0.042	1.222LysVal: 1.222 ± 0.035	0.222LysTrp: 0.222 ± 0.016	0.521LysTyr: 0.521 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	10.52LeuAla: 10.52 ± 0.144	0.618LeuCys: 0.618 ± 0.026	7.412LeuAsp: 7.412 ± 0.098	7.281LeuGlu: 7.281 ± 0.116	3.2LeuPhe: 3.2 ± 0.073	7.864LeuGly: 7.864 ± 0.123	1.483LeuHis: 1.483 ± 0.04	2.783LeuIle: 2.783 ± 0.06	1.619LeuLys: 1.619 ± 0.045	8.835LeuLeu: 8.835 ± 0.124	1.384LeuMet: 1.384 ± 0.034	1.941LeuAsn: 1.941 ± 0.045	4.264LeuPro: 4.264 ± 0.069	2.229LeuGln: 2.229 ± 0.048	5.505LeuArg: 5.505 ± 0.088	5.812LeuSer: 5.812 ± 0.093	5.302LeuThr: 5.302 ± 0.08	8.444LeuVal: 8.444 ± 0.116	0.854LeuTrp: 0.854 ± 0.03	2.316LeuTyr: 2.316 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.855MetAla: 1.855 ± 0.041	0.13MetCys: 0.13 ± 0.012	1.262MetAsp: 1.262 ± 0.037	1.259MetGlu: 1.259 ± 0.038	0.544MetPhe: 0.544 ± 0.023	1.466MetGly: 1.466 ± 0.041	0.32MetHis: 0.32 ± 0.02	0.566MetIle: 0.566 ± 0.023	0.46MetLys: 0.46 ± 0.023	1.538MetLeu: 1.538 ± 0.035	0.3MetMet: 0.3 ± 0.02	0.589MetAsn: 0.589 ± 0.024	0.806MetPro: 0.806 ± 0.029	0.517MetGln: 0.517 ± 0.023	1.094MetArg: 1.094 ± 0.035	1.581MetSer: 1.581 ± 0.038	1.529MetThr: 1.529 ± 0.046	1.269MetVal: 1.269 ± 0.035	0.153MetTrp: 0.153 ± 0.012	0.395MetTyr: 0.395 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.669AsnAla: 2.669 ± 0.054	0.233AsnCys: 0.233 ± 0.017	1.853AsnAsp: 1.853 ± 0.047	1.803AsnGlu: 1.803 ± 0.05	0.7AsnPhe: 0.7 ± 0.028	2.212AsnGly: 2.212 ± 0.065	0.582AsnHis: 0.582 ± 0.026	1.037AsnIle: 1.037 ± 0.034	0.429AsnLys: 0.429 ± 0.022	2.085AsnLeu: 2.085 ± 0.048	0.42AsnMet: 0.42 ± 0.019	0.592AsnAsn: 0.592 ± 0.027	1.633AsnPro: 1.633 ± 0.045	0.619AsnGln: 0.619 ± 0.025	1.695AsnArg: 1.695 ± 0.044	1.02AsnSer: 1.02 ± 0.038	1.355AsnThr: 1.355 ± 0.033	2.336AsnVal: 2.336 ± 0.048	0.285AsnTrp: 0.285 ± 0.016	0.669AsnTyr: 0.669 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.354ProAla: 4.354 ± 0.064	0.256ProCys: 0.256 ± 0.017	4.531ProAsp: 4.531 ± 0.084	5.172ProGlu: 5.172 ± 0.076	1.701ProPhe: 1.701 ± 0.045	3.616ProGly: 3.616 ± 0.064	0.906ProHis: 0.906 ± 0.029	1.884ProIle: 1.884 ± 0.049	0.992ProLys: 0.992 ± 0.035	3.768ProLeu: 3.768 ± 0.075	0.886ProMet: 0.886 ± 0.032	1.286ProAsn: 1.286 ± 0.041	2.266ProPro: 2.266 ± 0.06	