Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA382K21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.808AlaAla: 3.808 ± 0.341
0.409AlaCys: 0.409 ± 0.087
3.497AlaAsp: 3.497 ± 0.261
5.442AlaGlu: 5.442 ± 0.273
2.353AlaPhe: 2.353 ± 0.207
4.723AlaGly: 4.723 ± 0.286
1.095AlaHis: 1.095 ± 0.13
4.085AlaIle: 4.085 ± 0.254
3.644AlaLys: 3.644 ± 0.332
5.703AlaLeu: 5.703 ± 0.3
1.601AlaMet: 1.601 ± 0.16
2.059AlaAsn: 2.059 ± 0.193
2.108AlaPro: 2.108 ± 0.233
1.16AlaGln: 1.16 ± 0.143
3.105AlaArg: 3.105 ± 0.243
4.233AlaSer: 4.233 ± 0.284
2.778AlaThr: 2.778 ± 0.248
4.429AlaVal: 4.429 ± 0.38
0.801AlaTrp: 0.801 ± 0.111
1.487AlaTyr: 1.487 ± 0.143
0.0AlaXaa: 0.0 ± 0.0
Cys
0.441CysAla: 0.441 ± 0.08
0.082CysCys: 0.082 ± 0.04
0.523CysAsp: 0.523 ± 0.089
0.997CysGlu: 0.997 ± 0.148
0.245CysPhe: 0.245 ± 0.064
0.817CysGly: 0.817 ± 0.136
0.212CysHis: 0.212 ± 0.065
0.686CysIle: 0.686 ± 0.091
0.425CysLys: 0.425 ± 0.082
0.801CysLeu: 0.801 ± 0.118
0.098CysMet: 0.098 ± 0.043
0.212CysAsn: 0.212 ± 0.046
0.474CysPro: 0.474 ± 0.087
0.245CysGln: 0.245 ± 0.062
0.376CysArg: 0.376 ± 0.071
0.376CysSer: 0.376 ± 0.082
0.621CysThr: 0.621 ± 0.123
0.343CysVal: 0.343 ± 0.074
0.131CysTrp: 0.131 ± 0.047
0.229CysTyr: 0.229 ± 0.062
0.0CysXaa: 0.0 ± 0.0
Asp
3.285AspAla: 3.285 ± 0.266
0.425AspCys: 0.425 ± 0.079
3.138AspAsp: 3.138 ± 0.287
5.229AspGlu: 5.229 ± 0.319
2.37AspPhe: 2.37 ± 0.197
4.625AspGly: 4.625 ± 0.313
0.85AspHis: 0.85 ± 0.112
4.755AspIle: 4.755 ± 0.242
3.579AspLys: 3.579 ± 0.244
6.962AspLeu: 6.962 ± 0.383
1.569AspMet: 1.569 ± 0.195
3.448AspAsn: 3.448 ± 0.614
2.5AspPro: 2.5 ± 0.24
1.193AspGln: 1.193 ± 0.125
3.023AspArg: 3.023 ± 0.198
4.036AspSer: 4.036 ± 0.317
2.222AspThr: 2.222 ± 0.234
4.134AspVal: 4.134 ± 0.304
0.997AspTrp: 0.997 ± 0.137
2.68AspTyr: 2.68 ± 0.217
0.0AspXaa: 0.0 ± 0.0
Glu
4.837GluAla: 4.837 ± 0.281
0.523GluCys: 0.523 ± 0.091
6.226GluAsp: 6.226 ± 0.46
10.589GluGlu: 10.589 ± 0.687
3.317GluPhe: 3.317 ± 0.24
6.684GluGly: 6.684 ± 0.317
1.095GluHis: 1.095 ± 0.141
7.599GluIle: 7.599 ± 0.414
9.74GluLys: 9.74 ± 0.596
8.383GluLeu: 8.383 ± 0.438
1.798GluMet: 1.798 ± 0.192
7.06GluAsn: 7.06 ± 0.505
3.121GluPro: 3.121 ± 0.256
1.422GluGln: 1.422 ± 0.144
5.752GluArg: 5.752 ± 0.397
5.769GluSer: 5.769 ± 0.396
4.167GluThr: 4.167 ± 0.301
6.243GluVal: 6.243 ± 0.44
0.784GluTrp: 0.784 ± 0.106
2.435GluTyr: 2.435 ± 0.229
0.0GluXaa: 0.0 ± 0.0
Phe
2.272PheAla: 2.272 ± 0.206
0.425PheCys: 0.425 ± 0.096
2.484PheAsp: 2.484 ± 0.174
3.612PheGlu: 3.612 ± 0.253
1.912PhePhe: 1.912 ± 0.232
3.007PheGly: 3.007 ± 0.197
0.85PheHis: 0.85 ± 0.102
1.814PheIle: 1.814 ± 0.184
2.092PheLys: 2.092 ± 0.197
3.857PheLeu: 3.857 ± 0.277
0.85PheMet: 0.85 ± 0.124
1.438PheAsn: 1.438 ± 0.175
1.324PhePro: 1.324 ± 0.167
0.882PheGln: 0.882 ± 0.13
1.847PheArg: 1.847 ± 0.194
3.138PheSer: 3.138 ± 0.247
1.928PheThr: 1.928 ± 0.207
2.337PheVal: 2.337 ± 0.18
0.572PheTrp: 0.572 ± 0.096
1.34PheTyr: 1.34 ± 0.137
0.0PheXaa: 0.0 ± 0.0
Gly
4.87GlyAla: 4.87 ± 0.368
0.572GlyCys: 0.572 ± 0.11
4.657GlyAsp: 4.657 ± 0.29
6.749GlyGlu: 6.749 ± 0.328
3.072GlyPhe: 3.072 ± 0.251
6.21GlyGly: 6.21 ± 0.429
1.095GlyHis: 1.095 ± 0.123
5.524GlyIle: 5.524 ± 0.411
6.128GlyLys: 6.128 ± 0.373
5.932GlyLeu: 5.932 ± 0.34
1.765GlyMet: 1.765 ± 0.177
2.811GlyAsn: 2.811 ± 0.276
2.075GlyPro: 2.075 ± 0.186
1.438GlyGln: 1.438 ± 0.152
3.971GlyArg: 3.971 ± 0.297
5.246GlySer: 5.246 ± 0.444
3.464GlyThr: 3.464 ± 0.233
5.916GlyVal: 5.916 ± 0.36
1.128GlyTrp: 1.128 ± 0.129
2.549GlyTyr: 2.549 ± 0.211
0.0GlyXaa: 0.0 ± 0.0
His
0.735HisAla: 0.735 ± 0.1
0.196HisCys: 0.196 ± 0.057
0.931HisAsp: 0.931 ± 0.14
1.536HisGlu: 1.536 ± 0.159
0.654HisPhe: 0.654 ± 0.1
1.536HisGly: 1.536 ± 0.185
0.474HisHis: 0.474 ± 0.095
0.981HisIle: 0.981 ± 0.115
0.882HisLys: 0.882 ± 0.122
1.749HisLeu: 1.749 ± 0.173
0.327HisMet: 0.327 ± 0.072
0.67HisAsn: 0.67 ± 0.098
0.931HisPro: 0.931 ± 0.149
0.409HisGln: 0.409 ± 0.075
0.719HisArg: 0.719 ± 0.106
1.079HisSer: 1.079 ± 0.139
0.654HisThr: 0.654 ± 0.111
1.291HisVal: 1.291 ± 0.136
0.229HisTrp: 0.229 ± 0.056
0.474HisTyr: 0.474 ± 0.082
0.0HisXaa: 0.0 ± 0.0
Ile
4.461IleAla: 4.461 ± 0.3
0.703IleCys: 0.703 ± 0.117
4.282IleAsp: 4.282 ± 0.294
7.403IleGlu: 7.403 ± 0.468
3.056IlePhe: 3.056 ± 0.295
5.213IleGly: 5.213 ± 0.311
1.307IleHis: 1.307 ± 0.131
4.2IleIle: 4.2 ± 0.313
3.938IleLys: 3.938 ± 0.333
6.586IleLeu: 6.586 ± 0.405
1.275IleMet: 1.275 ± 0.189
2.386IleAsn: 2.386 ± 0.208
3.481IlePro: 3.481 ± 0.235
1.798IleGln: 1.798 ± 0.167
3.628IleArg: 3.628 ± 0.244
6.243IleSer: 6.243 ± 0.367
3.366IleThr: 3.366 ± 0.259
4.134IleVal: 4.134 ± 0.279
0.556IleTrp: 0.556 ± 0.096
2.01IleTyr: 2.01 ± 0.231
0.0IleXaa: 0.0 ± 0.0
Lys
3.906LysAla: 3.906 ± 0.306
0.36LysCys: 0.36 ± 0.085
4.167LysAsp: 4.167 ± 0.304
8.056LysGlu: 8.056 ± 0.5
2.582LysPhe: 2.582 ± 0.198
4.02LysGly: 4.02 ± 0.249
1.128LysHis: 1.128 ± 0.137
6.88LysIle: 6.88 ± 0.405
6.847LysLys: 6.847 ± 0.509
5.899LysLeu: 5.899 ± 0.441
1.798LysMet: 1.798 ± 0.178
4.134LysAsn: 4.134 ± 0.293
2.026LysPro: 2.026 ± 0.178
1.487LysGln: 1.487 ± 0.171
4.183LysArg: 4.183 ± 0.303
4.216LysSer: 4.216 ± 0.341
3.922LysThr: 3.922 ± 0.278
5.54LysVal: 5.54 ± 0.381
0.686LysTrp: 0.686 ± 0.121
1.928LysTyr: 1.928 ± 0.198
0.0LysXaa: 0.0 ± 0.0
Leu
6.308LeuAla: 6.308 ± 0.342
0.637LeuCys: 0.637 ± 0.099
6.21LeuAsp: 6.21 ± 0.372
9.609LeuGlu: 9.609 ± 0.504
3.138LeuPhe: 3.138 ± 0.312
6.733LeuGly: 6.733 ± 0.418
1.144LeuHis: 1.144 ± 0.156
6.112LeuIle: 6.112 ± 0.357
7.419LeuLys: 7.419 ± 0.489
7.386LeuLeu: 7.386 ± 0.485
1.552LeuMet: 1.552 ± 0.137
3.628LeuAsn: 3.628 ± 0.229
3.268LeuPro: 3.268 ± 0.204
2.157LeuGln: 2.157 ± 0.179
5.36LeuArg: 5.36 ± 0.32
7.501LeuSer: 7.501 ± 0.416
4.102LeuThr: 4.102 ± 0.264
5.556LeuVal: 5.556 ± 0.349
0.964LeuTrp: 0.964 ± 0.128
2.386LeuTyr: 2.386 ± 0.197
0.0LeuXaa: 0.0 ± 0.0
Met
1.111MetAla: 1.111 ± 0.165
0.18MetCys: 0.18 ± 0.053
1.422MetAsp: 1.422 ± 0.157
1.651MetGlu: 1.651 ± 0.181
0.621MetPhe: 0.621 ± 0.095
1.471MetGly: 1.471 ± 0.148
0.392MetHis: 0.392 ± 0.087
1.258MetIle: 1.258 ± 0.133
2.01MetLys: 2.01 ± 0.179
1.83MetLeu: 1.83 ± 0.177
0.67MetMet: 0.67 ± 0.1
0.899MetAsn: 0.899 ± 0.127
0.686MetPro: 0.686 ± 0.112
0.507MetGln: 0.507 ± 0.107
1.144MetArg: 1.144 ± 0.136
1.749MetSer: 1.749 ± 0.143
1.095MetThr: 1.095 ± 0.134
1.373MetVal: 1.373 ± 0.181
0.18MetTrp: 0.18 ± 0.046
0.376MetTyr: 0.376 ± 0.089
0.0MetXaa: 0.0 ± 0.0
Asn
2.582AsnAla: 2.582 ± 0.207
0.539AsnCys: 0.539 ± 0.131
1.994AsnAsp: 1.994 ± 0.199
3.432AsnGlu: 3.432 ± 0.231
2.01AsnPhe: 2.01 ± 0.207
2.664AsnGly: 2.664 ± 0.236
0.915AsnHis: 0.915 ± 0.124
3.497AsnIle: 3.497 ± 0.302
2.108AsnLys: 2.108 ± 0.18
5.491AsnLeu: 5.491 ± 0.289
0.654AsnMet: 0.654 ± 0.097
1.814AsnAsn: 1.814 ± 0.413
2.337AsnPro: 2.337 ± 0.229
1.405AsnGln: 1.405 ± 0.158
2.059AsnArg: 2.059 ± 0.179
3.236AsnSer: 3.236 ± 0.333
2.222AsnThr: 2.222 ± 0.253
3.285AsnVal: 3.285 ± 0.365
0.85AsnTrp: 0.85 ± 0.118
1.83AsnTyr: 1.83 ± 0.256
0.0AsnXaa: 0.0 ± 0.0
Pro
2.141ProAla: 2.141 ± 0.17
0.245ProCys: 0.245 ± 0.059
2.549ProAsp: 2.549 ± 0.226
4.102ProGlu: 4.102 ± 0.326
1.16ProPhe: 1.16 ± 0.135
3.121ProGly: 3.121 ± 0.187
0.85ProHis: 0.85 ± 0.122
2.5ProIle: 2.5 ± 0.207
2.337ProLys: 2.337 ± 0.202
3.17ProLeu: 3.17 ± 0.267
0.654ProMet: 0.654 ± 0.097
1.552ProAsn: 1.552 ± 0.158
2.075ProPro: 2.075 ± 0.188
0.817ProGln: 0.817 ± 0.129
1.585ProArg: 1.585 ± 0.153
3.383ProSer: 3.383 ± 0.255
1.798ProThr: 1.798 ± 0.199
2.729ProVal: 2.729 ± 0.227
0.343ProTrp: 0.343 ± 0.089
1.405ProTyr: 1.405 ± 0.141
0.0ProXaa: 0.0 ± 0.0
Gln
1.454GlnAla: 1.454 ± 0.132
0.147GlnCys: 0.147 ± 0.041
1.405GlnAsp: 1.405 ± 0.151
2.435GlnGlu: 2.435 ± 0.214
0.621GlnPhe: 0.621 ± 0.089
1.536GlnGly: 1.536 ± 0.135
0.392GlnHis: 0.392 ± 0.077
1.765GlnIle: 1.765 ± 0.177
1.961GlnLys: 1.961 ± 0.183
1.683GlnLeu: 1.683 ± 0.167
0.556GlnMet: 0.556 ± 0.111
1.275GlnAsn: 1.275 ± 0.15
0.784GlnPro: 0.784 ± 0.135
0.278GlnGln: 0.278 ± 0.079
1.356GlnArg: 1.356 ± 0.14
1.275GlnSer: 1.275 ± 0.123
0.931GlnThr: 0.931 ± 0.117
1.732GlnVal: 1.732 ± 0.167
0.212GlnTrp: 0.212 ± 0.072
0.49GlnTyr: 0.49 ± 0.087
0.0GlnXaa: 0.0 ± 0.0
Arg
3.203ArgAla: 3.203 ± 0.207
0.588ArgCys: 0.588 ± 0.085
3.007ArgAsp: 3.007 ± 0.221
5.442ArgGlu: 5.442 ± 0.445
1.798ArgPhe: 1.798 ± 0.162
4.004ArgGly: 4.004 ± 0.244
0.719ArgHis: 0.719 ± 0.112
3.922ArgIle: 3.922 ± 0.291
5.099ArgLys: 5.099 ± 0.337
4.51ArgLeu: 4.51 ± 0.294
1.356ArgMet: 1.356 ± 0.145
2.37ArgAsn: 2.37 ± 0.187
2.092ArgPro: 2.092 ± 0.167
1.275ArgGln: 1.275 ± 0.143
3.808ArgArg: 3.808 ± 0.306
2.615ArgSer: 2.615 ± 0.205
2.059ArgThr: 2.059 ± 0.197
4.069ArgVal: 4.069 ± 0.271
0.392ArgTrp: 0.392 ± 0.077
1.634ArgTyr: 1.634 ± 0.156
0.0ArgXaa: 0.0 ± 0.0
Ser
3.759SerAla: 3.759 ± 0.318
0.539SerCys: 0.539 ± 0.08
5.066SerAsp: 5.066 ± 0.393
7.076SerGlu: 7.076 ± 0.327
2.876SerPhe: 2.876 ± 0.215
6.046SerGly: 6.046 ± 0.421
1.16SerHis: 1.16 ± 0.125
4.625SerIle: 4.625 ± 0.288
4.706SerLys: 4.706 ± 0.337
6.651SerLeu: 6.651 ± 0.434
1.307SerMet: 1.307 ± 0.113
2.958SerAsn: 2.958 ± 0.267
2.958SerPro: 2.958 ± 0.236
1.863SerGln: 1.863 ± 0.161
3.791SerArg: 3.791 ± 0.224
5.442SerSer: 5.442 ± 0.443
3.481SerThr: 3.481 ± 0.282
4.249SerVal: 4.249 ± 0.321
0.833SerTrp: 0.833 ± 0.158
1.814SerTyr: 1.814 ± 0.189
0.0SerXaa: 0.0 ± 0.0
Thr
2.925ThrAla: 2.925 ± 0.205
0.539ThrCys: 0.539 ± 0.1
2.549ThrAsp: 2.549 ± 0.219
3.84ThrGlu: 3.84 ± 0.265
1.781ThrPhe: 1.781 ± 0.175
4.282ThrGly: 4.282 ± 0.299
0.882ThrHis: 0.882 ± 0.115
3.513ThrIle: 3.513 ± 0.269
2.794ThrLys: 2.794 ± 0.238
4.625ThrLeu: 4.625 ± 0.283
0.931ThrMet: 0.931 ± 0.122
1.879ThrAsn: 1.879 ± 0.192
2.01ThrPro: 2.01 ± 0.189
1.144ThrGln: 1.144 ± 0.123
2.043ThrArg: 2.043 ± 0.163
3.285ThrSer: 3.285 ± 0.255
2.696ThrThr: 2.696 ± 0.277
4.412ThrVal: 4.412 ± 0.372
0.523ThrTrp: 0.523 ± 0.085
1.389ThrTyr: 1.389 ± 0.177
0.0ThrXaa: 0.0 ± 0.0
Val
4.51ValAla: 4.51 ± 0.361
0.719ValCys: 0.719 ± 0.085
4.249ValAsp: 4.249 ± 0.339
6.651ValGlu: 6.651 ± 0.355
2.647ValPhe: 2.647 ± 0.235
5.327ValGly: 5.327 ± 0.367
0.981ValHis: 0.981 ± 0.121
3.889ValIle: 3.889 ± 0.313
5.164ValLys: 5.164 ± 0.266
5.801ValLeu: 5.801 ± 0.296
1.275ValMet: 1.275 ± 0.157
2.762ValAsn: 2.762 ± 0.247
2.794ValPro: 2.794 ± 0.199
1.601ValGln: 1.601 ± 0.143
3.579ValArg: 3.579 ± 0.199
5.442ValSer: 5.442 ± 0.36
4.331ValThr: 4.331 ± 0.389
4.755ValVal: 4.755 ± 0.375
0.752ValTrp: 0.752 ± 0.107
1.879ValTyr: 1.879 ± 0.189
0.0ValXaa: 0.0 ± 0.0
Trp
0.507TrpAla: 0.507 ± 0.102
0.131TrpCys: 0.131 ± 0.047
0.654TrpAsp: 0.654 ± 0.106
0.882TrpGlu: 0.882 ± 0.105
0.441TrpPhe: 0.441 ± 0.1
0.719TrpGly: 0.719 ± 0.105
0.229TrpHis: 0.229 ± 0.065
0.997TrpIle: 0.997 ± 0.129
1.177TrpLys: 1.177 ± 0.151
0.981TrpLeu: 0.981 ± 0.141
0.147TrpMet: 0.147 ± 0.048
0.686TrpAsn: 0.686 ± 0.135
0.212TrpPro: 0.212 ± 0.062
0.327TrpGln: 0.327 ± 0.07
0.85TrpArg: 0.85 ± 0.125
0.866TrpSer: 0.866 ± 0.113
0.588TrpThr: 0.588 ± 0.107
0.703TrpVal: 0.703 ± 0.1
0.212TrpTrp: 0.212 ± 0.059
0.278TrpTyr: 0.278 ± 0.089
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.405TyrAla: 1.405 ± 0.17
0.376TyrCys: 0.376 ± 0.089
2.01TyrAsp: 2.01 ± 0.206
2.811TyrGlu: 2.811 ± 0.229
1.324TyrPhe: 1.324 ± 0.165
2.435TyrGly: 2.435 ± 0.202
0.686TyrHis: 0.686 ± 0.094
1.422TyrIle: 1.422 ± 0.175
1.716TyrLys: 1.716 ± 0.186
3.17TyrLeu: 3.17 ± 0.258
0.425TyrMet: 0.425 ± 0.075
0.882TyrAsn: 0.882 ± 0.17
1.258TyrPro: 1.258 ± 0.147
0.882TyrGln: 0.882 ± 0.122
1.781TyrArg: 1.781 ± 0.171
2.075TyrSer: 2.075 ± 0.172
1.618TyrThr: 1.618 ± 0.174
1.896TyrVal: 1.896 ± 0.19
0.441TyrTrp: 0.441 ± 0.078
1.144TyrTyr: 1.144 ± 0.195
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 218 proteins (61194 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski