Amino acid dipepetide frequency for Neurospora tetrasperma (strain FGSC 2509 / P0656)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.932AlaAla: 9.932 ± 0.069	0.968AlaCys: 0.968 ± 0.014	4.13AlaAsp: 4.13 ± 0.033	5.249AlaGlu: 5.249 ± 0.048	2.793AlaPhe: 2.793 ± 0.026	6.025AlaGly: 6.025 ± 0.045	1.789AlaHis: 1.789 ± 0.018	3.879AlaIle: 3.879 ± 0.031	4.306AlaLys: 4.306 ± 0.037	7.168AlaLeu: 7.168 ± 0.048	1.945AlaMet: 1.945 ± 0.021	2.936AlaAsn: 2.936 ± 0.021	5.289AlaPro: 5.289 ± 0.048	3.48AlaGln: 3.48 ± 0.042	4.969AlaArg: 4.969 ± 0.036	7.338AlaSer: 7.338 ± 0.052	5.444AlaThr: 5.444 ± 0.037	5.333AlaVal: 5.333 ± 0.037	1.056AlaTrp: 1.056 ± 0.016	1.976AlaTyr: 1.976 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.872CysAla: 0.872 ± 0.015	0.268CysCys: 0.268 ± 0.008	0.605CysAsp: 0.605 ± 0.013	0.575CysGlu: 0.575 ± 0.011	0.492CysPhe: 0.492 ± 0.012	0.894CysGly: 0.894 ± 0.016	0.341CysHis: 0.341 ± 0.009	0.603CysIle: 0.603 ± 0.011	0.519CysLys: 0.519 ± 0.012	1.175CysLeu: 1.175 ± 0.017	0.255CysMet: 0.255 ± 0.007	0.427CysAsn: 0.427 ± 0.01	0.728CysPro: 0.728 ± 0.013	0.435CysGln: 0.435 ± 0.009	0.742CysArg: 0.742 ± 0.014	0.884CysSer: 0.884 ± 0.015	0.656CysThr: 0.656 ± 0.012	0.731CysVal: 0.731 ± 0.013	0.202CysTrp: 0.202 ± 0.007	0.325CysTyr: 0.325 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.441AspAla: 4.441 ± 0.03	0.585AspCys: 0.585 ± 0.011	4.617AspAsp: 4.617 ± 0.056	4.667AspGlu: 4.667 ± 0.042	2.055AspPhe: 2.055 ± 0.022	4.14AspGly: 4.14 ± 0.033	1.318AspHis: 1.318 ± 0.017	2.775AspIle: 2.775 ± 0.026	2.539AspLys: 2.539 ± 0.029	4.716AspLeu: 4.716 ± 0.035	1.278AspMet: 1.278 ± 0.016	1.994AspAsn: 1.994 ± 0.022	3.325AspPro: 3.325 ± 0.024	1.882AspGln: 1.882 ± 0.019	3.033AspArg: 3.033 ± 0.033	3.945AspSer: 3.945 ± 0.036	2.82AspThr: 2.82 ± 0.021	3.506AspVal: 3.506 ± 0.029	0.861AspTrp: 0.861 ± 0.014	1.542AspTyr: 1.542 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.537GluAla: 5.537 ± 0.047	0.581GluCys: 0.581 ± 0.011	4.414GluAsp: 4.414 ± 0.043	6.752GluGlu: 6.752 ± 0.077	1.828GluPhe: 1.828 ± 0.02	4.154GluGly: 4.154 ± 0.03	1.391GluHis: 1.391 ± 0.016	2.8GluIle: 2.8 ± 0.027	4.082GluLys: 4.082 ± 0.042	5.097GluLeu: 5.097 ± 0.042	1.511GluMet: 1.511 ± 0.017	2.229GluAsn: 2.229 ± 0.023	2.923GluPro: 2.923 ± 0.034	2.714GluGln: 2.714 ± 0.03	4.233GluArg: 4.233 ± 0.042	4.007GluSer: 4.007 ± 0.034	3.407GluThr: 3.407 ± 0.027	3.763GluVal: 3.763 ± 0.03	0.901GluTrp: 0.901 ± 0.015	1.576GluTyr: 1.576 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.8PheAla: 2.8 ± 0.027	0.515PheCys: 0.515 ± 0.009	2.087PheAsp: 2.087 ± 0.02	1.986PheGlu: 1.986 ± 0.021	1.451PhePhe: 1.451 ± 0.023	2.693PheGly: 2.693 ± 0.032	0.881PheHis: 0.881 ± 0.015	1.569PheIle: 1.569 ± 0.018	1.456PheLys: 1.456 ± 0.017	3.152PheLeu: 3.152 ± 0.03	0.745PheMet: 0.745 ± 0.012	1.354PheAsn: 1.354 ± 0.018	1.924PhePro: 1.924 ± 0.021	1.254PheGln: 1.254 ± 0.017	1.878PheArg: 1.878 ± 0.022	2.772PheSer: 2.772 ± 0.025	2.03PheThr: 2.03 ± 0.022	2.172PheVal: 2.172 ± 0.022	0.569PheTrp: 0.569 ± 0.011	0.974PheTyr: 0.974 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.397GlyAla: 5.397 ± 0.043	0.863GlyCys: 0.863 ± 0.016	3.663GlyAsp: 3.663 ± 0.033	3.987GlyGlu: 3.987 ± 0.032	2.641GlyPhe: 2.641 ± 0.022	7.327GlyGly: 7.327 ± 0.089	1.846GlyHis: 1.846 ± 0.022	3.2GlyIle: 3.2 ± 0.031	3.671GlyLys: 3.671 ± 0.03	5.805GlyLeu: 5.805 ± 0.038	1.68GlyMet: 1.68 ± 0.021	2.792GlyAsn: 2.792 ± 0.034	3.673GlyPro: 3.673 ± 0.031	2.797GlyGln: 2.797 ± 0.032	4.416GlyArg: 4.416 ± 0.037	6.101GlySer: 6.101 ± 0.052	4.18GlyThr: 4.18 ± 0.032	4.329GlyVal: 4.329 ± 0.035	1.162GlyTrp: 1.162 ± 0.017	2.106GlyTyr: 2.106 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.796HisAla: 1.796 ± 0.021	0.337HisCys: 0.337 ± 0.009	1.355HisAsp: 1.355 ± 0.015	1.317HisGlu: 1.317 ± 0.016	0.881HisPhe: 0.881 ± 0.015	1.882HisGly: 1.882 ± 0.025	1.21HisHis: 1.21 ± 0.022	1.12HisIle: 1.12 ± 0.015	0.957HisLys: 0.957 ± 0.013	2.191HisLeu: 2.191 ± 0.028	0.508HisMet: 0.508 ± 0.011	0.938HisAsn: 0.938 ± 0.016	1.806HisPro: 1.806 ± 0.022	1.256HisGln: 1.256 ± 0.023	1.593HisArg: 1.593 ± 0.02	1.896HisSer: 1.896 ± 0.023	1.285HisThr: 1.285 ± 0.016	1.388HisVal: 1.388 ± 0.019	0.321HisTrp: 0.321 ± 0.009	0.709HisTyr: 0.709 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.729IleAla: 3.729 ± 0.028	0.655IleCys: 0.655 ± 0.011	2.61IleAsp: 2.61 ± 0.021	2.635IleGlu: 2.635 ± 0.027	1.707IlePhe: 1.707 ± 0.023	2.794IleGly: 2.794 ± 0.031	1.12IleHis: 1.12 ± 0.016	2.27IleIle: 2.27 ± 0.028	2.237IleLys: 2.237 ± 0.023	3.989IleLeu: 3.989 ± 0.031	0.962IleMet: 0.962 ± 0.013	1.734IleAsn: 1.734 ± 0.02	3.059IlePro: 3.059 ± 0.025	1.752IleGln: 1.752 ± 0.02	2.672IleArg: 2.672 ± 0.023	3.48IleSer: 3.48 ± 0.026	2.799IleThr: 2.799 ± 0.026	2.828IleVal: 2.828 ± 0.027	0.651IleTrp: 0.651 ± 0.012	1.246IleTyr: 1.246 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.503LysAla: 4.503 ± 0.04	0.506LysCys: 0.506 ± 0.009	2.844LysAsp: 2.844 ± 0.026	3.945LysGlu: 3.945 ± 0.039	1.443LysPhe: 1.443 ± 0.018	3.304LysGly: 3.304 ± 0.027	1.129LysHis: 1.129 ± 0.015	2.19LysIle: 2.19 ± 0.022	4.013LysLys: 4.013 ± 0.049	4.041LysLeu: 4.041 ± 0.033	1.062LysMet: 1.062 ± 0.016	1.809LysAsn: 1.809 ± 0.022	2.947LysPro: 2.947 ± 0.029	2.001LysGln: 2.001 ± 0.022	3.686LysArg: 3.686 ± 0.031	3.427LysSer: 3.427 ± 0.03	2.976LysThr: 2.976 ± 0.029	2.907LysVal: 2.907 ± 0.029	0.713LysTrp: 0.713 ± 0.012	1.305LysTyr: 1.305 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.426LeuAla: 7.426 ± 0.04	1.122LeuCys: 1.122 ± 0.017	4.875LeuAsp: 4.875 ± 0.039	5.26LeuGlu: 5.26 ± 0.043	3.04LeuPhe: 3.04 ± 0.031	5.675LeuGly: 5.675 ± 0.039	2.086LeuHis: 2.086 ± 0.022	3.524LeuIle: 3.524 ± 0.035	4.159LeuLys: 4.159 ± 0.034	7.753LeuLeu: 7.753 ± 0.059	1.71LeuMet: 1.71 ± 0.021	3.012LeuAsn: 3.012 ± 0.026	5.636LeuPro: 5.636 ± 0.048	3.49LeuGln: 3.49 ± 0.029	5.479LeuArg: 5.479 ± 0.043	6.817LeuSer: 6.817 ± 0.042	4.681LeuThr: 4.681 ± 0.037	5.141LeuVal: 5.141 ± 0.044	1.12LeuTrp: 1.12 ± 0.015	2.123LeuTyr: 2.123 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.253MetAla: 2.253 ± 0.024	0.24MetCys: 0.24 ± 0.007	1.277MetAsp: 1.277 ± 0.017	1.384MetGlu: 1.384 ± 0.015	0.682MetPhe: 0.682 ± 0.012	1.602MetGly: 1.602 ± 0.022	0.452MetHis: 0.452 ± 0.009	0.887MetIle: 0.887 ± 0.013	1.007MetLys: 1.007 ± 0.015	1.734MetLeu: 1.734 ± 0.019	0.593MetMet: 0.593 ± 0.01	0.744MetAsn: 0.744 ± 0.014	1.298MetPro: 1.298 ± 0.019	0.797MetGln: 0.797 ± 0.012	1.258MetArg: 1.258 ± 0.018	1.876MetSer: 1.876 ± 0.017	1.344MetThr: 1.344 ± 0.019	1.365MetVal: 1.365 ± 0.019	0.257MetTrp: 0.257 ± 0.008	0.502MetTyr: 0.502 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.939AsnAla: 2.939 ± 0.027	0.427AsnCys: 0.427 ± 0.009	1.982AsnAsp: 1.982 ± 0.021	1.963AsnGlu: 1.963 ± 0.02	1.302AsnPhe: 1.302 ± 0.016	3.208AsnGly: 3.208 ± 0.037	0.951AsnHis: 0.951 ± 0.015	1.877AsnIle: 1.877 ± 0.02	1.789AsnLys: 1.789 ± 0.023	3.101AsnLeu: 3.101 ± 0.028	0.859AsnMet: 0.859 ± 0.015	1.997AsnAsn: 1.997 ± 0.035	2.596AsnPro: 2.596 ± 0.023	1.39AsnGln: 1.39 ± 0.02	2.017AsnArg: 2.017 ± 0.019	2.8AsnSer: 2.8 ± 0.028	2.255AsnThr: 2.255 ± 0.025	2.157AsnVal: 2.157 ± 0.023	0.532AsnTrp: 0.532 ± 0.011	1.031AsnTyr: 1.031 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.782ProAla: 5.782 ± 0.051	0.55ProCys: 0.55 ± 0.012	3.165ProAsp: 3.165 ± 0.028	3.864ProGlu: 3.864 ± 0.039	2.017ProPhe: 2.017 ± 0.022	4.303ProGly: 4.303 ± 0.038	1.445ProHis: 1.445 ± 0.019	2.619ProIle: 2.619 ± 0.023	2.924ProLys: 2.924 ± 0.031	4.86ProLeu: 4.86 ± 0.031	1.144ProMet: 1.144 ± 0.017	2.356ProAsn: 2.356 ± 0.023	6.264ProPro: 6.264 ± 0.076	2.732ProGln: 2.732 ± 0.04	3.679ProArg: 3.679 ± 0.036	6.647ProSer: 6.647 ± 0.066	4.52ProThr: 4.52 ± 0.04	3.899ProVal: 3.899 ± 0.036	0.728ProTrp: 0.728 ± 0.013	1.516ProTyr: 1.516 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.546GlnAla: 3.546 ± 0.037	0.433GlnCys: 0.433 ± 0.01	1.992GlnAsp: 1.992 ± 0.021	2.573GlnGlu: 2.573 ± 0.027	1.226GlnPhe: 1.226 ± 0.016	2.529GlnGly: 2.529 ± 0.026	1.273GlnHis: 1.273 ± 0.022	1.722GlnIle: 1.722 ± 0.019	2.061GlnLys: 2.061 ± 0.021	3.343GlnLeu: 3.343 ± 0.027	0.875GlnMet: 0.875 ± 0.018	1.488GlnAsn: 1.488 ± 0.017	3.024GlnPro: 3.024 ± 0.04	3.998GlnGln: 3.998 ± 0.085	2.743GlnArg: 2.743 ± 0.027	3.044GlnSer: 3.044 ± 0.03	2.344GlnThr: 2.344 ± 0.025	2.213GlnVal: 2.213 ± 0.025	0.537GlnTrp: 0.537 ± 0.01	1.106GlnTyr: 1.106 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.724ArgAla: 4.724 ± 0.034	0.722ArgCys: 0.722 ± 0.014	3.417ArgAsp: 3.417 ± 0.039	4.144ArgGlu: 4.144 ± 0.04	2.058ArgPhe: 2.058 ± 0.026	4.024ArgGly: 4.024 ± 0.039	1.67ArgHis: 1.67 ± 0.021	2.716ArgIle: 2.716 ± 0.026	3.597ArgLys: 3.597 ± 0.032	5.294ArgLeu: 5.294 ± 0.039	1.35ArgMet: 1.35 ± 0.018	2.279ArgAsn: 2.279 ± 0.021	3.827ArgPro: 3.827 ± 0.033	2.751ArgGln: 2.751 ± 0.028	5.413ArgArg: 5.413 ± 0.053	4.891ArgSer: 4.891 ± 0.045	3.331ArgThr: 3.331 ± 0.027	3.354ArgVal: 3.354 ± 0.024	0.906ArgTrp: 0.906 ± 0.012	1.642ArgTyr: 1.642 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.703SerAla: 6.703 ± 0.045	0.851SerCys: 0.851 ± 0.013	4.132SerAsp: 4.132 ± 0.038	4.053SerGlu: 4.053 ± 0.034	2.787SerPhe: 2.787 ± 0.026	5.867SerGly: 5.867 ± 0.049	2.039SerHis: 2.039 ± 0.023	3.578SerIle: 3.578 ± 0.029	3.646SerLys: 3.646 ± 0.035	6.826SerLeu: 6.826 ± 0.041	1.639SerMet: 1.639 ± 0.019	3.069SerAsn: 3.069 ± 0.029	6.014SerPro: 6.014 ± 0.066	3.29SerGln: 3.29 ± 0.032	5.088SerArg: 5.088 ± 0.042	9.897SerSer: 9.897 ± 0.098	5.851SerThr: 5.851 ± 0.046	4.516SerVal: 4.516 ± 0.03	1.045SerTrp: 1.045 ± 0.018	1.922SerTyr: 1.922 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.462ThrAla: 5.462 ± 0.037	0.731ThrCys: 0.731 ± 0.013	2.813ThrAsp: 2.813 ± 0.024	