Amino acid dipepetide frequency for Penicillium coprophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.411AlaAla: 8.411 ± 0.06	1.076AlaCys: 1.076 ± 0.019	4.187AlaAsp: 4.187 ± 0.029	5.011AlaGlu: 5.011 ± 0.042	3.155AlaPhe: 3.155 ± 0.031	5.672AlaGly: 5.672 ± 0.045	1.787AlaHis: 1.787 ± 0.021	4.466AlaIle: 4.466 ± 0.039	3.841AlaLys: 3.841 ± 0.034	7.749AlaLeu: 7.749 ± 0.053	2.039AlaMet: 2.039 ± 0.023	2.96AlaAsn: 2.96 ± 0.027	4.684AlaPro: 4.684 ± 0.049	3.376AlaGln: 3.376 ± 0.03	4.691AlaArg: 4.691 ± 0.034	7.16AlaSer: 7.16 ± 0.052	5.09AlaThr: 5.09 ± 0.039	5.263AlaVal: 5.263 ± 0.043	1.14AlaTrp: 1.14 ± 0.016	2.151AlaTyr: 2.151 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.951CysAla: 0.951 ± 0.016	0.239CysCys: 0.239 ± 0.008	0.674CysAsp: 0.674 ± 0.014	0.596CysGlu: 0.596 ± 0.013	0.554CysPhe: 0.554 ± 0.012	0.93CysGly: 0.93 ± 0.017	0.334CysHis: 0.334 ± 0.008	0.715CysIle: 0.715 ± 0.013	0.495CysLys: 0.495 ± 0.011	1.274CysLeu: 1.274 ± 0.017	0.282CysMet: 0.282 ± 0.007	0.441CysAsn: 0.441 ± 0.011	0.627CysPro: 0.627 ± 0.012	0.473CysGln: 0.473 ± 0.012	0.721CysArg: 0.721 ± 0.013	0.915CysSer: 0.915 ± 0.015	0.683CysThr: 0.683 ± 0.015	0.824CysVal: 0.824 ± 0.013	0.193CysTrp: 0.193 ± 0.007	0.348CysTyr: 0.348 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.442AspAla: 4.442 ± 0.036	0.605AspCys: 0.605 ± 0.013	3.854AspAsp: 3.854 ± 0.045	4.287AspGlu: 4.287 ± 0.042	2.208AspPhe: 2.208 ± 0.023	3.802AspGly: 3.802 ± 0.031	1.355AspHis: 1.355 ± 0.019	3.22AspIle: 3.22 ± 0.031	2.239AspLys: 2.239 ± 0.025	5.199AspLeu: 5.199 ± 0.037	1.314AspMet: 1.314 ± 0.016	1.895AspAsn: 1.895 ± 0.023	3.395AspPro: 3.395 ± 0.03	2.059AspGln: 2.059 ± 0.022	3.068AspArg: 3.068 ± 0.034	4.349AspSer: 4.349 ± 0.036	3.073AspThr: 3.073 ± 0.024	3.574AspVal: 3.574 ± 0.027	0.884AspTrp: 0.884 ± 0.017	1.596AspTyr: 1.596 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.098GluAla: 5.098 ± 0.046	0.627GluCys: 0.627 ± 0.012	4.084GluAsp: 4.084 ± 0.042	5.174GluGlu: 5.174 ± 0.058	2.009GluPhe: 2.009 ± 0.023	3.564GluGly: 3.564 ± 0.03	1.437GluHis: 1.437 ± 0.018	3.281GluIle: 3.281 ± 0.032	3.598GluLys: 3.598 ± 0.037	5.19GluLeu: 5.19 ± 0.041	1.508GluMet: 1.508 ± 0.018	2.406GluAsn: 2.406 ± 0.027	2.809GluPro: 2.809 ± 0.05	2.475GluGln: 2.475 ± 0.026	3.709GluArg: 3.709 ± 0.037	4.511GluSer: 4.511 ± 0.038	3.639GluThr: 3.639 ± 0.028	3.44GluVal: 3.44 ± 0.029	0.861GluTrp: 0.861 ± 0.014	