Amino acid dipepetide frequency for Nocardioides silvaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.36AlaAla: 19.36 ± 0.193	0.966AlaCys: 0.966 ± 0.029	8.835AlaAsp: 8.835 ± 0.084	8.554AlaGlu: 8.554 ± 0.103	3.579AlaPhe: 3.579 ± 0.057	12.067AlaGly: 12.067 ± 0.085	2.478AlaHis: 2.478 ± 0.041	4.714AlaIle: 4.714 ± 0.058	2.637AlaLys: 2.637 ± 0.052	13.038AlaLeu: 13.038 ± 0.126	2.505AlaMet: 2.505 ± 0.042	1.933AlaAsn: 1.933 ± 0.038	6.22AlaPro: 6.22 ± 0.075	3.225AlaGln: 3.225 ± 0.054	9.088AlaArg: 9.088 ± 0.102	5.951AlaSer: 5.951 ± 0.066	7.568AlaThr: 7.568 ± 0.09	11.653AlaVal: 11.653 ± 0.105	1.936AlaTrp: 1.936 ± 0.039	2.422AlaTyr: 2.422 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.914CysAla: 0.914 ± 0.028	0.091CysCys: 0.091 ± 0.009	0.505CysAsp: 0.505 ± 0.017	0.411CysGlu: 0.411 ± 0.018	0.235CysPhe: 0.235 ± 0.013	0.873CysGly: 0.873 ± 0.026	0.178CysHis: 0.178 ± 0.013	0.207CysIle: 0.207 ± 0.013	0.132CysLys: 0.132 ± 0.009	0.629CysLeu: 0.629 ± 0.022	0.111CysMet: 0.111 ± 0.01	0.15CysAsn: 0.15 ± 0.01	0.466CysPro: 0.466 ± 0.019	0.189CysGln: 0.189 ± 0.013	0.594CysArg: 0.594 ± 0.023	0.44CysSer: 0.44 ± 0.018	0.472CysThr: 0.472 ± 0.023	0.581CysVal: 0.581 ± 0.025	0.122CysTrp: 0.122 ± 0.01	0.172CysTyr: 0.172 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.241AspAla: 8.241 ± 0.082	0.411AspCys: 0.411 ± 0.018	5.093AspAsp: 5.093 ± 0.074	4.877AspGlu: 4.877 ± 0.068	1.715AspPhe: 1.715 ± 0.038	6.851AspGly: 6.851 ± 0.08	1.649AspHis: 1.649 ± 0.037	2.039AspIle: 2.039 ± 0.04	1.198AspLys: 1.198 ± 0.036	7.606AspLeu: 7.606 ± 0.078	0.805AspMet: 0.805 ± 0.026	1.123AspAsn: 1.123 ± 0.028	4.919AspPro: 4.919 ± 0.065	1.892AspGln: 1.892 ± 0.041	5.455AspArg: 5.455 ± 0.069	2.459AspSer: 2.459 ± 0.044	2.846AspThr: 2.846 ± 0.048	6.262AspVal: 6.262 ± 0.068	1.063AspTrp: 1.063 ± 0.028	1.331AspTyr: 1.331 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.479GluAla: 7.479 ± 0.107	0.382GluCys: 0.382 ± 0.015	3.543GluAsp: 3.543 ± 0.056	4.101GluGlu: 4.101 ± 0.061	1.479GluPhe: 1.479 ± 0.029	4.451GluGly: 4.451 ± 0.06	1.685GluHis: 1.685 ± 0.039	2.673GluIle: 2.673 ± 0.046	1.439GluLys: 1.439 ± 0.034	6.838GluLeu: 6.838 ± 0.084	1.054GluMet: 1.054 ± 0.028	1.001GluAsn: 1.001 ± 0.026	3.476GluPro: 3.476 ± 0.06	2.553GluGln: 2.553 ± 0.046	5.36GluArg: 5.36 ± 0.07	2.768GluSer: 2.768 ± 0.045	3.102GluThr: 3.102 ± 0.051	5.836GluVal: 5.836 ± 0.063	0.916GluTrp: 0.916 ± 0.025	1.092GluTyr: 1.092 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.69PheAla: 3.69 ± 0.057	0.267PheCys: 0.267 ± 0.013	2.157PheAsp: 2.157 ± 0.036	1.758PheGlu: 1.758 ± 0.037	0.901PhePhe: 0.901 ± 0.027	3.033PheGly: 3.033 ± 0.053	0.589PheHis: 0.589 ± 0.021	0.771PheIle: 0.771 ± 0.027	0.512PheLys: 0.512 ± 0.02	2.624PheLeu: 2.624 ± 0.053	0.421PheMet: 0.421 ± 0.018	0.618PheAsn: 0.618 ± 0.023	1.34PhePro: 1.34 ± 0.033	0.659PheGln: 0.659 ± 0.025	1.784PheArg: 1.784 ± 0.033	1.468PheSer: 1.468 ± 0.034	1.804PheThr: 1.804 ± 0.047	2.632PheVal: 2.632 ± 0.043	0.437PheTrp: 0.437 ± 0.017	0.61PheTyr: 0.61 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.224GlyAla: 10.224 ± 0.093	0.843GlyCys: 0.843 ± 0.029	5.784GlyAsp: 5.784 ± 0.087	5.354GlyGlu: 5.354 ± 0.068	2.992GlyPhe: 2.992 ± 0.048	8.337GlyGly: 8.337 ± 0.102	2.001GlyHis: 2.001 ± 0.04	3.774GlyIle: 3.774 ± 0.053	2.25GlyLys: 2.25 ± 0.044	9.213GlyLeu: 9.213 ± 0.087	1.896GlyMet: 1.896 ± 0.039	1.791GlyAsn: 1.791 ± 0.041	4.704GlyPro: 4.704 ± 0.065	2.499GlyGln: 2.499 ± 0.043	7.198GlyArg: 7.198 ± 0.08	5.384GlySer: 5.384 ± 0.065	5.753GlyThr: 5.753 ± 0.073	7.798GlyVal: 7.798 ± 0.092	1.766GlyTrp: 1.766 ± 0.04	2.211GlyTyr: 2.211 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.501HisAla: 2.501 ± 0.047	0.207HisCys: 0.207 ± 0.014	1.482HisAsp: 1.482 ± 0.031	1.27HisGlu: 1.27 ± 0.032	0.589HisPhe: 0.589 ± 0.019	2.196HisGly: 2.196 ± 0.045	0.724HisHis: 0.724 ± 0.028	0.535HisIle: 0.535 ± 0.017	0.318HisLys: 0.318 ± 0.014	2.315HisLeu: 2.315 ± 0.043	0.294HisMet: 0.294 ± 0.015	0.377HisAsn: 0.377 ± 0.017	1.601HisPro: 1.601 ± 0.037	0.659HisGln: 0.659 ± 0.023	1.942HisArg: 1.942 ± 0.043	0.828HisSer: 0.828 ± 0.024	1.038HisThr: 1.038 ± 0.027	1.9HisVal: 1.9 ± 0.04	0.329HisTrp: 0.329 ± 0.016	0.467HisTyr: 0.467 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.19IleAla: 5.19 ± 0.071	0.314IleCys: 0.314 ± 0.016	2.88IleAsp: 2.88 ± 0.05	2.47IleGlu: 2.47 ± 0.043	0.85IlePhe: 0.85 ± 0.023	3.916IleGly: 3.916 ± 0.063	0.654IleHis: 0.654 ± 0.023	1.092IleIle: 1.092 ± 0.031	0.827IleLys: 0.827 ± 0.024	2.602IleLeu: 2.602 ± 0.047	0.453IleMet: 0.453 ± 0.018	0.8IleAsn: 0.8 ± 0.022	1.824IlePro: 1.824 ± 0.039	0.779IleGln: 0.779 ± 0.025	2.332IleArg: 2.332 ± 0.046	1.849IleSer: 1.849 ± 0.041	2.332IleThr: 2.332 ± 0.046	3.265IleVal: 3.265 ± 0.054	0.434IleTrp: 0.434 ± 0.02	0.657IleTyr: 0.657 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.676LysAla: 