Amino acid dipepetide frequency for Tico virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.501AlaAla: 4.501 ± 2.978
1.25AlaCys: 1.25 ± 0.499
1.0AlaAsp: 1.0 ± 0.552
2.251AlaGlu: 2.251 ± 0.466
1.5AlaPhe: 1.5 ± 2.309
3.501AlaGly: 3.501 ± 0.916
2.001AlaHis: 2.001 ± 0.78
3.751AlaIle: 3.751 ± 1.293
2.751AlaLys: 2.751 ± 0.756
6.502AlaLeu: 6.502 ± 0.901
2.001AlaMet: 2.001 ± 0.485
1.75AlaAsn: 1.75 ± 0.406
1.75AlaPro: 1.75 ± 0.529
1.75AlaGln: 1.75 ± 0.586
2.751AlaArg: 2.751 ± 0.585
4.001AlaSer: 4.001 ± 0.49
3.001AlaThr: 3.001 ± 1.128
5.751AlaVal: 5.751 ± 0.848
0.0AlaTrp: 0.0 ± 0.0
1.75AlaTyr: 1.75 ± 0.586
0.0AlaXaa: 0.0 ± 0.0
Cys
1.0CysAla: 1.0 ± 0.561
0.25CysCys: 0.25 ± 0.154
1.75CysAsp: 1.75 ± 0.897
1.0CysGlu: 1.0 ± 0.561
2.001CysPhe: 2.001 ± 1.396
0.75CysGly: 0.75 ± 0.347
1.25CysHis: 1.25 ± 0.934
1.0CysIle: 1.0 ± 0.561
2.001CysLys: 2.001 ± 0.807
2.001CysLeu: 2.001 ± 1.104
0.25CysMet: 0.25 ± 0.154
1.5CysAsn: 1.5 ± 0.49
1.25CysPro: 1.25 ± 0.513
1.25CysGln: 1.25 ± 0.626
1.5CysArg: 1.5 ± 1.085
3.251CysSer: 3.251 ± 1.139
1.5CysThr: 1.5 ± 0.49
1.5CysVal: 1.5 ± 0.792
0.5CysTrp: 0.5 ± 0.309
0.75CysTyr: 0.75 ± 0.236
0.0CysXaa: 0.0 ± 0.0
Asp
2.751AspAla: 2.751 ± 1.234
1.0AspCys: 1.0 ± 0.613
6.002AspAsp: 6.002 ± 2.387
5.001AspGlu: 5.001 ± 0.676
2.751AspPhe: 2.751 ± 1.397
4.751AspGly: 4.751 ± 0.963
0.75AspHis: 0.75 ± 0.47
3.501AspIle: 3.501 ± 2.573
2.501AspLys: 2.501 ± 0.751
4.751AspLeu: 4.751 ± 1.826
1.75AspMet: 1.75 ± 0.529
1.75AspAsn: 1.75 ± 0.529
2.251AspPro: 2.251 ± 0.594
1.25AspGln: 1.25 ± 0.823
2.751AspArg: 2.751 ± 1.077
4.501AspSer: 4.501 ± 1.079
1.75AspThr: 1.75 ± 0.594
3.001AspVal: 3.001 ± 0.944
0.75AspTrp: 0.75 ± 0.347
2.001AspTyr: 2.001 ± 1.697
0.0AspXaa: 0.0 ± 0.0
Glu
5.001GluAla: 5.001 ± 0.978
2.751GluCys: 2.751 ± 1.042
5.001GluAsp: 5.001 ± 0.551
5.751GluGlu: 5.751 ± 1.216
3.501GluPhe: 3.501 ± 1.57
3.251GluGly: 3.251 ± 0.699
1.75GluHis: 1.75 ± 0.529
5.251GluIle: 5.251 ± 0.882
4.001GluLys: 4.001 ± 1.216
4.751GluLeu: 4.751 ± 1.532
2.001GluMet: 2.001 ± 0.299
2.001GluAsn: 2.001 ± 0.53
1.5GluPro: 1.5 ± 1.353
2.501GluGln: 2.501 ± 0.977
4.001GluArg: 4.001 ± 0.522
3.751GluSer: 3.751 ± 0.519
3.501GluThr: 3.501 ± 0.813
3.251GluVal: 3.251 ± 0.204
