Amino acid dipepetide frequency for Thaumarchaeota archaeon SCGC AB-539-E09

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.696AlaAla: 3.696 ± 0.211
0.615AlaCys: 0.615 ± 0.07
2.844AlaAsp: 2.844 ± 0.163
3.913AlaGlu: 3.913 ± 0.176
2.578AlaPhe: 2.578 ± 0.144
3.941AlaGly: 3.941 ± 0.22
1.174AlaHis: 1.174 ± 0.102
4.479AlaIle: 4.479 ± 0.182
3.41AlaLys: 3.41 ± 0.186
5.904AlaLeu: 5.904 ± 0.23
1.67AlaMet: 1.67 ± 0.106
1.838AlaAsn: 1.838 ± 0.115
1.886AlaPro: 1.886 ± 0.128
1.488AlaGln: 1.488 ± 0.103
3.221AlaArg: 3.221 ± 0.171
3.962AlaSer: 3.962 ± 0.162
3.109AlaThr: 3.109 ± 0.167
4.136AlaVal: 4.136 ± 0.2
0.734AlaTrp: 0.734 ± 0.061
2.229AlaTyr: 2.229 ± 0.135
0.0AlaXaa: 0.0 ± 0.0
Cys
0.643CysAla: 0.643 ± 0.083
0.119CysCys: 0.119 ± 0.029
0.58CysAsp: 0.58 ± 0.071
0.517CysGlu: 0.517 ± 0.056
0.363CysPhe: 0.363 ± 0.048
1.062CysGly: 1.062 ± 0.098
0.245CysHis: 0.245 ± 0.042
0.692CysIle: 0.692 ± 0.072
0.531CysLys: 0.531 ± 0.062
1.062CysLeu: 1.062 ± 0.086
0.321CysMet: 0.321 ± 0.052
0.342CysAsn: 0.342 ± 0.048
0.601CysPro: 0.601 ± 0.079
0.168CysGln: 0.168 ± 0.042
0.461CysArg: 0.461 ± 0.057
0.692CysSer: 0.692 ± 0.074
0.566CysThr: 0.566 ± 0.068
0.797CysVal: 0.797 ± 0.077
0.133CysTrp: 0.133 ± 0.034
0.398CysTyr: 0.398 ± 0.053
0.0CysXaa: 0.0 ± 0.0
Asp
3.291AspAla: 3.291 ± 0.198
0.496AspCys: 0.496 ± 0.052
3.186AspAsp: 3.186 ± 0.164
4.367AspGlu: 4.367 ± 0.208
2.376AspPhe: 2.376 ± 0.108
3.64AspGly: 3.64 ± 0.181
0.943AspHis: 0.943 ± 0.09
4.625AspIle: 4.625 ± 0.208
2.872AspLys: 2.872 ± 0.142
5.569AspLeu: 5.569 ± 0.192
1.446AspMet: 1.446 ± 0.098
2.131AspAsn: 2.131 ± 0.121
2.795AspPro: 2.795 ± 0.194
1.307AspGln: 1.307 ± 0.089
2.543AspArg: 2.543 ± 0.149
3.263AspSer: 3.263 ± 0.174
2.515AspThr: 2.515 ± 0.145
4.66AspVal: 4.66 ± 0.215
0.873AspTrp: 0.873 ± 0.101
2.32AspTyr: 2.32 ± 0.142
0.0AspXaa: 0.0 ± 0.0
Glu
4.695GluAla: 4.695 ± 0.218
0.538GluCys: 0.538 ± 0.07
3.71GluAsp: 3.71 ± 0.176
6.644GluGlu: 6.644 ± 0.316
2.431GluPhe: 2.431 ± 0.126
4.646GluGly: 4.646 ± 0.16
1.23GluHis: 1.23 ± 0.091
5.729GluIle: 5.729 ± 0.198
5.687GluLys: 5.687 ± 0.234
6.882GluLeu: 6.882 ± 0.258
1.879GluMet: 1.879 ± 0.103
3.375GluAsn: 3.375 ± 0.18
2.711GluPro: 2.711 ± 0.204
1.628GluGln: 1.628 ± 0.103
4.003GluArg: 4.003 ± 0.179
4.36GluSer: 4.36 ± 0.154
3.759GluThr: 3.759 ± 0.168
4.947GluVal: 4.947 ± 0.197
0.964GluTrp: 0.964 ± 0.093
2.83GluTyr: 2.83 ± 0.146
0.0GluXaa: 0.0 ± 0.0
Phe
1.879PheAla: 1.879 ± 0.117
0.356PheCys: 0.356 ± 0.051
2.508PheAsp: 2.508 ± 0.121
2.9PheGlu: 2.9 ± 0.144
2.201PhePhe: 2.201 ± 0.144
2.781PheGly: 2.781 ± 0.138
0.741PheHis: 0.741 ± 0.071
3.626PheIle: 3.626 ± 0.228
2.348PheLys: 2.348 ± 0.127
4.472PheLeu: 4.472 ± 0.224
0.936PheMet: 0.936 ± 0.081
2.285PheAsn: 2.285 ± 0.144
1.754PhePro: 1.754 ± 0.109
1.083PheGln: 1.083 ± 0.094
1.935PheArg: 1.935 ± 0.12
3.354PheSer: 3.354 ± 0.162
2.515PheThr: 2.515 ± 0.127
2.494PheVal: 2.494 ± 0.137
0.671PheTrp: 0.671 ± 0.06
1.719PheTyr: 1.719 ± 0.106
0.021PheXaa: 0.021 ± 0.013
Gly
4.003GlyAla: 4.003 ± 0.197
0.936GlyCys: 0.936 ± 0.092
3.731GlyAsp: 3.731 ± 0.182
4.562GlyGlu: 4.562 ± 0.215
3.2GlyPhe: 3.2 ± 0.192
5.443GlyGly: 5.443 ± 0.284
1.411GlyHis: 1.411 ± 0.116
5.617GlyIle: 5.617 ± 0.21
4.332GlyLys: 4.332 ± 0.214
6.498GlyLeu: 6.498 ± 0.268
2.11GlyMet: 2.11 ± 0.129
2.536GlyAsn: 2.536 ± 0.167
2.187GlyPro: 2.187 ± 0.129
1.53GlyGln: 1.53 ± 0.119
3.864GlyArg: 3.864 ± 0.177
4.423GlySer: 4.423 ± 0.16
3.249GlyThr: 3.249 ± 0.169
5.366GlyVal: 5.366 ± 0.234
1.083GlyTrp: 1.083 ± 0.086
3.479GlyTyr: 3.479 ± 0.158
0.0GlyXaa: 0.0 ± 0.0
His
0.985HisAla: 0.985 ± 0.088
0.196HisCys: 0.196 ± 0.037
1.09HisAsp: 1.09 ± 0.088
1.223HisGlu: 1.223 ± 0.09
0.873HisPhe: 0.873 ± 0.075
1.397HisGly: 1.397 ± 0.107
0.412HisHis: 0.412 ± 0.044
1.404HisIle: 1.404 ± 0.085
0.706HisLys: 0.706 ± 0.066
1.754HisLeu: 1.754 ± 0.114
0.37HisMet: 0.37 ± 0.048
0.762HisAsn: 0.762 ± 0.074
1.055HisPro: 1.055 ± 0.095
0.496HisGln: 0.496 ± 0.061
1.055HisArg: 1.055 ± 0.088
1.209HisSer: 1.209 ± 0.085
1.013HisThr: 1.013 ± 0.08
1.418HisVal: 1.418 ± 0.098
0.335HisTrp: 0.335 ± 0.043
0.81HisTyr: 0.81 ± 0.072
0.0HisXaa: 0.0 ± 0.0
Ile
4.59IleAla: 4.59 ± 0.195
0.943IleCys: 0.943 ± 0.087
4.961IleAsp: 4.961 ± 0.171
5.394IleGlu: 5.394 ± 0.202
3.549IlePhe: 3.549 ± 0.206
5.156IleGly: 5.156 ± 0.189
1.53IleHis: 1.53 ± 0.11
6.693IleIle: 6.693 ± 0.301
4.751IleLys: 4.751 ± 0.174
7.804IleLeu: 7.804 ± 0.27
1.949IleMet: 1.949 ± 0.129
3.752IleAsn: 3.752 ± 0.176
4.15IlePro: 4.15 ± 0.187
2.173IleGln: 2.173 ± 0.111
3.962IleArg: 3.962 ± 0.198
5.778IleSer: 5.778 ± 0.246
4.667IleThr: 4.667 ± 0.183
5.149IleVal: 5.149 ± 0.191
0.999IleTrp: 0.999 ± 0.111
2.955IleTyr: 2.955 ± 0.164
0.0IleXaa: 0.0 ± 0.0
Lys
3.766LysAla: 3.766 ± 0.18
0.454LysCys: 0.454 ± 0.066
2.976LysAsp: 2.976 ± 0.16
4.814LysGlu: 4.814 ± 0.184
2.18LysPhe: 2.18 ± 0.129
4.115LysGly: 4.115 ± 0.198
1.02LysHis: 1.02 ± 0.085
5.974LysIle: 5.974 ± 0.246
5.114LysLys: 5.114 ± 0.239
5.492LysLeu: 5.492 ± 0.218
1.984LysMet: 1.984 ± 0.128
3.591LysAsn: 3.591 ± 0.191
2.725LysPro: 2.725 ± 0.141
1.565LysGln: 1.565 ± 0.113
3.493LysArg: 3.493 ± 0.171
3.172LysSer: 3.172 ± 0.145
3.493LysThr: 3.493 ± 0.159
4.199LysVal: 4.199 ± 0.192
0.734LysTrp: 0.734 ± 0.069
2.676LysTyr: 2.676 ± 0.146
0.0LysXaa: 0.0 ± 0.0
Leu
5.617LeuAla: 5.617 ± 0.205
1.069LeuCys: 1.069 ± 0.076
5.659LeuAsp: 5.659 ± 0.208
6.98LeuGlu: 6.98 ± 0.285
4.262LeuPhe: 4.262 ± 0.224
6.973LeuGly: 6.973 ± 0.309
1.67LeuHis: 1.67 ± 0.103
7.616LeuIle: 7.616 ± 0.278
7.189LeuLys: 7.189 ± 0.238
9.118LeuLeu: 9.118 ± 0.331
2.62LeuMet: 2.62 ± 0.128
4.493LeuAsn: 4.493 ± 0.217
3.857LeuPro: 3.857 ± 0.166
2.403LeuGln: 2.403 ± 0.151
5.31LeuArg: 5.31 ± 0.223
6.714LeuSer: 6.714 ± 0.227
5.121LeuThr: 5.121 ± 0.207
6.086LeuVal: 6.086 ± 0.2
1.048LeuTrp: 1.048 ± 0.082
3.319LeuTyr: 3.319 ± 0.169
0.0LeuXaa: 0.0 ± 0.0
Met
1.733MetAla: 1.733 ± 0.118
0.238MetCys: 0.238 ± 0.036
1.481MetAsp: 1.481 ± 0.102
1.719MetGlu: 1.719 ± 0.125
1.027MetPhe: 1.027 ± 0.081
1.977MetGly: 1.977 ± 0.126
0.356MetHis: 0.356 ± 0.053
2.005MetIle: 2.005 ± 0.124
2.243MetLys: 2.243 ± 0.124
2.25MetLeu: 2.25 ± 0.141
0.838MetMet: 0.838 ± 0.078
1.453MetAsn: 1.453 ± 0.097
1.125MetPro: 1.125 ± 0.086
0.552MetGln: 0.552 ± 0.06
1.314MetArg: 1.314 ± 0.101
2.089MetSer: 2.089 ± 0.117
1.328MetThr: 1.328 ± 0.103
2.068MetVal: 2.068 ± 0.122
0.266MetTrp: 0.266 ± 0.038
0.859MetTyr: 0.859 ± 0.08
0.0MetXaa: 0.0 ± 0.0
Asn
2.327AsnAla: 2.327 ± 0.126
0.552AsnCys: 0.552 ± 0.071
2.138AsnAsp: 2.138 ± 0.132
2.886AsnGlu: 2.886 ± 0.136
1.782AsnPhe: 1.782 ± 0.122
2.711AsnGly: 2.711 ± 0.178
0.706AsnHis: 0.706 ± 0.076
3.969AsnIle: 3.969 ± 0.185
2.424AsnLys: 2.424 ± 0.145
4.723AsnLeu: 4.723 ± 0.208
1.258AsnMet: 1.258 ± 0.089
2.124AsnAsn: 2.124 ± 0.148
2.403AsnPro: 2.403 ± 0.147
1.132AsnGln: 1.132 ± 0.101
2.145AsnArg: 2.145 ± 0.121
2.851AsnSer: 2.851 ± 0.158
2.089AsnThr: 2.089 ± 0.131
3.319AsnVal: 3.319 ± 0.158
0.706AsnTrp: 0.706 ± 0.071
1.921AsnTyr: 1.921 ± 0.116
0.0AsnXaa: 0.0 ± 0.0
Pro
1.928ProAla: 1.928 ± 0.119
0.412ProCys: 0.412 ± 0.059
2.55ProAsp: 2.55 ± 0.146
3.906ProGlu: 3.906 ± 0.179
2.026ProPhe: 2.026 ± 0.12
2.746ProGly: 2.746 ± 0.142
0.887ProHis: 0.887 ± 0.087
2.997ProIle: 2.997 ± 0.162
2.25ProLys: 2.25 ± 0.151
4.325ProLeu: 4.325 ± 0.162
0.908ProMet: 0.908 ± 0.081
1.544ProAsn: 1.544 ± 0.108
2.208ProPro: 2.208 ± 0.172
1.034ProGln: 1.034 ± 0.093
2.166ProArg: 2.166 ± 0.126
2.767ProSer: 2.767 ± 0.147
2.124ProThr: 2.124 ± 0.144
2.921ProVal: 2.921 ± 0.148
0.552ProTrp: 0.552 ± 0.07
1.684ProTyr: 1.684 ± 0.099
0.0ProXaa: 0.0 ± 0.0
Gln
1.453GlnAla: 1.453 ± 0.1
0.189GlnCys: 0.189 ± 0.032
1.265GlnAsp: 1.265 ± 0.098
1.677GlnGlu: 1.677 ± 0.111
0.713GlnPhe: 0.713 ± 0.07
1.649GlnGly: 1.649 ± 0.112
0.538GlnHis: 0.538 ± 0.06
2.285GlnIle: 2.285 ± 0.12
1.845GlnLys: 1.845 ± 0.114
2.285GlnLeu: 2.285 ± 0.117
0.866GlnMet: 0.866 ± 0.087
1.188GlnAsn: 1.188 ± 0.096
0.964GlnPro: 0.964 ± 0.076
0.699GlnGln: 0.699 ± 0.063
1.537GlnArg: 1.537 ± 0.095
1.418GlnSer: 1.418 ± 0.091
1.314GlnThr: 1.314 ± 0.089
1.754GlnVal: 1.754 ± 0.119
0.293GlnTrp: 0.293 ± 0.048
1.09GlnTyr: 1.09 ± 0.083
0.0GlnXaa: 0.0 ± 0.0
Arg
2.76ArgAla: 2.76 ± 0.145
0.545ArgCys: 0.545 ± 0.057
2.9ArgAsp: 2.9 ± 0.139
3.85ArgGlu: 3.85 ± 0.183
2.396ArgPhe: 2.396 ± 0.13
3.927ArgGly: 3.927 ± 0.186
0.908ArgHis: 0.908 ± 0.09
4.157ArgIle: 4.157 ± 0.168
4.003ArgLys: 4.003 ± 0.229
4.912ArgLeu: 4.912 ± 0.209
1.502ArgMet: 1.502 ± 0.122
2.208ArgAsn: 2.208 ± 0.136
1.691ArgPro: 1.691 ± 0.104
1.23ArgGln: 1.23 ± 0.099
3.57ArgArg: 3.57 ± 0.178
3.032ArgSer: 3.032 ± 0.157
2.466ArgThr: 2.466 ± 0.124
3.738ArgVal: 3.738 ± 0.194
0.601ArgTrp: 0.601 ± 0.06
2.124ArgTyr: 2.124 ± 0.137
0.0ArgXaa: 0.0 ± 0.0
Ser
3.57SerAla: 3.57 ± 0.158
0.657SerCys: 0.657 ± 0.068
3.472SerAsp: 3.472 ± 0.168
4.919SerGlu: 4.919 ± 0.193
2.99SerPhe: 2.99 ± 0.156
5.128SerGly: 5.128 ± 0.202
1.362SerHis: 1.362 ± 0.092
5.226SerIle: 5.226 ± 0.236
3.885SerLys: 3.885 ± 0.186
6.714SerLeu: 6.714 ± 0.233
1.817SerMet: 1.817 ± 0.111
2.914SerAsn: 2.914 ± 0.139
2.585SerPro: 2.585 ± 0.134
1.712SerGln: 1.712 ± 0.126
3.41SerArg: 3.41 ± 0.163
4.486SerSer: 4.486 ± 0.224
3.41SerThr: 3.41 ± 0.176
4.374SerVal: 4.374 ± 0.188
1.027SerTrp: 1.027 ± 0.084
2.55SerTyr: 2.55 ± 0.149
0.0SerXaa: 0.0 ± 0.0
Thr
3.018ThrAla: 3.018 ± 0.163
0.545ThrCys: 0.545 ± 0.06
2.55ThrAsp: 2.55 ± 0.142
3.333ThrGlu: 3.333 ± 0.176
2.152ThrPhe: 2.152 ± 0.123
3.962ThrGly: 3.962 ± 0.176
1.104ThrHis: 1.104 ± 0.091
4.479ThrIle: 4.479 ± 0.181
2.564ThrLys: 2.564 ± 0.142
5.813ThrLeu: 5.813 ± 0.204
1.181ThrMet: 1.181 ± 0.089
2.082ThrAsn: 2.082 ± 0.133
2.369ThrPro: 2.369 ± 0.143
1.558ThrGln: 1.558 ± 0.101
2.452ThrArg: 2.452 ± 0.143
3.794ThrSer: 3.794 ± 0.168
2.823ThrThr: 2.823 ± 0.167
3.899ThrVal: 3.899 ± 0.175
0.783ThrTrp: 0.783 ± 0.067
1.921ThrTyr: 1.921 ± 0.157
0.0ThrXaa: 0.0 ± 0.0
Val
4.164ValAla: 4.164 ± 0.198
0.776ValCys: 0.776 ± 0.077
4.29ValAsp: 4.29 ± 0.197
5.38ValGlu: 5.38 ± 0.221
3.039ValPhe: 3.039 ± 0.16
4.5ValGly: 4.5 ± 0.224
1.209ValHis: 1.209 ± 0.094
5.415ValIle: 5.415 ± 0.225
4.458ValLys: 4.458 ± 0.192
6.4ValLeu: 6.4 ± 0.227
1.768ValMet: 1.768 ± 0.11
2.997ValAsn: 2.997 ± 0.133
2.62ValPro: 2.62 ± 0.163
1.886ValGln: 1.886 ± 0.138
3.27ValArg: 3.27 ± 0.171
5.003ValSer: 5.003 ± 0.238
4.094ValThr: 4.094 ± 0.182
5.38ValVal: 5.38 ± 0.262
0.831ValTrp: 0.831 ± 0.085
2.613ValTyr: 2.613 ± 0.147
0.0ValXaa: 0.0 ± 0.0
Trp
0.685TrpAla: 0.685 ± 0.072
0.126TrpCys: 0.126 ± 0.033
0.79TrpAsp: 0.79 ± 0.087
1.034TrpGlu: 1.034 ± 0.102
0.58TrpPhe: 0.58 ± 0.067
0.88TrpGly: 0.88 ± 0.077
0.314TrpHis: 0.314 ± 0.055
0.992TrpIle: 0.992 ± 0.098
0.978TrpLys: 0.978 ± 0.088
1.181TrpLeu: 1.181 ± 0.101
0.419TrpMet: 0.419 ± 0.054
0.762TrpAsn: 0.762 ± 0.073
0.44TrpPro: 0.44 ± 0.058
0.3TrpGln: 0.3 ± 0.05
0.776TrpArg: 0.776 ± 0.07
0.922TrpSer: 0.922 ± 0.078
0.629TrpThr: 0.629 ± 0.066
0.845TrpVal: 0.845 ± 0.076
0.286TrpTrp: 0.286 ± 0.042
0.545TrpTyr: 0.545 ± 0.065
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.019TyrAla: 2.019 ± 0.113
0.531TyrCys: 0.531 ± 0.062
2.536TyrAsp: 2.536 ± 0.156
2.634TyrGlu: 2.634 ± 0.16
1.859TyrPhe: 1.859 ± 0.128
2.927TyrGly: 2.927 ± 0.15
0.803TyrHis: 0.803 ± 0.081
2.927TyrIle: 2.927 ± 0.159
1.949TyrLys: 1.949 ± 0.117
3.962TyrLeu: 3.962 ± 0.183
1.069TyrMet: 1.069 ± 0.09
1.789TyrAsn: 1.789 ± 0.104
1.81TyrPro: 1.81 ± 0.128
1.076TyrGln: 1.076 ± 0.099
2.033TyrArg: 2.033 ± 0.122
2.921TyrSer: 2.921 ± 0.157
2.082TyrThr: 2.082 ± 0.113
2.55TyrVal: 2.55 ± 0.142
0.566TyrTrp: 0.566 ± 0.074
1.956TyrTyr: 1.956 ± 0.113
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.007XaaLeu: 0.007 ± 0.009
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.014XaaThr: 0.014 ± 0.009
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 646 proteins (143127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski