Amino acid dipepetide frequency for Physeter macrocephalus (Sperm whale) (Physeter catodon)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.367AlaAla: 7.367 ± 0.035	1.385AlaCys: 1.385 ± 0.01	3.039AlaAsp: 3.039 ± 0.012	4.972AlaGlu: 4.972 ± 0.02	2.542AlaPhe: 2.542 ± 0.012	4.941AlaGly: 4.941 ± 0.022	1.583AlaHis: 1.583 ± 0.008	2.6AlaIle: 2.6 ± 0.01	3.492AlaLys: 3.492 ± 0.024	7.27AlaLeu: 7.27 ± 0.024	1.417AlaMet: 1.417 ± 0.008	1.979AlaAsn: 1.979 ± 0.01	4.588AlaPro: 4.588 ± 0.022	3.399AlaGln: 3.399 ± 0.015	3.943AlaArg: 3.943 ± 0.017	6.11AlaSer: 6.11 ± 0.02	3.558AlaThr: 3.558 ± 0.016	4.773AlaVal: 4.773 ± 0.016	0.792AlaTrp: 0.792 ± 0.006	1.487AlaTyr: 1.487 ± 0.01	0.007AlaXaa: 0.007 ± 0.001
Cys	1.25CysAla: 1.25 ± 0.01	0.595CysCys: 0.595 ± 0.006	0.99CysAsp: 0.99 ± 0.009	1.239CysGlu: 1.239 ± 0.013	0.799CysPhe: 0.799 ± 0.007	1.664CysGly: 1.664 ± 0.016	0.642CysHis: 0.642 ± 0.007	0.887CysIle: 0.887 ± 0.008	1.099CysLys: 1.099 ± 0.009	2.115CysLeu: 2.115 ± 0.013	0.386CysMet: 0.386 ± 0.003	0.754CysAsn: 0.754 ± 0.007	1.393CysPro: 1.393 ± 0.013	1.06CysGln: 1.06 ± 0.009	1.284CysArg: 1.284 ± 0.009	1.963CysSer: 1.963 ± 0.014	1.049CysThr: 1.049 ± 0.008	1.272CysVal: 1.272 ± 0.012	0.281CysTrp: 0.281 ± 0.003	0.546CysTyr: 0.546 ± 0.005	0.003CysXaa: 0.003 ± 0.0
Asp	2.951AspAla: 2.951 ± 0.014	1.025AspCys: 1.025 ± 0.009	2.691AspAsp: 2.691 ± 0.016	3.481AspGlu: 3.481 ± 0.014	2.101AspPhe: 2.101 ± 0.01	3.341AspGly: 3.341 ± 0.017	1.144AspHis: 1.144 ± 0.008	2.496AspIle: 2.496 ± 0.013	2.479AspLys: 2.479 ± 0.012	5.031AspLeu: 5.031 ± 0.015	1.081AspMet: 1.081 ± 0.007	1.595AspAsn: 1.595 ± 0.01	2.963AspPro: 2.963 ± 0.015	1.839AspGln: 1.839 ± 0.01	2.473AspArg: 2.473 ± 0.011	4.283AspSer: 4.283 ± 0.015	2.446AspThr: 2.446 ± 0.014	3.129AspVal: 3.129 ± 0.014	0.62AspTrp: 0.62 ± 0.005	1.449AspTyr: 1.449 ± 0.01	0.005AspXaa: 0.005 ± 0.0
Glu	5.416GluAla: 5.416 ± 0.022	1.412GluCys: 1.412 ± 0.018	4.454GluAsp: 4.454 ± 0.018	8.167GluGlu: 8.167 ± 0.046	2.0GluPhe: 2.0 ± 0.01	4.28GluGly: 4.28 ± 0.017	1.521GluHis: 1.521 ± 0.008	3.119GluIle: 3.119 ± 0.018	5.556GluLys: 5.556 ± 0.032	6.589GluLeu: 6.589 ± 0.03	1.682GluMet: 1.682 ± 0.009	3.144GluAsn: 3.144 ± 0.017	3.401GluPro: 3.401 ± 0.019	3.292GluGln: 3.292 ± 0.017	4.282GluArg: 4.282 ± 0.019	4.575GluSer: 4.575 ± 0.019	3.433GluThr: 3.433 ± 0.015	4.223GluVal: 4.223 ± 0.017	0.684GluTrp: 0.684 ± 0.006	1.536GluTyr: 1.536 ± 0.01	0.005GluXaa: 0.005 ± 0.0
Phe	1.925PheAla: 1.925 ± 0.01	0.882PheCys: 0.882 ± 0.007	1.6PheAsp: 1.6 ± 0.01	1.996PheGlu: 1.996 ± 0.011	1.455PhePhe: 1.455 ± 0.009	2.103PheGly: 2.103 ± 0.012	1.023PheHis: 1.023 ± 0.007	1.669PheIle: 1.669 ± 0.011	1.695PheLys: 1.695 ± 0.009	3.826PheLeu: 3.826 ± 0.018	0.736PheMet: 0.736 ± 0.006	1.241PheAsn: 1.241 ± 0.008	1.997PhePro: 1.997 ± 0.011	1.756PheGln: 1.756 ± 0.008	1.945PheArg: 1.945 ± 0.01	3.361PheSer: 3.361 ± 0.012	1.938PheThr: 1.938 ± 0.011	2.013PheVal: 2.013 ± 0.011	0.448PheTrp: 0.448 ± 0.005	1.085PheTyr: 1.085 ± 0.007	0.005PheXaa: 0.005 ± 0.0
Gly	4.758GlyAla: 4.758 ± 0.022	1.258GlyCys: 1.258 ± 0.01	3.121GlyAsp: 3.121 ± 0.015	4.216GlyGlu: 4.216 ± 0.02	2.302GlyPhe: 2.302 ± 0.013	5.255GlyGly: 5.255 ± 0.03	1.717GlyHis: 1.717 ± 0.01	2.556GlyIle: 2.556 ± 0.011	3.703GlyLys: 3.703 ± 0.015	5.791GlyLeu: 5.791 ± 0.022	1.245GlyMet: 1.245 ± 0.008	2.237GlyAsn: 2.237 ± 0.011	4.523GlyPro: 4.523 ± 0.034	2.829GlyGln: 2.829 ± 0.013	3.996GlyArg: 3.996 ± 0.017	5.924GlySer: 5.924 ± 0.022	3.544GlyThr: 3.544 ± 0.016	3.5GlyVal: 3.5 ± 0.015	0.804GlyTrp: 0.804 ± 0.009	1.642GlyTyr: 1.642 ± 0.011	0.008GlyXaa: 0.008 ± 0.001
His	1.391HisAla: 1.391 ± 0.007	0.702HisCys: 0.702 ± 0.006	0.901HisAsp: 0.901 ± 0.007	1.315HisGlu: 1.315 ± 0.009	1.041HisPhe: 1.041 ± 0.007	1.564HisGly: 1.564 ± 0.01	0.924HisHis: 0.924 ± 0.009	1.19HisIle: 1.19 ± 0.009	1.266HisLys: 1.266 ± 0.007	2.946HisLeu: 2.946 ± 0.012	0.559HisMet: 0.559 ± 0.005	0.815HisAsn: 0.815 ± 0.006	1.725HisPro: 1.725 ± 0.01	1.402HisGln: 1.402 ± 0.012	1.643HisArg: 1.643 ± 0.01	2.324HisSer: 2.324 ± 0.012	1.524HisThr: 1.524 ± 0.013	1.564HisVal: 1.564 ± 0.009	0.336HisTrp: 0.336 ± 0.004	0.79HisTyr: 0.79 ± 0.006	0.004HisXaa: 0.004 ± 0.0
Ile	2.436IleAla: 2.436 ± 0.011	0.986IleCys: 0.986 ± 0.008	1.951IleAsp: 1.951 ± 0.012	2.53IleGlu: 2.53 ± 0.013	1.722IlePhe: 1.722 ± 0.012	2.068IleGly: 2.068 ± 0.013	1.326IleHis: 1.326 ± 0.01	2.154IleIle: 2.154 ± 0.013	2.504IleLys: 2.504 ± 0.013	4.264IleLeu: 4.264 ± 0.016	0.91IleMet: 0.91 ± 0.006	1.714IleAsn: 1.714 ± 0.009	2.545IlePro: 2.545 ± 0.013	2.26IleGln: 2.26 ± 0.014	2.293IleArg: 2.293 ± 0.01	3.568IleSer: 3.568 ± 0.014	2.415IleThr: 2.415 ± 0.011	2.313IleVal: 2.313 ± 0.012	0.465IleTrp: 0.465 ± 0.004	1.268IleTyr: 1.268 ± 0.009	0.004IleXaa: 0.004 ± 0.0
Lys	3.993LysAla: 3.993 ± 0.021	1.11LysCys: 1.11 ± 0.008	3.169LysAsp: 3.169 ± 0.019	5.249LysGlu: 5.249 ± 0.03	1.677LysPhe: 1.677 ± 0.008	3.212LysGly: 3.212 ± 0.019	1.416LysHis: 1.416 ± 0.01	2.69LysIle: 2.69 ± 0.014	4.675LysLys: 4.675 ± 0.028	5.172LysLeu: 5.172 ± 0.022	1.423LysMet: 1.423 ± 0.009	2.35LysAsn: 2.35 ± 0.012	3.124LysPro: 3.124 ± 0.019	2.707LysGln: 2.707 ± 0.016	3.332LysArg: 3.332 ± 0.014	3.995LysSer: 3.995 ± 0.018	3.093LysThr: 3.093 ± 0.014	3.359LysVal: 3.359 ± 0.013	0.594LysTrp: 0.594 ± 0.005	1.522LysTyr: 1.522 ± 0.015	0.004LysXaa: 0.004 ± 0.0
Leu	6.792LeuAla: 6.792 ± 0.022	2.122LeuCys: 2.122 ± 0.014	4.729LeuAsp: 4.729 ± 0.016	7.35LeuGlu: 7.35 ± 0.036	3.222LeuPhe: 3.222 ± 0.015	5.825LeuGly: 5.825 ± 0.018	2.752LeuHis: 2.752 ± 0.013	3.677LeuIle: 3.677 ± 0.016	5.837LeuLys: 5.837 ± 0.026	10.559LeuLeu: 10.559 ± 0.04	1.932LeuMet: 1.932 ± 0.01	3.42LeuAsn: 3.42 ± 0.014	6.24LeuPro: 6.24 ± 0.021	6.013LeuGln: 6.013 ± 0.029	6.024LeuArg: 6.024 ± 0.021	7.995LeuSer: 7.995 ± 0.023	4.92LeuThr: 4.92 ± 0.017	5.318LeuVal: 5.318 ± 0.02	1.098LeuTrp: 1.098 ± 0.009	2.441LeuTyr: 2.441 ± 0.013	0.011LeuXaa: 0.011 ± 0.001
Met	1.839MetAla: 1.839 ± 0.007	0.39MetCys: 0.39 ± 0.004	1.208MetAsp: 1.208 ± 0.008	1.838MetGlu: 1.838 ± 0.009	0.694MetPhe: 0.694 ± 0.005	1.201MetGly: 1.201 ± 0.008	0.465MetHis: 0.465 ± 0.004	0.784MetIle: 0.784 ± 0.006	1.382MetLys: 1.382 ± 0.008	1.905MetLeu: 1.905 ± 0.008	0.548MetMet: 0.548 ± 0.005	0.861MetAsn: 0.861 ± 0.006	1.064MetPro: 1.064 ± 0.008	0.951MetGln: 0.951 ± 0.007	1.042MetArg: 1.042 ± 0.007	1.519MetSer: 1.519 ± 0.009	1.076MetThr: 1.076 ± 0.007	1.335MetVal: 1.335 ± 0.007	0.228MetTrp: 0.228 ± 0.003	0.531MetTyr: 0.531 ± 0.005	0.002MetXaa: 0.002 ± 0.0
Asn	1.996AsnAla: 1.996 ± 0.011	0.782AsnCys: 0.782 ± 0.007	1.472AsnAsp: 1.472 ± 0.01	2.178AsnGlu: 2.178 ± 0.013	1.382AsnPhe: 1.382 ± 0.007	2.324AsnGly: 2.324 ± 0.015	0.923AsnHis: 0.923 ± 0.007	1.991AsnIle: 1.991 ± 0.01	2.149AsnLys: 2.149 ± 0.012	3.584AsnLeu: 3.584 ± 0.015	0.861AsnMet: 0.861 ± 0.006	1.417AsnAsn: 1.417 ± 0.01	2.092AsnPro: 2.092 ± 0.01	1.662AsnGln: 1.662 ± 0.011	1.774AsnArg: 1.774 ± 0.009	3.085AsnSer: 3.085 ± 0.015	1.907AsnThr: 1.907 ± 0.01	2.115AsnVal: 2.115 ± 0.011	0.438AsnTrp: 0.438 ± 0.004	1.059AsnTyr: 1.059 ± 0.009	0.003AsnXaa: 0.003 ± 0.0
Pro	5.457ProAla: 5.457 ± 0.027	1.138ProCys: 1.138 ± 0.01	2.857ProAsp: 2.857 ± 0.016	4.625ProGlu: 4.625 ± 0.02	1.912ProPhe: 1.912 ± 0.011	5.588ProGly: 5.588 ± 0.041	1.491ProHis: 1.491 ± 0.009	1.814ProIle: 1.814 ± 0.011	2.797ProLys: 2.797 ± 0.016	5.451ProLeu: 5.451 ± 0.022	1.029ProMet: 1.029 ± 0.008	1.756ProAsn: 1.756 ± 0.01	6.767ProPro: 6.767 ± 0.053	2.998ProGln: 2.998 ± 0.016	3.661ProArg: 3.661 ± 0.017	6.138ProSer: 6.138 ± 0.026	3.123ProThr: 3.123 ± 0.015	4.008ProVal: 4.008 ± 0.017	0.701ProTrp: 0.701 ± 0.007	1.502ProTyr: 1.502 ± 0.01	0.008ProXaa: 0.008 ± 0.001
Gln	3.704GlnAla: 3.704 ± 0.018	0.929GlnCys: 0.929 ± 0.008	2.397GlnAsp: 2.397 ± 0.011	4.052GlnGlu: 4.052 ± 0.022	1.331GlnPhe: 1.331 ± 0.008	2.891GlnGly: 2.891 ± 0.014	1.372GlnHis: 1.372 ± 0.008	1.98GlnIle: 1.98 ± 0.011	2.995GlnLys: 2.995 ± 0.017	4.914GlnLeu: 4.914 ± 0.024	1.124GlnMet: 1.124 ± 0.007	1.837GlnAsn: 1.837 ± 0.01	3.006GlnPro: 3.006 ± 0.017	3.291GlnGln: 3.291 ± 0.028	3.156GlnArg: 3.156 ± 0.015	3.292GlnSer: 3.292 ± 0.015	2.353GlnThr: 2.353 ± 0.011	2.839GlnVal: 2.839 ± 0.012	0.533GlnTrp: 0.533 ± 0.005	1.128GlnTyr: 1.128 ± 0.007	0.004GlnXaa: 0.004 ± 0.0
Arg	4.144ArgAla: 4.144 ± 0.018	1.235ArgCys: 1.235 ± 0.011	2.803ArgAsp: 2.803 ± 0.011	4.244ArgGlu: 4.244 ± 0.02	1.802ArgPhe: 1.802 ± 0.011	3.839ArgGly: 3.839 ± 0.02	1.59ArgHis: 1.59 ± 0.008	2.368ArgIle: 2.368 ± 0.009	3.742ArgLys: 3.742 ± 0.017	5.589ArgLeu: 5.589 ± 0.02	1.171ArgMet: 1.171 ± 0.008	2.066ArgAsn: 2.066 ± 0.011	3.538ArgPro: 3.538 ± 0.017	2.798ArgGln: 2.798 ± 0.014	4.711ArgArg: 4.711 ± 0.022	4.56ArgSer: 4.56 ± 0.025	2.882ArgThr: 2.882 ± 0.013	3.208ArgVal: 3.208 ± 0.012	0.698ArgTrp: 0.698 ± 0.005	1.376ArgTyr: 1.376 ± 0.009	0.005ArgXaa: 0.005 ± 0.0
Ser	5.63SerAla: 5.63 ± 0.02	1.792SerCys: 1.792 ± 0.013	4.041SerAsp: 4.041 ± 0.024	5.438SerGlu: 5.438 ± 0.023	2.975SerPhe: 2.975 ± 0.013	5.734SerGly: 5.734 ± 0.021	2.128SerHis: 2.128 ± 0.01	3.09SerIle: 3.09 ± 0.012	4.162SerLys: 4.162 ± 0.017	8.347SerLeu: 8.347 ± 0.024	1.572SerMet: 1.572 ± 0.008	2.615SerAsn: 2.615 ± 0.013	6.527SerPro: 6.527 ± 0.032	4.027SerGln: 4.027 ± 0.016	4.842SerArg: 4.842 ± 0.024	9.9SerSer: 9.9 ± 0.046	4.496SerThr: 4.496 ± 0.02	4.933SerVal: 4.933 ± 0.017	1.03SerTrp: 1.03 ± 0.008	1.976SerTyr: 1.976 ± 0.011	0.008SerXaa: 0.008 ± 0.001
Thr	3.82ThrAla: 3.82 ± 0.015	1.213ThrCys: 1.213 ± 0.01	2.419ThrAsp: 2.419 ± 0.011	3.54ThrGlu: 3.54 ± 0.016	1.983ThrPhe: 1.983 ± 0.009	3.491ThrGly: 3.491 ± 0.015	1.296ThrHis: 1.296 ± 0.011	2.161ThrIle: 2.161 ± 0.01	2.605ThrLys: 2.605 ± 0.013	5.157ThrLeu: 5.157 ± 0.018	1.066ThrMet: 1.066 ± 0.006	1.648ThrAsn: 1.648 ± 0.009	3.746ThrPro: 3.746 ± 0.02	2.317ThrGln: 2.317 ± 0.014	2.522ThrArg: 2.522 ± 0.012	4.726ThrSer: 4.726 ± 0.018	2.881ThrThr: 2.881 ± 0.019	3.738ThrVal: 3.738 ± 0.016	0.653ThrTrp: 0.653 ± 0.006	1.333ThrTyr: 1.333 ± 0.009	0.006ThrXaa: 0.006 ± 0.001
Val	4.264ValAla: 4.264 ± 0.016	1.415ValCys: 1.415 ± 0.011	2.929ValAsp: 2.929 ± 0.014	3.864ValGlu: 3.864 ± 0.016	2.237ValPhe: 2.237 ± 0.011	3.33ValGly: 3.33 ± 0.014	1.584ValHis: 1.584 ± 0.008	2.707ValIle: 2.707 ± 0.012	3.409ValLys: 3.409 ± 0.015	6.072ValLeu: 6.072 ± 0.021	1.254ValMet: 1.254 ± 0.007	2.217ValAsn: 2.217 ± 0.011	3.78ValPro: 3.78 ± 0.016	2.79ValGln: 2.79 ± 0.011	3.091ValArg: 3.091 ± 0.012	4.935ValSer: 4.935 ± 0.016	3.651ValThr: 3.651 ± 0.019	3.842ValVal: 3.842 ± 0.017	0.673ValTrp: 0.673 ± 0.006	1.552ValTyr: 1.552 ± 0.01	0.006ValXaa: 0.006 ± 0.001
Trp	0.787TrpAla: 0.787 ± 0.006	0.244TrpCys: 0.244 ± 0.003	0.641TrpAsp: 0.641 ± 0.006	0.788TrpGlu: 0.788 ± 0.006	0.41TrpPhe: 0.41 ± 0.004	0.71TrpGly: 0.71 ± 0.006	0.296TrpHis: 0.296 ± 0.004	0.497TrpIle: 0.497 ± 0.005	0.779TrpLys: 0.779 ± 0.006	1.171TrpLeu: 1.171 ± 0.009	0.313TrpMet: 0.313 ± 0.003	0.514TrpAsn: 0.514 ± 0.005	0.541TrpPro: 0.541 ± 0.005	0.51TrpGln: 0.51 ± 0.005	0.741TrpArg: 0.741 ± 0.007	0.862TrpSer: 0.862 ± 0.007	0.644TrpThr: 0.644 ± 0.006	0.645TrpVal: 0.645 ± 0.006	0.183TrpTrp: 0.183 ± 0.003	0.311TrpTyr: 0.311 ± 0.005	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.317TyrAla: 1.317 ± 0.008	0.653TyrCys: 0.653 ± 0.006	1.207TyrAsp: 1.207 ± 0.008	1.681TyrGlu: 1.681 ± 0.012	1.109TyrPhe: 1.109 ± 0.007	1.559TyrGly: 1.559 ± 0.01	0.728TyrHis: 0.728 ± 0.006	1.262TyrIle: 1.262 ± 0.007	1.533TyrLys: 1.533 ± 0.029	2.513TyrLeu: 2.513 ± 0.014	0.551TyrMet: 0.551 ± 0.006	1.013TyrAsn: 1.013 ± 0.007	1.252TyrPro: 1.252 ± 0.008	1.223TyrGln: 1.223 ± 0.007	1.61TyrArg: 1.61 ± 0.012	2.14TyrSer: 2.14 ± 0.01	1.382TyrThr: 1.382 ± 0.009	1.47TyrVal: 1.47 ± 0.009	0.329TyrTrp: 0.329 ± 0.005	0.891TyrTyr: 0.891 ± 0.006	0.003TyrXaa: 0.003 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.001	0.003XaaCys: 0.003 ± 0.0	0.004XaaAsp: 0.004 ± 0.0	0.007XaaGlu: 0.007 ± 0.001	0.004XaaPhe: 0.004 ± 0.0	0.008XaaGly: 0.008 ± 0.001	0.003XaaHis: 0.003 ± 0.0	0.004XaaIle: 0.004 ± 0.0	0.006XaaLys: 0.006 ± 0.001	0.009XaaLeu: 0.009 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.003XaaAsn: 0.003 ± 0.0	0.007XaaPro: 0.007 ± 0.001	0.005XaaGln: 0.005 ± 0.0	0.006XaaArg: 0.006 ± 0.0	0.007XaaSer: 0.007 ± 0.001	0.004XaaThr: 0.004 ± 0.0	0.007XaaVal: 0.007 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.022XaaXaa: 0.022 ± 0.005

Statistics based on 41868 proteins (27548336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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