Amino acid dipepetide frequency for Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.715AlaAla: 8.715 ± 0.058	1.172AlaCys: 1.172 ± 0.014	4.163AlaAsp: 4.163 ± 0.029	4.917AlaGlu: 4.917 ± 0.038	3.137AlaPhe: 3.137 ± 0.023	5.712AlaGly: 5.712 ± 0.037	1.803AlaHis: 1.803 ± 0.019	4.313AlaIle: 4.313 ± 0.028	3.599AlaLys: 3.599 ± 0.029	7.785AlaLeu: 7.785 ± 0.047	1.98AlaMet: 1.98 ± 0.02	2.811AlaAsn: 2.811 ± 0.022	4.545AlaPro: 4.545 ± 0.037	3.289AlaGln: 3.289 ± 0.027	4.854AlaArg: 4.854 ± 0.032	7.196AlaSer: 7.196 ± 0.041	5.283AlaThr: 5.283 ± 0.032	5.452AlaVal: 5.452 ± 0.035	1.203AlaTrp: 1.203 ± 0.015	2.287AlaTyr: 2.287 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.005CysAla: 1.005 ± 0.015	0.285CysCys: 0.285 ± 0.009	0.724CysAsp: 0.724 ± 0.012	0.626CysGlu: 0.626 ± 0.011	0.595CysPhe: 0.595 ± 0.011	0.98CysGly: 0.98 ± 0.014	0.386CysHis: 0.386 ± 0.008	0.766CysIle: 0.766 ± 0.012	0.485CysLys: 0.485 ± 0.01	1.462CysLeu: 1.462 ± 0.017	0.305CysMet: 0.305 ± 0.007	0.447CysAsn: 0.447 ± 0.008	0.706CysPro: 0.706 ± 0.011	0.508CysGln: 0.508 ± 0.01	0.875CysArg: 0.875 ± 0.014	1.038CysSer: 1.038 ± 0.017	0.764CysThr: 0.764 ± 0.012	0.867CysVal: 0.867 ± 0.014	0.231CysTrp: 0.231 ± 0.007	0.4CysTyr: 0.4 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.563AspAla: 4.563 ± 0.03	0.658AspCys: 0.658 ± 0.013	3.979AspAsp: 3.979 ± 0.042	4.165AspGlu: 4.165 ± 0.032	2.096AspPhe: 2.096 ± 0.02	3.921AspGly: 3.921 ± 0.029	1.296AspHis: 1.296 ± 0.016	3.121AspIle: 3.121 ± 0.022	2.13AspLys: 2.13 ± 0.02	5.135AspLeu: 5.135 ± 0.031	1.243AspMet: 1.243 ± 0.016	1.858AspAsn: 1.858 ± 0.018	3.348AspPro: 3.348 ± 0.023	1.873AspGln: 1.873 ± 0.019	3.138AspArg: 3.138 ± 0.03	4.018AspSer: 4.018 ± 0.029	3.056AspThr: 3.056 ± 0.027	3.656AspVal: 3.656 ± 0.025	0.925AspTrp: 0.925 ± 0.014	1.715AspTyr: 1.715 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.157GluAla: 5.157 ± 0.038	0.656GluCys: 0.656 ± 0.011	3.998GluAsp: 3.998 ± 0.032	5.39GluGlu: 5.39 ± 0.054	1.909GluPhe: 1.909 ± 0.018	3.73GluGly: 3.73 ± 0.026	1.388GluHis: 1.388 ± 0.017	2.973GluIle: 2.973 ± 0.021	3.377GluLys: 3.377 ± 0.029	5.094GluLeu: 5.094 ± 0.036	1.435GluMet: 1.435 ± 0.015	2.116GluAsn: 2.116 ± 0.019	2.781GluPro: 2.781 ± 0.039	2.488GluGln: 2.488 ± 0.02	3.893GluArg: 3.893 ± 0.031	4.275GluSer: 4.275 ± 0.034	3.462GluThr: 3.462 ± 0.029	3.611GluVal: 3.611 ± 0.028	0.897GluTrp: 0.897 ± 0.012	1.773GluTyr: 1.773 