0.75GluTrp: 0.75 ± 0.347
1.75GluTyr: 1.75 ± 0.805
0.0GluXaa: 0.0 ± 0.0
Phe
4.001PheAla: 4.001 ± 1.117
0.75PheCys: 0.75 ± 0.732
2.751PheAsp: 2.751 ± 1.314
2.501PheGlu: 2.501 ± 0.817
2.001PhePhe: 2.001 ± 0.728
1.0PheGly: 1.0 ± 0.53
0.75PheHis: 0.75 ± 0.236
2.251PheIle: 2.251 ± 0.477
3.251PheLys: 3.251 ± 0.743
4.501PheLeu: 4.501 ± 0.303
2.251PheMet: 2.251 ± 0.538
1.75PheAsn: 1.75 ± 0.426
2.001PhePro: 2.001 ± 0.46
0.5PheGln: 0.5 ± 0.163
3.001PheArg: 3.001 ± 0.944
5.751PheSer: 5.751 ± 1.375
1.25PheThr: 1.25 ± 0.507
3.251PheVal: 3.251 ± 0.498
1.0PheTrp: 1.0 ± 0.327
0.5PheTyr: 0.5 ± 0.709
0.0PheXaa: 0.0 ± 0.0
Gly
3.251GlyAla: 3.251 ± 1.062
1.5GlyCys: 1.5 ± 0.694
3.501GlyAsp: 3.501 ± 1.735
2.251GlyGlu: 2.251 ± 0.351
3.751GlyPhe: 3.751 ± 0.064
3.501GlyGly: 3.501 ± 0.754
1.75GlyHis: 1.75 ± 0.594
3.501GlyIle: 3.501 ± 1.497
2.751GlyLys: 2.751 ± 1.127
5.251GlyLeu: 5.251 ± 1.477
2.001GlyMet: 2.001 ± 0.464
1.75GlyAsn: 1.75 ± 0.795
1.5GlyPro: 1.5 ± 0.445
2.251GlyGln: 2.251 ± 0.477
3.751GlyArg: 3.751 ± 0.385
7.752GlySer: 7.752 ± 2.072
1.5GlyThr: 1.5 ± 0.49
4.001GlyVal: 4.001 ± 1.297
1.25GlyTrp: 1.25 ± 1.091
1.0GlyTyr: 1.0 ± 0.327
0.0GlyXaa: 0.0 ± 0.0
His
1.5HisAla: 1.5 ± 0.49
0.75HisCys: 0.75 ± 0.347
1.25HisAsp: 1.25 ± 0.499
1.5HisGlu: 1.5 ± 0.694
1.0HisPhe: 1.0 ± 0.364
2.251HisGly: 2.251 ± 0.868
0.5HisHis: 0.5 ± 0.163
1.5HisIle: 1.5 ± 0.564
2.001HisLys: 2.001 ± 0.367
2.001HisLeu: 2.001 ± 0.957
0.25HisMet: 0.25 ± 0.213
0.5HisAsn: 0.5 ± 0.309
1.75HisPro: 1.75 ± 0.889
0.5HisGln: 0.5 ± 0.309
1.75HisArg: 1.75 ± 0.529
3.501HisSer: 3.501 ± 0.761
1.25HisThr: 1.25 ± 0.409
1.5HisVal: 1.5 ± 0.564
0.0HisTrp: 0.0 ± 0.0
1.5HisTyr: 1.5 ± 0.445
0.0HisXaa: 0.0 ± 0.0
Ile
1.75IleAla: 1.75 ± 0.426
2.001IleCys: 2.001 ± 1.126
4.501IleAsp: 4.501 ± 0.947
3.251IleGlu: 3.251 ± 0.98
1.75IlePhe: 1.75 ± 0.426
5.001IleGly: 5.001 ± 1.382
1.0IleHis: 1.0 ± 0.364
6.252IleIle: 6.252 ± 1.11
3.751IleLys: 3.751 ± 1.574
4.251IleLeu: 4.251 ± 0.981
2.001IleMet: 2.001 ± 0.71
3.751IleAsn: 3.751 ± 1.621
1.75IlePro: 1.75 ± 0.594
3.001IleGln: 3.001 ± 0.431
4.501IleArg: 4.501 ± 1.374
4.001IleSer: 4.001 ± 0.196
2.251IleThr: 2.251 ± 1.485
4.001IleVal: 4.001 ± 0.623
0.25IleTrp: 0.25 ± 0.154
2.001IleTyr: 2.001 ± 0.946
0.0IleXaa: 0.0 ± 0.0
Lys
3.001LysAla: 3.001 ± 0.962
2.001LysCys: 2.001 ± 1.104
1.75LysAsp: 1.75 ± 0.426
3.001LysGlu: 3.001 ± 1.309
2.501LysPhe: 2.501 ± 1.243
2.251LysGly: 2.251 ± 1.312
1.75LysHis: 1.75 ± 0.594
3.501LysIle: 3.501 ± 0.516
4.251LysLys: 4.251 ± 1.074
5.751LysLeu: 5.751 ± 1.436
3.501LysMet: 3.501 ± 1.31
2.751LysAsn: 2.751 ± 1.478
1.75LysPro: 1.75 ± 0.406
2.001LysGln: 2.001 ± 0.654
2.501LysArg: 2.501 ± 1.814
4.751LysSer: 4.751 ± 0.923
3.751LysThr: 3.751 ± 0.88
4.751LysVal: 4.751 ± 1.921
1.5LysTrp: 1.5 ± 0.472
2.501LysTyr: 2.501 ± 1.987
0.0LysXaa: 0.0 ± 0.0
Leu
4.251LeuAla: 4.251 ± 1.576
1.25LeuCys: 1.25 ± 0.376
3.751LeuAsp: 3.751 ± 0.82
6.002LeuGlu: 6.002 ± 0.567
4.751LeuPhe: 4.751 ± 1.288
4.251LeuGly: 4.251 ± 0.667
3.001LeuHis: 3.001 ± 0.944
5.001LeuIle: 5.001 ± 1.18
5.001LeuLys: 5.001 ± 1.019
6.752LeuLeu: 6.752 ± 2.734
2.251LeuMet: 2.251 ± 0.526
2.751LeuAsn: 2.751 ± 0.467
2.751LeuPro: 2.751 ± 1.475
4.251LeuGln: 4.251 ± 0.962
7.502LeuArg: 7.502 ± 1.051
12.003LeuSer: 12.003 ± 1.556
5.751LeuThr: 5.751 ± 0.923
5.751LeuVal: 5.751 ± 1.11
0.5LeuTrp: 0.5 ± 0.309
2.251LeuTyr: 2.251 ± 0.552
0.0LeuXaa: 0.0 ± 0.0
Met
2.001MetAla: 2.001 ± 0.367
0.25MetCys: 0.25 ± 0.154
2.751MetAsp: 2.751 ± 1.127
2.001MetGlu: 2.001 ± 0.715
1.5MetPhe: 1.5 ± 1.353
2.001MetGly: 2.001 ± 1.95
1.75MetHis: 1.75 ± 0.406
2.001MetIle: 2.001 ± 0.864
3.001MetLys: 3.001 ± 0.636
2.501MetLeu: 2.501 ± 0.72
1.5MetMet: 1.5 ± 0.737
1.5MetAsn: 1.5 ± 0.564
0.5MetPro: 0.5 ± 0.309
1.5MetGln: 1.5 ± 0.694
1.75MetArg: 1.75 ± 0.863
4.251MetSer: 4.251 ± 1.289
1.75MetThr: 1.75 ± 0.944
1.25MetVal: 1.25 ± 0.376
0.5MetTrp: 0.5 ± 0.309
0.5MetTyr: 0.5 ± 0.457
0.0MetXaa: 0.0 ± 0.0
Asn
2.001AsnAla: 2.001 ± 0.606
0.75AsnCys: 0.75 ± 0.62
2.251AsnAsp: 2.251 ± 1.206
4.001AsnGlu: 4.001 ± 1.73
2.501AsnPhe: 2.501 ± 0.539
2.251AsnGly: 2.251 ± 0.677
1.0AsnHis: 1.0 ± 0.561
1.5AsnIle: 1.5 ± 0.972
3.001AsnLys: 3.001 ± 0.691
4.751AsnLeu: 4.751 ± 0.735
1.5AsnMet: 1.5 ± 0.481
2.251AsnAsn: 2.251 ± 1.041
2.001AsnPro: 2.001 ± 0.771
0.5AsnGln: 0.5 ± 0.163
1.0AsnArg: 1.0 ± 0.327
4.751AsnSer: 4.751 ± 1.096
1.25AsnThr: 1.25 ± 0.507
1.25AsnVal: 1.25 ± 0.626
0.5AsnTrp: 0.5 ± 0.163
1.0AsnTyr: 1.0 ± 0.49
0.0AsnXaa: 0.0 ± 0.0
Pro
1.75ProAla: 1.75 ± 1.402
0.25ProCys: 0.25 ± 0.213
2.251ProAsp: 2.251 ± 0.824
3.751ProGlu: 3.751 ± 1.051
1.5ProPhe: 1.5 ± 0.694
2.001ProGly: 2.001 ± 0.654
0.75ProHis: 0.75 ± 0.463
0.5ProIle: 0.5 ± 1.497
1.75ProLys: 1.75 ± 0.656
3.251ProLeu: 3.251 ± 0.857
0.75ProMet: 0.75 ± 0.423
2.001ProAsn: 2.001 ± 0.436
1.25ProPro: 1.25 ± 0.376
2.001ProGln: 2.001 ± 0.957
2.001ProArg: 2.001 ± 1.1
5.001ProSer: 5.001 ± 3.464
2.251ProThr: 2.251 ± 0.477
2.251ProVal: 2.251 ± 0.526
0.75ProTrp: 0.75 ± 0.677
1.25ProTyr: 1.25 ± 0.507
0.0ProXaa: 0.0 ± 0.0
Gln
1.25GlnAla: 1.25 ± 0.626
1.75GlnCys: 1.75 ± 0.656
2.001GlnAsp: 2.001 ± 0.553
3.751GlnGlu: 3.751 ± 0.834
1.75GlnPhe: 1.75 ± 0.93
2.001GlnGly: 2.001 ± 0.957
1.25GlnHis: 1.25 ± 0.507
2.501GlnIle: 2.501 ± 0.751
2.251GlnLys: 2.251 ± 0.844
2.251GlnLeu: 2.251 ± 1.861
1.75GlnMet: 1.75 ± 0.529
0.75GlnAsn: 0.75 ± 0.47
1.25GlnPro: 1.25 ± 0.408
1.25GlnGln: 1.25 ± 0.626
1.0GlnArg: 1.0 ± 0.745
3.001GlnSer: 3.001 ± 1.684
1.5GlnThr: 1.5 ± 0.49
3.001GlnVal: 3.001 ± 0.399
0.25GlnTrp: 0.25 ± 0.494
0.25GlnTyr: 0.25 ± 0.154
0.0GlnXaa: 0.0 ± 0.0
Arg
3.751ArgAla: 3.751 ± 0.288
2.001ArgCys: 2.001 ± 0.843
3.501ArgAsp: 3.501 ± 0.754
4.001ArgGlu: 4.001 ± 0.857
1.75ArgPhe: 1.75 ± 1.359
3.501ArgGly: 3.501 ± 1.181
0.0ArgHis: 0.0 ± 0.0
2.501ArgIle: 2.501 ± 0.645
3.251ArgLys: 3.251 ± 0.279
5.501ArgLeu: 5.501 ± 1.327
2.251ArgMet: 2.251 ± 1.86
2.501ArgAsn: 2.501 ± 0.715
3.751ArgPro: 3.751 ± 0.873
1.0ArgGln: 1.0 ± 0.364
1.75ArgArg: 1.75 ± 0.406
6.002ArgSer: 6.002 ± 0.977
3.751ArgThr: 3.751 ± 1.326
4.001ArgVal: 4.001 ± 0.49
0.75ArgTrp: 0.75 ± 0.677
1.5ArgTyr: 1.5 ± 0.472
0.0ArgXaa: 0.0 ± 0.0
Ser
5.501SerAla: 5.501 ± 0.85
2.751SerCys: 2.751 ± 1.733
5.501SerAsp: 5.501 ± 0.834
5.501SerGlu: 5.501 ± 0.512
3.751SerPhe: 3.751 ± 0.882
8.002SerGly: 8.002 ± 2.038
2.751SerHis: 2.751 ± 0.467
7.752SerIle: 7.752 ± 1.528
4.251SerLys: 4.251 ± 1.219
11.003SerLeu: 11.003 ± 0.971
2.251SerMet: 2.251 ± 0.424
3.001SerAsn: 3.001 ± 0.96
5.251SerPro: 5.251 ± 0.744
2.751SerGln: 2.751 ± 0.948
7.252SerArg: 7.252 ± 0.856
10.253SerSer: 10.253 ± 2.425
6.502SerThr: 6.502 ± 2.091
4.251SerVal: 4.251 ± 1.039
1.5SerTrp: 1.5 ± 0.564
1.5SerTyr: 1.5 ± 0.472
0.0SerXaa: 0.0 ± 0.0
Thr
2.251ThrAla: 2.251 ± 1.325
1.5ThrCys: 1.5 ± 0.378
1.75ThrAsp: 1.75 ± 0.805
3.501ThrGlu: 3.501 ± 1.074
2.001ThrPhe: 2.001 ± 0.436
2.501ThrGly: 2.501 ± 0.541
1.25ThrHis: 1.25 ± 0.376
3.751ThrIle: 3.751 ± 1.13
2.501ThrLys: 2.501 ± 1.026
7.252ThrLeu: 7.252 ± 1.651
1.5ThrMet: 1.5 ± 0.378
2.501ThrAsn: 2.501 ± 0.399
1.25ThrPro: 1.25 ± 0.761
2.001ThrGln: 2.001 ± 0.53
2.501ThrArg: 2.501 ± 1.037
4.251ThrSer: 4.251 ± 0.377
2.501ThrThr: 2.501 ± 0.817
3.501ThrVal: 3.501 ± 1.127
0.0ThrTrp: 0.0 ± 0.0
1.5ThrTyr: 1.5 ± 1.241
0.0ThrXaa: 0.0 ± 0.0
Val
3.251ValAla: 3.251 ± 1.026
2.501ValCys: 2.501 ± 0.561
3.001ValAsp: 3.001 ± 0.944
4.501ValGlu: 4.501 ± 0.53
2.751ValPhe: 2.751 ± 0.492
3.001ValGly: 3.001 ± 0.944
2.501ValHis: 2.501 ± 1.0
3.751ValIle: 3.751 ± 1.29
4.251ValLys: 4.251 ± 0.698
3.251ValLeu: 3.251 ± 0.73
3.001ValMet: 3.001 ± 1.113
2.501ValAsn: 2.501 ± 0.489
1.75ValPro: 1.75 ± 1.34
2.751ValGln: 2.751 ± 0.756
4.001ValArg: 4.001 ± 1.155
7.252ValSer: 7.252 ± 1.212
3.001ValThr: 3.001 ± 1.045
6.002ValVal: 6.002 ± 1.902
0.5ValTrp: 0.5 ± 0.309
2.001ValTyr: 2.001 ± 0.715
0.0ValXaa: 0.0 ± 0.0
Trp
0.25TrpAla: 0.25 ± 0.213
0.25TrpCys: 0.25 ± 0.154
0.0TrpAsp: 0.0 ± 0.0
0.75TrpGlu: 0.75 ± 0.463
0.5TrpPhe: 0.5 ± 0.163
1.0TrpGly: 1.0 ± 0.613
0.25TrpHis: 0.25 ± 0.213
0.5TrpIle: 0.5 ± 0.163
0.75TrpLys: 0.75 ± 0.47
1.0TrpLeu: 1.0 ± 0.617
0.25TrpMet: 0.25 ± 0.749
1.25TrpAsn: 1.25 ± 0.376
0.5TrpPro: 0.5 ± 0.697
0.25TrpGln: 0.25 ± 0.213
0.5TrpArg: 0.5 ± 0.163
1.0TrpSer: 1.0 ± 0.364
1.0TrpThr: 1.0 ± 0.386
1.5TrpVal: 1.5 ± 0.378
0.25TrpTrp: 0.25 ± 0.154
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.5TyrAla: 0.5 ± 0.697
0.75TyrCys: 0.75 ± 0.347
1.25TyrAsp: 1.25 ± 0.771
2.001TyrGlu: 2.001 ± 1.1
1.5TyrPhe: 1.5 ± 0.564
1.0TyrGly: 1.0 ± 0.364
0.75TyrHis: 0.75 ± 0.463
0.75TyrIle: 0.75 ± 0.236
2.251TyrLys: 2.251 ± 0.466
2.501TyrLeu: 2.501 ± 1.2
1.5TyrMet: 1.5 ± 0.354
1.5TyrAsn: 1.5 ± 0.481
1.5TyrPro: 1.5 ± 1.495
1.5TyrGln: 1.5 ± 0.711
1.25TyrArg: 1.25 ± 0.513
2.251TyrSer: 2.251 ± 0.868
0.75TyrThr: 0.75 ± 0.62
1.75TyrVal: 1.75 ± 0.908
0.25TyrTrp: 0.25 ± 0.213
1.25TyrTyr: 1.25 ± 0.541
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (4000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski