Amino acid dipepetide frequency for Nonomuraea phyllanthi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.603AlaAla: 20.603 ± 0.122	1.116AlaCys: 1.116 ± 0.02	7.614AlaAsp: 7.614 ± 0.054	8.343AlaGlu: 8.343 ± 0.06	3.717AlaPhe: 3.717 ± 0.039	13.577AlaGly: 13.577 ± 0.095	2.622AlaHis: 2.622 ± 0.032	4.372AlaIle: 4.372 ± 0.043	2.59AlaLys: 2.59 ± 0.041	14.368AlaLeu: 14.368 ± 0.098	2.846AlaMet: 2.846 ± 0.031	2.012AlaAsn: 2.012 ± 0.025	6.241AlaPro: 6.241 ± 0.049	3.449AlaGln: 3.449 ± 0.037	10.6AlaArg: 10.6 ± 0.073	5.718AlaSer: 5.718 ± 0.043	6.968AlaThr: 6.968 ± 0.051	11.705AlaVal: 11.705 ± 0.085	2.018AlaTrp: 2.018 ± 0.029	2.831AlaTyr: 2.831 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.013CysAla: 1.013 ± 0.018	0.107CysCys: 0.107 ± 0.007	0.494CysAsp: 0.494 ± 0.015	0.41CysGlu: 0.41 ± 0.012	0.219CysPhe: 0.219 ± 0.009	0.929CysGly: 0.929 ± 0.018	0.216CysHis: 0.216 ± 0.008	0.133CysIle: 0.133 ± 0.007	0.111CysLys: 0.111 ± 0.006	0.769CysLeu: 0.769 ± 0.016	0.12CysMet: 0.12 ± 0.006	0.13CysAsn: 0.13 ± 0.007	0.486CysPro: 0.486 ± 0.013	0.176CysGln: 0.176 ± 0.008	0.625CysArg: 0.625 ± 0.015	0.438CysSer: 0.438 ± 0.012	0.425CysThr: 0.425 ± 0.012	0.658CysVal: 0.658 ± 0.014	0.133CysTrp: 0.133 ± 0.007	0.168CysTyr: 0.168 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.892AspAla: 6.892 ± 0.046	0.356AspCys: 0.356 ± 0.01	3.577AspAsp: 3.577 ± 0.044	3.745AspGlu: 3.745 ± 0.033	1.596AspPhe: 1.596 ± 0.024	6.167AspGly: 6.167 ± 0.049	1.405AspHis: 1.405 ± 0.024	1.801AspIle: 1.801 ± 0.027	1.065AspLys: 1.065 ± 0.022	6.674AspLeu: 6.674 ± 0.051	0.838AspMet: 0.838 ± 0.018	0.917AspAsn: 0.917 ± 0.019	4.499AspPro: 4.499 ± 0.038	1.664AspGln: 1.664 ± 0.025	4.761AspArg: 4.761 ± 0.043	2.199AspSer: 2.199 ± 0.026	2.606AspThr: 2.606 ± 0.026	5.003AspVal: 5.003 ± 0.043	0.979AspTrp: 0.979 ± 0.021	1.259AspTyr: 1.259 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.031GluAla: 7.031 ± 0.056	0.366GluCys: 0.366 ± 0.01	2.505GluAsp: 2.505 ± 0.03	3.51GluGlu: 3.51 ± 0.046	1.463GluPhe: 1.463 ± 0.022	4.161GluGly: 4.161 ± 0.041	1.628GluHis: 1.628 ± 0.023	2.475GluIle: 2.475 ± 0.029	1.133GluLys: 1.133 ± 0.022	7.031GluLeu: 7.031 ± 0.058	0.929GluMet: 0.929 ± 0.018	0.885GluAsn: 0.885 ± 0.019	3.554GluPro: 3.554 ± 0.037	2.2GluGln: 2.2 ± 0.029	5.94GluArg: 5.94 ± 0.053	2.67GluSer: 2.67 ± 0.029	2.69GluThr: 2.69 ± 0.035	4.697GluVal: 4.697 ± 0.041	0.83GluTrp: 0.83 ± 0.017	1.044GluTyr: 1.044 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.814PheAla: 3.814 ± 0.033	0.257PheCys: 0.257 ± 0.009	2.047PheAsp: 2.047 ± 0.028	1.489PheGlu: 1.489 ± 0.019	0.914PhePhe: 0.914 ± 0.021	3.11PheGly: 3.11 ± 0.037	0.605PheHis: 0.605 ± 0.014	0.776PheIle: 0.776 ± 0.016	0.523PheLys: 0.523 ± 0.013	2.664PheLeu: 2.664 ± 0.036	0.456PheMet: 0.456 ± 0.013	0.581PheAsn: 0.581 ± 0.014	1.44PhePro: 1.44 ± 0.022	0.728PheGln: 0.728 ± 0.016	1.865PheArg: 1.865 ± 0.025	1.48PheSer: 1.48 ± 0.024	1.999PheThr: 1.999 ± 0.029	2.42PheVal: 2.42 ± 0.034	0.473PheTrp: 0.473 ± 0.012	0.649PheTyr: 0.649 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.423GlyAla: 10.423 ± 0.062	0.839GlyCys: 0.839 ± 0.017	5.314GlyAsp: 5.314 ± 0.045	5.362GlyGlu: 5.362 ± 0.043	2.898GlyPhe: 2.898 ± 0.029	8.792GlyGly: 8.792 ± 0.07	2.388GlyHis: 2.388 ± 0.033	3.387GlyIle: 3.387 ± 0.035	2.272GlyLys: 2.272 ± 0.034	9.938GlyLeu: 9.938 ± 0.062	2.058GlyMet: 2.058 ± 0.026	1.682GlyAsn: 1.682 ± 0.03	5.009GlyPro: 5.009 ± 0.047	2.795GlyGln: 2.795 ± 0.032	8.072GlyArg: 8.072 ± 0.059	4.939GlySer: 4.939 ± 0.04	5.655GlyThr: 5.655 ± 0.05	7.95GlyVal: 7.95 ± 0.058	1.762GlyTrp: 1.762 ± 0.026	2.456GlyTyr: 2.456 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.699HisAla: 2.699 ± 0.033	0.197HisCys: 0.197 ± 0.008	1.474HisAsp: 1.474 ± 0.02	1.264HisGlu: 1.264 ± 0.021	0.601HisPhe: 0.601 ± 0.013	2.273HisGly: 2.273 ± 0.029	0.679HisHis: 0.679 ± 0.015	0.668HisIle: 0.668 ± 0.014	0.31HisLys: 0.31 ± 0.011	2.528HisLeu: 2.528 ± 0.032	0.346HisMet: 0.346 ± 0.012	0.376HisAsn: 0.376 ± 0.013	1.741HisPro: 1.741 ± 0.023	0.636HisGln: 0.636 ± 0.015	1.958HisArg: 1.958 ± 0.025	0.92HisSer: 0.92 ± 0.017	1.072HisThr: 1.072 ± 0.016	1.881HisVal: 1.881 ± 0.025	0.348HisTrp: 0.348 ± 0.01	0.51HisTyr: 0.51 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.148IleAla: 5.148 ± 0.049	0.33IleCys: 0.33 ± 0.01	2.527IleAsp: 2.527 ± 0.032	2.282IleGlu: 2.282 ± 0.029	0.911IlePhe: 0.911 ± 0.019	3.661IleGly: 3.661 ± 0.034	0.644IleHis: 0.644 ± 0.014	1.093IleIle: 1.093 ± 0.021	0.785IleLys: 0.785 ± 0.019	2.664IleLeu: 2.664 ± 0.032	0.602IleMet: 0.602 ± 0.014	0.736IleAsn: 0.736 ± 0.017	1.879IlePro: 1.879 ± 0.026	0.781IleGln: 0.781 ± 0.016	2.536IleArg: 2.536 ± 0.03	1.983IleSer: 1.983 ± 0.028	2.431IleThr: 2.431 ± 0.028	3.229IleVal: 3.229 ± 0.032	0.47IleTrp: 0.47 ± 0.014	0.667IleTyr: 0.667 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.609LysAla: 