3.185ThrGlu: 3.185 ± 0.031	2.084ThrPhe: 2.084 ± 0.024	4.325ThrGly: 4.325 ± 0.038	1.339ThrHis: 1.339 ± 0.017	2.955ThrIle: 2.955 ± 0.031	2.82ThrLys: 2.82 ± 0.025	4.986ThrLeu: 4.986 ± 0.037	1.181ThrMet: 1.181 ± 0.017	2.181ThrAsn: 2.181 ± 0.021	4.737ThrPro: 4.737 ± 0.043	2.158ThrGln: 2.158 ± 0.02	3.248ThrArg: 3.248 ± 0.028	5.648ThrSer: 5.648 ± 0.045	5.404ThrThr: 5.404 ± 0.053	3.717ThrVal: 3.717 ± 0.037	0.775ThrTrp: 0.775 ± 0.014	1.494ThrTyr: 1.494 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.148ValAla: 5.148 ± 0.038	0.786ValCys: 0.786 ± 0.013	3.652ValAsp: 3.652 ± 0.03	4.012ValGlu: 4.012 ± 0.041	2.205ValPhe: 2.205 ± 0.027	3.964ValGly: 3.964 ± 0.034	1.357ValHis: 1.357 ± 0.018	2.753ValIle: 2.753 ± 0.025	3.016ValLys: 3.016 ± 0.028	5.183ValLeu: 5.183 ± 0.039	1.323ValMet: 1.323 ± 0.016	2.171ValAsn: 2.171 ± 0.021	3.874ValPro: 3.874 ± 0.032	2.279ValGln: 2.279 ± 0.025	3.472ValArg: 3.472 ± 0.026	4.494ValSer: 4.494 ± 0.034	3.517ValThr: 3.517 ± 0.029	4.335ValVal: 4.335 ± 0.037	0.859ValTrp: 0.859 ± 0.016	1.625ValTyr: 1.625 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.073TrpAla: 1.073 ± 0.014	0.208TrpCys: 0.208 ± 0.006	0.849TrpAsp: 0.849 ± 0.014	0.867TrpGlu: 0.867 ± 0.015	0.507TrpPhe: 0.507 ± 0.012	0.928TrpGly: 0.928 ± 0.016	0.337TrpHis: 0.337 ± 0.008	0.65TrpIle: 0.65 ± 0.012	0.823TrpLys: 0.823 ± 0.013	1.243TrpLeu: 1.243 ± 0.017	0.368TrpMet: 0.368 ± 0.009	0.573TrpAsn: 0.573 ± 0.012	0.592TrpPro: 0.592 ± 0.011	0.536TrpGln: 0.536 ± 0.01	0.928TrpArg: 0.928 ± 0.014	0.972TrpSer: 0.972 ± 0.016	0.862TrpThr: 0.862 ± 0.013	0.864TrpVal: 0.864 ± 0.015	0.275TrpTrp: 0.275 ± 0.007	0.403TrpTyr: 0.403 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.943TyrAla: 1.943 ± 0.023	0.381TyrCys: 0.381 ± 0.01	1.558TyrAsp: 1.558 ± 0.02	1.482TyrGlu: 1.482 ± 0.019	1.063TyrPhe: 1.063 ± 0.016	1.999TyrGly: 1.999 ± 0.023	0.771TyrHis: 0.771 ± 0.014	1.245TyrIle: 1.245 ± 0.016	1.126TyrLys: 1.126 ± 0.016	2.473TyrLeu: 2.473 ± 0.028	0.562TyrMet: 0.562 ± 0.01	1.092TyrAsn: 1.092 ± 0.018	1.48TyrPro: 1.48 ± 0.019	1.079TyrGln: 1.079 ± 0.017	1.562TyrArg: 1.562 ± 0.017	1.877TyrSer: 1.877 ± 0.018	1.536TyrThr: 1.536 ± 0.02	1.506TyrVal: 1.506 ± 0.02	0.387TyrTrp: 0.387 ± 0.009	0.89TyrTyr: 0.89 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11177 proteins (4951514 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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