Amino acid dipepetide frequency for Novipirellula aureliae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.062AlaAla: 10.062 ± 0.097	1.075AlaCys: 1.075 ± 0.026	5.848AlaAsp: 5.848 ± 0.064	6.288AlaGlu: 6.288 ± 0.07	3.303AlaPhe: 3.303 ± 0.037	6.854AlaGly: 6.854 ± 0.073	1.379AlaHis: 1.379 ± 0.026	6.178AlaIle: 6.178 ± 0.062	4.233AlaLys: 4.233 ± 0.061	7.187AlaLeu: 7.187 ± 0.071	2.737AlaMet: 2.737 ± 0.039	3.491AlaAsn: 3.491 ± 0.051	3.399AlaPro: 3.399 ± 0.057	2.765AlaGln: 2.765 ± 0.041	4.853AlaArg: 4.853 ± 0.058	6.614AlaSer: 6.614 ± 0.071	5.717AlaThr: 5.717 ± 0.078	6.566AlaVal: 6.566 ± 0.063	1.249AlaTrp: 1.249 ± 0.026	2.088AlaTyr: 2.088 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.728CysAla: 0.728 ± 0.022	0.288CysCys: 0.288 ± 0.012	0.772CysAsp: 0.772 ± 0.022	0.79CysGlu: 0.79 ± 0.024	0.517CysPhe: 0.517 ± 0.02	1.079CysGly: 1.079 ± 0.028	0.387CysHis: 0.387 ± 0.017	0.557CysIle: 0.557 ± 0.019	0.362CysLys: 0.362 ± 0.014	1.167CysLeu: 1.167 ± 0.028	0.225CysMet: 0.225 ± 0.011	0.354CysAsn: 0.354 ± 0.013	0.653CysPro: 0.653 ± 0.022	0.443CysGln: 0.443 ± 0.015	0.873CysArg: 0.873 ± 0.022	0.778CysSer: 0.778 ± 0.021	0.527CysThr: 0.527 ± 0.019	0.832CysVal: 0.832 ± 0.021	0.167CysTrp: 0.167 ± 0.01	0.333CysTyr: 0.333 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.17AspAla: 6.17 ± 0.068	0.719AspCys: 0.719 ± 0.021	4.184AspAsp: 4.184 ± 0.071	4.265AspGlu: 4.265 ± 0.047	2.517AspPhe: 2.517 ± 0.038	5.351AspGly: 5.351 ± 0.086	1.367AspHis: 1.367 ± 0.029	2.611AspIle: 2.611 ± 0.036	1.91AspLys: 1.91 ± 0.036	5.748AspLeu: 5.748 ± 0.055	1.034AspMet: 1.034 ± 0.025	1.815AspAsn: 1.815 ± 0.043	3.643AspPro: 3.643 ± 0.055	2.599AspGln: 2.599 ± 0.038	4.46AspArg: 4.46 ± 0.05	4.234AspSer: 4.234 ± 0.051	2.784AspThr: 2.784 ± 0.053	4.226AspVal: 4.226 ± 0.052	1.126AspTrp: 1.126 ± 0.022	1.748AspTyr: 1.748 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.741GluAla: 5.741 ± 0.058	0.542GluCys: 0.542 ± 0.017	2.973GluAsp: 2.973 ± 0.049	3.412GluGlu: 3.412 ± 0.057	2.206GluPhe: 2.206 ± 0.034	3.678GluGly: 3.678 ± 0.051	1.341GluHis: 1.341 ± 0.03	3.751GluIle: 3.751 ± 0.042	2.902GluLys: 2.902 ± 0.048	6.506GluLeu: 6.506 ± 0.062	1.736GluMet: 1.736 ± 0.035	2.364GluAsn: 2.364 ± 0.037	2.841GluPro: 2.841 ± 0.052	3.05GluGln: 3.05 ± 0.047	4.056GluArg: 4.056 ± 0.055	4.768GluSer: 4.768 ± 0.064	3.967GluThr: 3.967 ± 0.052	4.146GluVal: 4.146 ± 0.051	0.747GluTrp: 0.747 ± 0.02	1.506GluTyr: 1.506 ± 0.029	0.001GluXaa: 0.001 ± 0.001