2.676 ± 0.07	0.127LysCys: 0.127 ± 0.011	1.238LysAsp: 1.238 ± 0.033	1.225LysGlu: 1.225 ± 0.029	0.497LysPhe: 0.497 ± 0.021	1.628LysGly: 1.628 ± 0.034	0.469LysHis: 0.469 ± 0.02	0.843LysIle: 0.843 ± 0.029	0.837LysLys: 0.837 ± 0.036	1.804LysLeu: 1.804 ± 0.039	0.396LysMet: 0.396 ± 0.018	0.483LysAsn: 0.483 ± 0.022	1.242LysPro: 1.242 ± 0.034	0.677LysGln: 0.677 ± 0.019	1.52LysArg: 1.52 ± 0.035	1.06LysSer: 1.06 ± 0.029	1.13LysThr: 1.13 ± 0.034	2.077LysVal: 2.077 ± 0.041	0.266LysTrp: 0.266 ± 0.015	0.47LysTyr: 0.47 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.592LeuAla: 14.592 ± 0.132	0.71LeuCys: 0.71 ± 0.023	7.19LeuAsp: 7.19 ± 0.082	5.689LeuGlu: 5.689 ± 0.071	2.489LeuPhe: 2.489 ± 0.048	9.476LeuGly: 9.476 ± 0.091	2.056LeuHis: 2.056 ± 0.042	2.835LeuIle: 2.835 ± 0.053	1.758LeuLys: 1.758 ± 0.041	10.51LeuLeu: 10.51 ± 0.107	1.6LeuMet: 1.6 ± 0.034	1.586LeuAsn: 1.586 ± 0.037	5.78LeuPro: 5.78 ± 0.067	2.36LeuGln: 2.36 ± 0.047	7.644LeuArg: 7.644 ± 0.084	4.919LeuSer: 4.919 ± 0.07	6.401LeuThr: 6.401 ± 0.067	10.588LeuVal: 10.588 ± 0.116	1.229LeuTrp: 1.229 ± 0.036	1.497LeuTyr: 1.497 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.166MetAla: 2.166 ± 0.044	0.126MetCys: 0.126 ± 0.01	0.864MetAsp: 0.864 ± 0.024	0.78MetGlu: 0.78 ± 0.025	0.475MetPhe: 0.475 ± 0.018	1.322MetGly: 1.322 ± 0.032	0.342MetHis: 0.342 ± 0.017	0.713MetIle: 0.713 ± 0.021	0.446MetLys: 0.446 ± 0.018	1.734MetLeu: 1.734 ± 0.036	0.337MetMet: 0.337 ± 0.017	0.387MetAsn: 0.387 ± 0.017	1.084MetPro: 1.084 ± 0.028	0.437MetGln: 0.437 ± 0.017	1.39MetArg: 1.39 ± 0.033	1.356MetSer: 1.356 ± 0.03	1.648MetThr: 1.648 ± 0.035	1.487MetVal: 1.487 ± 0.038	0.194MetTrp: 0.194 ± 0.012	0.291MetTyr: 0.291 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.172AsnAla: 2.172 ± 0.045	0.157AsnCys: 0.157 ± 0.012	1.154AsnAsp: 1.154 ± 0.034	0.924AsnGlu: 0.924 ± 0.026	0.475AsnPhe: 0.475 ± 0.018	1.858AsnGly: 1.858 ± 0.037	0.407AsnHis: 0.407 ± 0.017	0.688AsnIle: 0.688 ± 0.022	0.411AsnLys: 0.411 ± 0.018	1.834AsnLeu: 1.834 ± 0.043	0.276AsnMet: 0.276 ± 0.012	0.444AsnAsn: 0.444 ± 0.022	1.39AsnPro: 1.39 ± 0.036	0.55AsnGln: 0.55 ± 0.022	1.286AsnArg: 1.286 ± 0.031	0.731AsnSer: 0.731 ± 0.024	1.015AsnThr: 1.015 ± 0.034	1.487AsnVal: 1.487 ± 0.032	0.255AsnTrp: 0.255 ± 0.012	0.382AsnTyr: 0.382 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.309ProAla: 7.309 ± 0.092	0.308ProCys: 