1.66GluTyr: 1.66 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.094PheAla: 3.094 ± 0.027	0.572PheCys: 0.572 ± 0.013	2.384PheAsp: 2.384 ± 0.024	2.155PheGlu: 2.155 ± 0.023	1.736PhePhe: 1.736 ± 0.023	2.878PheGly: 2.878 ± 0.034	0.959PheHis: 0.959 ± 0.016	1.96PheIle: 1.96 ± 0.024	1.49PheLys: 1.49 ± 0.021	3.549PheLeu: 3.549 ± 0.032	0.851PheMet: 0.851 ± 0.015	1.526PheAsn: 1.526 ± 0.018	2.022PhePro: 2.022 ± 0.023	1.48PheGln: 1.48 ± 0.017	1.969PheArg: 1.969 ± 0.02	3.073PheSer: 3.073 ± 0.028	2.189PheThr: 2.189 ± 0.022	2.469PheVal: 2.469 ± 0.022	0.66PheTrp: 0.66 ± 0.014	1.148PheTyr: 1.148 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.253GlyAla: 5.253 ± 0.045	0.884GlyCys: 0.884 ± 0.015	3.533GlyAsp: 3.533 ± 0.032	3.47GlyGlu: 3.47 ± 0.028	2.855GlyPhe: 2.855 ± 0.031	5.354GlyGly: 5.354 ± 0.06	1.694GlyHis: 1.694 ± 0.023	3.694GlyIle: 3.694 ± 0.029	3.306GlyLys: 3.306 ± 0.031	6.196GlyLeu: 6.196 ± 0.043	1.63GlyMet: 1.63 ± 0.021	2.566GlyAsn: 2.566 ± 0.023	3.349GlyPro: 3.349 ± 0.036	2.543GlyGln: 2.543 ± 0.029	3.871GlyArg: 3.871 ± 0.034	5.761GlySer: 5.761 ± 0.045	3.917GlyThr: 3.917 ± 0.032	4.344GlyVal: 4.344 ± 0.037	1.151GlyTrp: 1.151 ± 0.018	2.143GlyTyr: 2.143 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.83HisAla: 1.83 ± 0.019	0.34HisCys: 0.34 ± 0.008	1.339HisAsp: 1.339 ± 0.02	1.36HisGlu: 1.36 ± 0.019	0.925HisPhe: 0.925 ± 0.015	1.74HisGly: 1.74 ± 0.02	0.828HisHis: 0.828 ± 0.017	1.286HisIle: 1.286 ± 0.016	0.883HisLys: 0.883 ± 0.014	2.284HisLeu: 2.284 ± 0.025	0.535HisMet: 0.535 ± 0.012	0.891HisAsn: 0.891 ± 0.015	1.672HisPro: 1.672 ± 0.022	1.021HisGln: 1.021 ± 0.015	1.581HisArg: 1.581 ± 0.021	1.941HisSer: 1.941 ± 0.024	1.355HisThr: 1.355 ± 0.019	1.448HisVal: 1.448 ± 0.018	0.366HisTrp: 0.366 ± 0.009	0.698HisTyr: 0.698 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.43IleAla: 4.43 ± 0.039	0.826IleCys: 0.826 ± 0.017	3.003IleAsp: 3.003 ± 0.026	3.002IleGlu: 3.002 ± 0.026	2.203IlePhe: 2.203 ± 0.024	3.46IleGly: 3.46 ± 0.035	1.268IleHis: 1.268 ± 0.018	2.722IleIle: 2.722 ± 0.027	2.221IleLys: 2.221 ± 0.024	4.804IleLeu: 4.804 ± 0.043	1.133IleMet: 1.133 ± 0.017	1.929IleAsn: 1.929 ± 0.018	3.301IlePro: 3.301 ± 0.025	2.072IleGln: 2.072 ± 0.023	2.829IleArg: 2.829 ± 0.025	4.214IleSer: 4.214 ± 0.034	2.948IleThr: 2.948 ± 0.026	3.29IleVal: 3.29 ± 0.031	0.761IleTrp: 0.761 ± 0.013	1.495IleTyr: 1.495 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.97LysAla: 3.97 ± 0.04	0.496LysCys: 0.496 ± 0.01	2.719LysAsp: 2.719 ± 0.024	3.191LysGlu: 3.191 ± 0.032	1.49LysPhe: 1.49 ± 0.02	2.857LysGly: 2.857 ± 0.03	1.068LysHis: 1.068 ± 0.015	2.352LysIle: 2.352 ± 0.026	3.088LysLys: 3.088 ± 0.042	3.998LysLeu: 3.998 ± 0.036	1.016LysMet: 1.016 ± 0.015	1.802LysAsn: 1.802 ± 0.021	2.616LysPro: 2.616 ± 0.032	1.865LysGln: 1.865 ± 0.02	3.208LysArg: 3.208 ± 0.033	3.634LysSer: 3.634 ± 0.034	2.772LysThr: 2.772 ± 0.031	2.712LysVal: 2.712 ± 0.024	0.659LysTrp: 0.659 ± 0.013	1.359LysTyr: 1.359 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.838LeuAla: 7.838 ± 0.049	1.233LeuCys: 1.233 ± 0.018	5.254LeuAsp: 5.254 ± 0.04	5.569LeuGlu: 5.569 ± 0.042	3.426LeuPhe: 3.426 ± 0.031	6.038LeuGly: 6.038 ± 0.044	2.297LeuHis: 2.297 ± 0.028	4.222LeuIle: 4.222 ± 0.034	4.089LeuLys: 4.089 ± 0.037	8.486LeuLeu: 8.486 ± 0.068	1.922LeuMet: 1.922 ± 0.023	3.281LeuAsn: 3.281 ± 0.029	5.436LeuPro: 5.436 ± 0.036	3.908LeuGln: 3.908 ± 0.04	5.606LeuArg: 5.606 ± 0.04	7.565LeuSer: 7.565 ± 0.046	4.844LeuThr: 4.844 ± 0.033	5.534LeuVal: 5.534 ± 0.037	1.218LeuTrp: 1.218 ± 0.02	2.398LeuTyr: 2.398 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.233MetAla: 2.233 ± 0.022	0.255MetCys: 0.255 ± 0.008	1.32MetAsp: 1.32 ± 0.017	1.333MetGlu: 1.333 ± 0.02	0.815MetPhe: 0.815 ± 0.014	1.594MetGly: 1.594 ± 0.022	0.519MetHis: 0.519 ± 0.012	1.15MetIle: 1.15 ± 0.017	1.039MetLys: 1.039 ± 0.014	1.889MetLeu: 1.889 ± 0.022	0.625MetMet: 0.625 ± 0.013	0.87MetAsn: 0.87 ± 0.015	1.296MetPro: 1.296 ± 0.019	0.912MetGln: 0.912 ± 0.013	1.26MetArg: 1.26 ± 0.015	2.023MetSer: 2.023 ± 0.022	1.414MetThr: 1.414 ± 0.018	1.402MetVal: 1.402 ± 0.02	0.273MetTrp: 0.273 ± 0.008	0.534MetTyr: 0.534 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.171AsnAla: 3.171 ± 0.026	0.451AsnCys: 0.451 ± 0.012	2.002AsnAsp: 2.002 ± 0.022	2.104AsnGlu: 2.104 ± 0.024	1.459AsnPhe: 1.459 ± 0.017	2.881AsnGly: 2.881 ± 0.026	0.875AsnHis: 0.875 ± 0.013	2.141AsnIle: 2.141 ± 0.022	1.571AsnLys: 1.571 ± 0.024	3.4AsnLeu: 3.4 ± 0.031	0.918AsnMet: 0.918 ± 0.015	1.473AsnAsn: 1.473 ± 0.017	2.597AsnPro: 2.597 ± 0.025	1.426AsnGln: 1.426 ± 0.02	1.961AsnArg: 1.961 ± 0.02	2.888AsnSer: 2.888 ± 0.028	2.237AsnThr: 2.237 ± 0.022	2.346AsnVal: 2.346 ± 0.025	0.576AsnTrp: 0.576 ± 0.011	1.083AsnTyr: 1.083 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.089ProAla: 5.089 ± 0.05	0.523ProCys: 0.523 ± 0.013	3.201ProAsp: 3.201 ± 0.031	3.904ProGlu: 3.904 ± 0.043	2.123ProPhe: 2.123 ± 0.027	3.865ProGly: 3.865 ± 0.037	1.377ProHis: 1.377 ± 0.02	2.741ProIle: 2.741 ± 0.03	2.651ProLys: 2.651 ± 0.027	4.747ProLeu: 4.747 ± 0.037	1.175ProMet: 1.175 ± 0.017	2.254ProAsn: 2.254 ± 0.027	4.582ProPro: 4.582 ± 0.064	2.414ProGln: 2.414 ± 0.034	3.367ProArg: 3.367 ± 0.036	6.037ProSer: 6.037 ± 0.052	4.002ProThr: 4.002 ± 0.04	3.676ProVal: 3.676 ± 0.04	0.75ProTrp: 0.75 ± 0.012	1.479ProTyr: 1.479 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.37GlnAla: 3.37 ± 0.033	0.444GlnCys: 0.444 ± 0.011	2.076GlnAsp: 2.076 ± 0.024	2.396GlnGlu: 2.396 ± 0.028	1.372GlnPhe: 1.372 ± 0.018	2.426GlnGly: 2.426 ± 0.024	1.066GlnHis: 1.066 ± 0.017	2.07GlnIle: 2.07 ± 0.021	2.032GlnLys: 2.032 ± 0.024	3.514GlnLeu: 3.514 ± 0.033	0.955GlnMet: 0.955 ± 0.017	1.653GlnAsn: 1.653 ± 0.023	2.548GlnPro: 2.548 ± 0.033	2.161GlnGln: 2.161 ± 0.041	2.571GlnArg: 2.571 ± 0.026	3.408GlnSer: 3.408 ± 0.034	2.44GlnThr: 2.44 ± 0.024	2.232GlnVal: 2.232 ± 0.023	0.593GlnTrp: 0.593 ± 0.013	1.177GlnTyr: 1.177 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.526ArgAla: 4.526 ± 0.037	0.68ArgCys: 0.68 ± 0.012	3.312ArgAsp: 3.312 ± 0.03	3.669ArgGlu: 3.669 ± 0.036	2.149ArgPhe: 2.149 ± 0.023	3.63ArgGly: 3.63 ± 0.035	1.496ArgHis: 1.496 ± 0.022	2.919ArgIle: 2.919 ± 0.025	3.281ArgLys: 3.281 ± 0.035	5.371ArgLeu: 5.371 ± 0.041	1.328ArgMet: 1.328 ± 0.018	2.227ArgAsn: 2.227 ± 0.025	3.401ArgPro: 3.401 ± 0.035	2.518ArgGln: 2.518 ± 0.026	4.734ArgArg: 4.734 ± 0.049	4.718ArgSer: 4.718 ± 0.042	3.211ArgThr: 3.211 ± 0.027	3.355ArgVal: 3.355 ± 0.03	0.93ArgTrp: 0.93 ± 0.015	1.603ArgTyr: 1.603 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.657SerAla: 6.657 ± 0.049	0.864SerCys: 0.864 ± 0.016	4.365SerAsp: 4.365 ± 0.037	4.358SerGlu: 4.358 ± 0.037	3.163SerPhe: 3.163 ± 0.025	5.586SerGly: 5.586 ± 0.044	2.081SerHis: 2.081 ± 0.025	4.307SerIle: 4.307 ± 0.031	3.766SerLys: 3.766 ± 0.034	7.5SerLeu: 7.5 ± 0.05	1.867SerMet: 1.867 ± 0.022	3.147SerAsn: 3.147 ± 0.029	5.577SerPro: 5.577 ± 0.06	3.476SerGln: 3.476 ± 0.032	4.968SerArg: 4.968 ± 0.047	8.711SerSer: 8.711 ± 0.078	5.659SerThr: 5.659 ± 0.043	4.85SerVal: 4.85 ± 0.039	1.173SerTrp: 1.173 ± 0.016	2.152SerTyr: 2.152 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.074ThrAla: 5.074 ± 0.041	0.725ThrCys: 0.725 ± 0.012	2.892ThrAsp: 2.892 ± 0.026	3.367ThrGlu: 3.367 ± 0.036	2.21ThrPhe: 2.21 ± 0.022	4.222ThrGly: 4.222 ± 0.038	1.33ThrHis: 1.33 ± 0.019	3.192ThrIle: 3.192 ± 0.029	2.636ThrLys: 2.636 ± 0.027	5.336ThrLeu: 5.336 ± 0.036	1.248ThrMet: 1.248 ± 0.016	2.151ThrAsn: 2.151 ± 0.021	4.352ThrPro: 4.352 ± 0.045	2.19ThrGln: 2.19 ± 0.023	3.079ThrArg: 3.079 ± 0.027	5.297ThrSer: 5.297 ± 0.043	4.096ThrThr: 4.096 ± 0.043	3.8ThrVal: 3.8 ± 0.034	0.865ThrTrp: 0.865 ± 0.017	1.622ThrTyr: 1.622 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.205ValAla: 5.205 ± 0.036	0.849ValCys: 0.849 ± 0.014	3.708ValAsp: 3.708 ± 0.03	3.764ValGlu: 3.764 ± 0.032	2.585ValPhe: 2.585 ± 0.027	3.983ValGly: 3.983 ± 0.038	1.443ValHis: 1.443 ± 0.017	3.194ValIle: 3.194 ± 0.032	2.772ValLys: 2.772 ± 0.024	5.631ValLeu: 5.631 ± 0.042	1.364ValMet: 1.364 ± 0.019	2.294ValAsn: 2.294 ± 0.025	3.572ValPro: 3.572 ± 0.037	2.409ValGln: 2.409 ± 0.022	3.335ValArg: 3.335 ± 0.029	4.834ValSer: 4.834 ± 0.034	3.555ValThr: 3.555 ± 0.034	4.201ValVal: 4.201 ± 0.04	0.84ValTrp: 0.84 ± 0.016	1.731ValTyr: 1.731 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.016	0.189TrpCys: 0.189 ± 0.007	0.899TrpAsp: 0.899 ± 0.015	0.839TrpGlu: 0.839 ± 0.014	0.529TrpPhe: 0.529 ± 0.01	0.934TrpGly: 0.934 ± 0.015	0.347TrpHis: 0.347 ± 0.01	0.791TrpIle: 0.791 ± 0.013	0.79TrpLys: 0.79 ± 0.014	1.361TrpLeu: 1.361 ± 0.018	0.391TrpMet: 0.391 ± 0.01	0.662TrpAsn: 0.662 ± 0.012	0.584TrpPro: 0.584 ± 0.013	0.565TrpGln: 0.565 ± 0.011	0.941TrpArg: 0.941 ± 0.015	1.1TrpSer: 1.1 ± 0.016	0.93TrpThr: 0.93 ± 0.015	0.909TrpVal: 0.909 ± 0.017	0.283TrpTrp: 0.283 ± 0.008	0.44TrpTyr: 0.44 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.12TyrAla: 2.12 ± 0.021	0.392TyrCys: 0.392 ± 0.008	1.614TyrAsp: 1.614 ± 0.023	1.53TyrGlu: 1.53 ± 0.017	1.202TyrPhe: 1.202 ± 0.016	2.098TyrGly: 2.098 ± 0.025	0.762TyrHis: 0.762 ± 0.013	1.485TyrIle: 1.485 ± 0.021	1.082TyrLys: 1.082 ± 0.014	2.688TyrLeu: 2.688 ± 0.03	0.653TyrMet: 0.653 ± 0.012	1.135TyrAsn: 1.135 ± 0.019	1.535TyrPro: 1.535 ± 0.022	1.16TyrGln: 1.16 ± 0.018	1.594TyrArg: 1.594 ± 0.022	2.088TyrSer: 2.088 ± 0.024	1.629TyrThr: 1.629 ± 0.021	1.598TyrVal: 1.598 ± 0.022	0.455TyrTrp: 0.455 ± 0.011	0.92TyrTyr: 0.92 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8993 proteins (4534520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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