Amino acid dipepetide frequency for Thermomonas fusca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.243AlaAla: 20.243 ± 0.273	1.337AlaCys: 1.337 ± 0.042	7.641AlaAsp: 7.641 ± 0.104	7.209AlaGlu: 7.209 ± 0.123	4.318AlaPhe: 4.318 ± 0.08	12.422AlaGly: 12.422 ± 0.147	2.694AlaHis: 2.694 ± 0.052	5.582AlaIle: 5.582 ± 0.093	3.785AlaLys: 3.785 ± 0.087	17.438AlaLeu: 17.438 ± 0.223	3.769AlaMet: 3.769 ± 0.066	2.993AlaAsn: 2.993 ± 0.064	6.731AlaPro: 6.731 ± 0.115	6.074AlaGln: 6.074 ± 0.104	10.858AlaArg: 10.858 ± 0.157	6.765AlaSer: 6.765 ± 0.109	6.163AlaThr: 6.163 ± 0.095	8.695AlaVal: 8.695 ± 0.105	2.003AlaTrp: 2.003 ± 0.057	2.403AlaTyr: 2.403 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.131CysAla: 1.131 ± 0.036	0.114CysCys: 0.114 ± 0.011	0.464CysAsp: 0.464 ± 0.024	0.469CysGlu: 0.469 ± 0.028	0.265CysPhe: 0.265 ± 0.02	0.891CysGly: 0.891 ± 0.032	0.209CysHis: 0.209 ± 0.015	0.375CysIle: 0.375 ± 0.022	0.204CysLys: 0.204 ± 0.015	0.777CysLeu: 0.777 ± 0.031	0.153CysMet: 0.153 ± 0.014	0.228CysAsn: 0.228 ± 0.015	0.446CysPro: 0.446 ± 0.026	0.208CysGln: 0.208 ± 0.015	0.616CysArg: 0.616 ± 0.028	0.441CysSer: 0.441 ± 0.023	0.415CysThr: 0.415 ± 0.023	0.659CysVal: 0.659 ± 0.026	0.136CysTrp: 0.136 ± 0.013	0.196CysTyr: 0.196 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	9.948AspAla: 9.948 ± 0.143	0.477AspCys: 0.477 ± 0.027	3.403AspAsp: 3.403 ± 0.074	3.302AspGlu: 3.302 ± 0.074	2.1AspPhe: 2.1 ± 0.046	6.067AspGly: 6.067 ± 0.098	1.049AspHis: 1.049 ± 0.03	2.521AspIle: 2.521 ± 0.062	1.634AspLys: 1.634 ± 0.05	5.4AspLeu: 5.4 ± 0.093	1.157AspMet: 1.157 ± 0.04	1.296AspAsn: 1.296 ± 0.036	3.327AspPro: 3.327 ± 0.069	1.42AspGln: 1.42 ± 0.047	3.744AspArg: 3.744 ± 0.071	2.323AspSer: 2.323 ± 0.057	2.507AspThr: 2.507 ± 0.055	4.268AspVal: 4.268 ± 0.079	1.124AspTrp: 1.124 ± 0.039	1.596AspTyr: 1.596 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.754GluAla: 7.754 ± 0.125	0.357GluCys: 0.357 ± 0.021	2.524GluAsp: 2.524 ± 0.057	2.442GluGlu: 2.442 ± 0.07	1.726GluPhe: 1.726 ± 0.047	3.905GluGly: 3.905 ± 0.079	1.379GluHis: 1.379 ± 0.038	2.494GluIle: 2.494 ± 0.057	1.589GluLys: 1.589 ± 0.044	6.17GluLeu: 6.17 ± 0.096	1.142GluMet: 1.142 ± 0.035	1.113GluAsn: 1.113 ± 0.045	2.403GluPro: 2.403 ± 0.05	2.365GluGln: 2.365 ± 0.067	5.131GluArg: 5.131 ± 0.088	2.308GluSer: 2.308 ± 0.052	2.466GluThr: 2.466 ± 0.058	3.954GluVal: 3.954 ± 0.074	0.653GluTrp: 0.653 ± 0.03	1.071GluTyr: 1.071 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.614PheAla: 4.614 ± 0.077	0.343PheCys: 0.343 ± 0.02	2.707PheAsp: 2.707 ± 0.053	1.945PheGlu: 1.945 ± 0.048	1.183PhePhe: 1.183 ± 0.046	3.311PheGly: 3.311 ± 0.07	0.8PheHis: 0.8 ± 0.03	1.176PheIle: 1.176 ± 0.043	0.89PheLys: 0.89 ± 0.038	2.988PheLeu: 2.988 ± 0.061	0.614PheMet: 0.614 ± 0.029	1.002PheAsn: 1.002 ± 0.038	1.359PhePro: 1.359 ± 0.04	0.91PheGln: 0.91 ± 0.036	2.197PheArg: 2.197 ± 0.055	1.915PheSer: 1.915 ± 0.054	1.586PheThr: 1.586 ± 0.051	2.496PheVal: 2.496 ± 0.052	0.457PheTrp: 0.457 ± 0.028	0.758PheTyr: 0.758 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.42GlyAla: 9.42 ± 0.109	0.898GlyCys: 0.898 ± 0.034	5.066GlyAsp: 5.066 ± 0.099	4.996GlyGlu: 4.996 ± 0.078	3.47GlyPhe: 3.47 ± 0.062	7.544GlyGly: 7.544 ± 0.152	2.038GlyHis: 2.038 ± 0.052	4.304GlyIle: 4.304 ± 0.079	3.405GlyLys: 3.405 ± 0.081	8.932GlyLeu: 8.932 ± 0.114	2.505GlyMet: 2.505 ± 0.057	2.478GlyAsn: 2.478 ± 0.065	2.898GlyPro: 2.898 ± 0.057	3.164GlyGln: 3.164 ± 0.078	6.262GlyArg: 6.262 ± 0.103	4.841GlySer: 4.841 ± 0.106	4.096GlyThr: 4.096 ± 0.108	6.483GlyVal: 6.483 ± 0.096	1.748GlyTrp: 1.748 ± 0.05	2.373GlyTyr: 2.373 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	3.269HisAla: 3.269 ± 0.071	0.277HisCys: 0.277 ± 0.017	1.302HisAsp: 1.302 ± 0.035	1.074HisGlu: 1.074 ± 0.034	0.798HisPhe: 0.798 ± 0.028	2.317HisGly: 2.317 ± 0.058	0.617HisHis: 0.617 ± 0.029	0.74HisIle: 0.74 ± 0.029	0.513HisLys: 0.513 ± 0.023	2.123HisLeu: 2.123 ± 0.049	0.417HisMet: 0.417 ± 0.023	0.47HisAsn: 0.47 ± 0.026	1.483HisPro: 1.483 ± 0.048	0.59HisGln: 0.59 ± 0.029	1.678HisArg: 1.678 ± 0.045	0.915HisSer: 0.915 ± 0.03	0.846HisThr: 0.846 ± 0.032	1.583HisVal: 1.583 ± 0.046	0.415HisTrp: 0.415 ± 0.026	0.57HisTyr: 0.57 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.56IleAla: 6.56 ± 0.097	0.311IleCys: 0.311 ± 0.018	3.475IleAsp: 3.475 ± 0.062	3.001IleGlu: 3.001 ± 0.058	1.045IlePhe: 1.045 ± 0.036	4.308IleGly: 4.308 ± 0.087	0.822IleHis: 0.822 ± 0.032	1.256IleIle: 1.256 ± 0.046	1.09IleLys: 1.09 ± 0.037	3.062IleLeu: 3.062 ± 0.071	0.495IleMet: 0.495 ± 0.023	1.187IleAsn: 1.187 ± 0.042	2.036IlePro: 2.036 ± 0.049	1.029IleGln: 1.029 ± 0.036	2.777IleArg: 2.777 ± 0.057	2.025IleSer: 2.025 ± 0.059	1.964IleThr: 1.964 ± 0.061	3.247IleVal: 3.247 ± 0.068	0.378IleTrp: 0.378 ± 0.022	0.788IleTyr: 0.788 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.639LysAla: 3.639 ± 0.082	0.145LysCys: 0.145 ± 0.014	1.548LysAsp: 1.548 ± 0.047	1.202LysGlu: 1.202 ± 0.046	0.805LysPhe: 0.805 ± 0.034	2.085LysGly: 2.085 ± 0.054	0.621LysHis: 0.621 ± 0.029	1.237LysIle: 1.237 ± 0.043	1.072LysLys: 1.072 ± 0.065	3.202LysLeu: 3.202 ± 0.067	0.615LysMet: 0.615 ± 0.027	0.673LysAsn: 0.673 ± 0.032	2.109LysPro: 2.109 ± 0.056	1.225LysGln: 1.225 ± 0.045	2.267LysArg: 2.267 ± 0.05	1.368LysSer: 1.368 ± 0.035	1.589LysThr: 1.589 ± 0.048	2.196LysVal: 2.196 ± 0.053	0.322LysTrp: 0.322 ± 0.018	0.63LysTyr: 0.63 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	16.737LeuAla: 16.737 ± 0.198	0.945LeuCys: 0.945 ± 0.034	7.102LeuAsp: 7.102 ± 0.098	5.582LeuGlu: 5.582 ± 0.091	3.336LeuPhe: 3.336 ± 0.07	9.075LeuGly: 9.075 ± 0.095	2.594LeuHis: 2.594 ± 0.052	3.497LeuIle: 3.497 ± 0.074	3.007LeuLys: 3.007 ± 0.063	13.208LeuLeu: 13.208 ± 0.194	2.038LeuMet: 2.038 ± 0.047	2.194LeuAsn: 2.194 ± 0.054	6.831LeuPro: 6.831 ± 0.108	4.317LeuGln: 4.317 ± 0.076	9.843LeuArg: 9.843 ± 0.141	5.478LeuSer: 5.478 ± 0.096	4.484LeuThr: 4.484 ± 0.076	7.7LeuVal: 7.7 ± 0.101	1.428LeuTrp: 1.428 ± 0.046	2.135LeuTyr: 2.135 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.953MetAla: 2.953 ± 0.062	0.131MetCys: 0.131 ± 0.013	1.176MetAsp: 1.176 ± 0.038	0.976MetGlu: 0.976 ± 0.036	0.643MetPhe: 0.643 ± 0.032	1.622MetGly: 1.622 ± 0.044	0.468MetHis: 0.468 ± 0.022	0.832MetIle: 0.832 ± 0.031	0.744MetLys: 0.744 ± 0.031	2.543MetLeu: 2.543 ± 0.057	0.483MetMet: 0.483 ± 0.026	0.65MetAsn: 0.65 ± 0.029	1.523MetPro: 1.523 ± 0.043	1.059MetGln: 1.059 ± 0.036	1.873MetArg: 1.873 ± 0.054	1.443MetSer: 1.443 ± 0.04	1.319MetThr: 1.319 ± 0.04	1.504MetVal: 1.504 ± 0.047	0.205MetTrp: 0.205 ± 0.013	0.344MetTyr: 0.344 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.418AsnAla: 3.418 ± 0.074	0.199AsnCys: 0.199 ± 0.016	1.301AsnAsp: 1.301 ± 0.043	1.047AsnGlu: 1.047 ± 0.04	0.867AsnPhe: 0.867 ± 0.037	2.281AsnGly: 2.281 ± 0.054	0.487AsnHis: 0.487 ± 0.024	1.06AsnIle: 1.06 ± 0.039	0.599AsnLys: 0.599 ± 0.029	2.46AsnLeu: 2.46 ± 0.06	0.42AsnMet: 0.42 ± 0.024	0.573AsnAsn: 0.573 ± 0.036	1.742AsnPro: 1.742 ± 0.05	0.708AsnGln: 0.708 ± 0.031	1.761AsnArg: 1.761 ± 0.044	1.103AsnSer: 1.103 ± 0.045	1.194AsnThr: 1.194 ± 0.041	1.72AsnVal: 1.72 ± 0.045	0.335AsnTrp: 0.335 ± 0.022	0.579AsnTyr: 0.579 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	8.076ProAla: 8.076 ± 0.147	0.32ProCys: 0.32 ± 0.022	3.343ProAsp: 3.343 ± 0.066	3.177ProGlu: 3.177 ± 0.061	1.557ProPhe: 1.557 ± 0.043	4.758ProGly: 4.758 ± 0.073	1.062ProHis: 1.062 ± 0.038	1.711ProIle: 1.711 ± 0.053	1.477ProLys: 1.477 ± 0.044	5.526ProLeu: 5.526 ± 0.089	1.373ProMet: 1.373 ± 0.041	1.121ProAsn: 1.121 ± 0.042	2.837ProPro: 2.837 ± 0.076	2.2ProGln: 2.2 ± 0.05	3.428ProArg: 3.428 ± 0.074	2.343ProSer: 2.343 ± 0.053	2.244ProThr: 2.244 ± 0.061	4.122ProVal: 4.122 ± 0.069	0.826ProTrp: 0.826 ± 0.031	1.075ProTyr: 1.075 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	5.87GlnAla: 5.87 ± 0.104	0.232GlnCys: 0.232 ± 0.015	1.518GlnAsp: 1.518 ± 0.046	1.485GlnGlu: 1.485 ± 0.044	1.113GlnPhe: 1.113 ± 0.036	2.689GlnGly: 2.689 ± 0.062	0.844GlnHis: 0.844 ± 0.032	1.427GlnIle: 1.427 ± 0.04	0.99GlnLys: 0.99 ± 0.038	4.431GlnLeu: 4.431 ± 0.08	0.803GlnMet: 0.803 ± 0.029	0.663GlnAsn: 0.663 ± 0.028	2.394GlnPro: 2.394 ± 0.065	1.95GlnGln: 1.95 ± 0.067	3.77GlnArg: 3.77 ± 0.079	1.554GlnSer: 1.554 ± 0.043	1.474GlnThr: 1.474 ± 0.039	2.961GlnVal: 2.961 ± 0.066	0.611GlnTrp: 0.611 ± 0.029	0.751GlnTyr: 0.751 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.541ArgAla: 9.541 ± 0.134	0.573ArgCys: 0.573 ± 0.026	4.83ArgAsp: 4.83 ± 0.084	4.752ArgGlu: 4.752 ± 0.089	2.958ArgPhe: 2.958 ± 0.065	5.755ArgGly: 5.755 ± 0.091	1.935ArgHis: 1.935 ± 0.05	4.174ArgIle: 4.174 ± 0.067	2.219ArgLys: 2.219 ± 0.054	8.807ArgLeu: 8.807 ± 0.137	2.105ArgMet: 2.105 ± 0.05	2.022ArgAsn: 2.022 ± 0.047	3.338ArgPro: 3.338 ± 0.065	3.032ArgGln: 3.032 ± 0.056	6.206ArgArg: 6.206 ± 0.109	3.725ArgSer: 3.725 ± 0.068	3.168ArgThr: 3.168 ± 0.06	5.31ArgVal: 5.31 ± 0.074	1.493ArgTrp: 1.493 ± 0.047	2.09ArgTyr: 2.09 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.181SerAla: 6.181 ± 0.084	0.375SerCys: 0.375 ± 0.022	2.619SerAsp: 2.619 ± 0.058	2.391SerGlu: 2.391 ± 0.055	1.774SerPhe: 1.774 ± 0.044	5.12SerGly: 5.12 ± 0.129	1.078SerHis: 1.078 ± 0.039	2.097SerIle: 2.097 ± 0.058	1.412SerLys: 1.412 ± 0.044	5.272SerLeu: 5.272 ± 0.072	1.154SerMet: 1.154 ± 0.033	1.285SerAsn: 1.285 ± 0.043	2.549SerPro: 2.549 ± 0.067	1.665SerGln: 1.665 ± 0.049	3.527SerArg: 3.527 ± 0.059	2.613SerSer: 2.613 ± 0.067	2.343SerThr: 2.343 ± 0.056	3.532SerVal: 3.532 ± 0.068	0.724SerTrp: 0.724 ± 0.03	1.187SerTyr: 1.187 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.675ThrAla: 5.675 ± 0.11	0.369ThrCys: 0.369 ± 0.023	2.399ThrAsp: 2.399 ± 