2.609 ± 0.035	0.117LysCys: 0.117 ± 0.007	1.133LysAsp: 1.133 ± 0.021	1.193LysGlu: 1.193 ± 0.023	0.418LysPhe: 0.418 ± 0.012	1.74LysGly: 1.74 ± 0.026	0.419LysHis: 0.419 ± 0.012	0.911LysIle: 0.911 ± 0.019	0.634LysLys: 0.634 ± 0.02	1.972LysLeu: 1.972 ± 0.025	0.36LysMet: 0.36 ± 0.01	0.43LysAsn: 0.43 ± 0.015	1.266LysPro: 1.266 ± 0.023	0.654LysGln: 0.654 ± 0.016	1.403LysArg: 1.403 ± 0.024	1.014LysSer: 1.014 ± 0.02	1.149LysThr: 1.149 ± 0.025	1.912LysVal: 1.912 ± 0.029	0.272LysTrp: 0.272 ± 0.009	0.41LysTyr: 0.41 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.2LeuAla: 16.2 ± 0.094	0.778LeuCys: 0.778 ± 0.017	6.752LeuAsp: 6.752 ± 0.052	4.93LeuGlu: 4.93 ± 0.039	2.734LeuPhe: 2.734 ± 0.035	9.504LeuGly: 9.504 ± 0.064	2.167LeuHis: 2.167 ± 0.024	3.842LeuIle: 3.842 ± 0.041	1.945LeuLys: 1.945 ± 0.028	11.37LeuLeu: 11.37 ± 0.078	1.822LeuMet: 1.822 ± 0.026	1.779LeuAsn: 1.779 ± 0.025	6.427LeuPro: 6.427 ± 0.051	2.16LeuGln: 2.16 ± 0.028	8.99LeuArg: 8.99 ± 0.063	5.669LeuSer: 5.669 ± 0.045	6.498LeuThr: 6.498 ± 0.045	9.157LeuVal: 9.157 ± 0.06	1.332LeuTrp: 1.332 ± 0.022	1.932LeuTyr: 1.932 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.497MetAla: 2.497 ± 0.028	0.133MetCys: 0.133 ± 0.007	0.928MetAsp: 0.928 ± 0.019	0.861MetGlu: 0.861 ± 0.016	0.53MetPhe: 0.53 ± 0.014	1.433MetGly: 1.433 ± 0.022	0.349MetHis: 0.349 ± 0.009	0.862MetIle: 0.862 ± 0.016	0.459MetLys: 0.459 ± 0.013	1.954MetLeu: 1.954 ± 0.029	0.359MetMet: 0.359 ± 0.01	0.432MetAsn: 0.432 ± 0.011	1.179MetPro: 1.179 ± 0.022	0.407MetGln: 0.407 ± 0.011	1.715MetArg: 1.715 ± 0.022	1.38MetSer: 1.38 ± 0.022	1.549MetThr: 1.549 ± 0.021	1.469MetVal: 1.469 ± 0.022	0.254MetTrp: 0.254 ± 0.009	0.347MetTyr: 0.347 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.144AsnAla: 2.144 ± 0.029	0.141AsnCys: 0.141 ± 0.007	0.969AsnAsp: 0.969 ± 0.019	0.815AsnGlu: 0.815 ± 0.02	0.477AsnPhe: 0.477 ± 0.013	1.898AsnGly: 1.898 ± 0.031	0.375AsnHis: 0.375 ± 0.011	0.632AsnIle: 0.632 ± 0.015	0.37AsnLys: 0.37 ± 0.014	1.827AsnLeu: 1.827 ± 0.024	0.291AsnMet: 0.291 ± 0.01	0.408AsnAsn: 0.408 ± 0.015	1.367AsnPro: 1.367 ± 0.021	0.517AsnGln: 0.517 ± 0.015	1.296AsnArg: 1.296 ± 0.023	0.831AsnSer: 0.831 ± 0.018	1.015AsnThr: 1.015 ± 0.02	1.506AsnVal: 1.506 ± 0.024	0.294AsnTrp: 0.294 ± 0.01	0.413AsnTyr: 0.413 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.266ProAla: 8.266 ± 0.064	0.343ProCys: 0.343 ± 0.01	4.322ProAsp: 4.322 ± 0.043	4.158ProGlu: 4.158 ± 0.039	1.619ProPhe: 1.619 ± 0.025	6.73ProGly: 6.73 ± 0.047	1.285ProHis: 1.285 ± 0.021	1.745ProIle: 1.745 ± 0.024	1.107ProLys: 1.107 ± 0.019	5.272ProLeu: 5.272 ± 0.037	1.144ProMet: 1.144 ± 0.018	0.923ProAsn: 0.923 ± 0.019	3.739ProPro: 3.739 ± 0.045	1.487ProGln: 1.487 ± 0.022	3.984ProArg: 3.984 ± 0.04	3.325ProSer: 3.325 ± 0.038	2.878ProThr: 2.878 ± 0.037	5.165ProVal: 5.165 ± 0.04	0.963ProTrp: 0.963 ± 0.018	1.526ProTyr: 1.526 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.065GlnAla: 4.065 ± 0.038	0.146GlnCys: 0.146 ± 0.006	1.277GlnAsp: 1.277 ± 0.018	1.465GlnGlu: 1.465 ± 0.025	0.673GlnPhe: 0.673 ± 0.016	2.181GlnGly: 2.181 ± 0.026	0.577GlnHis: 0.577 ± 0.012	1.176GlnIle: 1.176 ± 0.018	0.519GlnLys: 0.519 ± 0.014	2.791GlnLeu: 2.791 ± 0.032	0.477GlnMet: 0.477 ± 0.013	0.474GlnAsn: 0.474 ± 0.011	1.677GlnPro: 1.677 ± 0.031	1.06GlnGln: 1.06 ± 0.028	2.318GlnArg: 2.318 ± 0.027	1.191GlnSer: 1.191 ± 0.021	1.266GlnThr: 1.266 ± 0.023	2.608GlnVal: 2.608 ± 0.032	0.47GlnTrp: 0.47 ± 0.013	0.528GlnTyr: 0.528 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.029ArgAla: 10.029 ± 0.07	0.6ArgCys: 0.6 ± 0.017	4.447ArgAsp: 4.447 ± 0.034	4.845ArgGlu: 4.845 ± 0.04	2.446ArgPhe: 2.446 ± 0.03	5.84ArgGly: 5.84 ± 0.043	2.294ArgHis: 2.294 ± 0.028	3.192ArgIle: 3.192 ± 0.031	1.608ArgLys: 1.608 ± 0.024	9.79ArgLeu: 9.79 ± 0.067	1.923ArgMet: 1.923 ± 0.024	1.378ArgAsn: 1.378 ± 0.022	5.091ArgPro: 5.091 ± 0.048	2.484ArgGln: 2.484 ± 0.026	8.26ArgArg: 8.26 ± 0.067	3.978ArgSer: 3.978 ± 0.039	4.722ArgThr: 4.722 ± 0.041	6.345ArgVal: 6.345 ± 0.053	1.47ArgTrp: 1.47 ± 0.024	1.917ArgTyr: 1.917 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.324SerAla: 6.324 ± 0.05	0.427SerCys: 0.427 ± 0.011	2.623SerAsp: 2.623 ± 0.028	2.425SerGlu: 2.425 ± 0.028	1.597SerPhe: 1.597 ± 0.023	5.911SerGly: 5.911 ± 0.048	0.989SerHis: 0.989 ± 0.019	1.727SerIle: 1.727 ± 0.025	0.974SerLys: 0.974 ± 0.018	4.816SerLeu: 4.816 ± 0.046	1.213SerMet: 1.213 ± 0.021	0.857SerAsn: 0.857 ± 0.018	3.283SerPro: 3.283 ± 0.036	1.255SerGln: 1.255 ± 0.023	3.846SerArg: 3.846 ± 0.034	2.793SerSer: 2.793 ± 0.037	2.864SerThr: 2.864 ± 0.032	4.182SerVal: 4.182 ± 0.038	1.015SerTrp: 1.015 ± 0.019	1.22SerTyr: 1.22 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	7.589ThrAla: 7.589 ± 0.06	0.456ThrCys: 0.456 ± 0.013	2.966ThrAsp: 2.966 ± 0.034	2.711ThrGlu: 2.711 ± 0.034	1.765ThrPhe: 1.765 ± 0.026	6.158ThrGly: 6.158 ± 0.046	1.096ThrHis: 1.096 ± 0.021	2.099ThrIle: 2.099 ± 0.028	1.089ThrLys: 1.089 ± 0.022	5.728ThrLeu: 5.728 ± 0.04	1.167ThrMet: 1.167 ± 0.02	0.965ThrAsn: 0.965 ± 0.02	3.828ThrPro: 3.828 ± 0.039	1.292ThrGln: 1.292 ± 0.022	3.958ThrArg: 3.958 ± 0.035	3.118ThrSer: 3.118 ± 0.032	3.497ThrThr: 3.497 ± 0.05	5.475ThrVal: 5.475 ± 0.044	1.005ThrTrp: 1.005 ± 0.017	1.381ThrTyr: 1.381 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.501ValAla: 11.501 ± 0.079	0.708ValCys: 0.708 ± 0.015	4.662ValAsp: 4.662 ± 0.041	4.934ValGlu: 4.934 ± 0.047	2.529ValPhe: 2.529 ± 0.031	6.465ValGly: 6.465 ± 0.051	1.844ValHis: 1.844 ± 0.026	3.331ValIle: 3.331 ± 0.033	1.807ValLys: 1.807 ± 0.027	9.618ValLeu: 9.618 ± 0.069	1.532ValMet: 1.532 ± 0.021	1.731ValAsn: 1.731 ± 0.024	5.249ValPro: 5.249 ± 0.034	1.945ValGln: 1.945 ± 0.028	7.127ValArg: 7.127 ± 0.048	4.696ValSer: 4.696 ± 0.041	5.821ValThr: 5.821 ± 0.04	8.019ValVal: 8.019 ± 0.06	1.162ValTrp: 1.162 ± 0.019	1.639ValTyr: 1.639 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.694TrpAla: 1.694 ± 0.028	0.157TrpCys: 0.157 ± 0.007	0.851TrpAsp: 0.851 ± 0.018	0.77TrpGlu: 0.77 ± 0.017	0.515TrpPhe: 0.515 ± 0.014	1.104TrpGly: 1.104 ± 0.021	0.428TrpHis: 0.428 ± 0.012	0.6TrpIle: 0.6 ± 0.013	0.354TrpLys: 0.354 ± 0.011	1.91TrpLeu: 1.91 ± 0.027	0.324TrpMet: 0.324 ± 0.01	0.446TrpAsn: 0.446 ± 0.013	0.896TrpPro: 0.896 ± 0.018	0.603TrpGln: 0.603 ± 0.014	1.513TrpArg: 1.513 ± 0.026	1.012TrpSer: 1.012 ± 0.019	1.018TrpThr: 1.018 ± 0.02	1.054TrpVal: 1.054 ± 0.021	0.377TrpTrp: 0.377 ± 0.012	0.378TrpTyr: 0.378 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.773TyrAla: 2.773 ± 0.031	0.187TyrCys: 0.187 ± 0.008	1.519TyrAsp: 1.519 ± 0.026	1.23TyrGlu: 1.23 ± 0.022	0.67TyrPhe: 0.67 ± 0.017	2.357TyrGly: 2.357 ± 0.03	0.472TyrHis: 0.472 ± 0.013	0.538TyrIle: 0.538 ± 0.013	0.36TyrLys: 0.36 ± 0.013	2.304TyrLeu: 2.304 ± 0.027	0.285TyrMet: 0.285 ± 0.009	0.441TyrAsn: 0.441 ± 0.014	1.13TyrPro: 1.13 ± 0.02	0.648TyrGln: 0.648 ± 0.016	1.891TyrArg: 1.891 ± 0.025	0.988TyrSer: 0.988 ± 0.02	1.221TyrThr: 1.221 ± 0.023	1.887TyrVal: 1.887 ± 0.024	0.376TyrTrp: 0.376 ± 0.012	0.51TyrTyr: 0.51 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9721 proteins (3182504 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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