0.308 ± 0.014	4.767ProAsp: 4.767 ± 0.07	4.169ProGlu: 4.169 ± 0.054	1.489ProPhe: 1.489 ± 0.031	5.645ProGly: 5.645 ± 0.064	1.135ProHis: 1.135 ± 0.031	1.712ProIle: 1.712 ± 0.035	1.115ProLys: 1.115 ± 0.032	4.743ProLeu: 4.743 ± 0.055	1.01ProMet: 1.01 ± 0.031	0.854ProAsn: 0.854 ± 0.027	3.185ProPro: 3.185 ± 0.074	1.409ProGln: 1.409 ± 0.036	3.564ProArg: 3.564 ± 0.055	3.058ProSer: 3.058 ± 0.056	3.666ProThr: 3.666 ± 0.064	5.294ProVal: 5.294 ± 0.061	0.954ProTrp: 0.954 ± 0.026	1.293ProTyr: 1.293 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.379GlnAla: 3.379 ± 0.053	0.161GlnCys: 0.161 ± 0.011	1.311GlnAsp: 1.311 ± 0.031	1.501GlnGlu: 1.501 ± 0.035	0.695GlnPhe: 0.695 ± 0.024	1.988GlnGly: 1.988 ± 0.037	0.709GlnHis: 0.709 ± 0.025	1.106GlnIle: 1.106 ± 0.027	0.547GlnLys: 0.547 ± 0.026	3.035GlnLeu: 3.035 ± 0.048	0.499GlnMet: 0.499 ± 0.02	0.418GlnAsn: 0.418 ± 0.017	1.687GlnPro: 1.687 ± 0.036	1.23GlnGln: 1.23 ± 0.035	2.503GlnArg: 2.503 ± 0.045	1.184GlnSer: 1.184 ± 0.033	1.374GlnThr: 1.374 ± 0.033	2.865GlnVal: 2.865 ± 0.041	0.411GlnTrp: 0.411 ± 0.018	0.573GlnTyr: 0.573 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.762ArgAla: 8.762 ± 0.091	0.518ArgCys: 0.518 ± 0.021	4.648ArgAsp: 4.648 ± 0.059	4.55ArgGlu: 4.55 ± 0.058	2.372ArgPhe: 2.372 ± 0.045	5.539ArgGly: 5.539 ± 0.062	1.756ArgHis: 1.756 ± 0.038	3.296ArgIle: 3.296 ± 0.047	1.625ArgLys: 1.625 ± 0.037	8.146ArgLeu: 8.146 ± 0.096	1.74ArgMet: 1.74 ± 0.035	1.406ArgAsn: 1.406 ± 0.034	4.283ArgPro: 4.283 ± 0.069	2.168ArgGln: 2.168 ± 0.042	7.398ArgArg: 7.398 ± 0.107	4.176ArgSer: 4.176 ± 0.056	4.611ArgThr: 4.611 ± 0.065	6.179ArgVal: 6.179 ± 0.073	1.464ArgTrp: 1.464 ± 0.034	1.64ArgTyr: 1.64 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.977SerAla: 5.977 ± 0.068	0.379SerCys: 0.379 ± 0.021	3.098SerAsp: 3.098 ± 0.048	2.622SerGlu: 2.622 ± 0.043	1.693SerPhe: 1.693 ± 0.041	5.528SerGly: 5.528 ± 0.065	0.97SerHis: 0.97 ± 0.026	1.865SerIle: 1.865 ± 0.036	0.989SerLys: 0.989 ± 0.028	4.661SerLeu: 4.661 ± 0.066	1.2SerMet: 1.2 ± 0.029	0.946SerAsn: 0.946 ± 0.027	2.86SerPro: 2.86 ± 0.049	1.25SerGln: 1.25 ± 0.028	3.533SerArg: 3.533 ± 0.053	3.052SerSer: 3.052 ± 0.058	3.341SerThr: 3.341 ± 0.048	4.231SerVal: 4.231 ± 0.064	0.951SerTrp: 0.951 ± 0.03	1.459SerTyr: 1.459 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	7.429ThrAla: 7.429 ± 0.079	0.461ThrCys: 0.461 ± 0.019	3.888ThrAsp: 3.888 ± 0.059	3.276ThrGlu: 3.276 ± 0.046	1.896ThrPhe: 1.896 ± 0.036	6.128ThrGly: 6.128 ± 0.09	1.132ThrHis: 1.132 ± 0.03	2.392ThrIle: 2.392 ± 0.049	1.247ThrLys: 1.247 ± 0.033	5.468ThrLeu: 5.468 ± 0.063	1.035ThrMet: 1.035 ± 0.026	1.146ThrAsn: 1.146 ± 0.03	3.72ThrPro: 3.72 ± 0.047	1.334ThrGln: 1.334 ± 0.031	3.856ThrArg: 3.856 ± 0.05	3.457ThrSer: 3.457 ± 0.048	4.161ThrThr: 4.161 ± 0.074	5.738ThrVal: 5.738 ± 0.07	1.004ThrTrp: 1.004 ± 0.03	1.479ThrTyr: 1.479 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	12.58ValAla: 12.58 ± 0.131	0.71ValCys: 0.71 ± 0.022	6.56ValAsp: 6.56 ± 0.069	5.798ValGlu: 5.798 ± 0.07	2.4ValPhe: 2.4 ± 0.048	7.85ValGly: 7.85 ± 0.087	1.903ValHis: 1.903 ± 0.041	3.209ValIle: 3.209 ± 0.058	1.707ValLys: 1.707 ± 0.043	10.004ValLeu: 10.004 ± 0.103	1.457ValMet: 1.457 ± 0.032	1.698ValAsn: 1.698 ± 0.039	5.106ValPro: 5.106 ± 0.065	2.164ValGln: 2.164 ± 0.044	6.956ValArg: 6.956 ± 0.08	4.47ValSer: 4.47 ± 0.06	5.959ValThr: 5.959 ± 0.073	10.594ValVal: 10.594 ± 0.123	1.187ValTrp: 1.187 ± 0.032	1.485ValTyr: 1.485 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.644TrpAla: 1.644 ± 0.034	0.157TrpCys: 0.157 ± 0.009	0.916TrpAsp: 0.916 ± 0.026	0.782TrpGlu: 0.782 ± 0.026	0.548TrpPhe: 0.548 ± 0.022	1.064TrpGly: 1.064 ± 0.03	0.372TrpHis: 0.372 ± 0.015	0.583TrpIle: 0.583 ± 0.021	0.329TrpLys: 0.329 ± 0.018	1.844TrpLeu: 1.844 ± 0.034	0.294TrpMet: 0.294 ± 0.013	0.35TrpAsn: 0.35 ± 0.015	0.786TrpPro: 0.786 ± 0.026	0.589TrpGln: 0.589 ± 0.019	1.318TrpArg: 1.318 ± 0.035	0.998TrpSer: 0.998 ± 0.028	0.997TrpThr: 0.997 ± 0.025	1.374TrpVal: 1.374 ± 0.029	0.418TrpTrp: 0.418 ± 0.019	0.299TrpTyr: 0.299 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.442TyrAla: 2.442 ± 0.046	0.178TyrCys: 0.178 ± 0.011	1.92TyrAsp: 1.92 ± 0.036	1.117TyrGlu: 1.117 ± 0.032	0.704TyrPhe: 0.704 ± 0.023	2.023TyrGly: 2.023 ± 0.04	0.364TyrHis: 0.364 ± 0.017	0.472TyrIle: 0.472 ± 0.02	0.342TyrLys: 0.342 ± 0.017	2.259TyrLeu: 2.259 ± 0.053	0.197TyrMet: 0.197 ± 0.012	0.385TyrAsn: 0.385 ± 0.017	1.009TyrPro: 1.009 ± 0.029	0.551TyrGln: 0.551 ± 0.018	1.557TyrArg: 1.557 ± 0.036	0.999TyrSer: 0.999 ± 0.028	1.032TyrThr: 1.032 ± 0.031	1.955TyrVal: 1.955 ± 0.038	0.324TyrTrp: 0.324 ± 0.017	0.467TyrTyr: 0.467 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4220 proteins (1369492 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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