1.007ProGln: 1.007 ± 0.033	2.332ProArg: 2.332 ± 0.047	2.665ProSer: 2.665 ± 0.058	3.449ProThr: 3.449 ± 0.082	4.011ProVal: 4.011 ± 0.062	0.502ProTrp: 0.502 ± 0.022	1.218ProTyr: 1.218 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.367GlnAla: 2.367 ± 0.052	0.176GlnCys: 0.176 ± 0.015	1.193GlnAsp: 1.193 ± 0.035	1.619GlnGlu: 1.619 ± 0.048	1.089GlnPhe: 1.089 ± 0.032	1.557GlnGly: 1.557 ± 0.044	0.523GlnHis: 0.523 ± 0.022	0.939GlnIle: 0.939 ± 0.034	0.599GlnLys: 0.599 ± 0.026	2.452GlnLeu: 2.452 ± 0.05	0.538GlnMet: 0.538 ± 0.024	0.724GlnAsn: 0.724 ± 0.029	1.187GlnPro: 1.187 ± 0.036	1.075GlnGln: 1.075 ± 0.037	2.152GlnArg: 2.152 ± 0.053	1.608GlnSer: 1.608 ± 0.042	1.517GlnThr: 1.517 ± 0.041	1.642GlnVal: 1.642 ± 0.034	0.351GlnTrp: 0.351 ± 0.02	0.864GlnTyr: 0.864 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.975ArgAla: 5.975 ± 0.077	0.48ArgCys: 0.48 ± 0.023	4.387ArgAsp: 4.387 ± 0.07	6.603ArgGlu: 6.603 ± 0.09	2.449ArgPhe: 2.449 ± 0.055	4.372ArgGly: 4.372 ± 0.064	1.24ArgHis: 1.24 ± 0.038	3.044ArgIle: 3.044 ± 0.06	1.395ArgLys: 1.395 ± 0.048	6.218ArgLeu: 6.218 ± 0.089	1.364ArgMet: 1.364 ± 0.038	1.768ArgAsn: 1.768 ± 0.042	2.645ArgPro: 2.645 ± 0.058	1.819ArgGln: 1.819 ± 0.047	5.14ArgArg: 5.14 ± 0.092	3.444ArgSer: 3.444 ± 0.06	3.918ArgThr: 3.918 ± 0.068	5.115ArgVal: 5.115 ± 0.07	0.755ArgTrp: 0.755 ± 0.034	2.013ArgTyr: 2.013 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.219SerAla: 5.219 ± 0.082	0.327SerCys: 0.327 ± 0.021	4.259SerAsp: 4.259 ± 0.073	4.843SerGlu: 4.843 ± 0.084	1.95SerPhe: 1.95 ± 0.048	5.454SerGly: 5.454 ± 0.072	0.974SerHis: 0.974 ± 0.03	2.387SerIle: 2.387 ± 0.047	1.236SerLys: 1.236 ± 0.039	4.956SerLeu: 4.956 ± 0.072	1.131SerMet: 1.131 ± 0.035	1.398SerAsn: 1.398 ± 0.036	2.59SerPro: 2.59 ± 0.052	1.304SerGln: 1.304 ± 0.04	3.056SerArg: 3.056 ± 0.055	2.986SerSer: 2.986 ± 0.066	3.493SerThr: 3.493 ± 0.068	5.365SerVal: 5.365 ± 0.08	0.583SerTrp: 0.583 ± 0.024	1.455SerTyr: 1.455 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.844ThrAla: 6.844 ± 0.087	0.394ThrCys: 0.394 ± 0.024	5.561ThrAsp: 5.561 ± 0.1	5.111ThrGlu: 5.111 ± 0.074	2.324ThrPhe: 2.324 ± 0.051	5.463ThrGly: 5.463 ± 0.08	1.217ThrHis: 1.217 ± 0.037	2.623ThrIle: 2.623 ± 0.062	1.093ThrLys: 1.093 ± 0.034	5.97ThrLeu: 5.97 ± 0.087	1.06ThrMet: 1.06 ± 0.033	1.531ThrAsn: 1.531 ± 0.042	3.662ThrPro: 3.662 ± 0.087	1.367ThrGln: 1.367 ± 0.04	3.197ThrArg: 3.197 ± 0.058	2.808ThrSer: 2.808 ± 0.061	4.314ThrThr: 4.314 ± 0.079	7.107ThrVal: 7.107 ± 0.101	0.59ThrTrp: 0.59 ± 0.027	1.864ThrTyr: 1.864 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	10.148ValAla: 10.148 ± 0.162	0.73ValCys: 0.73 ± 0.027	7.313ValAsp: 7.313 ± 0.108	8.219ValGlu: 8.219 ± 0.122	3.242ValPhe: 3.242 ± 0.069	8.228ValGly: 8.228 ± 0.122	1.627ValHis: 1.627 ± 0.042	3.169ValIle: 3.169 ± 0.069	1.387ValLys: 1.387 ± 0.041	7.838ValLeu: 7.838 ± 0.124	1.317ValMet: 1.317 ± 0.037	1.938ValAsn: 1.938 ± 0.047	4.366ValPro: 4.366 ± 0.07	1.87ValGln: 1.87 ± 0.046	5.267ValArg: 5.267 ± 0.069	5.096ValSer: 5.096 ± 0.065	6.006ValThr: 6.006 ± 0.092	9.73ValVal: 9.73 ± 0.142	0.797ValTrp: 0.797 ± 0.028	2.343ValTyr: 2.343 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.875TrpAla: 0.875 ± 0.03	0.09TrpCys: 0.09 ± 0.009	0.72TrpAsp: 0.72 ± 0.026	0.798TrpGlu: 0.798 ± 0.028	0.446TrpPhe: 0.446 ± 0.025	0.789TrpGly: 0.789 ± 0.032	0.238TrpHis: 0.238 ± 0.014	0.378TrpIle: 0.378 ± 0.019	0.276TrpLys: 0.276 ± 0.017	1.197TrpLeu: 1.197 ± 0.035	0.229TrpMet: 0.229 ± 0.014	0.364TrpAsn: 0.364 ± 0.019	0.463TrpPro: 0.463 ± 0.021	0.371TrpGln: 0.371 ± 0.021	0.851TrpArg: 0.851 ± 0.033	0.637TrpSer: 0.637 ± 0.023	0.744TrpThr: 0.744 ± 0.027	0.889TrpVal: 0.889 ± 0.035	0.184TrpTrp: 0.184 ± 0.013	0.342TrpTyr: 0.342 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.739TyrAla: 2.739 ± 0.052	0.265TyrCys: 0.265 ± 0.017	2.725TyrAsp: 2.725 ± 0.052	2.542TyrGlu: 2.542 ± 0.057	0.952TyrPhe: 0.952 ± 0.031	2.456TyrGly: 2.456 ± 0.049	0.639TyrHis: 0.639 ± 0.026	0.873TyrIle: 0.873 ± 0.034	0.427TyrLys: 0.427 ± 0.023	2.563TyrLeu: 2.563 ± 0.058	0.405TyrMet: 0.405 ± 0.019	0.658TyrAsn: 0.658 ± 0.026	1.274TyrPro: 1.274 ± 0.031	0.717TyrGln: 0.717 ± 0.025	1.987TyrArg: 1.987 ± 0.047	1.213TyrSer: 1.213 ± 0.042	1.618TyrThr: 1.618 ± 0.036	2.427TyrVal: 2.427 ± 0.05	0.333TyrTrp: 0.333 ± 0.02	0.883TyrTyr: 0.883 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3455 proteins (969895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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