Hepatitis C virus genotype 1a (isolate H77) (HCV)

Taxonomy: Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Hepacivirus; Hepacivirus C; Hepatitis C virus genotype 1; Hepatitis C virus subtype 1a

Average proteome isoelectric point is 8.35

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 2 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
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* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    

Protein with the lowest isoelectric point:
>sp|P27958|POLG_HCV77 Genome polyprotein OS=Hepatitis C virus genotype 1a (isolate H77) OX=63746 PE=1 SV=3
MM1 pKa = 7.02STNPKK6 pKa = 8.89PQRR9 pKa = 11.84KK10 pKa = 6.64TKK12 pKa = 10.42RR13 pKa = 11.84NTNRR17 pKa = 11.84RR18 pKa = 11.84PQDD21 pKa = 3.19VKK23 pKa = 11.12FPGGGQIVGGVYY35 pKa = 10.66LLPRR39 pKa = 11.84RR40 pKa = 11.84GPRR43 pKa = 11.84LGVRR47 pKa = 11.84ATRR50 pKa = 11.84KK51 pKa = 7.58TSEE54 pKa = 3.85RR55 pKa = 11.84SQPRR59 pKa = 11.84GRR61 pKa = 11.84RR62 pKa = 11.84QPIPKK67 pKa = 9.59ARR69 pKa = 11.84RR70 pKa = 11.84PEE72 pKa = 3.84GRR74 pKa = 11.84TWAQPGYY81 pKa = 9.32PWPLYY86 pKa = 10.66GNEE89 pKa = 4.09GCGWAGWLLSPRR101 pKa = 11.84GSRR104 pKa = 11.84PSWGPTDD111 pKa = 3.29PRR113 pKa = 11.84RR114 pKa = 11.84RR115 pKa = 11.84SRR117 pKa = 11.84NLGKK121 pKa = 10.85VIDD124 pKa = 3.97TLTCGFADD132 pKa = 3.75LMGYY136 pKa = 9.34IPLVGAPLGGAARR149 pKa = 11.84ALAHH153 pKa = 5.78GVRR156 pKa = 11.84VLEE159 pKa = 5.04DD160 pKa = 3.44GVNYY164 pKa = 8.67ATGNLPGCSFSIFLLALLSCLTVPASAYY192 pKa = 7.58QVRR195 pKa = 11.84NSSGLYY201 pKa = 10.01HH202 pKa = 5.77VTNDD206 pKa = 3.94CPNSSVVYY214 pKa = 9.19EE215 pKa = 4.02AADD218 pKa = 4.68AILHH222 pKa = 5.76TPGCVPCVRR231 pKa = 11.84EE232 pKa = 4.55GNASRR237 pKa = 11.84CWVAVTPTVATRR249 pKa = 11.84DD250 pKa = 3.51GKK252 pKa = 11.25LPTTQLRR259 pKa = 11.84RR260 pKa = 11.84HH261 pKa = 6.37IDD263 pKa = 3.6LLVGSATLCSALYY276 pKa = 10.88VGDD279 pKa = 3.7LCGSVFLVGQLFTFSPRR296 pKa = 11.84HH297 pKa = 5.22HH298 pKa = 6.95WTTQDD303 pKa = 4.11CNCSIYY309 pKa = 9.95PGHH312 pKa = 6.19ITGHH316 pKa = 5.05RR317 pKa = 11.84MAWNMMMNWSPTAALVVAQLLRR339 pKa = 11.84IPQAIMDD346 pKa = 4.91MIAGAHH352 pKa = 5.67WGVLAGIKK360 pKa = 9.59YY361 pKa = 10.47FSMVGNWAKK370 pKa = 10.94VLVVLLLFAGVDD382 pKa = 3.57AEE384 pKa = 4.48THH386 pKa = 4.24VTGGNAGRR394 pKa = 11.84TTAGLVGLLTPGAKK408 pKa = 9.75QNIQLINTNGSWHH421 pKa = 6.65INSTALNCNEE431 pKa = 4.19SLNTGWLAGLFYY443 pKa = 9.73QHH445 pKa = 6.89KK446 pKa = 9.47FNSSGCPEE454 pKa = 4.06RR455 pKa = 11.84LASCRR460 pKa = 11.84RR461 pKa = 11.84LTDD464 pKa = 4.35FAQGWGPISYY474 pKa = 10.96ANGSGLDD481 pKa = 3.41EE482 pKa = 5.9RR483 pKa = 11.84PYY485 pKa = 10.22CWHH488 pKa = 6.35YY489 pKa = 10.29PPRR492 pKa = 11.84PCGIVPAKK500 pKa = 9.97SVCGPVYY507 pKa = 10.55CFTPSPVVVGTTDD520 pKa = 3.09RR521 pKa = 11.84SGAPTYY527 pKa = 11.0SWGANDD533 pKa = 3.4TDD535 pKa = 4.23VFVLNNTRR543 pKa = 11.84PPLGNWFGCTWMNSTGFTKK562 pKa = 10.5VCGAPPCVIGGVGNNTLLCPTDD584 pKa = 3.81CFRR587 pKa = 11.84KK588 pKa = 10.09YY589 pKa = 10.54PEE591 pKa = 4.06ATYY594 pKa = 10.48SRR596 pKa = 11.84CGSGPRR602 pKa = 11.84ITPRR606 pKa = 11.84CMVDD610 pKa = 2.96YY611 pKa = 9.47PYY613 pKa = 11.11RR614 pKa = 11.84LWHH617 pKa = 5.87YY618 pKa = 9.2PCTINYY624 pKa = 7.46TIFKK628 pKa = 9.44VRR630 pKa = 11.84MYY632 pKa = 10.87VGGVEE637 pKa = 4.23HH638 pKa = 7.17RR639 pKa = 11.84LEE641 pKa = 4.47AACNWTRR648 pKa = 11.84GEE650 pKa = 4.08RR651 pKa = 11.84CDD653 pKa = 5.26LEE655 pKa = 5.56DD656 pKa = 4.43RR657 pKa = 11.84DD658 pKa = 4.2RR659 pKa = 11.84SEE661 pKa = 5.24LSPLLLSTTQWQVLPCSFTTLPALSTGLIHH691 pKa = 6.97LHH693 pKa = 5.11QNIVDD698 pKa = 3.63VQYY701 pKa = 11.06LYY703 pKa = 11.42GVGSSIASWAIKK715 pKa = 9.15WEE717 pKa = 4.14YY718 pKa = 10.9VVLLFLLLADD728 pKa = 4.95ARR730 pKa = 11.84VCSCLWMMLLISQAEE745 pKa = 3.93AALEE749 pKa = 3.82NLVILNAASLAGTHH763 pKa = 6.1GLVSFLVFFCFAWYY777 pKa = 10.26LKK779 pKa = 10.06GRR781 pKa = 11.84WVPGAVYY788 pKa = 10.37ALYY791 pKa = 10.84GMWPLLLLLLALPQRR806 pKa = 11.84AYY808 pKa = 10.83ALDD811 pKa = 3.8TEE813 pKa = 4.98VAASCGGVVLVGLMALTLSPYY834 pKa = 8.32YY835 pKa = 10.31KK836 pKa = 10.1RR837 pKa = 11.84YY838 pKa = 10.03ISWCMWWLQYY848 pKa = 11.18FLTRR852 pKa = 11.84VEE854 pKa = 4.29AQLHH858 pKa = 4.93VWVPPLNVRR867 pKa = 11.84GGRR870 pKa = 11.84DD871 pKa = 3.28AVILLTCVVHH881 pKa = 6.24PALVFDD887 pKa = 3.65ITKK890 pKa = 10.55LLLAIFGPLWILQASLLKK908 pKa = 9.99VPYY911 pKa = 9.43FVRR914 pKa = 11.84VQGLLRR920 pKa = 11.84ICALARR926 pKa = 11.84KK927 pKa = 8.7IAGGHH932 pKa = 4.48YY933 pKa = 9.9VQMAIIKK940 pKa = 10.04LGALTGTCVYY950 pKa = 10.98NHH952 pKa = 7.36LAPLRR957 pKa = 11.84DD958 pKa = 3.39WAHH961 pKa = 5.92NGLRR965 pKa = 11.84DD966 pKa = 3.47LAVAVEE972 pKa = 4.1PVVFSRR978 pKa = 11.84MEE980 pKa = 4.01TKK982 pKa = 10.85LITWGADD989 pKa = 2.86TAACGDD995 pKa = 4.67IINGLPVSARR1005 pKa = 11.84RR1006 pKa = 11.84GQEE1009 pKa = 3.59ILLGPADD1016 pKa = 3.85GMVSKK1021 pKa = 10.42GWRR1024 pKa = 11.84LLAPITAYY1032 pKa = 10.28AQQTRR1037 pKa = 11.84GLLGCIITSLTGRR1050 pKa = 11.84DD1051 pKa = 3.34KK1052 pKa = 11.42NQVEE1056 pKa = 4.54GEE1058 pKa = 4.27VQIVSTATQTFLATCINGVCWTVYY1082 pKa = 10.09HH1083 pKa = 6.4GAGTRR1088 pKa = 11.84TIASPKK1094 pKa = 9.79GPVIQTYY1101 pKa = 9.49TNVDD1105 pKa = 3.03QDD1107 pKa = 4.21LVGWPAPQGSRR1118 pKa = 11.84SLTPCTCGSSDD1129 pKa = 3.64LYY1131 pKa = 11.23LVTRR1135 pKa = 11.84HH1136 pKa = 6.28ADD1138 pKa = 3.45VIPVRR1143 pKa = 11.84RR1144 pKa = 11.84RR1145 pKa = 11.84GDD1147 pKa = 3.24SRR1149 pKa = 11.84GSLLSPRR1156 pKa = 11.84PISYY1160 pKa = 10.76LKK1162 pKa = 10.52GSSGGPLLCPTGHH1175 pKa = 6.91AVGLFRR1181 pKa = 11.84AAVCTRR1187 pKa = 11.84GVAKK1191 pKa = 10.32AVDD1194 pKa = 4.84FIPVEE1199 pKa = 4.0NLEE1202 pKa = 4.23TTMRR1206 pKa = 11.84SPVFTDD1212 pKa = 3.2NSSPPAVPQSFQVAHH1227 pKa = 6.25LHH1229 pKa = 6.36APTGSGKK1236 pKa = 7.57STKK1239 pKa = 10.21VPAAYY1244 pKa = 9.45AAKK1247 pKa = 9.7GYY1249 pKa = 10.15KK1250 pKa = 9.95VLVLNPSVAATLGFGAYY1267 pKa = 8.02MSKK1270 pKa = 10.38AHH1272 pKa = 6.52GVDD1275 pKa = 3.36PNIRR1279 pKa = 11.84TGVRR1283 pKa = 11.84TITTGSPITYY1293 pKa = 8.3STYY1296 pKa = 11.23GKK1298 pKa = 10.11FLADD1302 pKa = 4.15AGCSGGAYY1310 pKa = 10.08DD1311 pKa = 6.15IIICDD1316 pKa = 3.74EE1317 pKa = 4.25CHH1319 pKa = 6.0STDD1322 pKa = 3.09ATSISGIGTVLDD1334 pKa = 3.65QAEE1337 pKa = 4.26TAGARR1342 pKa = 11.84LVVLATATPPGSVTVSHH1359 pKa = 6.82PNIEE1363 pKa = 4.18EE1364 pKa = 4.2VALSTTGEE1372 pKa = 3.72IPFYY1376 pKa = 11.01GKK1378 pKa = 10.47AIPLEE1383 pKa = 4.31VIKK1386 pKa = 10.68GGRR1389 pKa = 11.84HH1390 pKa = 7.03LIFCHH1395 pKa = 6.09SKK1397 pKa = 10.46KK1398 pKa = 10.67KK1399 pKa = 10.24CDD1401 pKa = 3.38EE1402 pKa = 4.26LAAKK1406 pKa = 10.12LVALGINAVAYY1417 pKa = 10.38YY1418 pKa = 10.17RR1419 pKa = 11.84GLDD1422 pKa = 3.32VSVIPTSGDD1431 pKa = 3.46VVVVSTDD1438 pKa = 2.93ALMTGFTGDD1447 pKa = 3.43FDD1449 pKa = 5.59SVIDD1453 pKa = 4.35CNTCVTQTVDD1463 pKa = 4.01FSLDD1467 pKa = 3.24PTFTIEE1473 pKa = 4.28TTTLPQDD1480 pKa = 3.32AVSRR1484 pKa = 11.84TQRR1487 pKa = 11.84RR1488 pKa = 11.84GRR1490 pKa = 11.84TGRR1493 pKa = 11.84GKK1495 pKa = 9.03PGIYY1499 pKa = 9.71RR1500 pKa = 11.84FVAPGEE1506 pKa = 4.31RR1507 pKa = 11.84PSGMFDD1513 pKa = 3.15SSVLCEE1519 pKa = 4.99CYY1521 pKa = 10.23DD1522 pKa = 4.46AGCAWYY1528 pKa = 9.49EE1529 pKa = 3.86LTPAEE1534 pKa = 4.18TTVRR1538 pKa = 11.84LRR1540 pKa = 11.84AYY1542 pKa = 9.06MNTPGLPVCQDD1553 pKa = 3.24HH1554 pKa = 6.85LGFWEE1559 pKa = 5.27GVFTGLTHH1567 pKa = 7.16IDD1569 pKa = 3.13AHH1571 pKa = 6.25FLSQTKK1577 pKa = 9.84QSGEE1581 pKa = 3.84NFPYY1585 pKa = 10.4LVAYY1589 pKa = 8.99QATVCARR1596 pKa = 11.84AQAPPPSWDD1605 pKa = 3.29QMRR1608 pKa = 11.84KK1609 pKa = 9.45CLIRR1613 pKa = 11.84LKK1615 pKa = 9.49PTLHH1619 pKa = 6.57GPTPLLYY1626 pKa = 10.61RR1627 pKa = 11.84LGAVQNEE1634 pKa = 4.33VTLTHH1639 pKa = 7.6PITKK1643 pKa = 10.38YY1644 pKa = 10.98IMTCMSADD1652 pKa = 3.78LEE1654 pKa = 4.94VVTSTWVLVGGVLAALAAYY1673 pKa = 9.06CLSTGCVVIVGRR1685 pKa = 11.84IVLSGKK1691 pKa = 9.21PAIIPDD1697 pKa = 3.83RR1698 pKa = 11.84EE1699 pKa = 3.98VLYY1702 pKa = 10.91QEE1704 pKa = 3.92FDD1706 pKa = 3.34EE1707 pKa = 5.03MEE1709 pKa = 4.51EE1710 pKa = 4.45CSQHH1714 pKa = 6.62LPYY1717 pKa = 10.02IEE1719 pKa = 3.91QGMMLAEE1726 pKa = 4.03QFKK1729 pKa = 10.74QKK1731 pKa = 11.03ALGLLQTASRR1741 pKa = 11.84HH1742 pKa = 5.59AEE1744 pKa = 4.06VITPAVQTNWQKK1756 pKa = 11.64LEE1758 pKa = 4.19VFWAKK1763 pKa = 10.68HH1764 pKa = 3.93MWNFISGIQYY1774 pKa = 10.64LAGLSTLPGNPAIASLMAFTAAVTSPLTTGQTLLFNILGGWVAAQLAAPGAATAFVGAGLAGAALDD1840 pKa = 3.89SVGLGKK1846 pKa = 10.64VLVDD1850 pKa = 3.24ILAGYY1855 pKa = 8.94GAGVAGALVAFKK1867 pKa = 10.47IMSGEE1872 pKa = 4.18VPSTEE1877 pKa = 4.51DD1878 pKa = 4.52LVNLLPAILSPGALAVGVVFASILRR1903 pKa = 11.84RR1904 pKa = 11.84RR1905 pKa = 11.84VGPGEE1910 pKa = 4.82GAVQWMNRR1918 pKa = 11.84LIAFASRR1925 pKa = 11.84GNHH1928 pKa = 5.24VSPTHH1933 pKa = 5.58YY1934 pKa = 10.73VPEE1937 pKa = 4.92SDD1939 pKa = 3.03AAARR1943 pKa = 11.84VTAILSSLTVTQLLRR1958 pKa = 11.84RR1959 pKa = 11.84LHH1961 pKa = 5.2QWISSEE1967 pKa = 4.01CTTPCSGSWLRR1978 pKa = 11.84DD1979 pKa = 2.72IWDD1982 pKa = 4.44WICEE1986 pKa = 4.08VLSDD1990 pKa = 4.42FKK1992 pKa = 10.84TWLKK1996 pKa = 10.72AKK1998 pKa = 10.38LMPQLPGIPFVSCQRR2013 pKa = 11.84GYY2015 pKa = 10.33RR2016 pKa = 11.84GVWRR2020 pKa = 11.84GDD2022 pKa = 3.27GIMHH2026 pKa = 6.34TRR2028 pKa = 11.84CHH2030 pKa = 6.78CGAEE2034 pKa = 4.16ITGHH2038 pKa = 5.15VKK2040 pKa = 10.42NGTMRR2045 pKa = 11.84IVGPRR2050 pKa = 11.84TCKK2053 pKa = 10.73NMWSGTFFINAYY2065 pKa = 5.29TTGPCTPLPAPNYY2078 pKa = 10.05KK2079 pKa = 9.79FALWRR2084 pKa = 11.84VSAEE2088 pKa = 3.84EE2089 pKa = 3.76YY2090 pKa = 10.35VEE2092 pKa = 3.73IRR2094 pKa = 11.84RR2095 pKa = 11.84VGDD2098 pKa = 3.08FHH2100 pKa = 7.55YY2101 pKa = 10.94VSGMTTDD2108 pKa = 4.11NLKK2111 pKa = 