0.057	1.936ThrGlu: 1.936 ± 0.045	1.399ThrPhe: 1.399 ± 0.048	4.41ThrGly: 4.41 ± 0.1	0.962ThrHis: 0.962 ± 0.033	1.933ThrIle: 1.933 ± 0.059	0.924ThrLys: 0.924 ± 0.035	5.863ThrLeu: 5.863 ± 0.1	0.865ThrMet: 0.865 ± 0.035	0.967ThrAsn: 0.967 ± 0.042	3.021ThrPro: 3.021 ± 0.058	1.496ThrGln: 1.496 ± 0.044	3.286ThrArg: 3.286 ± 0.055	2.186ThrSer: 2.186 ± 0.059	2.384ThrThr: 2.384 ± 0.066	3.675ThrVal: 3.675 ± 0.093	0.552ThrTrp: 0.552 ± 0.023	0.928ThrTyr: 0.928 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.935ValAla: 9.935 ± 0.139	0.65ValCys: 0.65 ± 0.026	4.383ValAsp: 4.383 ± 0.062	4.397ValGlu: 4.397 ± 0.077	2.533ValPhe: 2.533 ± 0.06	5.468ValGly: 5.468 ± 0.095	1.582ValHis: 1.582 ± 0.052	3.083ValIle: 3.083 ± 0.063	1.968ValLys: 1.968 ± 0.048	8.523ValLeu: 8.523 ± 0.111	1.52ValMet: 1.52 ± 0.047	1.927ValAsn: 1.927 ± 0.053	3.657ValPro: 3.657 ± 0.064	2.539ValGln: 2.539 ± 0.056	5.378ValArg: 5.378 ± 0.09	3.595ValSer: 3.595 ± 0.066	3.272ValThr: 3.272 ± 0.086	5.988ValVal: 5.988 ± 0.107	0.831ValTrp: 0.831 ± 0.033	1.334ValTyr: 1.334 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.29TrpAla: 1.29 ± 0.039	0.157TrpCys: 0.157 ± 0.015	0.646TrpAsp: 0.646 ± 0.025	0.535TrpGlu: 0.535 ± 0.028	0.561TrpPhe: 0.561 ± 0.026	0.905TrpGly: 0.905 ± 0.033	0.356TrpHis: 0.356 ± 0.02	0.662TrpIle: 0.662 ± 0.033	0.469TrpLys: 0.469 ± 0.021	2.417TrpLeu: 2.417 ± 0.066	0.448TrpMet: 0.448 ± 0.025	0.46TrpAsn: 0.46 ± 0.024	0.767TrpPro: 0.767 ± 0.032	0.779TrpGln: 0.779 ± 0.032	1.45TrpArg: 1.45 ± 0.044	0.795TrpSer: 0.795 ± 0.036	0.645TrpThr: 0.645 ± 0.029	0.957TrpVal: 0.957 ± 0.041	0.309TrpTrp: 0.309 ± 0.022	0.318TrpTyr: 0.318 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.869TyrAla: 2.869 ± 0.058	0.185TyrCys: 0.185 ± 0.014	1.218TyrAsp: 1.218 ± 0.043	1.026TyrGlu: 1.026 ± 0.035	0.798TyrPhe: 0.798 ± 0.031	1.989TyrGly: 1.989 ± 0.063	0.401TyrHis: 0.401 ± 0.021	0.699TyrIle: 0.699 ± 0.03	0.56TyrLys: 0.56 ± 0.027	2.391TyrLeu: 2.391 ± 0.055	0.415TyrMet: 0.415 ± 0.023	0.55TyrAsn: 0.55 ± 0.03	1.123TyrPro: 1.123 ± 0.034	0.798TyrGln: 0.798 ± 0.03	1.979TyrArg: 1.979 ± 0.047	1.161TyrSer: 1.161 ± 0.05	1.072TyrThr: 1.072 ± 0.046	1.514TyrVal: 1.514 ± 0.043	0.377TyrTrp: 0.377 ± 0.025	0.536TyrTyr: 0.536 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2622 proteins (884264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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