Amino acid dipepetide frequency for Callosobruchus maculatus (Southern cowpea weevil) (Pulse bruchid)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.671AlaAla: 5.671 ± 0.059	1.174AlaCys: 1.174 ± 0.024	3.07AlaAsp: 3.07 ± 0.019	4.012AlaGlu: 4.012 ± 0.035	2.113AlaPhe: 2.113 ± 0.014	3.454AlaGly: 3.454 ± 0.03	1.336AlaHis: 1.336 ± 0.012	3.287AlaIle: 3.287 ± 0.02	3.936AlaLys: 3.936 ± 0.024	5.4AlaLeu: 5.4 ± 0.028	1.421AlaMet: 1.421 ± 0.013	2.518AlaAsn: 2.518 ± 0.017	3.007AlaPro: 3.007 ± 0.028	2.469AlaGln: 2.469 ± 0.022	2.822AlaArg: 2.822 ± 0.019	4.655AlaSer: 4.655 ± 0.027	3.684AlaThr: 3.684 ± 0.022	4.214AlaVal: 4.214 ± 0.024	0.549AlaTrp: 0.549 ± 0.009	1.65AlaTyr: 1.65 ± 0.015	0.0AlaXaa: 0.0 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.016	0.537CysCys: 0.537 ± 0.009	1.288CysAsp: 1.288 ± 0.02	1.317CysGlu: 1.317 ± 0.023	0.804CysPhe: 0.804 ± 0.01	1.401CysGly: 1.401 ± 0.035	0.597CysHis: 0.597 ± 0.009	1.259CysIle: 1.259 ± 0.022	1.415CysLys: 1.415 ± 0.021	1.942CysLeu: 1.942 ± 0.024	0.456CysMet: 0.456 ± 0.008	1.068CysAsn: 1.068 ± 0.016	1.197CysPro: 1.197 ± 0.041	0.824CysGln: 0.824 ± 0.016	1.219CysArg: 1.219 ± 0.033	1.801CysSer: 1.801 ± 0.032	1.302CysThr: 1.302 ± 0.028	1.263CysVal: 1.263 ± 0.026	0.222CysTrp: 0.222 ± 0.005	0.682CysTyr: 0.682 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.012AspAla: 3.012 ± 0.018	1.123AspCys: 1.123 ± 0.018	3.732AspAsp: 3.732 ± 0.034	4.255AspGlu: 4.255 ± 0.029	2.247AspPhe: 2.247 ± 0.017	3.019AspGly: 3.019 ± 0.021	1.28AspHis: 1.28 ± 0.014	3.594AspIle: 3.594 ± 0.026	3.626AspLys: 3.626 ± 0.028	4.788AspLeu: 4.788 ± 0.025	1.276AspMet: 1.276 ± 0.013	2.652AspAsn: 2.652 ± 0.021	2.538AspPro: 2.538 ± 0.034	1.824AspGln: 1.824 ± 0.014	2.636AspArg: 2.636 ± 0.041	4.197AspSer: 4.197 ± 0.026	2.953AspThr: 2.953 ± 0.022	3.488AspVal: 3.488 ± 0.022	0.584AspTrp: 0.584 ± 0.009	1.865AspTyr: 1.865 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	4.238GluAla: 4.238 ± 0.033	1.392GluCys: 1.392 ± 0.038	4.447GluAsp: 4.447 ± 0.031	6.633GluGlu: 6.633 ± 0.071	2.142GluPhe: 2.142 ± 0.018	3.217GluGly: 3.217 ± 0.03	1.632GluHis: 1.632 ± 0.018	4.123GluIle: 4.123 ± 0.031	5.734GluLys: 5.734 ± 0.043	5.798GluLeu: 5.798 ± 0.042	1.659GluMet: 1.659 ± 0.015	3.85GluAsn: 3.85 ± 0.027	2.65GluPro: 2.65 ± 0.03	2.856GluGln: 2.856 ± 0.024	3.636GluArg: 3.636 ± 0.038	4.445GluSer: 4.445 ± 0.028	3.788GluThr: 3.788 ± 0.029	4.318GluVal: 4.318 ± 0.026	0.625GluTrp: 0.625 ± 0.008	2.086GluTyr: 2.086 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.024PheAla: 2.024 ± 0.014	0.857PheCys: 0.857 ± 0.01	2.075PheAsp: 2.075 ± 0.017	2.353PheGlu: 2.353 ± 0.016	1.588PhePhe: 1.588 ± 0.015	2.297PheGly: 2.297 ± 0.023	0.908PheHis: 0.908 ± 0.008	2.216PheIle: 2.216 ± 0.018	2.458PheLys: 2.458 ± 0.022	3.635PheLeu: 3.635 ± 0.026	0.884PheMet: 0.884 ± 0.01	1.8PheAsn: 1.8 ± 0.014	1.585PhePro: 1.585 ± 0.014	1.448PheGln: 1.448 ± 0.012	1.815PheArg: 1.815 ± 0.015	3.05PheSer: 3.05 ± 0.021	2.122PheThr: 2.122 ± 0.017	2.418PheVal: 2.418 ± 0.015	0.436PheTrp: 0.436 ± 0.006	1.331PheTyr: 1.331 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	3.369GlyAla: 3.369 ± 0.029	1.067GlyCys: 1.067 ± 0.02	2.931GlyAsp: 2.931 ± 0.025	3.207GlyGlu: 3.207 ± 0.022	2.113GlyPhe: 2.113 ± 0.019	5.179GlyGly: 5.179 ± 0.088	1.423GlyHis: 1.423 ± 0.014	3.013GlyIle: 3.013 ± 0.021	3.55GlyLys: 3.55 ± 0.025	4.255GlyLeu: 4.255 ± 0.023	1.261GlyMet: 1.261 ± 0.016	2.506GlyAsn: 2.506 ± 0.022	2.426GlyPro: 2.426 ± 0.034	2.09GlyGln: 2.09 ± 0.024	2.909GlyArg: 2.909 ± 0.024	4.46GlySer: 4.46 ± 0.035	3.153GlyThr: 3.153 ± 0.026	3.32GlyVal: 3.32 ± 0.021	0.59GlyTrp: 0.59 ± 0.008	2.013GlyTyr: 2.013 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.294HisAla: 1.294 ± 0.013	0.672HisCys: 0.672 ± 0.016	1.161HisAsp: 1.161 ± 0.013	1.396HisGlu: 1.396 ± 0.014	1.022HisPhe: 1.022 ± 0.011	1.318HisGly: 1.318 ± 0.014	1.033HisHis: 1.033 ± 0.017	1.59HisIle: 1.59 ± 0.015	1.539HisLys: 1.539 ± 0.015	2.502HisLeu: 2.502 ± 0.018	0.728HisMet: 0.728 ± 0.015	1.219HisAsn: 1.219 ± 0.013	1.478HisPro: 1.478 ± 0.021	1.207HisGln: 1.207 ± 0.012	1.397HisArg: 1.397 ± 0.012	1.955HisSer: 1.955 ± 0.015	1.424HisThr: 1.424 ± 0.015	1.445HisVal: 1.445 ± 0.017	0.272HisTrp: 0.272 ± 0.006	0.856HisTyr: 0.856 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.355IleAla: 3.355 ± 0.022	1.368IleCys: 1.368 ± 0.018	3.102IleAsp: 3.102 ± 0.021	3.853IleGlu: 3.853 ± 0.027	2.349IlePhe: 2.349 ± 0.019	2.827IleGly: 2.827 ± 0.02	1.508IleHis: 1.508 ± 0.019	3.353IleIle: 3.353 ± 0.022	3.987IleLys: 3.987 ± 0.031	5.25IleLeu: 5.25 ± 0.029	1.244IleMet: 1.244 ± 0.013	2.766IleAsn: 2.766 ± 0.022	2.841IlePro: 2.841 ± 0.02	2.379IleGln: 2.379 ± 0.016	2.805IleArg: 2.805 ± 0.017	4.496IleSer: 4.496 ± 0.023	3.265IleThr: 3.265 ± 0.02	3.511IleVal: 3.511 ± 0.025	0.588IleTrp: 0.588 ± 0.008	1.883IleTyr: 1.883 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.85LysAla: 3.85 ± 0.026	1.577LysCys: 1.577 ± 0.024	3.91LysAsp: 3.91 ± 0.028	5.535LysGlu: 5.535 ± 0.042	2.297LysPhe: 2.297 ± 0.017	3.102LysGly: 3.102 ± 0.029	1.97LysHis: 1.97 ± 0.034	4.231LysIle: 4.231 ± 0.029	6.373LysLys: 6.373 ± 0.061	6.24LysLeu: 6.24 ± 0.039	1.74LysMet: 1.74 ± 0.012	3.667LysAsn: 3.667 ± 0.027	3.368LysPro: 3.368 ± 0.041	3.139LysGln: 3.139 ± 0.025	4.01LysArg: 4.01 ± 0.029	5.112LysSer: 5.112 ± 0.039	4.139LysThr: 4.139 ± 0.031	4.103LysVal: 4.103 ± 0.026	0.696LysTrp: 0.696 ± 0.009	2.418LysTyr: 2.418 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	5.306LeuAla: 5.306 ± 0.029	1.82LeuCys: 1.82 ± 0.015	4.812LeuAsp: 4.812 ± 0.03	6.3LeuGlu: 6.3 ± 0.049	3.29LeuPhe: 3.29 ± 0.025	4.287LeuGly: 4.287 ± 0.024	2.32LeuHis: 2.32 ± 0.017	4.55LeuIle: 4.55 ± 0.026	6.691LeuLys: 6.691 ± 0.042	8.539LeuLeu: 8.539 ± 0.049	1.948LeuMet: 1.948 ± 0.012	4.446LeuAsn: 4.446 ± 0.022	4.402LeuPro: 4.402 ± 0.026	4.342LeuGln: 4.342 ± 0.034	4.875LeuArg: 4.875 ± 0.027	6.586LeuSer: 6.586 ± 0.03	4.971LeuThr: 4.971 ± 0.023	5.012LeuVal: 5.012 ± 0.028	0.853LeuTrp: 0.853 ± 0.01	2.807LeuTyr: 2.807 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.546MetAla: 1.546 ± 0.012	0.471MetCys: 0.471 ± 0.007	1.318MetAsp: 1.318 ± 0.012	1.636MetGlu: 1.636 ± 0.015	0.923MetPhe: 0.923 ± 0.01	1.193MetGly: 1.193 ± 0.014	0.518MetHis: 0.518 ± 0.007	1.179MetIle: 1.179 ± 0.012	1.692MetLys: 1.692 ± 0.013	2.101MetLeu: 2.101 ± 0.016	0.628MetMet: 0.628 ± 0.008	1.096MetAsn: 1.096 ± 0.01	1.076MetPro: 1.076 ± 0.011	1.003MetGln: 1.003 ± 0.012	1.129MetArg: 1.129 ± 0.011	1.835MetSer: 1.835 ± 0.015	1.263MetThr: 1.263 ± 0.01	1.443MetVal: 1.443 ± 0.01	0.254MetTrp: 0.254 ± 0.004	0.795MetTyr: 0.795 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.732AsnAla: 2.732 ± 0.024	1.116AsnCys: 1.116 ± 0.016	2.515AsnAsp: 2.515 ± 0.019	3.172AsnGlu: 3.172 ± 0.023	2.003AsnPhe: 2.003 ± 0.015	2.856AsnGly: 2.856 ± 0.029	1.226AsnHis: 1.226 ± 0.016	3.362AsnIle: 3.362 ± 0.021	3.41AsnLys: 3.41 ± 0.024	4.476AsnLeu: 4.476 ± 0.025	1.169AsnMet: 1.169 ± 0.012	2.739AsnAsn: 2.739 ± 0.023	2.218AsnPro: 2.218 ± 0.024	1.899AsnGln: 1.899 ± 0.019	2.45AsnArg: 2.45 ± 0.016	3.788AsnSer: 3.788 ± 0.024	2.638AsnThr: 2.638 ± 0.018	3.144AsnVal: 3.144 ± 0.02	0.532AsnTrp: 0.532 ± 0.009	1.717AsnTyr: 1.717 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	3.165ProAla: 3.165 ± 0.037	1.038ProCys: 1.038 ± 0.051	2.622ProAsp: 2.622 ± 0.016	3.654ProGlu: 3.654 ± 0.049	1.693ProPhe: 1.693 ± 0.017	2.835ProGly: 2.835 ± 0.043	1.241ProHis: 1.241 ± 0.013	2.424ProIle: 2.424 ± 0.02	3.398ProLys: 3.398 ± 0.03	3.815ProLeu: 3.815 ± 0.025	0.98ProMet: 0.98 ± 0.011	2.324ProAsn: 2.324 ± 0.025	4.719ProPro: 4.719 ± 0.064	2.243ProGln: 2.243 ± 0.026	2.302ProArg: 2.302 ± 0.018	4.363ProSer: 4.363 ± 0.05	3.206ProThr: 3.206 ± 0.039	3.323ProVal: 3.323 ± 0.026	0.44ProTrp: 0.44 ± 0.007	1.686ProTyr: 1.686 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	2.602GlnAla: 2.602 ± 0.019	0.923GlnCys: 0.923 ± 0.019	1.949GlnAsp: 1.949 ± 0.014	3.003GlnGlu: 3.003 ± 0.026	1.432GlnPhe: 1.432 ± 0.011	1.927GlnGly: 1.927 ± 0.016	1.28GlnHis: 1.28 ± 0.014	2.293GlnIle: 2.293 ± 0.015	3.026GlnLys: 3.026 ± 0.026	3.856GlnLeu: 3.856 ± 0.031	1.058GlnMet: 1.058 ± 0.011	2.357GlnAsn: 2.357 ± 0.018	2.191GlnPro: 2.191 ± 0.028	3.472GlnGln: 3.472 ± 0.082	2.295GlnArg: 2.295 ± 0.018	2.906GlnSer: 2.906 ± 0.022	2.322GlnThr: 2.322 ± 0.029	2.414GlnVal: 2.414 ± 0.018	0.457GlnTrp: 0.457 ± 0.007	1.348GlnTyr: 1.348 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	2.762ArgAla: 2.762 ± 0.02	1.135ArgCys: 1.135 ± 0.015	2.668ArgAsp: 2.668 ± 0.019	3.353ArgGlu: 3.353 ± 0.025	1.886ArgPhe: 1.886 ± 0.016	2.672ArgGly: 2.672 ± 0.024	1.515ArgHis: 1.515 ± 0.014	2.845ArgIle: 2.845 ± 0.017	4.239ArgLys: 4.239 ± 0.033	4.482ArgLeu: 4.482 ± 0.029	1.239ArgMet: 1.239 ± 0.011	2.58ArgAsn: 2.58 ± 0.017	2.591ArgPro: 2.591 ± 0.046	2.314ArgGln: 2.314 ± 0.029	3.844ArgArg: 3.844 ± 0.032	4.15ArgSer: 4.15 ± 0.033	2.712ArgThr: 2.712 ± 0.017	2.616ArgVal: 2.616 ± 0.019	0.572ArgTrp: 0.572 ± 0.007	1.751ArgTyr: 1.751 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	4.54SerAla: 4.54 ± 0.029	1.68SerCys: 1.68 ± 0.038	4.386SerAsp: 4.386 ± 0.029	5.023SerGlu: 5.023 ± 0.031	2.813SerPhe: 2.813 ± 0.02	4.553SerGly: 4.553 ± 0.037	1.757SerHis: 1.757 ± 0.014	4.075SerIle: 4.075 ± 0.022	5.33SerLys: 5.33 ± 0.035	6.565SerLeu: 6.565 ± 0.029	1.711SerMet: 1.711 ± 0.013	3.827SerAsn: 3.827 ± 0.023	4.489SerPro: 4.489 ± 0.047	3.143SerGln: 3.143 ± 0.021	3.92SerArg: 3.92 ± 0.03	8.077SerSer: 8.077 ± 0.054	5.106SerThr: 5.106 ± 0.036	4.564SerVal: 4.564 ± 0.025	0.737SerTrp: 0.737 ± 0.01	2.305SerTyr: 2.305 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	3.699ThrAla: 3.699 ± 0.023	1.273ThrCys: 1.273 ± 0.026	3.054ThrAsp: 3.054 ± 0.039	3.88ThrGlu: 3.88 ± 0.027	2.237ThrPhe: 2.237 ± 0.02	3.199ThrGly: 3.199 ± 0.028	1.299ThrHis: 1.299 ± 0.016	3.334ThrIle: 3.334 ± 0.018	3.828ThrLys: 3.828 ± 0.023	5.001ThrLeu: 5.001 ± 0.029	1.218ThrMet: 1.218 ± 0.01	2.697ThrAsn: 2.697 ± 0.019	3.523ThrPro: 3.523 ± 0.034	2.136ThrGln: 2.136 ± 0.016	2.557ThrArg: 2.557 ± 0.02	4.965ThrSer: 4.965 ± 0.033	4.346ThrThr: 4.346 ± 0.05	4.021ThrVal: 4.021 ± 0.029	0.556ThrTrp: 0.556 ± 0.009	1.784ThrTyr: 1.784 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	3.996ValAla: 3.996 ± 0.023	1.427ValCys: 1.427 ± 0.021	3.362ValAsp: 3.362 ± 0.018	4.149ValGlu: 4.149 ± 0.034	2.379ValPhe: 2.379 ± 0.018	3.125ValGly: 3.125 ± 0.021	1.479ValHis: 1.479 ± 0.013	3.51ValIle: 3.51 ± 0.022	4.247ValLys: 4.247 ± 0.026	5.434ValLeu: 5.434 ± 0.025	1.426ValMet: 1.426 ± 0.011	2.843ValAsn: 2.843 ± 0.019	3.262ValPro: 3.262 ± 0.025	2.551ValGln: 2.551 ± 0.017	2.941ValArg: 2.941 ± 0.019	4.566ValSer: 4.566 ± 0.022	3.891ValThr: 3.891 ± 0.03	4.182ValVal: 4.182 ± 0.029	0.639ValTrp: 0.639 ± 0.01	1.882ValTyr: 1.882 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.517TrpAla: 0.517 ± 0.007	0.205TrpCys: 0.205 ± 0.006	0.538TrpAsp: 0.538 ± 0.009	0.592TrpGlu: 0.592 ± 0.009	0.42TrpPhe: 0.42 ± 0.008	0.505TrpGly: 0.505 ± 0.011	0.246TrpHis: 0.246 ± 0.006	0.613TrpIle: 0.613 ± 0.01	0.765TrpLys: 0.765 ± 0.01	1.024TrpLeu: 1.024 ± 0.012	0.3TrpMet: 0.3 ± 0.006	0.535TrpAsn: 0.535 ± 0.007	0.409TrpPro: 0.409 ± 0.008	0.428TrpGln: 0.428 ± 0.007	0.63TrpArg: 0.63 ± 0.007	0.794TrpSer: 0.794 ± 0.009	0.566TrpThr: 0.566 ± 0.008	0.538TrpVal: 0.538 ± 0.008	0.164TrpTrp: 0.164 ± 0.004	0.353TrpTyr: 0.353 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.68TyrAla: 1.68 ± 0.013	0.828TyrCys: 0.828 ± 0.01	1.75TyrAsp: 1.75 ± 0.015	1.947TyrGlu: 1.947 ± 0.015	1.548TyrPhe: 1.548 ± 0.013	1.865TyrGly: 1.865 ± 0.018	0.942TyrHis: 0.942 ± 0.01	1.881TyrIle: 1.881 ± 0.016	2.235TyrLys: 2.235 ± 0.027	3.055TyrLeu: 3.055 ± 0.021	0.756TyrMet: 0.756 ± 0.008	1.67TyrAsn: 1.67 ± 0.015	1.501TyrPro: 1.501 ± 0.019	1.34TyrGln: 1.34 ± 0.013	1.735TyrArg: 1.735 ± 0.013	2.4TyrSer: 2.4 ± 0.02	1.755TyrThr: 1.755 ± 0.017	1.949TyrVal: 1.949 ± 0.015	0.377TyrTrp: 0.377 ± 0.006	1.278TyrTyr: 1.278 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 30448 proteins (11845985 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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