10.63CPCQIPSPEE2120 pKa = 4.37FFTEE2124 pKa = 3.82LDD2126 pKa = 3.37GVRR2129 pKa = 11.84LHH2131 pKa = 7.21RR2132 pKa = 11.84FAPPCKK2138 pKa = 8.52PLLRR2142 pKa = 11.84EE2143 pKa = 3.9EE2144 pKa = 4.07VSFRR2148 pKa = 11.84VGLHH2152 pKa = 6.38EE2153 pKa = 4.41YY2154 pKa = 9.9PVGSQLPCEE2163 pKa = 4.63PEE2165 pKa = 3.85PDD2167 pKa = 3.85VAVLTSMLTDD2177 pKa = 4.35PSHH2180 pKa = 6.11ITAEE2184 pKa = 3.99AAGRR2188 pKa = 11.84RR2189 pKa = 11.84LARR2192 pKa = 11.84GSPPSMASSSASQLSAPSLKK2212 pKa = 9.61ATCTANHH2219 pKa = 7.33DD2220 pKa = 4.11SPDD2223 pKa = 3.62AEE2225 pKa = 4.57LIEE2228 pKa = 5.73ANLLWRR2234 pKa = 11.84QEE2236 pKa = 3.79MGGNITRR2243 pKa = 11.84VEE2245 pKa = 4.29SEE2247 pKa = 4.21NKK2249 pKa = 9.79VVILDD2254 pKa = 3.76SFDD2257 pKa = 3.91PLVAEE2262 pKa = 3.98EE2263 pKa = 4.72DD2264 pKa = 3.66EE2265 pKa = 5.33RR2266 pKa = 11.84EE2267 pKa = 4.07VSVPAEE2273 pKa = 3.9ILRR2276 pKa = 11.84KK2277 pKa = 9.2SRR2279 pKa = 11.84RR2280 pKa = 11.84FAPALPVWARR2290 pKa = 11.84PDD2292 pKa = 3.69YY2293 pKa = 11.17NPLLVEE2299 pKa = 4.18TWKK2302 pKa = 11.07KK2303 pKa = 10.12PDD2305 pKa = 3.4YY2306 pKa = 9.87EE2307 pKa = 4.22PPVVHH2312 pKa = 6.88GCPLPPPRR2320 pKa = 11.84SPPVPPPRR2328 pKa = 11.84KK2329 pKa = 9.32KK2330 pKa = 9.26RR2331 pKa = 11.84TVVLTEE2337 pKa = 4.01STLPTALAEE2346 pKa = 4.12LATKK2350 pKa = 10.64SFGSSSTSGITGDD2363 pKa = 3.34NTTTSSEE2370 pKa = 4.21PAPSGCPPDD2379 pKa = 4.46SDD2381 pKa = 4.06VEE2383 pKa = 4.89SYY2385 pKa = 11.76SSMPPLEE2392 pKa = 4.89GEE2394 pKa = 4.49PGDD2397 pKa = 4.71PDD2399 pKa = 4.59LSDD2402 pKa = 4.68GSWSTVSSGADD2413 pKa = 3.22TEE2415 pKa = 5.7DD2416 pKa = 3.75VVCCSMSYY2424 pKa = 9.74SWTGALVTPCAAEE2437 pKa = 4.08EE2438 pKa = 3.95QKK2440 pKa = 11.27LPINALSNSLLRR2452 pKa = 11.84HH2453 pKa = 5.91HH2454 pKa = 6.6NLVYY2458 pKa = 10.19STTSRR2463 pKa = 11.84SACQRR2468 pKa = 11.84KK2469 pKa = 9.69KK2470 pKa = 10.74KK2471 pKa = 9.11VTFDD2475 pKa = 3.28RR2476 pKa = 11.84LQVLDD2481 pKa = 3.64SHH2483 pKa = 6.38YY2484 pKa = 11.03QDD2486 pKa = 3.18VLKK2489 pKa = 10.3EE2490 pKa = 4.1VKK2492 pKa = 10.12AAASKK2497 pKa = 10.94VKK2499 pKa = 10.82ANLLSVEE2506 pKa = 4.58EE2507 pKa = 4.54ACSLAPPHH2515 pKa = 5.95SAKK2518 pKa = 10.84SKK2520 pKa = 9.96FGYY2523 pKa = 8.84GAKK2526 pKa = 10.04DD2527 pKa = 3.57VRR2529 pKa = 11.84CHH2531 pKa = 5.43ARR2533 pKa = 11.84KK2534 pKa = 9.39AVAHH2538 pKa = 6.62INSVWKK2544 pKa = 10.39DD2545 pKa = 3.56LLEE2548 pKa = 5.19DD2549 pKa = 3.65SVTPIDD2555 pKa = 3.68TTIMAKK2561 pKa = 10.35NEE2563 pKa = 4.13VFCVQPEE2570 pKa = 3.99KK2571 pKa = 10.89GGRR2574 pKa = 11.84KK2575 pKa = 7.4PARR2578 pKa = 11.84LIVFPDD2584 pKa = 3.52LGVRR2588 pKa = 11.84VCEE2591 pKa = 4.62KK2592 pKa = 9.4MALYY2596 pKa = 10.52DD2597 pKa = 3.92VVSKK2601 pKa = 11.21LPLAVMGSSYY2611 pKa = 10.91GFQYY2615 pKa = 11.03SPGQRR2620 pKa = 11.84VEE2622 pKa = 4.48FLVQAWKK2629 pKa = 10.61SKK2631 pKa = 7.47KK2632 pKa = 8.39TPMGLSYY2639 pKa = 9.72DD2640 pKa = 3.87TRR2642 pKa = 11.84CFDD2645 pKa = 3.63STVTEE2650 pKa = 3.89SDD2652 pKa = 2.71IRR2654 pKa = 11.84TEE2656 pKa = 3.75EE2657 pKa = 5.27AIYY2660 pKa = 9.91QCCDD2664 pKa = 3.64LDD2666 pKa = 3.69PQARR2670 pKa = 11.84VAIKK2674 pKa = 10.52SLTEE2678 pKa = 3.57RR2679 pKa = 11.84LYY2681 pKa = 11.41VGGPLTNSRR2690 pKa = 11.84GEE2692 pKa = 3.79NCGYY2696 pKa = 9.73RR2697 pKa = 11.84RR2698 pKa = 11.84CRR2700 pKa = 11.84ASRR2703 pKa = 11.84VLTTSCGNTLTRR2715 pKa = 11.84YY2716 pKa = 8.94IKK2718 pKa = 10.68ARR2720 pKa = 11.84AACRR2724 pKa = 11.84AAGLQDD2730 pKa = 3.51CTMLVCGDD2738 pKa = 4.34DD2739 pKa = 3.57LVVICEE2745 pKa = 4.23SAGVQEE2751 pKa = 4.81DD2752 pKa = 3.9AASLRR2757 pKa = 11.84AFTEE2761 pKa = 3.53AMTRR2765 pKa = 11.84YY2766 pKa = 8.86SAPPGDD2772 pKa = 4.37PPQPEE2777 pKa = 4.22YY2778 pKa = 11.02DD2779 pKa = 3.7LEE2781 pKa = 5.89LITSCSSNVSVAHH2794 pKa = 6.84DD2795 pKa = 3.78GAGKK2799 pKa = 9.8RR2800 pKa = 11.84VYY2802 pKa = 10.88YY2803 pKa = 8.66LTRR2806 pKa = 11.84DD2807 pKa = 3.34PTTPLARR2814 pKa = 11.84AAWEE2818 pKa = 4.37TARR2821 pKa = 11.84HH2822 pKa = 5.17TPVNSWLGNIIMFAPTLWARR2842 pKa = 11.84MILMTHH2848 pKa = 6.46FFSVLIARR2856 pKa = 11.84DD2857 pKa = 3.58QLEE2860 pKa = 3.83QALNCEE2866 pKa = 4.7IYY2868 pKa = 10.02GACYY2872 pKa = 10.27SIEE2875 pKa = 4.28PLDD2878 pKa = 4.68LPPIIQRR2885 pKa = 11.84LHH2887 pKa = 5.87GLSAFSLHH2895 pKa = 6.68SYY2897 pKa = 10.7SPGEE2901 pKa = 3.99INRR2904 pKa = 11.84VAACLRR2910 pKa = 11.84KK2911 pKa = 10.11LGVPPLRR2918 pKa = 11.84AWRR2921 pKa = 11.84HH2922 pKa = 4.79RR2923 pKa = 11.84AWSVRR2928 pKa = 11.84ARR2930 pKa = 11.84LLARR2934 pKa = 11.84GGKK2937 pKa = 9.39AAICGKK2943 pKa = 10.11YY2944 pKa = 9.84LFNWAVRR2951 pKa = 11.84TKK2953 pKa = 11.03LKK2955 pKa = 9.21LTPITAAGRR2964 pKa = 11.84LDD2966 pKa = 3.52LSGWFTAGYY2975 pKa = 9.49SGGDD2979 pKa = 3.05IYY2981 pKa = 11.16HH2982 pKa = 6.29SVSHH2986 pKa = 6.73ARR2988 pKa = 11.84PRR2990 pKa = 11.84WFWFCLLLLAAGVGIYY3006 pKa = 10.22LLPNRR3011 pKa = 4.87