Phe	3.78PheAla: 3.78 ± 0.055	0.558PheCys: 0.558 ± 0.017	2.963PheAsp: 2.963 ± 0.046	2.458PheGlu: 2.458 ± 0.036	1.546PhePhe: 1.546 ± 0.03	3.3PheGly: 3.3 ± 0.049	0.828PheHis: 0.828 ± 0.02	1.58PheIle: 1.58 ± 0.029	1.121PheLys: 1.121 ± 0.022	3.441PheLeu: 3.441 ± 0.046	0.708PheMet: 0.708 ± 0.02	1.255PheAsn: 1.255 ± 0.025	1.575PhePro: 1.575 ± 0.03	1.296PheGln: 1.296 ± 0.027	2.332PheArg: 2.332 ± 0.042	2.585PheSer: 2.585 ± 0.035	1.969PheThr: 1.969 ± 0.039	2.964PheVal: 2.964 ± 0.044	0.552PheTrp: 0.552 ± 0.017	1.003PheTyr: 1.003 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.298GlyAla: 5.298 ± 0.063	1.051GlyCys: 1.051 ± 0.028	4.656GlyAsp: 4.656 ± 0.064	4.44GlyGlu: 4.44 ± 0.052	3.049GlyPhe: 3.049 ± 0.044	6.236GlyGly: 6.236 ± 0.091	1.576GlyHis: 1.576 ± 0.029	4.184GlyIle: 4.184 ± 0.045	3.611GlyLys: 3.611 ± 0.047	6.575GlyLeu: 6.575 ± 0.072	2.012GlyMet: 2.012 ± 0.041	2.809GlyAsn: 2.809 ± 0.057	2.854GlyPro: 2.854 ± 0.042	2.826GlyGln: 2.826 ± 0.035	4.654GlyArg: 4.654 ± 0.053	5.244GlySer: 5.244 ± 0.067	4.333GlyThr: 4.333 ± 0.084	5.298GlyVal: 5.298 ± 0.057	1.238GlyTrp: 1.238 ± 0.029	2.159GlyTyr: 2.159 ± 0.037	0.001GlyXaa: 0.001 ± 0.001
His	1.827HisAla: 1.827 ± 0.031	0.344HisCys: 0.344 ± 0.013	1.291HisAsp: 1.291 ± 0.029	1.205HisGlu: 1.205 ± 0.028	0.991HisPhe: 0.991 ± 0.024	1.61HisGly: 1.61 ± 0.034	0.674HisHis: 0.674 ± 0.02	0.796HisIle: 0.796 ± 0.021	0.528HisLys: 0.528 ± 0.017	2.143HisLeu: 2.143 ± 0.034	0.331HisMet: 0.331 ± 0.014	0.617HisAsn: 0.617 ± 0.019	1.362HisPro: 1.362 ± 0.027	0.891HisGln: 0.891 ± 0.025	1.639HisArg: 1.639 ± 0.034	1.409HisSer: 1.409 ± 0.027	0.901HisThr: 0.901 ± 0.023	1.413HisVal: 1.413 ± 0.027	0.405HisTrp: 0.405 ± 0.014	0.652HisTyr: 0.652 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.251IleAla: 6.251 ± 0.055	0.687IleCys: 0.687 ± 0.02	4.526IleAsp: 4.526 ± 0.054	4.468IleGlu: 4.468 ± 0.053	1.59IlePhe: 1.59 ± 0.031	4.591IleGly: 4.591 ± 0.053	1.21IleHis: 1.21 ± 0.023	2.109IleIle: 2.109 ± 0.039	1.751IleLys: 1.751 ± 0.036	4.429IleLeu: 4.429 ± 0.063	0.841IleMet: 0.841 ± 0.023	1.717IleAsn: 1.717 ± 0.035	2.664IlePro: 2.664 ± 0.045	1.884IleGln: 1.884 ± 0.034	3.731IleArg: 3.731 ± 0.048	3.375IleSer: 3.375 ± 0.045	2.841IleThr: 2.841 ± 0.05	4.325IleVal: 4.325 ± 0.051	0.591IleTrp: 0.591 ± 0.018	1.278IleTyr: 1.278 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.321LysAla: 3.321 ± 0.049	0.349LysCys: 0.349 ± 0.012	1.899LysAsp: 1.899 ± 0.039	2.181LysGlu: 2.181 ± 0.041	1.189LysPhe: 1.189 ± 0.026	2.238LysGly: 2.238 ± 0.04	0.894LysHis: 0.894 ± 0.021	2.165LysIle: 2.165 ± 0.041	2.021LysLys: 2.021 ± 0.052	3.942LysLeu: 3.942 ± 0.053	1.076LysMet: 1.076 ± 0.028	1.464LysAsn: 1.464 ± 0.03	2.336LysPro: 2.336 ± 0.042	1.851LysGln: 1.851 ± 0.035	2.849LysArg: 2.849 ± 0.048	2.669LysSer: 2.669 ± 0.042	2.56LysThr: 2.56 ± 0.042	2.511LysVal: 2.511 ± 0.04	0.568LysTrp: 0.568 ± 0.016	0.964LysTyr: 0.964 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	9.759LeuAla: 9.759 ± 0.088	1.205LeuCys: 1.205 ± 0.026	5.888LeuAsp: 5.888 ± 0.059	5.474LeuGlu: 5.474 ± 0.057	3.598LeuPhe: 3.598 ± 0.058	6.821LeuGly: 6.821 ± 0.06	1.878LeuHis: 1.878 ± 0.033	4.961LeuIle: 4.961 ± 0.053	3.69LeuLys: 3.69 ± 0.053	9.437LeuLeu: 9.437 ± 0.095	2.134LeuMet: 2.134 ± 0.037	2.902LeuAsn: 2.902 ± 0.043	5.11LeuPro: 5.11 ± 0.059	3.467LeuGln: 3.467 ± 0.042	6.354LeuArg: 6.354 ± 0.076	6.968LeuSer: 6.968 ± 0.062	5.232LeuThr: 5.232 ± 0.059	6.804LeuVal: 6.804 ± 0.065	1.157LeuTrp: 1.157 ± 0.025	2.115LeuTyr: 2.115 ± 0.028	0.001LeuXaa: 0.001 ± 0.001
Met	2.182MetAla: 2.182 ± 0.036	0.194MetCys: 0.194 ± 0.009	1.133MetAsp: 1.133 ± 0.025	1.168MetGlu: 1.168 ± 0.027	0.791MetPhe: 0.791 ± 0.02	1.548MetGly: 1.548 ± 0.032	0.491MetHis: 0.491 ± 0.017	1.483MetIle: 1.483 ± 0.028	1.17MetLys: 1.17 ± 0.027	2.499MetLeu: 2.499 ± 0.047	0.687MetMet: 0.687 ± 0.02	1.025MetAsn: 1.025 ± 0.024	1.372MetPro: 1.372 ± 0.025	1.061MetGln: 1.061 ± 0.025	1.529MetArg: 1.529 ± 0.03	1.645MetSer: 1.645 ± 0.029	1.574MetThr: 1.574 ± 0.029	1.68MetVal: 1.68 ± 0.031	0.22MetTrp: 0.22 ± 0.011	0.407MetTyr: 0.407 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.115AsnAla: 3.115 ± 0.05	0.354AsnCys: 0.354 ± 0.013	2.276AsnAsp: 2.276 ± 0.052	2.23AsnGlu: 2.23 ± 0.036	1.143AsnPhe: 1.143 ± 0.026	2.812AsnGly: 2.812 ± 0.06	0.854AsnHis: 0.854 ± 0.018	1.489AsnIle: 1.489 ± 0.028	1.03AsnLys: 1.03 ± 0.025	3.116AsnLeu: 3.116 ± 0.041	0.63AsnMet: 0.63 ± 0.018	1.213AsnAsn: 1.213 ± 0.037	2.105AsnPro: 2.105 ± 0.035	1.62AsnGln: 1.62 ± 0.03	2.63AsnArg: 2.63 ± 0.041	2.115AsnSer: 2.115 ± 0.037	1.703AsnThr: 1.703 ± 0.044	2.592AsnVal: 2.592 ± 0.044	0.583AsnTrp: 0.583 ± 0.018	0.938AsnTyr: 0.938 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.302ProAla: 4.302 ± 0.061	0.415ProCys: 0.415 ± 0.014	3.157ProAsp: 3.157 ± 0.046	3.479ProGlu: 3.479 ± 0.052	1.858ProPhe: 1.858 ± 0.031	3.397ProGly: 3.397 ± 0.053	0.984ProHis: 0.984 ± 0.024	3.005ProIle: 3.005 ± 0.043	2.032ProLys: 2.032 ± 0.04	4.42ProLeu: 4.42 ± 0.047	1.229ProMet: 1.229 ± 0.025	2.043ProAsn: 2.043 ± 0.034	2.491ProPro: 2.491 ± 0.053	1.747ProGln: 1.747 ± 0.03	2.493ProArg: 2.493 ± 0.038	3.853ProSer: 3.853 ± 0.05	3.103ProThr: 3.103 ± 0.051	3.52ProVal: 3.52 ± 0.044	0.692ProTrp: 0.692 ± 0.018	1.176ProTyr: 1.176 ± 0.023	0.001ProXaa: 0.001 ± 0.001
Gln	3.612GlnAla: 3.612 ± 0.047	0.388GlnCys: 0.388 ± 0.013	1.73GlnAsp: 1.73 ± 0.03	1.914GlnGlu: 1.914 ± 0.034	1.466GlnPhe: 1.466 ± 0.029	2.239GlnGly: 2.239 ± 0.038	0.79GlnHis: 0.79 ± 0.022	2.357GlnIle: 2.357 ± 0.035	1.505GlnLys: 1.505 ± 0.031	4.102GlnLeu: 4.102 ± 0.054	1.048GlnMet: 1.048 ± 0.026	1.301GlnAsn: 1.301 ± 0.024	2.06GlnPro: 2.06 ± 0.037	2.015GlnGln: 2.015 ± 0.045	2.752GlnArg: 2.752 ± 0.042	2.929GlnSer: 2.929 ± 0.041	2.579GlnThr: 2.579 ± 0.034	2.581GlnVal: 2.581 ± 0.034	0.68GlnTrp: 0.68 ± 0.018	0.978GlnTyr: 0.978 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.519ArgAla: 4.519 ± 0.046	0.83ArgCys: 0.83 ± 0.022	3.78ArgAsp: 3.78 ± 0.053	3.908ArgGlu: 3.908 ± 0.055	2.983ArgPhe: 2.983 ± 0.041	4.039ArgGly: 4.039 ± 0.055	1.437ArgHis: 1.437 ± 0.028	3.967ArgIle: 3.967 ± 0.056	2.641ArgLys: 2.641 ± 0.042	7.027ArgLeu: 7.027 ± 0.08	1.821ArgMet: 1.821 ± 0.035	2.106ArgAsn: 2.106 ± 0.036	2.856ArgPro: 2.856 ± 0.039	2.746ArgGln: 2.746 ± 0.044	5.043ArgArg: 5.043 ± 0.074	4.64ArgSer: 4.64 ± 0.062	3.267ArgThr: 3.267 ± 0.044	4.469ArgVal: 4.469 ± 0.047	1.159ArgTrp: 1.159 ± 0.026	2.027ArgTyr: 2.027 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	5.68SerAla: 5.68 ± 0.061	0.727SerCys: 0.727 ± 0.021	4.648SerAsp: 4.648 ± 0.057	4.59SerGlu: 4.59 ± 0.053	2.575SerPhe: 2.575 ± 0.034	5.893SerGly: 5.893 ± 0.07	1.37SerHis: 1.37 ± 0.025	4.123SerIle: 4.123 ± 0.049	2.549SerLys: 2.549 ± 0.047	6.917SerLeu: 6.917 ± 0.066	1.714SerMet: 1.714 ± 0.03	2.412SerAsn: 2.412 ± 0.044	3.498SerPro: 3.498 ± 0.046	2.613SerGln: 2.613 ± 0.039	4.301SerArg: 4.301 ± 0.048	4.765SerSer: 4.765 ± 0.056	3.764SerThr: 3.764 ± 0.054	5.123SerVal: 5.123 ± 0.056	0.944SerTrp: 0.944 ± 0.025	1.563SerTyr: 1.563 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.16ThrAla: 5.16 ± 0.077	0.544ThrCys: 0.544 ± 0.017	3.406ThrAsp: 3.406 ± 0.062	3.154ThrGlu: 3.154 ± 0.045	2.123ThrPhe: 2.123 ± 0.048	4.309ThrGly: 4.309 ± 0.063	1.113ThrHis: 1.113 ± 0.024	3.704ThrIle: 3.704 ± 0.065	2.075ThrLys: 2.075 ± 0.036	5.616ThrLeu: 5.616 ± 0.056	1.33ThrMet: 1.33 ± 0.028	1.953ThrAsn: 1.953 ± 0.048	3.26ThrPro: 3.26 ± 0.053	1.878ThrGln: 1.878 ± 0.03	3.243ThrArg: 3.243 ± 0.046	3.756ThrSer: 3.756 ± 0.053	3.458ThrThr: 3.458 ± 0.06	4.221ThrVal: 4.221 ± 0.071	0.792ThrTrp: 0.792 ± 0.023	1.397ThrTyr: 1.397 ± 0.031	0.001ThrXaa: 0.001 ± 0.001
Val	7.155ValAla: 7.155 ± 0.064	1.018ValCys: 1.018 ± 0.023	4.863ValAsp: 4.863 ± 0.062	4.567ValGlu: 4.567 ± 0.053	2.669ValPhe: 2.669 ± 0.04	5.183ValGly: 5.183 ± 0.066	1.439ValHis: 1.439 ± 0.027	3.981ValIle: 3.981 ± 0.049	2.424ValLys: 2.424 ± 0.042	6.65ValLeu: 6.65 ± 0.064	1.652ValMet: 1.652 ± 0.037	2.281ValAsn: 2.281 ± 0.049	3.396ValPro: 3.396 ± 0.044	2.336ValGln: 2.336 ± 0.038	4.442ValArg: 4.442 ± 0.051	4.903ValSer: 4.903 ± 0.058	4.178ValThr: 4.178 ± 0.08	5.686ValVal: 5.686 ± 0.071	1.029ValTrp: 1.029 ± 0.022	1.709ValTyr: 1.709 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.057TrpAla: 1.057 ± 0.024	0.198TrpCys: 0.198 ± 0.01	0.798TrpAsp: 0.798 ± 0.021	0.665TrpGlu: 0.665 ± 0.017	0.638TrpPhe: 0.638 ± 0.02	0.934TrpGly: 0.934 ± 0.023	0.387TrpHis: 0.387 ± 0.012	0.928TrpIle: 0.928 ± 0.022	0.738TrpLys: 0.738 ± 0.021	1.57TrpLeu: 1.57 ± 0.032	0.478TrpMet: 0.478 ± 0.015	0.587TrpAsn: 0.587 ± 0.017	0.664TrpPro: 0.664 ± 0.021	0.726TrpGln: 0.726 ± 0.019	0.885TrpArg: 0.885 ± 0.022	0.935TrpSer: 0.935 ± 0.024	0.824TrpThr: 0.824 ± 0.021	0.96TrpVal: 0.96 ± 0.024	0.267TrpTrp: 0.267 ± 0.012	0.374TrpTyr: 0.374 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.168TyrAla: 2.168 ± 0.032	0.346TyrCys: 0.346 ± 0.013	1.721TyrAsp: 1.721 ± 0.038	1.576TyrGlu: 1.576 ± 0.033	1.064TyrPhe: 1.064 ± 0.022	1.99TyrGly: 1.99 ± 0.033	0.631TyrHis: 0.631 ± 0.021	0.93TyrIle: 0.93 ± 0.024	0.754TyrLys: 0.754 ± 0.02	2.466TyrLeu: 2.466 ± 0.032	0.435TyrMet: 0.435 ± 0.015	0.84TyrAsn: 0.84 ± 0.024	1.256TyrPro: 1.256 ± 0.024	1.208TyrGln: 1.208 ± 0.026	2.147TyrArg: 2.147 ± 0.034	1.583TyrSer: 1.583 ± 0.039	1.214TyrThr: 1.214 ± 0.032	1.645TyrVal: 1.645 ± 0.029	0.445TyrTrp: 0.445 ± 0.017	0.767TyrTyr: 0.767 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5806 proteins (2067535 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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