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.01PheAla: 3.01 ± 0.022	0.614PheCys: 0.614 ± 0.012	2.223PheAsp: 2.223 ± 0.022	2.057PheGlu: 2.057 ± 0.02	1.682PhePhe: 1.682 ± 0.021	2.798PheGly: 2.798 ± 0.024	0.995PheHis: 0.995 ± 0.012	1.867PheIle: 1.867 ± 0.02	1.306PheLys: 1.306 ± 0.017	3.708PheLeu: 3.708 ± 0.029	0.782PheMet: 0.782 ± 0.013	1.369PheAsn: 1.369 ± 0.016	2.043PhePro: 2.043 ± 0.022	1.418PheGln: 1.418 ± 0.015	2.066PheArg: 2.066 ± 0.02	3.04PheSer: 3.04 ± 0.025	2.215PheThr: 2.215 ± 0.02	2.426PheVal: 2.426 ± 0.019	0.678PheTrp: 0.678 ± 0.01	1.191PheTyr: 1.191 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.141GlyAla: 5.141 ± 0.04	0.946GlyCys: 0.946 ± 0.014	3.589GlyAsp: 3.589 ± 0.025	3.601GlyGlu: 3.601 ± 0.025	2.806GlyPhe: 2.806 ± 0.025	5.408GlyGly: 5.408 ± 0.049	1.697GlyHis: 1.697 ± 0.018	3.571GlyIle: 3.571 ± 0.027	3.18GlyLys: 3.18 ± 0.029	6.258GlyLeu: 6.258 ± 0.037	1.607GlyMet: 1.607 ± 0.018	2.391GlyAsn: 2.391 ± 0.02	3.332GlyPro: 3.332 ± 0.026	2.54GlyGln: 2.54 ± 0.023	4.074GlyArg: 4.074 ± 0.025	5.684GlySer: 5.684 ± 0.033	3.977GlyThr: 3.977 ± 0.032	4.537GlyVal: 4.537 ± 0.038	1.224GlyTrp: 1.224 ± 0.014	2.253GlyTyr: 2.253 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.921HisAla: 1.921 ± 0.02	0.375HisCys: 0.375 ± 0.009	1.342HisAsp: 1.342 ± 0.015	1.349HisGlu: 1.349 ± 0.017	0.94HisPhe: 0.94 ± 0.011	1.739HisGly: 1.739 ± 0.019	0.966HisHis: 0.966 ± 0.019	1.283HisIle: 1.283 ± 0.015	0.839HisLys: 0.839 ± 0.012	2.438HisLeu: 2.438 ± 0.02	0.523HisMet: 0.523 ± 0.009	0.871HisAsn: 0.871 ± 0.013	1.803HisPro: 1.803 ± 0.017	1.006HisGln: 1.006 ± 0.013	1.623HisArg: 1.623 ± 0.018	1.873HisSer: 1.873 ± 0.021	1.361HisThr: 1.361 ± 0.018	1.489HisVal: 1.489 ± 0.015	0.388HisTrp: 0.388 ± 0.009	0.767HisTyr: 0.767 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.185IleAla: 4.185 ± 0.026	0.851IleCys: 0.851 ± 0.013	2.817IleAsp: 2.817 ± 0.021	2.745IleGlu: 2.745 ± 0.024	2.083IlePhe: 2.083 ± 0.022	3.219IleGly: 3.219 ± 0.031	1.327IleHis: 1.327 ± 0.015	2.649IleIle: 2.649 ± 0.024	1.939IleLys: 1.939 ± 0.02	4.847IleLeu: 4.847 ± 0.032	1.042IleMet: 1.042 ± 0.013	1.787IleAsn: 1.787 ± 0.017	3.229IlePro: 3.229 ± 0.024	1.963IleGln: 1.963 ± 0.019	2.893IleArg: 2.893 ± 0.024	3.959IleSer: 3.959 ± 0.027	2.914IleThr: 2.914 ± 0.024	3.213IleVal: 3.213 ± 0.023	0.745IleTrp: 0.745 ± 0.012	1.532IleTyr: 1.532 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.742LysAla: 3.742 ± 0.03	0.497LysCys: 0.497 ± 0.009	2.475LysAsp: 2.475 ± 0.021	3.109LysGlu: 3.109 ± 0.031	1.288LysPhe: 1.288 ± 0.014	2.739LysGly: 2.739 ± 0.024	1.049LysHis: 1.049 ± 0.012	2.059LysIle: 2.059 ± 0.022	2.789LysLys: 2.789 ± 0.036	3.754LysLeu: 3.754 ± 0.028	0.917LysMet: 0.917 ± 0.013	1.55LysAsn: 1.55 ± 0.017	2.488LysPro: 2.488 ± 0.024	1.741LysGln: 1.741 ± 0.018	3.127LysArg: 3.127 ± 0.027	3.17LysSer: 3.17 ± 0.026	2.494LysThr: 2.494 ± 0.023	2.639LysVal: 2.639 ± 0.025	0.62LysTrp: 0.62 ± 0.01	1.329LysTyr: 1.329 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.916LeuAla: 7.916 ± 0.04	1.336LeuCys: 1.336 ± 0.017	5.242LeuAsp: 5.242 ± 0.031	5.467LeuGlu: 5.467 ± 0.036	3.507LeuPhe: 3.507 ± 0.026	6.161LeuGly: 6.161 ± 0.034	2.424LeuHis: 2.424 ± 0.021	4.158LeuIle: 4.158 ± 0.031	3.848LeuLys: 3.848 ± 0.029	8.984LeuLeu: 8.984 ± 0.051	1.875LeuMet: 1.875 ± 0.02	3.169LeuAsn: 3.169 ± 0.024	5.675LeuPro: 5.675 ± 0.033	4.018LeuGln: 4.018 ± 0.032	5.921LeuArg: 5.921 ± 0.035	7.714LeuSer: 7.714 ± 0.039	5.045LeuThr: 5.045 ± 0.031	5.688LeuVal: 5.688 ± 0.034	1.283LeuTrp: 1.283 ± 0.016	2.614LeuTyr: 2.614 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.165MetAla: 2.165 ± 0.02	0.262MetCys: 0.262 ± 0.007	1.249MetAsp: 1.249 ± 0.015	1.287MetGlu: 1.287 ± 0.016	0.766MetPhe: 0.766 ± 0.011	1.493MetGly: 1.493 ± 0.016	0.499MetHis: 0.499 ± 0.008	1.05MetIle: 1.05 ± 0.014	0.951MetLys: 0.951 ± 0.012	1.904MetLeu: 1.904 ± 0.02	0.581MetMet: 0.581 ± 0.01	0.787MetAsn: 0.787 ± 0.013	1.243MetPro: 1.243 ± 0.016	0.873MetGln: 0.873 ± 0.011	1.286MetArg: 1.286 ± 0.014	1.91MetSer: 1.91 ± 0.018	1.33MetThr: 1.33 ± 0.016	1.392MetVal: 1.392 ± 0.015	0.26MetTrp: 0.26 ± 0.007	0.556MetTyr: 0.556 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.966AsnAla: 2.966 ± 0.024	0.468AsnCys: 0.468 ± 0.009	1.851AsnAsp: 1.851 ± 0.021	1.933AsnGlu: 1.933 ± 0.018	1.322AsnPhe: 1.322 ± 0.013	2.794AsnGly: 2.794 ± 0.022	0.854AsnHis: 0.854 ± 0.013	2.038AsnIle: 2.038 ± 0.021	1.406AsnLys: 1.406 ± 0.017	3.199AsnLeu: 3.199 ± 0.027	0.821AsnMet: 0.821 ± 0.012	1.478AsnAsn: 1.478 ± 0.02	2.429AsnPro: 2.429 ± 0.022	1.302AsnGln: 1.302 ± 0.014	1.924AsnArg: 1.924 ± 0.019	2.598AsnSer: 2.598 ± 0.024	2.169AsnThr: 2.169 ± 0.021	2.283AsnVal: 2.283 ± 0.02	0.569AsnTrp: 0.569 ± 0.01	1.094AsnTyr: 1.094 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.133ProAla: 5.133 ± 0.038	0.607ProCys: 0.607 ± 0.011	3.262ProAsp: 3.262 ± 0.026	3.868ProGlu: 3.868 ± 0.035	2.14ProPhe: 2.14 ± 0.019	3.888ProGly: 3.888 ± 0.029	1.402ProHis: 1.402 ± 0.017	2.569ProIle: 2.569 ± 0.025	2.385ProLys: 2.385 ± 0.024	4.88ProLeu: 4.88 ± 0.034	1.074ProMet: 1.074 ± 0.017	2.137ProAsn: 2.137 ± 0.018	4.788ProPro: 4.788 ± 0.064	2.454ProGln: 2.454 ± 0.027	3.386ProArg: 3.386 ± 0.028	6.115ProSer: 6.115 ± 0.046	4.011ProThr: 4.011 ± 0.032	3.719ProVal: 3.719 ± 0.029	0.827ProTrp: 0.827 ± 0.012	1.594ProTyr: 1.594 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.393GlnAla: 3.393 ± 0.031	0.503GlnCys: 0.503 ± 0.01	2.042GlnAsp: 2.042 ± 0.019	2.4GlnGlu: 2.4 ± 0.026	1.308GlnPhe: 1.308 ± 0.018	2.433GlnGly: 2.433 ± 0.023	1.085GlnHis: 1.085 ± 0.015	1.895GlnIle: 1.895 ± 0.018	1.869GlnLys: 1.869 ± 0.02	3.617GlnLeu: 3.617 ± 0.029	0.885GlnMet: 0.885 ± 0.012	1.488GlnAsn: 1.488 ± 0.017	2.581GlnPro: 2.581 ± 0.03	2.39GlnGln: 2.39 ± 0.041	2.658GlnArg: 2.658 ± 0.022	3.211GlnSer: 3.211 ± 0.028	2.356GlnThr: 2.356 ± 0.019	2.232GlnVal: 2.232 ± 0.02	0.609GlnTrp: 0.609 ± 0.01	1.214GlnTyr: 1.214 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.617ArgAla: 4.617 ± 0.03	0.821ArgCys: 0.821 ± 0.013	3.347ArgAsp: 3.347 ± 0.033	3.812ArgGlu: 3.812 ± 0.034	2.217ArgPhe: 2.217 ± 0.023	3.715ArgGly: 3.715 ± 0.032	1.602ArgHis: 1.602 ± 0.02	2.941ArgIle: 2.941 ± 0.025	3.269ArgLys: 3.269 ± 0.025	5.746ArgLeu: 5.746 ± 0.032	1.341ArgMet: 1.341 ± 0.014	2.144ArgAsn: 2.144 ± 0.02	3.522ArgPro: 3.522 ± 0.031	2.675ArgGln: 2.675 ± 0.025	5.094ArgArg: 5.094 ± 0.043	4.852ArgSer: 4.852 ± 0.038	3.31ArgThr: 3.31 ± 0.024	3.553ArgVal: 3.553 ± 0.025	0.988ArgTrp: 0.988 ± 0.014	1.805ArgTyr: 1.805 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.624SerAla: 6.624 ± 0.037	0.98SerCys: 0.98 ± 0.014	4.253SerAsp: 4.253 ± 0.029	4.158SerGlu: 4.158 ± 0.03	3.113SerPhe: 3.113 ± 0.024	5.559SerGly: 5.559 ± 0.038	2.031SerHis: 2.031 ± 0.019	4.065SerIle: 4.065 ± 0.027	3.323SerLys: 3.323 ± 0.026	7.575SerLeu: 7.575 ± 0.042	1.733SerMet: 1.733 ± 0.019	2.938SerAsn: 2.938 ± 0.025	5.44SerPro: 5.44 ± 0.044	3.333SerGln: 3.333 ± 0.027	5.048SerArg: 5.048 ± 0.043	9.025SerSer: 9.025 ± 0.076	5.756SerThr: 5.756 ± 0.04	4.798SerVal: 4.798 ± 0.032	1.191SerTrp: 1.191 ± 0.014	2.211SerTyr: 2.211 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.24ThrAla: 5.24 ± 0.034	0.814ThrCys: 0.814 ± 0.013	2.977ThrAsp: 2.977 ± 0.02	3.174ThrGlu: 3.174 ± 0.028	2.239ThrPhe: 2.239 ± 0.02	4.296ThrGly: 4.296 ± 0.029	1.369ThrHis: 1.369 ± 0.014	3.184ThrIle: 3.184 ± 0.026	2.37ThrLys: 2.37 ± 0.022	5.457ThrLeu: 5.457 ± 0.029	1.238ThrMet: 1.238 ± 0.015	2.099ThrAsn: 2.099 ± 0.022	4.256ThrPro: 4.256 ± 0.036	2.093ThrGln: 2.093 ± 0.021	3.11ThrArg: 3.11 ± 0.024	5.379ThrSer: 5.379 ± 0.036	4.698ThrThr: 4.698 ± 0.046	3.938ThrVal: 3.938 ± 0.03	0.914ThrTrp: 0.914 ± 0.013	1.763ThrTyr: 1.763 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.266ValAla: 5.266 ± 0.031	0.927ValCys: 0.927 ± 0.013	3.757ValAsp: 3.757 ± 0.027	3.859ValGlu: 3.859 ± 0.03	2.525ValPhe: 2.525 ± 0.023	4.081ValGly: 4.081 ± 0.035	1.505ValHis: 1.505 ± 0.017	3.103ValIle: 3.103 ± 0.024	2.675ValLys: 2.675 ± 0.023	5.819ValLeu: 5.819 ± 0.041	1.388ValMet: 1.388 ± 0.016	2.248ValAsn: 2.248 ± 0.018	3.707ValPro: 3.707 ± 0.025	2.462ValGln: 2.462 ± 0.019	3.596ValArg: 3.596 ± 0.028	4.833ValSer: 4.833 ± 0.026	3.651ValThr: 3.651 ± 0.029	4.419ValVal: 4.419 ± 0.036	0.907ValTrp: 0.907 ± 0.014	1.891ValTyr: 1.891 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.152TrpAla: 1.152 ± 0.015	0.214TrpCys: 0.214 ± 0.006	0.916TrpAsp: 0.916 ± 0.012	0.886TrpGlu: 0.886 ± 0.013	0.569TrpPhe: 0.569 ± 0.01	0.98TrpGly: 0.98 ± 0.013	0.372TrpHis: 0.372 ± 0.008	0.804TrpIle: 0.804 ± 0.013	0.801TrpLys: 0.801 ± 0.012	1.452TrpLeu: 1.452 ± 0.016	0.393TrpMet: 0.393 ± 0.009	0.65TrpAsn: 0.65 ± 0.01	0.653TrpPro: 0.653 ± 0.011	0.584TrpGln: 0.584 ± 0.011	1.022TrpArg: 1.022 ± 0.013	1.096TrpSer: 1.096 ± 0.013	0.984TrpThr: 0.984 ± 0.013	0.966TrpVal: 0.966 ± 0.013	0.3TrpTrp: 0.3 ± 0.008	0.464TrpTyr: 0.464 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.307TyrAla: 2.307 ± 0.022	0.468TyrCys: 0.468 ± 0.01	1.69TyrAsp: 1.69 ± 0.017	1.599TyrGlu: 1.599 ± 0.018	1.248TyrPhe: 1.248 ± 0.015	2.169TyrGly: 2.169 ± 0.025	0.845TyrHis: 0.845 ± 0.012	1.53TyrIle: 1.53 ± 0.017	1.033TyrLys: 1.033 ± 0.015	2.929TyrLeu: 2.929 ± 0.025	0.682TyrMet: 0.682 ± 0.01	1.161TyrAsn: 1.161 ± 0.014	1.673TyrPro: 1.673 ± 0.016	1.158TyrGln: 1.158 ± 0.016	1.782TyrArg: 1.782 ± 0.018	2.169TyrSer: 2.169 ± 0.022	1.772TyrThr: 1.772 ± 0.019	1.742TyrVal: 1.742 ± 0.017	0.498TyrTrp: 0.498 ± 0.01	1.056TyrTyr: 1.056 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12982 proteins (6024818 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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