Molecular weight:
327.15 kDa
Isoelectric point according different methods:






Protein with the highest isoelectric point:
>sp|P27958|POLG_HCV77 Genome polyprotein OS=Hepatitis C virus genotype 1a (isolate H77) OX=63746 PE=1 SV=3
MM1 pKa = 7.02STNPKK6 pKa = 8.94PQRR9 pKa = 11.84KK10 pKa = 8.75KK11 pKa = 10.41PNVTPTVAHH20 pKa = 6.1RR21 pKa = 11.84TSSSRR26 pKa = 11.84VAVRR30 pKa = 11.84SLVEE34 pKa = 4.58FTCCRR39 pKa = 11.84AGALDD44 pKa = 3.91WVCARR49 pKa = 11.84RR50 pKa = 11.84GRR52 pKa = 11.84LPSGRR57 pKa = 11.84NLEE60 pKa = 4.14VDD62 pKa = 3.43VSLSPRR68 pKa = 11.84HH69 pKa = 5.32VGPRR73 pKa = 11.84AGPGLSPGTLGPSMAMRR90 pKa = 11.84VAGGRR95 pKa = 11.84DD96 pKa = 4.36GSCLPVALGLAGAPQTPGVGRR117 pKa = 11.84AIWVRR122 pKa = 11.84SSIPLRR128 pKa = 11.84AASPTSWGTYY138 pKa = 8.93RR139 pKa = 11.84SSAPLLEE146 pKa = 4.67ALPGPWRR153 pKa = 11.84MASGFWKK160 pKa = 9.08TAA162 pKa = 3.09

Molecular weight:
17.01 kDa
Isoelectric point according different methods:






Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

2

0

2

3173

162

3011

1586.5

172.08

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

9.36 ± 0.772

3.341 ± 0.384

3.845 ± 0.879

3.719 ± 0.823

2.805 ± 0.693

8.541 ± 1.134

2.175 ± 0.415

4.129 ± 1.276

3.215 ± 0.329

10.148 ± 0.664

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.828 ± 0.283

2.868 ± 0.448

7.091 ± 1.773

2.742 ± 0.665

6.272 ± 2.134

7.28 ± 1.689

7.154 ± 0.433

8.005 ± 0.009

2.364 ± 0.319

3.12 ± 1.104

Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski