Amino acid dipepetide frequency for Mytilus coruscus (Sea mussel)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.892AlaAla: 2.892 ± 0.014	1.165AlaCys: 1.165 ± 0.01	2.809AlaAsp: 2.809 ± 0.013	3.026AlaGlu: 3.026 ± 0.013	2.007AlaPhe: 2.007 ± 0.008	2.457AlaGly: 2.457 ± 0.013	0.985AlaHis: 0.985 ± 0.007	3.123AlaIle: 3.123 ± 0.012	3.324AlaLys: 3.324 ± 0.013	4.077AlaLeu: 4.077 ± 0.015	1.159AlaMet: 1.159 ± 0.007	2.384AlaAsn: 2.384 ± 0.01	1.724AlaPro: 1.724 ± 0.013	1.651AlaGln: 1.651 ± 0.01	2.052AlaArg: 2.052 ± 0.011	3.76AlaSer: 3.76 ± 0.015	2.92AlaThr: 2.92 ± 0.015	3.406AlaVal: 3.406 ± 0.012	0.463AlaTrp: 0.463 ± 0.005	1.521AlaTyr: 1.521 ± 0.009	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.007	0.651CysCys: 0.651 ± 0.007	1.491CysAsp: 1.491 ± 0.01	1.349CysGlu: 1.349 ± 0.011	0.945CysPhe: 0.945 ± 0.006	1.343CysGly: 1.343 ± 0.01	0.622CysHis: 0.622 ± 0.007	1.496CysIle: 1.496 ± 0.009	1.765CysLys: 1.765 ± 0.012	1.975CysLeu: 1.975 ± 0.011	0.494CysMet: 0.494 ± 0.004	1.43CysAsn: 1.43 ± 0.01	1.089CysPro: 1.089 ± 0.013	1.029CysGln: 1.029 ± 0.008	1.19CysArg: 1.19 ± 0.008	2.056CysSer: 2.056 ± 0.013	1.424CysThr: 1.424 ± 0.01	1.332CysVal: 1.332 ± 0.01	0.203CysTrp: 0.203 ± 0.003	0.828CysTyr: 0.828 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	2.495AspAla: 2.495 ± 0.011	1.277AspCys: 1.277 ± 0.009	4.239AspAsp: 4.239 ± 0.024	4.268AspGlu: 4.268 ± 0.017	2.529AspPhe: 2.529 ± 0.011	3.29AspGly: 3.29 ± 0.017	1.415AspHis: 1.415 ± 0.009	4.931AspIle: 4.931 ± 0.02	4.315AspLys: 4.315 ± 0.015	5.024AspLeu: 5.024 ± 0.018	1.427AspMet: 1.427 ± 0.009	3.599AspAsn: 3.599 ± 0.014	2.027AspPro: 2.027 ± 0.011	2.151AspGln: 2.151 ± 0.011	2.606AspArg: 2.606 ± 0.014	4.53AspSer: 4.53 ± 0.018	3.454AspThr: 3.454 ± 0.014	3.784AspVal: 3.784 ± 0.017	0.616AspTrp: 0.616 ± 0.005	1.967AspTyr: 1.967 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	2.972GluAla: 2.972 ± 0.015	1.365GluCys: 1.365 ± 0.012	4.119GluAsp: 4.119 ± 0.017	5.5GluGlu: 5.5 ± 0.025	2.234GluPhe: 2.234 ± 0.01	2.787GluGly: 2.787 ± 0.015	1.576GluHis: 1.576 ± 0.011	4.711GluIle: 4.711 ± 0.017	5.674GluLys: 5.674 ± 0.022	5.213GluLeu: 5.213 ± 0.02	1.66GluMet: 1.66 ± 0.009	4.591GluAsn: 4.591 ± 0.016	1.956GluPro: 1.956 ± 0.012	2.687GluGln: 2.687 ± 0.015	3.105GluArg: 3.105 ± 0.016	4.578GluSer: 4.578 ± 0.017	4.045GluThr: 4.045 ± 0.019	3.613GluVal: 3.613 ± 0.014	0.653GluTrp: 0.653 ± 0.006	2.04GluTyr: 2.04 ± 0.009	0.0GluXaa: 0.0 ± 0.0
Phe	1.742PheAla: 1.742 ± 0.009	0.988PheCys: 0.988 ± 0.007	2.476PheAsp: 2.476 ± 0.011	2.348PheGlu: 2.348 ± 0.011	1.448PhePhe: 1.448 ± 0.01	2.239PheGly: 2.239 ± 0.011	1.046PheHis: 1.046 ± 0.007	2.647PheIle: 2.647 ± 0.012	2.666PheLys: 2.666 ± 0.01	3.498PheLeu: 3.498 ± 0.012	0.934PheMet: 0.934 ± 0.006	2.172PheAsn: 2.172 ± 0.01	1.545PhePro: 1.545 ± 0.009	1.661PheGln: 1.661 ± 0.008	1.784PheArg: 1.784 ± 0.008	3.216PheSer: 3.216 ± 0.012	2.409PheThr: 2.409 ± 0.01	2.492PheVal: 2.492 ± 0.011	0.46PheTrp: 0.46 ± 0.004	1.437PheTyr: 1.437 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	2.274GlyAla: 2.274 ± 0.012	1.126GlyCys: 1.126 ± 0.009	2.864GlyAsp: 2.864 ± 0.014	2.773GlyGlu: 2.773 ± 0.012	2.118GlyPhe: 2.118 ± 0.011	3.166GlyGly: 3.166 ± 0.027	1.519GlyHis: 1.519 ± 0.01	3.49GlyIle: 3.49 ± 0.014	3.998GlyLys: 3.998 ± 0.018	3.913GlyLeu: 3.913 ± 0.017	1.241GlyMet: 1.241 ± 0.01	3.14GlyAsn: 3.14 ± 0.015	1.84GlyPro: 1.84 ± 0.016	2.197GlyGln: 2.197 ± 0.013	2.535GlyArg: 2.535 ± 0.014	4.107GlySer: 4.107 ± 0.017	3.144GlyThr: 3.144 ± 0.015	2.835GlyVal: 2.835 ± 0.013	0.599GlyTrp: 0.599 ± 0.006	2.11GlyTyr: 2.11 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.101HisAla: 1.101 ± 0.007	0.627HisCys: 0.627 ± 0.008	1.381HisAsp: 1.381 ± 0.009	1.36HisGlu: 1.36 ± 0.008	1.119HisPhe: 1.119 ± 0.007	1.4HisGly: 1.4 ± 0.01	0.835HisHis: 0.835 ± 0.008	1.689HisIle: 1.689 ± 0.011	1.668HisLys: 1.668 ± 0.009	2.359HisLeu: 2.359 ± 0.012	0.605HisMet: 0.605 ± 0.005	1.35HisAsn: 1.35 ± 0.009	1.038HisPro: 1.038 ± 0.008	1.158HisGln: 1.158 ± 0.009	1.269HisArg: 1.269 ± 0.009	2.007HisSer: 2.007 ± 0.011	1.475HisThr: 1.475 ± 0.01	1.594HisVal: 1.594 ± 0.011	0.29HisTrp: 0.29 ± 0.004	0.915HisTyr: 0.915 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.208IleAla: 3.208 ± 0.013	1.656IleCys: 1.656 ± 0.01	4.079IleAsp: 4.079 ± 0.015	4.221IleGlu: 4.221 ± 0.014	2.472IlePhe: 2.472 ± 0.012	3.178IleGly: 3.178 ± 0.014	1.692IleHis: 1.692 ± 0.009	4.086IleIle: 4.086 ± 0.018	4.651IleLys: 4.651 ± 0.016	5.583IleLeu: 5.583 ± 0.017	1.37IleMet: 1.37 ± 0.007	3.772IleAsn: 3.772 ± 0.016	3.143IlePro: 3.143 ± 0.015	3.0IleGln: 3.0 ± 0.016	2.928IleArg: 2.928 ± 0.011	5.391IleSer: 5.391 ± 0.018	4.053IleThr: 4.053 ± 0.019	4.055IleVal: 4.055 ± 0.016	0.645IleTrp: 0.645 ± 0.005	2.134IleTyr: 2.134 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.474LysAla: 3.474 ± 0.014	1.836LysCys: 1.836 ± 0.012	4.53LysAsp: 4.53 ± 0.019	5.54LysGlu: 5.54 ± 0.024	2.606LysPhe: 2.606 ± 0.011	3.481LysGly: 3.481 ± 0.025	1.969LysHis: 1.969 ± 0.012	4.751LysIle: 4.751 ± 0.015	6.163LysLys: 6.163 ± 0.028	6.354LysLeu: 6.354 ± 0.019	1.828LysMet: 1.828 ± 0.009	4.016LysAsn: 4.016 ± 0.014	3.042LysPro: 3.042 ± 0.019	3.496LysGln: 3.496 ± 0.012	3.984LysArg: 3.984 ± 0.014	5.911LysSer: 5.911 ± 0.019	5.008LysThr: 5.008 ± 0.016	4.007LysVal: 4.007 ± 0.014	0.828LysTrp: 0.828 ± 0.006	2.613LysTyr: 2.613 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	4.001LeuAla: 4.001 ± 0.015	1.957LeuCys: 1.957 ± 0.011	4.8LeuAsp: 4.8 ± 0.017	5.465LeuGlu: 5.465 ± 0.022	3.329LeuPhe: 3.329 ± 0.014	3.696LeuGly: 3.696 ± 0.014	2.331LeuHis: 2.331 ± 0.012	4.656LeuIle: 4.656 ± 0.016	6.771LeuLys: 6.771 ± 0.02	7.623LeuLeu: 7.623 ± 0.028	1.925LeuMet: 1.925 ± 0.01	4.684LeuAsn: 4.684 ± 0.015	3.94LeuPro: 3.94 ± 0.016	4.462LeuGln: 4.462 ± 0.017	4.042LeuArg: 4.042 ± 0.015	6.968LeuSer: 6.968 ± 0.02	5.083LeuThr: 5.083 ± 0.018	4.531LeuVal: 4.531 ± 0.015	0.797LeuTrp: 0.797 ± 0.006	2.867LeuTyr: 2.867 ± 0.014	0.0LeuXaa: 0.0 ± 0.0
Met	1.406MetAla: 1.406 ± 0.008	0.504MetCys: 0.504 ± 0.005	1.359MetAsp: 1.359 ± 0.007	1.654MetGlu: 1.654 ± 0.008	1.01MetPhe: 1.01 ± 0.007	1.001MetGly: 1.001 ± 0.007	0.476MetHis: 0.476 ± 0.005	1.379MetIle: 1.379 ± 0.008	1.976MetLys: 1.976 ± 0.01	1.918MetLeu: 1.918 ± 0.01	0.686MetMet: 0.686 ± 0.006	1.329MetAsn: 1.329 ± 0.007	0.935MetPro: 0.935 ± 0.008	0.907MetGln: 0.907 ± 0.007	0.998MetArg: 0.998 ± 0.007	2.002MetSer: 2.002 ± 0.012	1.512MetThr: 1.512 ± 0.01	1.299MetVal: 1.299 ± 0.007	0.236MetTrp: 0.236 ± 0.003	0.822MetTyr: 0.822 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.58AsnAla: 2.58 ± 0.011	1.388AsnCys: 1.388 ± 0.01	3.335AsnAsp: 3.335 ± 0.014	3.685AsnGlu: 3.685 ± 0.015	2.244AsnPhe: 2.244 ± 0.009	3.417AsnGly: 3.417 ± 0.017	1.359AsnHis: 1.359 ± 0.008	4.595AsnIle: 4.595 ± 0.016	4.29AsnLys: 4.29 ± 0.016	4.763AsnLeu: 4.763 ± 0.015	1.417AsnMet: 1.417 ± 0.009	3.739AsnAsn: 3.739 ± 0.017	2.24AsnPro: 2.24 ± 0.011	2.471AsnGln: 2.471 ± 0.013	2.728AsnArg: 2.728 ± 0.013	4.537AsnSer: 4.537 ± 0.016	3.698AsnThr: 3.698 ± 0.016	3.671AsnVal: 3.671 ± 0.016	0.579AsnTrp: 0.579 ± 0.005	1.869AsnTyr: 1.869 ± 0.007	0.0AsnXaa: 0.0 ± 0.0
Pro	2.033ProAla: 2.033 ± 0.012	0.872ProCys: 0.872 ± 0.01	2.458ProAsp: 2.458 ± 0.013	2.708ProGlu: 2.708 ± 0.014	1.546ProPhe: 1.546 ± 0.007	2.305ProGly: 2.305 ± 0.019	0.921ProHis: 0.921 ± 0.007	2.339ProIle: 2.339 ± 0.015	2.868ProLys: 2.868 ± 0.015	3.347ProLeu: 3.347 ± 0.016	0.84ProMet: 0.84 ± 0.007	2.228ProAsn: 2.228 ± 0.011	2.653ProPro: 2.653 ± 0.023	1.64ProGln: 1.64 ± 0.011	1.834ProArg: 1.834 ± 0.012	3.723ProSer: 3.723 ± 0.023	2.787ProThr: 2.787 ± 0.021	2.965ProVal: 2.965 ± 0.014	0.41ProTrp: 0.41 ± 0.005	1.361ProTyr: 1.361 ± 0.008	0.0ProXaa: 0.0 ± 0.0
Gln	1.947GlnAla: 1.947 ± 0.011	0.968GlnCys: 0.968 ± 0.008	2.154GlnAsp: 2.154 ± 0.011	2.789GlnGlu: 2.789 ± 0.014	1.561GlnPhe: 1.561 ± 0.008	1.936GlnGly: 1.936 ± 0.014	1.233GlnHis: 1.233 ± 0.01	2.759GlnIle: 2.759 ± 0.012	3.284GlnLys: 3.284 ± 0.015	3.611GlnLeu: 3.611 ± 0.015	1.112GlnMet: 1.112 ± 0.008	2.868GlnAsn: 2.868 ± 0.012	1.803GlnPro: 1.803 ± 0.015	2.563GlnGln: 2.563 ± 0.02	2.243GlnArg: 2.243 ± 0.013	3.426GlnSer: 3.426 ± 0.014	2.899GlnThr: 2.899 ± 0.017	2.12GlnVal: 2.12 ± 0.01	0.513GlnTrp: 0.513 ± 0.005	1.535GlnTyr: 1.535 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	1.961ArgAla: 1.961 ± 0.01	1.05ArgCys: 1.05 ± 0.008	2.46ArgAsp: 2.46 ± 0.014	2.908ArgGlu: 2.908 ± 0.015	1.848ArgPhe: 1.848 ± 0.008	2.278ArgGly: 2.278 ± 0.014	1.322ArgHis: 1.322 ± 0.009	2.861ArgIle: 2.861 ± 0.013	4.27ArgLys: 4.27 ± 0.016	4.09ArgLeu: 4.09 ± 0.015	1.137ArgMet: 1.137 ± 0.007	2.955ArgAsn: 2.955 ± 0.012	1.956ArgPro: 1.956 ± 0.011	2.379ArgGln: 2.379 ± 0.015	3.113ArgArg: 3.113 ± 0.018	3.66ArgSer: 3.66 ± 0.016	2.784ArgThr: 2.784 ± 0.013	2.311ArgVal: 2.311 ± 0.012	0.533ArgTrp: 0.533 ± 0.004	1.69ArgTyr: 1.69 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	3.82SerAla: 3.82 ± 0.016	1.849SerCys: 1.849 ± 0.012	5.23SerAsp: 5.23 ± 0.018	5.028SerGlu: 5.028 ± 0.018	3.199SerPhe: 3.199 ± 0.012	4.464SerGly: 4.464 ± 0.019	1.907SerHis: 1.907 ± 0.011	4.774SerIle: 4.774 ± 0.017	5.7SerLys: 5.7 ± 0.02	6.557SerLeu: 6.557 ± 0.019	1.764SerMet: 1.764 ± 0.01	4.627SerAsn: 4.627 ± 0.018	3.734SerPro: 3.734 ± 0.025	3.238SerGln: 3.238 ± 0.013	3.723SerArg: 3.723 ± 0.016	8.134SerSer: 8.134 ± 0.037	5.401SerThr: 5.401 ± 0.028	5.066SerVal: 5.066 ± 0.017	0.786SerTrp: 0.786 ± 0.007	2.571SerTyr: 2.571 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	3.25ThrAla: 3.25 ± 0.015	1.676ThrCys: 1.676 ± 0.013	4.004ThrAsp: 4.004 ± 0.02	4.373ThrGlu: 4.373 ± 0.02	2.572ThrPhe: 2.572 ± 0.01	3.413ThrGly: 3.413 ± 0.017	1.327ThrHis: 1.327 ± 0.008	3.97ThrIle: 3.97 ± 0.016	4.291ThrLys: 4.291 ± 0.014	4.974ThrLeu: 4.974 ± 0.018	1.337ThrMet: 1.337 ± 0.01	3.481ThrAsn: 3.481 ± 0.015	2.998ThrPro: 2.998 ± 0.019	2.271ThrGln: 2.271 ± 0.013	2.528ThrArg: 2.528 ± 0.012	5.527ThrSer: 5.527 ± 0.025	4.86ThrThr: 4.86 ± 0.049	4.335ThrVal: 4.335 ± 0.019	0.633ThrTrp: 0.633 ± 0.005	1.979ThrTyr: 1.979 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	2.892ValAla: 2.892 ± 0.013	1.509ValCys: 1.509 ± 0.01	3.583ValAsp: 3.583 ± 0.013	3.624ValGlu: 3.624 ± 0.012	2.477ValPhe: 2.477 ± 0.011	2.714ValGly: 2.714 ± 0.012	1.512ValHis: 1.512 ± 0.01	4.017ValIle: 4.017 ± 0.016	4.442ValLys: 4.442 ± 0.019	5.166ValLeu: 5.166 ± 0.016	1.374ValMet: 1.374 ± 0.008	3.516ValAsn: 3.516 ± 0.016	2.54ValPro: 2.54 ± 0.014	2.538ValGln: 2.538 ± 0.012	2.6ValArg: 2.6 ± 0.012	4.643ValSer: 4.643 ± 0.017	4.026ValThr: 4.026 ± 0.019	3.897ValVal: 3.897 ± 0.016	0.62ValTrp: 0.62 ± 0.006	2.071ValTyr: 2.071 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.427TrpAla: 0.427 ± 0.004	0.263TrpCys: 0.263 ± 0.003	0.563TrpAsp: 0.563 ± 0.005	0.585TrpGlu: 0.585 ± 0.005	0.449TrpPhe: 0.449 ± 0.004	0.485TrpGly: 0.485 ± 0.005	0.251TrpHis: 0.251 ± 0.004	0.723TrpIle: 0.723 ± 0.006	0.945TrpLys: 0.945 ± 0.007	0.915TrpLeu: 0.915 ± 0.007	0.276TrpMet: 0.276 ± 0.004	0.669TrpAsn: 0.669 ± 0.005	0.362TrpPro: 0.362 ± 0.004	0.397TrpGln: 0.397 ± 0.004	0.546TrpArg: 0.546 ± 0.005	0.803TrpSer: 0.803 ± 0.008	0.737TrpThr: 0.737 ± 0.007	0.506TrpVal: 0.506 ± 0.005	0.15TrpTrp: 0.15 ± 0.003	0.393TrpTyr: 0.393 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.486TyrAla: 1.486 ± 0.008	0.926TyrCys: 0.926 ± 0.009	2.01TyrAsp: 2.01 ± 0.012	1.874TyrGlu: 1.874 ± 0.009	1.492TyrPhe: 1.492 ± 0.009	1.939TyrGly: 1.939 ± 0.015	0.943TyrHis: 0.943 ± 0.008	2.32TyrIle: 2.32 ± 0.011	2.374TyrLys: 2.374 ± 0.014	2.967TyrLeu: 2.967 ± 0.015	0.82TyrMet: 0.82 ± 0.007	2.058TyrAsn: 2.058 ± 0.012	1.273TyrPro: 1.273 ± 0.009	1.429TyrGln: 1.429 ± 0.009	1.76TyrArg: 1.76 ± 0.009	2.595TyrSer: 2.595 ± 0.011	2.081TyrThr: 2.081 ± 0.013	1.943TyrVal: 1.943 ± 0.01	0.431TyrTrp: 0.431 ± 0.005	1.258TyrTyr: 1.258 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 64248 proteins (29520201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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